Bcl-X(L) is up-regulated by HTLV-I and HTLV-II in vitro and in ex vivo ATLL samples

Blood

Volumn 96, Issue 1, 2000, Pages 275-281

  Nicot, Christophe ^a   Mahieux, Renaud ^a   Takemoto, Shigeki ^a   Franchini, Genoveffa ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BAD; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL X; TAX PROTEIN; TRANSACTIVATOR PROTEIN;

APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS 2; LEUKEMIA CELL LINE; LEUKEMOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; T CELL LEUKEMIA;

EID: 0034235836     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.1.275     Document Type: Article

References (63)

1. Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science. 1995;267: 1456.
2. Reed JC. Dysregulation of apoptosis in cancer. Cancer J Sci Am. 1998;4:S8.
3. Reed JC. Mechanisms of apoptosis avoidance in cancer. Curr Opin Oncol. 1999;11:68.
4. Chao DT, Korsmeyer SJ. Bcl2 family: regulators of cell death. Annu Rev Immunol. 1998;16:395.
5. Reed JC. Bcl-2 family proteins. Oncogene. 1998; 17:3225.
6. Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science. 1998;281:1322.
7. Korsmeyer SJ. Bcl2 gene family and the regulation of programmed cell death. Cancer Res. 1999;59(suppl 7):1693s.
8. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. The release of cytochrome c from mitochondria: a primary site for Bcl2 regulation of apoptosis. Science. 1997;275:1132.
9. Steller H. Mechanisms and genes of cellular suicide. Science. 1995;267:1445.
10. Yang E, Korsmeyer SJ. Molecular thanatopsis: a discourse on the Bcl2 family and cell death. Blood. 1996;88:386.
11. Cheng EH, Levine B, Boise LH, Thompson CB, Hardwick JM. Bax-independent inhibition of apoptosis by Bcl-XL. Nature. 1996;379:554.
12. Knudson CM, Korsmeyer SJ. Bcl2 and Bax function independently to regulate cell death. Nat Genet. 1997;16:358.
13. Zha H, Reed JC. Heterodimerization-independent functions of cell death regulatory proteins Bax and Bcl2 in yeast and mammalian cells. J Biol Chem. 1997;272:31482.
14. Meinl E, Fickenscher H, Thome M, Tschopp J, Fleckenstein B. Anti-apoptotic strategies of lymphotropic viruses. Immunology Today. 1998;19: 474.
15. Franchini G. Molecular mechanisms of human T-cell leukemia/lymphotropic virus type I infection. Blood. 1995;86:3619.
16. Akagi T, Ono H, Shimotohno K. Characterization of T cells immortalized by Tax1 of human T-cell leukemia virus type 1. Blood. 1995;86:4243.
17. Yamaoka S, Inoue H, Sakurai M, et al. Constitutive activation of NF-kappa B is essential for transformation of rat fibroblasts by the human T-cell teukemia virus type I Tax protein. EMBO J. 1996;15:873.
18. Akagi T, Ono H, Tsuchida N, Shimotohno K. Aberrant expression and function of p53 in T-cells immortalized by HTLV-I Tax1. FEBS Lett. 1997;406: 263.
19. Suzuki T, Kitao S, Matsushime H, Yoshida M. HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4. EMBO J. 1996;15:1607.
20. Suzuki T, Narita T, Uchida-Toita M, Yoshida M. Down-regulation of the INK4 family of cyclin-dependent kinase inhibitors by tax protein of HTLV-1 through two distinct mechanisms. Virology. 1999; 259:384.
21. Ceresto A, Diella F, Mulloy JC, et al. p53 functional impairment and high p21 waf1/cip expression in human T-cell lymphotropic/leukemia virus type I-transformed T cells. Blood. 1996;88:1551.
22. Jin DY, Spencer F, Jeang KT. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell. 1998; 93:81.
23. Jeang KT, Widen SG, Semmes OJ, Wilson SH. HTLV-I trans-activator protein, tax, is a trans-repressor of the human beta-polymerase gene. Science. 1990;247:1082.
24. Kao SY, Marriott SJ. Disruption of nucleotide excision repair by the human T-cell leukemia virus type 1 Tax protein. J Virol. 1999;73:4299.
25. Bazarbachi A, El-Sabban ME, Nasr R, et al. Arsenic trioxide and interferon-α synergize to induce cell cycle arrest and apoptosis in human T-cell lymphotropic virus type I-transformed cells. Blood. 1999;93:278.
26. Chen GQ, Zhu J, Shi XG, et al. In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As) in the treatment of acute promyelocytic leukemia: As induces NB4 cell apoptosis with downregulation of Bcl2 expression and modulation of PML-RAR/PML proteins. Blood. 1996;88:1052.
27. Gill P, Harrington W, Kaplan M, et al. Treatment of adult T-cell teukemia-lymphoma with a combination of interferon alpha and zidovudine. N Engl J Med. 1995;332:1744.
28. Hermine O, Bouscary D, Gessain A, et al. Treatment of HTLV-I associated adult T-cell leukemia-lymphoma with a combination of zidovudine and alpha inferferon. N Engl J Med. 1995;332:1749.
29. Smith MR, Greene WC. Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes. Genes Dev. 1990;4:1875.
30. Ross TM, Minella AC, Fang ZY, Pettiford SM, Green PL. Mutational analysis of human T-cell leukemia virus type 2 Tax. J Virol. 1997;71:8912.
31. Aillet F, Matsutani H, Elbim C, et al. Human immunodeficiency virus induces a dual regulation of Bcl2, resulting in persistent infection of CD4+ T-or monocytic cell lines. J Virol. 1998;72:9698.
32. L-dependent mechanism. Mol Cell Biol. 1999;19:2624.
33. Nicot C, Astier-Gin T, Guillemain B. Activation of Bcl2 expression in human endothelial cells chronically expressing the human T-cell lymphotropic virus type I. Virology. 1997;236:47.
34. Cereseto A, Kislyakova T, Washington Parks R, Nicot C, Franchini G. Differential response to genotoxic stress in immortalized or transformed human T-lymphotropic virus type I-infected T-cells. J Gen Virol. 1999;80:1575.
35. Brauweiler A, Garrus JE, Reed JC, Nyborg JK. Repression of bax gene expression by the HTLV-1 Tax protein: implications for suppression of apoptosis in virally infected cells. Virology. 1997;231:135.
36. L expression by human T-cell leukemia virus type 1 Tax through NF-κB in apoptosis-resistant T-cell transfectants with Tax. J Virol. 1999;73:7981.
37. Brimmell M, Mendolia R, Mangion J, Packham G. Bax frameshift mutations in cell lines derived from human haemopoietic malignancies are associated with resistance to apoptosis and microsatellite instability. Oncogene. 1998;16:1803.
38. Lee HH, Dadgostar H, Chen Q, Shu J, Cheng G. NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes. Proc Natl Acad Sci U S A. 1999; 96:9136.
39. Minn AJ, Kettlun CS, Liang H. Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanisms. EMBO J. 1999; 18:632.
40. Shinoura N, Yoshida Y, Asai A, Kirino T, Hamada H. Relative level of expression of Bax and Bcl-xL determines the cellular fate of apoptosis/necrosis induced by the overexpression of Bax. Oncogene. 1999;18:5703.
41. Hogarth LA, Hall AG. Increased Bax expression is associated with an increased risk of relapse in childhood acute lymphocytic leukemia. Blood. 1999;93:2671.
42. Mori N, Fujii M, Ikeda S, et al. Constitutive activation of NF-kappaB in primary adult T-cell leukemia cells. Blood. 1999;93:2360.
43. Arima N, Matsushita K, Obata H, et al. NF-kappaB involvement in the activation of primary adult T-cell leukemia cells and its clinical implications. Exp Hematol. 1999;27:1168.
44. Kitajima I, Shinohara T, Bilakovics J, Brown DA, Xu X, Nerenberg M. Ablation of transplanted HTLV-I Tax transformed tumors in mice by antisense inhibition of NF-kappaB. Science. 1992; 258:1792.
45. Higgins KA, Perez JR, Coleman TA, et al. Antisense inhibition of the p65 subunit of NF-kappaB blocks tumorigenicity and causes tumor regression. Proc Natl Acad SCi U S A. 1993;90:9901.
46. Tu Y, Renner S, Xu F, et al. Bcl-x expression in multiple myeloma: possible indicator of chemo-resistance. Cancer Res. 1998:58:256.
47. Xerri L, Parc P, Brousset P, et al. Predominant expression of the long isoform of Bcl-x (Bcl-xL) in human lymphomas. Br J Hematol. 1996;92:900.
48. Olopade OI, Adeyanju MO, Safa AR, et al. Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases. Cancer J Sci Am. 1997;3:230.
49. Maurer CA, Friess H, Buhler SS, et al. Apoptosis inhibiting factor Bcl-xL might be the crucial member of the Bcl2 gene family in colorectal cancer. Dig Dis Sci. 1998;43:2641.
50. Liu JR, Fletcher B, Page C, Hu C, Numez G, Baker V. Bcl-xL is expressed in ovarian carcinoma and modulates chemotherapy-induced apoptosis. Gynecol Oncol. 1998;70:398.
51. Kondo S, Shinomura Y, Kanayama S, et al. Overexpression of bcl-xL gene in human gastric adenomas and carcinomas. Int J Cancer. 1996;68: 727.
52. Migone TS, Lin JX, Cereseto A, et al. Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I. Science. 1995;269:79.
53. Takemoto S, Mulloy JC, Cereseto A, et al. Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins. Proc Natl Acad Sci U S A. 1997; 94:13897.
54. pan-p) transform T-cells independently of Jak/STAT activation. J Virol. 1998; 72:4408.
55. Reed JC, Cuddy M, Haldar S, et al. BCL2-mediated tumorigenicity of a human T-lymphoid cell line: synergy with MYC and inhibition by BCL2 antisense. Proc Natl Acad Sci U S A. 1990;87: 3660.
56. Harris AW, Strasser A, Bath ML, Elefanty AG, Cory S. Lymphomas and plasmacytomas in transgenic mice involving bcl2, myc and v-abl. Curr Top Microbiol Immunol. 1997;224:221.
57. Duyao MP, Kessler DJ, Spicer DB, Sonenshein GE. Transactivation of the c-myc gene by HTLV-1 tax is mediated by NFkB. Curr Top Microbiol Immunol. 1992;182:421.
58. Saggioro D, D'agostino DM, Chieco-Bianchi L. Analysis of Tax-expressing cell lines generated from HTLV-I tax-transgenic mice: correlation between c-myc overexpression and neoplastic potential. Exp Cell Res. 1999;247:525.
59. Pozzatti R. Vogel J, Jay G. The human T-lymphotropic virus type 1 tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells. Mol Cell Biol. 1990;10:413.
60. Matsumoto K, Akashi K, Shibata H, Yutsudo M, Hakura A. Single amino acid substitution (58Pro-Ser) in HTLV-I Tax results in loss of ras cooperative focus formation in rat embryo fibroblasts. Virology. 1994;200:813.
61. Cherbonnel-Lasserre C, Dosanjh MK. Suppression of apoptosis by over-expression of Bcl2 or Bcl-xL promotes survival and mutagenesis after oxidative damage. Biochimie. 1997;79:613.
62. Datta R, Manome Y, Taneja N, et al. Over-expression of Bel-XL by cytotoxic drug exposure confers resistance to ionizing radiation-induced internucleosomal DNA fragmentation. Cell Growth Differ. 1995;6:363.
63. Simonian PL, Grillot DA, Nunez G. Bcl2 and Bcl-XL can differentially block chemotherapy-induced cell death. Blood. 1997;90:1208.