Heterogeneity in the clonal T cell response: Implications for models of T cell activation and cytokine phenotype development

Immunologic Research

Volumn 17, Issue 3, 1998, Pages 279-302

  Weaver, Casey T ^a   Saparov, Arman ^a   Kraus, Lisa A ^a   Rogers, William O ^a   Hockett, Richard D ^a   Bucy, R Pat ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Heterogeneity; Phenotype development; Single cell analysis; Th1 Th2

Indexed keywords

CD4 ANTIGEN; CYTOKINE; T LYMPHOCYTE RECEPTOR;

ANALYTIC METHOD; ANIMAL CELL; ANTIGEN SPECIFICITY; APOPTOSIS; GENE EXPRESSION; HELPER CELL; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0031840915     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02786452     Document Type: Review

References (99)

1. + thymocytes controlled by MHC class II gene products. Nature 1988;336:471-473.
2. + T cells mediated by MHC class II-bearing stromal cell in the thymic cortex. Nature 1989;341: 649-651.
3. Berg LJ, Pullen AM, de St. Groth BF, Mathis D, Benoist C, Davis MM: Antigen MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand. Cell 1989;58: 1035-1046.
4. Nilokic-Zugic J, Bevan MJ: Role of self-peptides in positively selecting the T-cell repertoire. Nature 1990; 344:65-67.
5. Shortman K, Egerton M, Spangrude GJ, Scollay RG: The generation and fate of thymocytes. Sem Immunol 1990;2:3-12.
6. Strominger JL: Developmental biology of T cell receptors. Science 1989;244:943-950.
7. Hogquist KA, Jameson SC, Heath WR, Howard JL, Bevan MJ, Carbone FR: T cell receptor antagonist peptides induce positive selection. Cell 1994;76:17-27.
8. + thymocytes and activated mature lymphocytes in normal mice but not in the lupus-prone strain, MRL lpr/lpr. Proc Natl Acad Sci USA 1993;90: 10,340-10,344.
9. Jameson SC, Bevan MJ: T Cell Receptor antagonists and partial agonists. Immunity 1995;2:1-11.
10. Jameson SC, Hogquist KA, Bevan MJ: Positive selection in the thymus. Ann Rev Immunol 1995;13:93-126.
11. Mueller DL, Jenkins MK, Schwartz RH: Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Ann Rev Immunol 1989;7:445-480.
12. Schwartz RH: Acquisition of immunologic self-tolerance. Cell 1989;57: 1073-1081.
13. Weaver CT, Unanue ER: The costimulatory function of antigen-presenting cells. Immunol Today 1990; 11:49-55.
14. Abbas AK: Die and let live: eliminating dangerous lymphocytes. Cell 1996;84:655-657.
15. Butcher EC, Picker LJ: Lymphocyte homing and homeostasis. Science 1996;272:60-66.
16. Nagata S, Golstein P: The Fas death factor. Science 1995;267: 1449-1456.
17. Nagata S, Suda T: Fas and Fas ligand: lpr and gld mutations. Immunol Today 1995;16:39-43.
18. Krummel MF, Allison JP: CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med 1995;182: 459-465.
19. Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH: Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical regulatory role of CTLA-4. Immunity 1995;3: 541-547.
20. Jenkins MK, Schwartz RH: Antigen presentation by chemically modified splenocytes induced antigen-specific T cell unresponsiveness in vitro and in vivo. J Exp Med 1987; 165:302-319.
21. Schwartz RH: A cell culture model for T lymphocyte clonal energy. Science 1990;248:1349-1356.
22. Schwartz RH: Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 1992;71:1065-1068.
23. Jenkins MK, Chen C, Jung G, Mueller DL, Schwartz RH: Inhibition of antigenspecific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody. J Immunol 1990;144:16-22.
24. Burkly LC, Lo D, Kanagawa O, Brinster RL, Flavell RA: T-cell tolerance by clonal energy in transgenic mice with nonlymphoid expression of MHC class II I-E. Nature 1989;342:564-566.
25. Murphy KM, Weaver CT, Elish M, Allen PM, Loh DY: Peripheral tolerance to allogeneic class II histocompatibility antigens expressed in transgenic mice: evidence against a clonal-deletion mechanism. Proc Natl Acad Sci USA 1989;86: 10,034-10.038.
26. Roberts JL, Sharrow SO, Singer A: Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities. J Exp Med 1990; 171:935-940.
27. 1 bone marrow chimeras prepared with supralethal irradiation. Evidence for clonal deletion and anergy. J Exp Med 1990;171: 1101-1121.
28. Rammensee H-G, Kroschewski R, Frangoulis B: Clonal anergy induced in mature V β6+ T lymphocytes on immunizing M1s-1b mice with M1s-1a expressing cells. Nature 1989;339:541-544.
29. Rocha B, von Boehmer H: Peripheral selection of the T cell repertoire. Science 1991;251: 1225-1228.
30. Tomita Y, Nishimura Y, Harada N, Eto M, Ayukawa K, Yoshikai Y, Nomoto K: Evidence for involvement of clonal energy in MHC class I and class II disparate skin allograft tolerance after the termination of intrathymic clonal deletion. J Immunol 1990;145:4026-4036.
31. Paul WE, Seder RA: Lymphocyte responses and cytokines. Cell 1994; 76:241-251.
32. + T cells. Ann Rev Immunol 1994;12:635-671
33. O'Garra A, Murphy K: Role of cytokines in determining T-lymphocyte function. Curr Opin Immunol 1994;6:458-466.
34. Fearon DT, Locksley RM: The instructive role of innate immunity in the acquired immune response. Science 1996;272:50-54.
35. Mosmann TR, Coffman RL: TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Ann Rev Immunol 1989;7:145-173.
36. Snapper CM, Paul WE: Interleron-γ and B cell stimulatory factor-1 reciprocally regulate 1g isotype production. Science 1987;236: 944-947.
37. Croft M, Swain SL: B cell response to T helper cell subsets: II. Both the stage of T cell differentiation and the cytokines secreted determine the extent and nature of helper activity. J Immunol 1991; 147:3679-3689.
38. DeKruyff RH, Ju ST, Hunt AJ, Mosmann TR, Umetsu DT: Induction of antigen specific antibody responses in primed and unprimed B cells. Functional heterogeneity among Th1 and Th2 T cell clones. J Immunol 1989;142:2575-2582.
39. Sher A, Coffman RL: Regulation of immunity to parasites by T cells and T cell-derived cytokines. Ann Rev Immunol 1992;10:385-409.
40. Hsieh C-S, Heimberger AB, Gold JS, O'Garra A, Murphy KM: Differential regulation of T helper phenotype development by interleukins 4 and 10 in an γβ T-cell-receptor transgenic system. Proc Natl Acad Sci USA 1992;89: 6065-6069.
41. + T cells from T cell receptor transgenic mice. J Exp Med 1992;176:1091-1098.
42. + T cells through IL-12 produced by Listeria-induced macrophages. Science 1993;260:547-549.
43. + alpha beta-TCR transgenic T cells is macrophage dependent. Intl Immunol 1993;5:371-382.
44. Szabo SJ, Jacobson NG, Dighe AS, Gubler U, Murphy KM: Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity 1995;2: 665-675.
45. Pernis A, Gupta S, Gollob KJ, Garfein E, Coffman RL, Schindler C, Rothman P: Lack of interferon γ receptor chain and the prevention of interferon γ signaling in Th1 cells. Science 1995;269:245-247.
46. Kuchroo VK, Das MP, Brown JA, Ranger AM, Zamvill SS, Weiner HL, Nabavi N, Glimcher LH: B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease. Cell 1995;80:707-718.
47. Freeman GJ, Boussiotis VA, Anumanthan A, Bernstein GM, Ke XY, Rennert PD, Gray GS, Gribben JG, Nadler LM: B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity 1995;2:523-532.
48. + T lymphocytes. Immunol Today 1988;9:268-277.
49. + T cells. J Immunol 1995;154:4915-4923.
50. + T helper cell phenotype development in a T cell receptor-αβ transgenic model. J Exp Med 1995;132:1579-1584.
51. Kelso A, Owens T: Production of two hemopoietic growth factors is differentially regulated in single T lymphocytes activated with an anti-T cell receptor antibody. J Immunol 1988;140:1159-1167.
52. Kelso A, Gough NM: Coexpression of granulocyte-macrophage colony-stimulating factor, gamma interferon, and interleukins 3 and 4 is random in murine alloreactive T lymphocyte clones. Proc Natl Acad Sci USA 1988;85:9189-9193.
53. + T cells and clones activated in vivo and in vitro. Immunol Rev 1991;123:85-114.
54. Bucy RP, Panoskaltsis-Mortari A, Huang G-Q, Li J, Karr L, Ross M, Russell JH, Murphy KM, Weaver CT: Heterogeneity of single-cell cytokine gene expression in clonal T cell populations. J Exp Med 1994;180:1251-262.
55. Karr L, Panoskaltsis-Mortari A, Li J, Oevore-Carter D, Weaver CT, Bucy RP: In situ hybridization for cytokine mRNA with digoxigenin labeled riboprobes: sensitivity of detection and double applications. J Immunol Methods 1995;182: 93-106.
56. + TCR thymocytes in vivo. Science 1990;250:1720-1723.
57. + T cells is regulated by the antigen-presenting cell. J Immunol 1993;150:3832-3842.
58. Fiering S, Northrop JP, Nolan GP, Matilla PS, Crabtree GR, Mermenberg LA: Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor. Genes Dev 1993; 4:1823-1834.
59. Karttunen J, Shastri N: Measurement of ligand-induced activation in single viable T cells using the lacZ reporter gene. Proc Natl Acad Sci USA 1991;88:3972-3976.
60. Walters MC, Fiering S, Eidemiller J, Magis W, Groudine M, Martin DI: Enhancers increase the probability but not the level of gene expression. Proc Natl Acad Sci USA 1995;92:7125-7129.
61. Assenmacher M, Schmitz J, Radbruch A: Flow cytometric determination of cytokines in activated murine T helper lymphocytes: expression of interleukin-10 in interferon-γ and in interleukin-4-expressing cells. Eur J Immunol 1994;24:1097-1101.
62. Jung T, Schauer U, Heusser C, Neumcann C, Rieger C: Detection of intracellular cytokines by flow cytometry. J Immunol Meth 1993; 159:197-207.
63. Openshaw P, Murphy EE, Hosken NA, Maino V, Davis K, Murphy K, O'Garra A: Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J Exp Med 1995;182:1357-1367.
64. Picker U, Singh MK, Zdraveski Z, Treer JR, Waldrop SL, Bergstresser PR, Maino VC: Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry. Blood 1995; 86:1408-1419.
65. + T-cell phenotype development. Proc Natl Acad Sci USA 1995;92:7565-7569.
66. Hockett RD, Janowski KM, Bucy RP: Simultaneous quantitation of multiple cytokine mRNAs by RT-PCR utilizing plate based EIA methodology. J Immunol Meth 1995;187: 273-285.
67. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL: Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities end secreted proteins. J Immunol 1986;136:2348-2357.
68. Mosmann TR, Coffman RL: TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Ann Rev Immunol 1989;7:145-173.
69. + T cell subset with an unrestricted cytokine profile. J Immunol 1989;143:518-525.
70. Mosmann TR, Sad S: The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 1996;17:138-146.
71. Abbas AK, Murphy KM, Sher A: Functional diversity of helper T lymphocytes. Nature 1996;383: 787-793.
72. O'Garra A, Murphy KM: T-cell subsets in autoimmunity. Curr Opin Immunol 1993;5:880-886.
73. Bruno L, Kirberg J, von Boehmer H: On the cellular basis of immunological T cell memory. Immunity 1995;2:37-43.
74. + T cells from αβ-TCR transgenic mice: a distinct mucosal cytokine phenotype in the absence of transgene-specific antigen. Eur J Immunol 1997;27:1774-1781.
75. Swain SL, Bradley LM, Croft M, Tonkonogy S, Atkins G, Weinberg AD, Duncan DD, Hedrick SM, Dutton RW, Huston G: Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development. Immunol Rev 1991;123:115-144.
76. Kamogawa Y, Minasi LE, Carding SR, Bottomly K, Flavell RA: The relationship of IL-4-and IFN-γ-producing T cells studied by ablation of IL-4-producing cells. Cell 1993; 75:985-995.
77. + T cells. J Immunol 1997; 158:1085-1094.
78. Valitutti S, Muller S, Cella M, Padovan E, Lanzavecchia A: Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 1995;375:148-151.
79. Viola A, Lanzavecchia A: T cell activation determined by T cell receptor number and tunable thresholds. Science 1996;273:104-106.
80. Valitutti S, Muller S, Dessing M, Lanzavecchia A: Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy. J Exp Med 1996;183:1917-1921.
81. Racioppi L, Ronchese F, Matis LA, Germain RN: Peptide-major histocompatibility complex class II complexes with mixed agonist/ antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling. J Exp Med 1993; 177:1047-1060.
82. Evavold BD, Sloan-Lancuster J, Allen IM: Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands. Immunol Today 1993;14:602-609.
83. Sloan-Lancaster J, Allen PM: Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Ann Rev Immunol 1996;14:1-21
84. + T cells and induces synthesis of IL-3 and IFN-γ but not IL-4 or 1L-6. Int Immunol 1992; 4:475-485.
85. Quill H, Schwartz RH: Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: Specific induction of long-lived state of proliferative nonresponsivencss. J Immunol 1987;138:3704-3712.
86. + T cells. J Immunol 1995;155:45-57.
87. Bradley LM, Croft M, Swain SL: T-cell memory: new perspectives. Immunol Today 1993;14:197-199.
88. Swain SL, Reth M: Lymphocyte activation and effector functions. Curr Opin Immunol 1994;6:355-358.
89. Ahmed R, Gray D: Immunological memory and protective immunity: understanding their relation. Science 1996;272:54-60.
90. Swain SL: Generation and in vivo persistence of polurized Th1 and Th2 memory cells. Immunity 1994; 1:543-552.
91. McHeyzer-Williams MG, Davis MM: Antigen-specific development of primary and memory T cells in vivo. Science 1995;268:106-111.
92. Kearney ER, Pape KA, Loh DY, Jenkins MK: Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity 1994;1:327-339.
93. + T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J Immunol 1995;155: 1032-1036.
94. Rogers WO, Weaver CT, Kraus LA, Li J, Li L, Bucy RP: Visualization of antigen specific T cell activation and cytokine expression in vivo. J Immunol 1997;158:649-657.
95. Elson CO, Tomasi M, Dertzbaugh MP, Thaggard G, Hunter R, Weaver C: Oralantigen delivery by way of a multiple e mulsion system enhances oral tolerance. Ann N Y Acad Sci 1996;778:156-162.
96. + T cells. J Exp Med 1995; 182:1591-1596.
97. Pfeiffer C, Stein J, Southwood S, Ketelaar H, Sette A, Bottomly K: Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J Exp Med 1995;181: 1569-1574.
98. Tough DF, Sprent J: Turnover of naive-and memory-phenotype T cells. J Exp Med 1994;179:1127-1135.
99. Hunter RL, Olsen MR, Buynitzky S: Adjuvant activity of nonionic block copolymers. IV. Effect of molecular weight and formulation on titer and isotype of antibody. Vaccine 1991;9:250-256.