The surface protein superfamily of Trypanosoma cruzi stimulates a polarized Th1 response that becomes anergic

Journal of Immunology

Volumn 162, Issue 10, 1999, Pages 6092-6099

  Millar, Amanda E ^a   Wleklinski Lee, Monika ^a   Kahn, Stuart J ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MEMBRANE PROTEIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLONAL ANERGY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNIZATION; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS; TRYPOMASTIGOTE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, PROTOZOAN; ANTIGENS, SURFACE; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CHAGAS DISEASE; CLONAL ANERGY; INTERFERON TYPE II; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; PROTOZOAN PROTEINS; T-LYMPHOCYTES; TH1 CELLS; TRYPANOSOMA CRUZI;

EID: 0033563014     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. +) T lymphocytes. Infect. Immun. 57:2246.
2. Rotlenberg, M. E., M. Bakhiet, T. Olsson, K. Kristensson, T. Mak, H. Wigzell, and A. Orn. 1993. Differential susceptibilities of mice genomically deleted of CD4 and CD8 to infections with Trypanosoma cruzi or Trypanosoma brucei. Infect. Immun. 61:5129
3. 2-microglobulin-deficient mice to Trypanosoma cruzi infection. Nature 356:338.
4. Tarleton, R. L., M. J. Grusby, M. Postan, and L. H. Glimcher. 1996. Trypanosoma cruzi infection in MHC-deficient mice: further evidence for the role of both class I-and class II-restricted T cells in immune resistance and disease. Int. Immunol. 8:13.
5. Harel-Bellan, A., M. Joskowicz, D. Fradelizi, and H. Eisen. 1983. Modification of T-cell proliferation and interleukin 2 production in mice infected with Trypanosoma cruzi. Proc. Natl Acad. Sci. USA 80:3466.
6. Abrahamsohn, I. A., and R. L. Coffman. 1995. Cytokine and nitric oxide regulation of the immunosuppression in Trypanosoma cruzi infection. J. Immunol. 155:3955.
7. Reed, S. G., C. E. Brownell, D. M. Russo, J. S. Silva, K. H. Grabstein, and P. J. Morrissey. 1994. IL-10 mediates susceptibility to Trypanosoma cruzi infection. J. Immunol. 153:3135.
8. Silva, J. S., D. R. Twardzik, and S. G. Reed. 1991. Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor β (TGF-β). J. Exp. Med. 174:539.
9. Choromanski, L., and R. E. Kuhn. 1985. Interleukin 2 enhances specific and nonspecific immune responses in experimental Chagas' disease. Infect. Immun. 50:354.
10. Minoprio, P. M., H. Eisen, L. Forni, L.-M. R D'Imperio, M. Joskowicz, and A. Coutinho. 1986. Polyclonal lymphocyte responses to murine Trypanosoma cruzi infection. I. Quantitation of both T-and B-cell responses. Scand. J. Immunol. 24:661.
11. Hoft, D. F., R. G. Lynch, and L. V. Kirchhoff. 1993. Kinetic analysis of antigen-specific immune responses in resistant and susceptible mice during infection with Trypanosoma cruzi. J. Immunol. 151:7038.
12. Zhang, L., and R. L. Tarleton. 1996. Characterization of cytokine production in murine Trypanosoma cruzi infection by in situ immunocytochemistry: lack of association between susceptibility and type 2 cytokine production. Eur. J. Immunol. 26:102.
13. Reed, S. G. 1988. In vivo administration of recombinant IFN-γ induces macrophage activation, and prevents acute disease, immune suppression, and death in experimental Trypanosoma cruzi infections. J. Immunol. 140:4342.
14. De Magistris, M. T., J. Alexander, M. Coggeshall, A. Altman, F. C. Gaeta, H. M. Grey, and A. Sette. 1992. Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor. Cell 68:625.
15. Evavold, B. D., and P. M. Allen. 1991. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252:1308.
16. Pfeiffer, C., J. Stein, S. Southwood, H. Ketelaar, A. Sette, and K. Bottomly. 1995. Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J. Exp. Med. 181:1569.
17. Sloan-Lancaster, J., B. D. Evavold, and P. M. Allen. 1993. Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells. Nature 363:156.
18. Gilbert, S. C., M. Plebanski, S. Gupta, J. Morris, M. Cox, M. Aidoo, D. Kwiatkowski, B. M. Greenwood, H. C. Whittle, and A. V. Hill. 1998. Association of malaria parasite population structure, HLA, and immunological antagonism. Science 279:1173.
19. Bertoletti, A., A. Sette, F. V. Chisari, A. Penna, M. Levrero, M. de Carli, F. Fiaccadori, and C. Ferrari. 1994. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells. Nature 369:407.
20. Klenerman, P., S. Rowland-Jones, S. McAdam, J. Edwards, S. Daenke, D. Lalloo, B. Koppe, W. Rosenberg, D. Boyd, A. Edwards, et al. 1994. Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants. Nature 369:403.
21. Kahn, S. J., and M. Wleklinski. 1997. The surface glycoproteins of Trypanosoma cruzi encode a superfamily of variant T cell epitopes. J. Immunol. 159:4444.
22. Schwartz, R. H. 1996. Models of T cell anergy: is there a common molecular mechanism? J. Exp. Med. 184:1.
23. Plata, F., F. Garcia-Pons, and H. Eisen. 1984. Antigenic polymorphism of Trypanosoma cruzi: clonal analysis of trypomastigote surface antigens. Eur. J. Immunol. 14:392.
24. Hoff, R. 1974. A method for counting and concentrating living Trypanosoma cruzi in blood lysed with ammonium chloride. J. Parasitol. 60:527.
25. Grabstein, K. H., C. R. Maliszewski, K. Shanebeck, T. A. Sato, M. K. Spriggs, W. C. Fanslow, and R. J. Armitage. 1993. The regulation of T cell-dependent antibody formation in vitro by CD40 ligand and IL-2. J. Immunol. 150:3141.
26. + cells correlate with resolution of lesions in murine cutaneous leishmaniasis. J. Immunol. 149:2715.
27. Miller, R. A. 1991. Quantitation of functional T cells by limiting dilution. In Current Protocols in Immunology. J. E. Coligan, A. M. Kruisbeek, D. Margulies, E Shevach, and W. Strober, eds. Green Publishing and Wiley-Interscience, New York, p. 3.15.1.
28. Taguchi, T., J. R. McGhee, R. L. Coffman, K. W. Beagley, J. H. Eldridge, K. Takatsu, and H. Kiyono. 1990. Detection of individual mouse splenic T cells producing IFN-γ and IL-5 using the enzyme-linked immunospot (ELISPOT) assay. J. Immunol. Methods 128:65.
29. Van Parijs, L., and A. K. Abbas. 1998. Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science 280:243.
30. Davis, L., P. Lipsky, and K. Bottomly. 1995. Measurement of human and murine interleukin 2 and interleukin 4. In Current Protocols in Immunology. J. E. Coligan, A. M. Kruisbeek, D. Margulies, E. Shevach, and W. Strober, eds. Green Publishing and Wiley-Interscience, New York, p. 6.3.1.
31. Sloan-Lancaster, J., B. D. Evavold, and P. M. Allen. 1994. Th2 cell clonal anergy as a consequence of partial activation. J. Exp. Med. 180:1195.
32. + T cell function during in vivo memory or tolerance induction. Immunity 8:581.
33. Dutra, W. O., O. A. Martins-Filho, J. R. Cancado, J. C. Pinto-Dias, Z. Brener, G. Gazzinelli, J. F. Carvalho, and D. G. Colley. 1996. Chagasic patients lack CD28 expression on many of their circulating T lymphocytes. Scand. J. Immunol. 43:88.
34. Frosch, S., D. Kuntzlin, and B. Fleischer. 1997. Infection with Trypanosoma cruzi selectively upregulates B7-2 molecules on macrophages and enhances their costimulatory activity. Infect. Immun. 65:971.
35. La Flamme, A. C., S. J. Kahn, A. Y. Rudensky, and W. C. Van Voorhis. 1997. Trypanosoma cruji-infected macrophages are defective in major histocompati-bility complex class II antigen presentation. Ear. J. Immunol 27:3085.
36. Silva, J. S., P. J. Morrissey, K. H. Grabstein, K. M. Mohler, D. Anderson, and S. G. Reed. 1992. Interleukin 10 and interferon γ regulation of experimental Trypanosoma cruzi infection. J. Exp. Med. 175:169.
37. Van Voorhis, W. C., and H. Eisen. 1989. FL-160. A surface antigen of Trypanosoma cruzi that mimics mammalian nervous tissue. J. Exp. Med. 169:641.
38. Kahn, S., W. C. Van Voorhis, and H. Eisen. 1990. The major 85-kD surface antigen of the mammalian form of Trypanosoma cruzi is encoded by a large heterogeneous family of simultaneously expressed genes. J. Exp. Med. 172:589.
39. Kahn, S., T. G. Colbert, J. C. Wallace, N. A. Hoagland, and H. Eisen. 1991. The major 85-kDa surface antigen of the mammalian-stage forms of Trypanosoma cruzi is a family of siaudases. Proc. Natl. Acad. Sci. USA 88:4481.
40. Van Voorhis, W. C., L. Barrett, R. Koelling, and A. G. Farr. 1993. FL-160 proteins of Trypanosoma cruzi are expressed from a multigene family and contain two distinct epitopes that mimic nervous tissues. J. Exp. Med. 178:681.
41. Campetella, O., D. Sanchez, J. J. Cazzulo, and A. C. C. Frasch. 1992. A superfamily of Trypanosoma cruzi surface antigens. Parasitol. Today 8:378.
42. Van Voorhis, W. C. 1992. Coculture of human peripheral blood mononuclear cells with Trypanosoma cruzi leads to proliferation of lymphocytes and cytokine production. J. Immunol. 148:239.
43. + T cell responses: the alternative approaches. Annu. Rev. Immunol. 15:297.
44. Pape, K. A., E. R. Kearney, A. Khoruts, A. Mondino, R. Merica, Z. M. Chen, E. Ingulli, J. White, J. G. Johnson, and M. K. Jenkins. 1997. Use of adoptive transfer of T-cell-antigen-receptor-transgenic T cell for the study of T-cell activation in vivo. Immunol. Rev. 156:67.
45. DosReis, G. A. 1997. Cell-mediated immunity in experimental Trypanosoma cruzi infection. Parasitol. Today 13:335.
46. McCabe, R. E., S. G. Meagher, and B. T. Mullins. 1991. Endogenous interferon-γ, macrophage activation, and murine host defense against acute infection with Trypanosoma cruzi. J. Infect. Dis. 163:912.
47. Torrico, F., H. Heremans, M. T. Rivera, M. T. Van, A. Billiau, and Y. Carlier. 1991. Endogenous IFN-γ is required for resistance to acute Trypanosoma cruzi infection in mice. J. Immunol. 146:3626.