Percent body fat and lean mass explain the gender difference in leptin: Analysis and interpretation of leptin in Hispanic and non-Hispanic white adults

Obesity Research

Volumn 8, Issue 8, 2000, Pages 543-552

  Marshall, Julie A ^a,b   Grunwald, Gary K ^a   Donahoo, William T ^a   Scarbro, Sharon ^a   Shetterly, Susan M ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Age; Body composition; Dual energy X ray absorptiometry; Serum leptin

Indexed keywords

PIERINAE;

LEPTIN;

ADIPOSE TISSUE; ADULT; AGE; AGED; ARTICLE; BLOOD; BODY COMPOSITION; BODY MASS; CAUCASIAN; COHORT ANALYSIS; DIET RESTRICTION; FEMALE; GENETICS; HISPANIC; HUMAN; MALE; MIDDLE AGED; RADIODENSITOMETRY; REGRESSION ANALYSIS; SEXUAL DEVELOPMENT; SKELETAL MUSCLE;

ADIPOSE TISSUE; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; BODY COMPOSITION; BODY MASS INDEX; COHORT STUDIES; DENSITOMETRY, X-RAY; EUROPEAN CONTINENTAL ANCESTRY GROUP; FASTING; FEMALE; HISPANIC AMERICANS; HUMANS; LEPTIN; MALE; MIDDLE AGED; MUSCLE, SKELETAL; REGRESSION ANALYSIS; SEX CHARACTERISTICS;

EID: 0034332018     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1038/oby.2000.70     Document Type: Article

References (43)

1. Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996;334:292-5.
2. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman J. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425-32.
3. Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 1997;387:903-8.
4. Woods SC, Seeley RJ, Porte D, Schwartz MW. Signals that regulate food intake and energy homeostasis. Science. 1998; 280:1378-83.
5. Schwartz MW, Peskind E, Raskind M, Boyko EJ, Porte D. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med. 1996;2:589-93.
6. Jensen MD, Hensrud D, O'Brien PC, Nielsen S. Collection and interpretation of plasma leptin concentration data in humans. Obes Res. 1999;7:241-5.
7. Hamman RF, Marshall JA, Baxter J, et al. The San Luis Valley Diabetes Study: methods and prevalence of non-insulin-dependent diabetes mellitus. Am J Epidemiol. 1989;129: 295-311.
8. World Health Organization. Diabetes Mellitus: Report of a WHO Study Group. Geneva: World Health Organization; 1985. Technical Report Series No. 727.
9. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986;Feb 8:307-10.
10. Neter J, Kutner MH, Nachtscheim CJ, Wasserman W. Applied Linear Statistical Models. 4th ed. Chicago: McGraw-Hill; 1996, pp. 474-7.
11. Havel PJ, Kasim-Karakas S, Dubuc GR, Mueller W, Phinney SD. Gender differences in plasma leptin concentrations. Nat Med. 1996;2:949-50.
12. Rosenbaum M, Nicolson M, Hirsch J, et al. Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrin Metab. 1996;81:3424-7.
13. Bennett FI, McFarlane-Anderson N, Wilks R, Luke A, Cooper RS, Forrester TE. Leptin concentrations in women is influenced by regional distribution of adipose tissue. Am J Clin Nutr. 1997;66:1340-4.
14. Ellis KJ, Micolson M. Leptin levels and body fatness in children: effects of gender, ethnicity, and sexual development. Pediatr Res. 1997;42:484-8.
15. Sumner AE, Galkner B, Kushner H, Considine RV. Relationship of leptin concentration to gender, menopause, age, diabetes, and fat mass in African Americans. Obes Res. 1998;6:128-33.
16. 2 data. J Appl Physiol. 1993:2238-92.
17. Allison DB, Paultre F, Goran MI, Poehlman ET, Heymsfield SB. Statistical considerations regarding the use of ratios to adjust data. Int J Obes. 1995;19:644-52.
18. Wei M, Stern MP, Haffner SM. Serum leptin levels in Mexican Americans and non-Hispanic whites: association with body mass index and cigarette smoking. Ann Epidemiol. 1997;7:81-6.
19. Akaike H. Information theory and an extension of the maximum likelihood principle. In: Petrov BN, Csaki F, eds. Second International Symposium on Information Theory. Budapest: Akademia Kaido; 1973, pp. 267-81.
20. Akaike H. On entropy maximization principle. In: Krishnaiah PR, ed. Applications of Statistics. Amsterdam: North-Holland, 1977, pp. 27-41.
21. Schwarz G. Estimating the dimension of a model. Ann Statistics. 1978;6:461-4.
22. Kaas RE, Raftery AE. Bayes factors. J Am Stat Assoc. 1995;90:773-95.
23. Nagy TR, Gower BA, Trowbridge CA, Dezenberg C, Shewchuk RM, Goran MI. Effects of gender, ethnicity, body composition, and fat distribution on serum leptin concentrations in children. J Clin Endocrinol Metab. 1997;82:2148-52.
24. Ostlund RE, Yang JW, Klein S, Gingerich R. Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. J Clin Endocrinol Metab. 1996;81:3909-13.
25. Hickey MS, Israel RG, Gardiner SN, et al. Gender differences in serum leptin levels in humans. Biochem Molecular Med. 1996;59:1-6.
26. Saad MF, Damani S, Gingerich RL, et al. Sexual dimorphism in plasma leptin concentration. J Clin Endocrinol Metab. 1997;82:579-84.
27. Kennedy A, Gettys TW, Watson P, et al. The metabolic significance of leptin in humans: gender-based differences in relationship between adiposity, insulin sensitivity and energy expenditure. J Clin Endocrinol Metab. 1997;82:1293-300.
28. Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med. 1995;1:1155-61.
29. Vettor R, De Pergola G, Pagano C, et al. Gender differences in serum leptin in obese people: relationships with testosterone, body fat distribution and insulin sensitivity. Eur J Clin Invest. 1997;27:1016-24.
30. Paolisso G, Rizzo MR, Mone CM, et al. Plasma sex hormones are significantly associated with plasma leptin concentration in healthy subjects. Clin Endocrinol. 1998;48:291-7.
31. Behre HM, Simoni M, Nieschlag E. Strong association between serum levels of leptin and testosterone in men. Clin Endocrinol. 1997;47:237-40.
32. Blum WF, Englaro P, Hanitsch S, et al. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. J Clin Endocrinol Metab. 1997;82:2904-10.
33. Wabitsch M, Blum WF, Muche R, et al. Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J Clin Invest. 1997;100: 808-13.
34. Ertl T, Funke S, Sarkany I, et al. Postnatal changes of leptin levels in full-term and preterm neonates: their relation to intrauterine growth, gender and testosterone. Biol Neonate. 1999;75:167-76.
35. Luukkaa V, Pesonen U, Huhtaniemi I, et al. Inverse correlation between serum testosterone and leptin in men. J Clin Endocrinol Metab. 1998;83:3243-6.
36. Elbers JM, Asscheman H, Seidell JC, Frolich M, Meinders AE, Gooren LJ. Reversal of the sex difference in serum leptin levels upon cross-sex hormone administration in transsexuals. J Clin Endocrinol Metab. 1997;82:3267-70.
37. 3-adrenoceptor in the regulation of body composition. J Clin Invest. 1997;100:1098-1106.
38. Nicklas BJ, Toth MJ, Goldberg AP, Poehlman ET. Racial differences in plasma leptin concentrations in obese postmenopausal women. J Clin Endocrinol Metab. 1997;82: 315-7.
39. Ravussin E, Pratley RE, Maffei M, et al. Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nat Med. 1997;3:238-40.
40. Hodge AM, De Courten MP, Dowse GK, et al. Do leptin levels predict weight gain? - a 5-year follow-up study in Mauritius. Obes Res. 1998;6:319-25.
41. Nicklas BJ, Katzel LI, Ryan AS, Dennis KE, Goldberg AP. Gender differences in the response of plasma leptin concentrations to weight loss in obese older individuals. Obes Res. 1997;5:62-8.
42. Nagy TR, Davies SL, Hunter GR, Darnell B, Weinsier RL. Serum leptin concentrations and weight gain in postobese, postmenopausal women. Obes Res. 1998;6:257-61.
43. Comuzzie AG, Hixson JE, Almasy L, et al. A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Nat Genet. 1997;15: 273-5.