Differentiation-specific regulation of transgene expression in a diploid epithelial cell line derived from the normal F344 rat liver

Journal of Pathology

Volumn 187, Issue 3, 1999, Pages 365-373

  Ott, Michael ^a,b   Rajvanshi, Pankaj ^a,e   Sokhi, Rana P ^a,c   Alpini, Gianfranco ^a,d   Aragona, Emma ^a,e   Dabeva, Mariana ^a,e   Shafritz, David A ^a,e   Gupta, Sanjeev ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c BROOKLYN HOSPITAL CENTER   (United States)

^d TEXAS A AND M UNIVERSITY   (United States)

^e NONE   (Italy)

Author keywords

Cell line; Differentiation; Gene expression; Liver; Regeneration

Indexed keywords

ALBUMIN; ALPHA FETOPROTEIN; BUTYRIC ACID; CYTOKERATIN 19; DNA; GALACTOSAMINE; GAMMA GLUTAMYLTRANSFERASE; GAMMA INTERFERON; GLUCOSE 6 PHOSPHATASE; GLYCOGEN; HISTONE H4; MESSENGER RNA; TRANSFERRIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DIPLOIDY; EPITHELIUM CELL; GENE CONTROL; GENE EXPRESSION; IN SITU HYBRIDIZATION; LIVER; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; TRANSGENE;

ANIMALS; BIOLOGICAL MARKERS; CELL LINE; DIPLOIDY; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; INTERFERON TYPE II; LAC OPERON; LIVER; MALE; RATS; RATS, INBRED F344; STEM CELLS; TRANSGENES;

EID: 0032945255     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199902)187:3<365::AID-PATH237>3.0.CO;2-Z     Document Type: Article

References (40)

1. Farber E. Similarities in the sequence of early histologic changes induced in the liver of rats by ethionine, 2-acetylammofluorene and 3-methyl-4-dimethylaminoazobenzene. Cancer Res 1956; 16: 142-148.
2. Thorgeirsson SS. Hepatic stem cells. Am J Pathol 1993; 142: 1331-1333.
3. Sell S. Liver stem cells. Mod Pathol 1994; 7: 105-112.
4. Alison M, Golding M, Lalani EN, Nagy P, Thorgeirsson S, Sarraf C. Wholesale hepatocytic differentiation in the rat from ductular oval cells, the progeny of biliary stem cells. J Hepatol 1997; 26: 343-352.
5. LeBouton AV. Growth, mitosis and morphogenesis of the simple liver acinus in neonatal rats. Dev Biol 1974; 41: 22-30.
6. Haruna Y, Saito K, Spaulding S, Nalesnik MA, Gerber MA. Identification of bipotential progenitor cells in human liver development. Hepatology 1996; 23: 476-481.
7. Petropoulos CJ, Yaswen P, Panzica M, Fausto N. Cell lineages in liver carcinogenesis: possible clues from studies of the distribution of α-fetoprotein RNA sequences in cell populations isolated from normal, regenerating, and preneoplastic rat livers. Cancer Res 1985; 45: 5762-5768.
8. Tournier S, Legres L, Schoevaert D, Feldmann G, Bernuau D. Cellular analysis of α-fetoprotein gene activation during carbon tetrachloride and D-galactosamine-induced acute liver injury in rats. Lab Invest 1988; 59: 657-665.
9. Dunsford HA, Sell S. Production of monoclonal antibodies to preneoplastic liver cell populations induced by chemical carcinogens in rats and to transplantable Morris hepatomas. Cancer Res 1989; 49: 4887-4893.
10. Dabeva M, Shafritz DA. Activation, proliferation, and differentiation on progenitor cells into hepatocytes in the D-galactosamine model of liver regeneration. Am J Pathol 1993; 143: 1606-1620.
11. Evarts RP, Nagy P, Marsden E, Thorgeirsson SS. A precursor-product relationship exists between oval cells and hepatocytes in the rat liver. Carcinogenesis 1987; 8: 1737-1740.
12. Germain L, Noel M, Gourdeau H, Marceau N. Promotion of growth and differentiation of rat ductular oval cells in primary culture. Cancer Res 1988; 48: 368-378.
13. Evarts RP, Nagy P, Nakatsukasa H, Marsden E, Thorgeirsson SS. In vivo differentiation of rat liver oval cells into hepatocytes. Cancer Res 1989; 49: 1541-1547.
14. Yasui O, Miura N, Terada K, Kawarada Y, Koyama K, Sugiyama T. Isolation of oval cells from Long-Evans cinnamon rats and their transformation into hepatocytes in vivo in the rat liver. Hepatology 1997; 25: 329-334.
15. Coleman WB, Wennerberg AE, Smith GJ, Grisham JW. Regulation of the differentiation of diploid and some aneuploid rat liver epithelial (stemlike) cells by the hepatic microenvironment. Am J Pathol 1993; 142: 1373-1382.
16. Herring AS, Raychaudhuri R, Kelley S, Iype PT. Repeated establishments of diploid epithelial cell culture from normal and partially hepatectomized rats. In Vitro 1983; 19: 576-588.
17. McMahon JB, Richards WL, del Campo AA, Song M-KH, Thorgeirsson SS. Differential effects of transforming growth factor-β on proliferation of normal and malignant rat liver epithelial cells in culture. Cancer Res 1986; 46: 4665-4671.
18. Garfield S, Huber BE, Nagy P, Cordingley MG, Thorgeirsson SS. Neoplastic transformation and lineage switching of rat liver epithelial cells by retrovirus-associated oncogenes. Mol Carcinogenesis 1988; 1: 189-195.
19. Goyette M, Faris R, Braun L, Hixson D, Fausto N. Expression of hepatocyte and oval cell antigens in hepatoccllular carcinomas produced by oncogene-transfected liver epithelial cells. Cancer Res 1990; 50: 4809-4817.
20. Dabeva MD, Hwang SG, Vasa SRG, et al. Differentiation of pancreatic epithelial progenitor cells into hepatocytes following transplantation into rat liver. Proc Natl Acad Sci USA 1997; 94: 7356-7361.
21. Casio S, Zaret KS. Hepatocyte differentiation initiates during endodermalmesenchymal interactions prior to liver formation. Development 1991; 113: 217-225.
22. Rogler LE. Selective bipotential differentiation of mouse embryonic hepatoblasts in vitro. Am J Pathol 1997; 150: 591-602.
23. Dabeva MD, Hurston E, Shafritz DA. Transcription factor and liver-specific mRNA expression in facultative epithelial progenitor cells of liver and pancreas. Ant J Pathol 1995; 147: 1633-1648.
24. Gupta S, LaBrecque DR, Shafritz DA. Mitogenic effects of hepatic stimulator substance on cultured non parenchymal liver epithelial cells. Hepatalogy 1992; 15:485-491.
25. Aragona E, Burk RD, Ott M, Shafritz DA, Gupta S. Cell-type specific mechanisms regulate hepatitis B virus transgene expression in liver and other organs. J Pathol 1996; 180: 441-449.
26. Rajvanshi P, Kerr A, Bhargava KK, Burk RD, Gupta S. Studies of liver repopulation using the dipeptidyl peptidase IV deficient rat and other rodent recipients: cell size and structure relationships regulate capacity for increased transplanted hepatocyte mass in the liver lobule. Hepatology 1996; 23: 482-496.
27. Price J, Turner D, Cepko C. Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer. Proc Natl Acad Sci USA 1987; 84: 156-160.
28. Sigal S, Gupta S, Gebhard DF Jr, Holst P, Neufeld D, Reid LM. Evidence for a terminal differentiating process in the liver. Differentiation 1995; 59: 35-42.
29. Salmon SE, Buick RN. Preparation of permanent slides of intact soft-agar colony cultures of hematopoietic and tumor stem cells. Cancer Res 1979; 39: 1133-1136.
30. Gupta S, Alpini G, Vemuru RP, Hurston E, Shafritz DA. Butyrate synchronization of hepatocytes: modulation of cycling and cell cycle regulated gene expression. Growth Factors 1994; 10: 171-180.
31. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanithium thiocyanate phenol chloroform extraction. Anal Biochem 1987; 162: 156-159.
32. Panduro A, Shalaby F, Weiner F, Biempica L, Zern MA, Shafritz DA. Transcriptional switch from albumin to α-fetoprotein and changes in transcription of other genes during carbon tetrachloride induced liver regeneration. Biochemistry 1986; 25: 1414-1420.
33. Griswold MD, Collard M, Hugly S, Huggenvik J. The use of specific cDNA probes to assay Sertoli cell functions. Adv Exp Med Biol 1986; 205: 301-317.
34. Lu B, Gupta S. Federoff H. Ex vivo gene transfer using a defective herpes simplex viral vector. Hepatology 1995; 21: 752-759.
35. Sigal S. Rajvanshi P, Reid LM, Gupta S. Demonstration of differentiation in hepatocyte progenitor cells using dipeptidyl peptidase IV deficient mutant rats. Cell Mol Biol Res 1995; 41: 39-47.
36. Gupta S, Wilson JM, Roy Chowdhury J. Hepatocyte transplantation: development of new systems for liver repopulation and gene therapy. Semin Liver Dis 1992; 12: 321-331.
37. Block GD, Locker J, Bowen WC, et al. Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF, and TGF-alpha in a chemically defined (HGM) medium. J Cell Biol 1996; 132: 1133-1149.
38. Xu L, Yee JK, Wolff JA, Friedmann T. Factors affecting long-term stability of Moloney murine leukemia virus-based vectors. Virology 1989; 171: 331-341.
39. Fenjves ES, Yao SN, Kurachi K, Taichman LB. Loss of expression of a retrovirus-transduced gene in human keratinocytes. J Invest Dermatol 1996; 106: 576-578.
40. Qin L, Ding Y, Pahud D, Imperiale M, Bromberg J. Promoter attenuation in gene therapy: interferon-γ and tumor necrosis factor-α inhibit transgene expression. Hum Gene Ther 1997; 8: 2019-2029.