p53 Functional impairment and high p21(waf1/cip1) expression in human T- cell lymphotropic/leukemia virus type I - Transformed T cells

Blood

Volumn 88, Issue 5, 1996, Pages 1551-1560

  Cereseto, Anna ^b   Diella, Francesca ^b   Mulloy, James C ^b   Cara, Andrea ^b   Michieli, Paolo ^b   Grassmann, Ralph ^b   Franchini, Genoveffa ^a   Klotman, Mary E ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CYCLIN DEPENDENT KINASE; MESSENGER RNA; PROTEIN P21; PROTEIN P53; TAX PROTEIN;

ARTICLE; CELL CYCLE; CELL TRANSFORMATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS INFECTION; IONIZING RADIATION; LEUKEMIA CELL LINE; PRIORITY JOURNAL; T CELL LEUKEMIA; T LYMPHOCYTE; TUMOR SUPPRESSOR GENE;

EID: 0029817961     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.5.1551.bloodjournal8851551     Document Type: Article

References (70)

1. Gallo RC: The first human retrovirus. Sci Am 255:88, 1986
2. Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC: Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 77:7415, 1980
3. Yoshida M, Miyoshi I, Hinuma Y: Isolation and characterization of retrovirus from cell lines of human T-cell leukemia and its implication in disease. Proc Natl Acad Sci USA 79:2031, 1982
4. Miyoshi I, Kubonishi I, Yoshimoto S, Akagi T, Ohtsuki Y, Shiraishi Y, Nagata K, Hinuma Y: Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and leukaemic T cells. Nature 294:770, 1981
5. Gessain A, Barin F, Vernant JC, Gout O, Maurs L, Calendar A, de The G: Antibodies to human T-Lymphotropic virus type I in patients with tropical spastic paraparesis. Lancet 2:407, 1985
6. Osame M, Usuku K, Izumo S, Ijichi N, Amitini H, Igata A: HTLV-1 associated myelopathy, a new clinical entity (letter). Lancet 1:1031, 1986
7. Rodger-Johnson P, Gajdusek DC, Morgan OS, Zaninovic V, Sarin PS, Graham DS: HTLV-I and HTLV-III antibodies and tropical spastic paraparesis (letter). Lancet 2:1247, 1985
8. Takatsuki K, Uchiayama T, Sagawa K, Yodoi J: Adult T-cell leukemia in Japan, in Seno S, Takaku F, Irino S (eds): Topics in Hematology. Amsterdam, The Netherlands, Excerpta Medicia, 1977, p 73
9. Popovic M, Lange-Wantzin G, Sarin PS, Mann D, Gallo RC: Transformation of human umbilical cord blood T cells by human T-cell leukemia/lymphoma virus. Proc Natl Acad Sci USA 80:5402, 1983
10. Markham PD, Salahuddin SZ, Kalyanaraman VS, Popovic M, Sarin P, Gallo RC: Infection and transformation of fresh human umbilical cord blood cells by multiple sources of human T-cell leukemia-lymphoma virus (HTLV). Int J Cancer 31:413, 1983
11. Yamamoto N, Okada M, Koyanagi Y, Kannagi M, Hinuma Y: Transformation of human leukocytes by cocultivation with an adult T cell leukemia virus producer cell line. Science 217:737, 1982
12. Inoue J, Seiki M, Taniguchi T, Tsuru S, Yoshida M: Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1. EMBO J 5:2883, 1986
13. Maruyama M, Shibuya H, Harada H, Hatakeyama M, Seiki M, Fujita T, Inoue J, Yoshida M, Taniguchi T: Evidence for aberrant activation of interleukin-2 autocrine loop by HTLV-I-encoded p40xI and T3/Ti complex triggering. Cell 48:343, 1987
14. Migone TS, Lin JX, Cereseto A, Mulloy JC, O'Shea JJ, Franchini G, Leonard WJ: Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I. Science 269:79, 1995
15. Xu X, Kang SH, Heidenreich O, Okerholm M, O'Shea JJ, Nerenberg MI: Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 (HTLV-1) Tax protein or virus-transformed cells. J Clin Invest 96:1548, 1995
16. Franchini G: Molecular mechanisms of human T-cell leukemia/lymphotropic virus type I infection. Blood 86:3619, 1995
17. Cross SL, Feinberg MB, Wolf JB, Holbrook NJ, Wong-Staal F, Leonard WJ: Regulation of the human interleukin-2 receptor alpha chain promoter: Activation of a nonfunctional promoter by the transactivator gene of HTLV-I. Cell 49:47, 1987
18. Siekevitz M, Feinberg MB, Holbrook N, Wong-Stall F, Greene WC: Activation of interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus type I. Proc Natl Acad Sci USA 84:5389, 1987
19. Miyatake S, Seiki M, Yoshida M, Arai K: T-cell activation signals and human T-cell leukemia virus type-I encoded p40x protein activate the mouse granulocyte-macrophage colony-stimulating factor gene through a common DNA element. Mol Cell Biol 8:5581, 1988
20. Nimer SD, Gasson JC, Hu K, Smalberg I, Williams JL, Chen IS, Rosenblatt JD: Activation of the GM-CSF promoter by HTLV-I and -II tax proteins. Oncogene 4:671, 1989
21. Fujii M, Sassone-Corsi P, Verma IM: C-Fos promoter transactivation by the tax1 protein of human T-cell leukemia virus type I. Proc Natl Acad Sci USA 85:8526, 1988
22. Jeang KT, Widen SG, Semmes IV OJ, Wilson SH: HTLV-I trans-activator protein, tax is a trans-repressor of the human beta-polymerase gene. Science 247:1082, 1990
23. Grassmann R, Dengler C, Muller-Fleckenstein I, Fleckenstein B, McGuire K, Dokhelar MC, Sodroski JG, Haseltine WA: Transformation to continuous growth of primary human T-lymphocytes by human T-cell leukemia virus type I X-region genes transduced by Herpesvirus saimiri vector. Proc Natl Acad Sci USA 86:3351, 1989
24. Akagi T, Shimotohno K: Proliferative response of Tax1-transduced primary human T cells to anti-CD3 antibody stimulation by an interleukin-2 independent pathway. J Virol 67:1211, 1993
25. Tanaka A, Takahashi C, Yamaoka S, Nosaka T, Maki M, Hatawaka M: Oncogenic transformation by the tax gene of HTLV-I in vitro. Proc Natl Acad Sci USA 87:1071, 1990
26. Grossman WJ, Kimata JT, Wong F-H, Zutter M, Ley TJ, Ratner L: Development of leukemia in mice transgenic for tax gene of human T-cell leukemia virus type I. Proc Natl Acad Sci USA 92:1057, 1995
27. Hinrichs SH, Nerenberg M, Reynolds K, Khoury G, Jay G: A transgenic mouse model for human neurofibromatosis. Science 237:1340, 1987
28. Nerenberg M, Hinrichs SH, Reynolds RK, Khoury G, Jay G: The tat gene of human T-lymphotropic virus type I induces mesenchymal tumors in transgenic mice. Science 237:1324, 1987
29. Greenblatt MS, Bennett WP, Hollstein M, Harris CC: Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis. Cancer Res 54:4855, 1994
30. Cheng J, Haas M: Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines. Mol Cell Biol 10:5502, 1990
31. Cesarman E, Chadburn A, Inghirami G, Gaidano G, Knowles DM: Structural and functional analysis of oncogenes and tumor suppressor genes in adult T-cell leukemia/lymphoma shows frequent p53 mutations. Blood 80:3205, 1992
32. Sugito S, Yamato K, Sameshima Y, Yokota J, Yano S, Miyoshi I: Adult T-cell leukemia: Structures and expression of the p53 gene, Int J Cancer 49:880, 1991
33. Sakashita A, Hattori T, Miller CW, Suzushima H, Asou N, Takatsuki K, Koeffler HP: Mutations of the p53 gene in adult T-cell leukemia. Blood 79:477, 1992
34. Nagai H, Kinoshita T, Imamura J, Murakami Y, Hayashi K, Mukai K, Ikeda S, Tobinai K, Saito H, Shimoyama M, Shimotohno K: Genetic alteration of p53 in some patients with adult T-cell leukemia. Jpn J Cancer Res 82:1421, 1991
35. Reid RL, Lindholm PF, Mireskandari A, Dittmer J, Brady JN: Stabilization of wild-type p53 in human T-lymphocytes transformed by HTLV-I. Oncogene 8:3029, 1993
36. Chang F, Syrjanen S, Kurvinen K, Syrjanen K: The p53 tumor suppressor gene as a common cellular target in human carcinogenesis. Am J Gastroenterol 88:174, 1993
37. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ: The p21 Cdk-interacting protein Cip 1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805, 1993
38. El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B: WAF1, a potential mediator of p53 tumor suppression. Cell 75:817, 1993
39. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashe R, Beach D: P21 is a universal inhibitor of cyclin kinases. Nature 366:701, 1993
40. Zhang H, Xiong Y, Beach D: Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes. Mol Biol Cell 4:897, 1993
41. Macleod KF, Sherry N, Hannon G, Beach D, Tokino T, Kinzler K, Vogelstein B, Jacks T: p53 dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev 9:935, 1995
42. Michieli P, Chedid M, Lin D, Pierce JH, Mercer WE, Givol D: Induction of WAF1/CIP1 by a p53 independent pathway. Cancer Res 54:3391, 1994
43. Hall WW, Kaplan MH, Salahuddin SZ, Oyaizu N, Gurgo C, Coronesi M, Nagashima K, Gallo RC: Concomitant infections with T-cell leukemia viruses (HTLVs) and human immunodeficiency virus (HIV): Identification of HTLV-II infection in intravenous drug abusers (IVDAs), in Blattner WA (ed): Human Retrovirology: HTLV. New York, NY, Raven, 1990, p 115
44. Salahuddin SZ, Markam PD, Wong-Stall F, Franchini G, Kalyanaraman VS, Gallo RC: Restricted expression of human T-cell leukemia-lymphoma virus (HTLV) in transformed human umbilical cord blood lymphocytes. Virology 129:51, 1983
45. Popovic M, Sarin PS, Robert-Guroff M, Kalyanaraman VS, Mann D, Minowada J, Gallo RC: Isolation and transmission of human retrovirus (human T-cell leukemia virus). Science 219:856, 1983
46. Aldovini A, De Rossi A, Feinberg MB, Wong-Stall F, Franchini G: Molecular analysis of a deletion mutant provirus of type I human T-cell lymphotropic virus: Evidence for a doubly spliced x-lor mRNA. Proc Natl Acad Sci USA 83:38, 1986
47. Gessain A, Saal F, Giron ML, Lasneret J, Lagaye S, Gout O, De The G, Sigaux F, Peries J: Cell surface phenotype and human T lymphotropic virus type 1 antigen expression in 12 T cell lines derived from peripheral blood and cerebrospinal fluid of West Indian, Guyanese and African patients with tropical spastic paraparesis. J Gen Virol 71:333, 1990
48. Berneman ZN, Gartenhaus RB, Reitz MS Jr. Blattner WA, Manns A, Hanchard B, Ikehara O, Gallo RC, Klotman ME: Expression of alternatively spliced human T-lymphotropic virus type I pX mRNA in infected cell lines and in primary uncultured cells from patients with adult T-cell leuketmia/lymphoma and healthy carriers. Proc Natl Acad Sci USA 89:3005, 1992
49. tax protein in the human T cell line, Jurkat. J Virol 63:3220, 1989
50. Lehman TA, Bennet WP, Metcalf RA, Welsh JA, Ecker J, Modali RV, Ullrich S, Romano JW, Appella E, Testa JR, Gerwin BI, Harris CC: p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines. Cancer Res 51:4090, 1991
51. Chomczynski P, Sacchi N: Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156, 1987
52. Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning (ed 2). Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press, 1989
53. Carrier F, Smith ML, Bae I, Kilpatrick KE, Lansing TJ, Chen C-Y, Engelstein M, Friend SH, Henner WD, Gilmer TM, Kastan MB, Fornace AJ Jr: Characterization of human Gadd45, a p53-regulated protein. J Biol Chem 269:32672, 1994
54. Diella F, Normanno N, Merlo GR, Salomon DS, Callahan R: Absence of p53 point mutations in nontransformed human mammary epithelial cell lines. Biochem (Life Sci Adv) 12:47, 1993
55. Rapley R, Flora S, Walker MR: Direct PCR sequencing of murine immunoglobulin genes using E. coli single-stranded DNA-binding protein. PCR Methods Appl 2:99, 1992
56. Kastan MB, Zhan Q, El-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B, Fornace AJ Jr: A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in Ataxia-Telangiectasia. Cell 71:587, 1992
57. Gartenhaus RB, Wang P: Functional inactivation of wild-type p53 protein correlates with loss of IL-2 dependence in HTLV-I transformed human T-lymphocytes. Leukemia 9:2082, 1955
58. Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T: p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362:847, 1993
59. Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, Hooper ML, Wyllie AH: Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362:849, 1993
60. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW: Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51:6304, 1991
61. Barak Y, Juven T, Haffner R, Oren M: Mdm-2 expression is induced by wild-type p53 activity. EMBO 12:461, 1993
62. Wu X, Bayle JH, Olson D, Levine AJ: The p53-mdm2 autoregulatory feedback loop. Genes Dev 7:1126, 1993
63. Yamato K, Oka T, Hiroi M, Iwahara Y, Sugito S, Tsuchida N, Miyoshi I: Aberrant expression of p53 tumor suppressor gene in adult T-cell leukemia and HTLV-I-infected cells. Jpn J Cancer Res 84:4, 1993
64. Fujii M, Sassone-Corsi P, Verma IM: c-fos promoter transactivation by the tax1 protein of human T-cell leukemia virus type 1. Proc Natl Acad Sci USA 85:8526, 1988
65. Alexandre C, Charnay P, Verrier B: Transactivation of Krox-20 and Krox-24 promoters by HTLV-I Tax protein through common regulatory elements. Oncogene 6:1851, 1991
66. Fujii M, Niki T, Mori T, Matsuda T, Matsui M, Nomura N, Seiki M: HTLV-I Tax induces expression of various immediate early serum responsive genes. Oncogene 6:1023, 1991
67. Zhang H, Hannon GH, Beach D: p21-containing cyclin kinases exist in both active and inactive states. Genes Dev 8:1750, 1994
68. Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372:570, 1994
69. waf1/cip1 in human brain tumors. Oncogene 11:2021, 1995
70. Zhang W, Kornblau SM, Kobayashi T, Gambel A, Claxton D, Deisseroth AB: High level of constitutive WAF1/CIP1 protein are associated with chemoresistance in acute myelogenous leukemia. Clin Cancer Res 1:1051, 1995