Coupled effects of polybrene and calf serum on the efficiency of retroviral transduction and the stability of retroviral vectors

Human Gene Therapy

Volumn 8, Issue 3, 1997, Pages 285-291

  Andreadis, Stylianos ^a,c   Palsson, Bernhard O ^b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c Shriners Burns Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEXADIMETHRINE BROMIDE; VIRUS VECTOR;

ANIMAL CELL; ARTICLE; GENE THERAPY; GENE TRANSFER; GENETIC TRANSDUCTION; MOLECULAR STABILITY; MOLONEY LEUKEMIA ONCOVIRUS; MOUSE; NONHUMAN; RETROVIRUS; SERUM; SUPERNATANT; VIRUS CELL INTERACTION; VIRUS INACTIVATION;

ANIMALIA; MOLONEY MURINE LEUKEMIA VIRUS; MURINAE; ONCOVIRINAE; UNIDENTIFIED RETROVIRUS;

EID: 0030773892     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1997.8.3-285     Document Type: Article

References (43)

1. ANDERSEN, K., and NEXO, B. (1983). Entry of murine retroviruses into mouse fibroblasts. Virology 125, 85-98.
2. ANDERSON W. (1992). Human gene therapy. Science 256, 808-813.
3. ANDREADIS, S., and PALSSON, B. (1996). Kinetics of retrovirus-mediated gene transfer: the importance of intracellular half-life. J. Theoret. Biol. 182, 1-20.
4. AUBIN, R., WEINFELD, M., MIRZAYANS, R., and PATERSON, M. (1994). Polybrene/DMSO-assisted gene transfer. Generating stable transfectants with nanogram amounts of DNA. Mol. Biotechnol. 1, 29-18.
5. BROOKS, R. (1976). Regulation of fibroblast cell cycle by serum. Nature 260, 248-250.
6. BUNNELL, B., MUUL, L., DONAHUE, R., BLAESE, R., and MORGAN, R. (1995). High-efficiency retroviral-mediated gene transfer into human and nonhuman primate peripheral blood lymphocytes. Proc. Natl. Acad. Sci USA 92, 7739-7743.
7. CAMPISI, J., MORREO, G., and PARDEE, A. (1984). Kinetics of g1 transit following brief starvation for serum factors. Exp. Cell Res. 152, 459-466.
8. CHUCK, A., and PALSSON, B. (1996a). Consistent and high rates of gene transfer can be obtained using the flow through transduction over a wide range of retroviral titers. Hum. Gene Ther. 7, 743-750.
9. CHUCK, S. (1995). "Directed retroviral motion as a means of enhancing gene transfer for gene therapy." Ph.D. thesis, University of Michigan.
10. COELEN, R., JOSE, D., and MAY, J. (1983). The effect of hexadimethrine bromide (polybrene) on the infection of primate retroviruses SSV1/SSAV1 and BaEV. Arch. Virol. 75, 307-311.
11. COFFIN, J. (1990). Retroviridae and their replication. In Fundamental Virology. B.N. Fields and D.M. Knipe, eds. (Raven Press, New York, NY) pp. 645-708.
12. COFFIN, J. (1992). Structure and classification of retroviruses. In The Retroviridae. J.A. Levy, ed. (Plenum Press, New York, NY) pp. 19-49.
13. COLLER, B. (1980). Polybrene-induced platelet agglutination and reduction in electrophoretic mobility: enhancement by von Willebrand factor and inhibition by vancomycin. Blood 55, 276-281.
14. CRYSTAL, R. (1995). Transfer of genes to humans: early lessons and obstacles to success. Science 270, 404-410.
15. DANOS, O., and MULLIGAN, R. (1988). Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges. Proc. Natl. Acad. Sci. USA 85, 6460-6464.
16. HAYWOOD, A. (1991). Evidence for multiple steps in enveloped virus binding. In Cell and Model Membrane Interactions. S. Ohki, ed. (Plenum Press, New York, NY) pp. 337-374.
17. HAYWOOD, A., and BOYER, B. (1982). Sendai virus membrane fusion: Time course and effect of temperature, pH, calcium and receptor concentration. Biochemistry 21, 6041-6046.
18. HODGSON, C. (1995). The vector void in gene therapy. Bio/Technology 13, 222-225.
19. KOTANI, H., NEWTON, P., III, ZHANG, S., CHIANG, Y., OTTO, E., WEAVER, L., BLAESE, R., ANDERSON, W., and MCGARRIRY, G. (1994). Improved methods of retroviral vector transduction and production for gene therapy. Hum. Gene Ther. 5, 19-28.
20. LALEZARI, P. (1987). The manual hexadimethrine bromide (polybrene) test. Effects of serum proteins and practical applications. Transfusion 27, 295-301.
21. LARSSON, O., ZETTERBERG, A., and ENGSTROM, W. (1985). Consequences of parental exposure to serum free medium for progeny cell division. J. Cell Sci. 75, 259-268.
22. LAYNE, S., SPOUGE, J., and DEMBO, M. (1989a). Analytic results for quantifying HIV infectivity. Bull. Math. Biol. 51, 715-730.
23. LAYNE, S., SPOUGE, J., and DEMBO, M. (1989b). Quantifying the infectivity of human immunodeficiency virus. Proc. Natl. Acad. Sci. USA 86, 4644-4648.
24. LAYNE, S., MERGES, M., DEMBO, M., SPOUGE, J., CONLEY, S., MOORE, J., RAINA, J., RENZ, H., GELDERBLOM, H., and NARA, P. (1992). Factors underlying spontaneous inactivation and susceptibility to neutralization of human immunodeficiency virus. Virology 189, 695-714.
25. LEDOUX, J.M., MORGAN, J.R., SNOW, R.G., and YARMUSH, M.L. (1996). Proteoglycans secreted by packaging cell lines inhibit retrovirus infection. J. Virol. 70, 6468-6473.
26. LEWIS, P.F., and EMERMAN, M. (1994). Passage through mitosis is required for oncoretroviruses but not for human immunodeficiency virus. J. Virol. 68, 510-516.
27. LUCIW, P., and LEUNG, N. (1992). Mechanisms of retroviral integration. In The Retroviridae. J.A. Levy, ed. (Plenum Press, New York, NY) pp. 159-298.
28. MCCLAIN, D., and FULLER, A. (1994). Cell-specific kinetics and efficiency of herpes simplex virus type 1 entry are determined by two distinct phases of attachment. Virology 198, 690-702.
29. MILLER, A. (1992a). Human gene therapy comes of age. Nature 357, 455-460.
30. MILLER, A. (1992b). Retroviral vectors. Curr. Top. Microbiol. Immunol. 158, 1-24.
31. MILLER, D., ADAM, M., and MILLER, A. (1990). Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection. Mol. Cell. Biol. 10, 4239-4242.
32. MULLIGAN, R. (1993). The basic science of gene therapy. Science 260, 926-932.
33. OVERBEEK, J. (1952). Kinetics of flocculation. In Colloid science. H.R. Kruyt, ed. (Elsevier Publishing Company, Amsterdam, The Netherlands) pp. 279-301.
34. PATT, L., and HOUCK, J. (1985). Opposing effects of the polycation hexadimethrine (polybrene) on normal and leukemic lymphocytes. Pharmacology 30, 109-114.
35. PAUL, R., MORRIS, D., HESS, B., DUNN, J., and OVERELL, R. (1993). Increased viral titer through concentration of viral harvests from retroviral packaging cell lines. Hum. Gene Ther. 4, 609-615.
36. ROE, T., REYNOLDS, T., YU, G., and BROWN, P. (1993). Integration of murine leukemia virus DNA depends on mitosis. EMBO J. 12, 2099-2108.
37. SANES, J., RUBENSTEIN, J., and NICOLAS, J. (1986). Use of a recombinant retrovirus to study post implantation cell lineage in mouse embryos. EMBO J. 5, 3133-3142.
38. SPRINGETT, G., MOEN, R., ANDERSON, S., BLAESE, R., and ANDERSON, W. (1989). Infection efficiency of T lymphocytes with amphotropic retroviral vectors is cell cycle dependent. J. Virol. 63, 3865-3869.
39. TOYOSHIMA, K., and VOGT, P. (1969). Enhancement and inhibition of avian sarcoma viruses by polycations and polyanions. Virology 38, 414-426.
40. WEISS, R. (1984). Experimental biology and assay of retroviruses. In RNA Tumor Viruses. R.A. Weiss, N.M. Teich, H.E. Varmus, and J. Coffin, eds. (Cold Spring Harbor Laboratory, Cold Spring Harbor, NY) pp. 209-260.
41. WEISS, R., SOMMERFELT, M., MCCLURE, M., CLAPHAM, P., and WEBER, J. (1989). Retrovirus receptors on human cells. In Cell Biology of Virus Entry, Replication, and Pathogenesis. R.W. Compans, A. Helenius and M.B. Oldstone, eds. (Alan R. Liss, New York, NY) pp. 67-74.
42. WICKHAM, T., SHULER, M., HAMMER, D., GRANADOS, R., and WOOD, H. (1992). Equilibrium and kinetic analysis of Autographa californica nuclear polyedrosis virus attachment to different insect cell lines. J. Gen. Virol. 73, 3185-3194.
43. ZETTERBERG, A., and LARSSON, O. (1985). Kinetic analysis of regulatory events in G1 leading to proliferation or quiescence of Swiss 3T3 cells. Proc. Natl. Acad. Sci. USA 82, 5365-5369.