Cross-reactive rubella virus and glutamic acid decarboxylase (65 and 67) protein determinants recognised by T cells of patients with Type I diabetes mellitus

Diabetologia

Volumn 43, Issue 6, 2000, Pages 750-762

  Ou, D ^a   Mitchell, L A ^a   Metzger, D L ^a   Gillam, S ^a   Tingle, A J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Autoimmune disease; Autoreactivity; Coxsackie; Glutamic acid decarboxylase; Rubella; T cell epitope; Type I diabetes

Indexed keywords

GLUTAMATE DECARBOXYLASE; VIRUS PROTEIN;

ARTICLE; AUTOIMMUNITY; CELL CULTURE; CROSS REACTION; CYTOTOXICITY TEST; DISEASE ASSOCIATION; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; NONHUMAN; PRIORITY JOURNAL; RUBELLA; RUBELLA VIRUS; T LYMPHOCYTE;

EID: 0034124170     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051373     Document Type: Article

References (68)

1. 1. Yoon JW, Jun HS, Santamaria P (1998) Cellular and molecular mechanisms for the initiation and progression of β cell destruction resulting from the collaboration between macrophages and T cells. Autoimmunity 27: 109-122
2. 2. Bach JF (1994) Insulin-dependent diabetes mellitus as an autoimmune disease. Endocrine Rev 15: 516-541
3. 3. See DM, Tilles JG (1996) Pathogenesis of viral-induced diabetes. Current Opinion in Infections Diseases 9: 161-164
4. 4. Yoon JW (1995) A new look at viruses in Type I diabetes. Diabetes Metab Rev 11: 83-107
5. 5. Ginsberg-Fellner F, Fedum B, Cooper Z (1986) Interrelationship of congenital rubella and Type I insulin-dependent diabetes. In: Jaworski MA, Molner GD, Rajotte RV, Singh B (eds) The immunology of diabetes mellitus. Elsevier Science, Amsterdam, pp 279-286
6. 6. Menser MA., Forrest JM, Honeyman MC, Burgess JA (1974) Diabetes, HLA-antigens, and congenital rubella. Lancet ii: 1508-1509
7. 7. Ginsberg-Fellner F, Witt ME, Yagihashi S et al. (1984) Congenital rubella syndrome as a model for Type I (insulin-dependent) diabetes mellitus:increased prevalence of islet cell surface antibodies. Diabetologia 27: 87-89
8. 8. Horwitz MS, Bradley LM, Harbertson J, Krahl T, Lee J, Sarvetnick N (1998) Diabetes induce by Coxsackie virus:Initiation by bystander damage and not molecular mimicry. Nat Med 4: 781-785
9. 9. von Herrath MG, Evans CF, Horwitz MS, Oldstone MBA (1996) Using transgenic mouse models to dissect the pathogenesis of virus-induced autoimmune disorders of the islets of langerhans and the central nervous system. Immunol Rev 152:111-143
10. 10. Nepom GT (1995) Glutamic acid decarboxylase and other autoantigens in IDDM. Cur Opin Immunol 7: 825-830
11. 11. Roep BO (1996) T-cell responses to autoantigens in IDDM:The search for the holy grail. Diabetes 45: 1147-1156
12. 12. Bach JM, Otto H, Nepom GT et al. (1997) High affinity presentation of an autoantigenic peptide in Type I diabetes by an HLA class II protein encoded in a haplotype protecting from disease. J Autoimmunity 10: 375-386
13. 13. Bach JF, Koutouzov S, van Endert PM (1998) Are there unique autoantigens triggering autoimmune disease? Immunol Rev 164: 139-155
14. 14. Bu DF, Erlander MG, Hitz BC et al. (1992) Two human glutamate decarboxylases, 65-KDa GAD and 67-KDa GAD are each encoded by single gene. Proc Natl Acad Sci USA 89: 2115-2119
15. 15. Kaufman DL, Erlander, MG, Clare-Salzler M, Atkinson MA, Maclaren NK, Jobin AJ (1992) Autoimmunity to two forms of Glutamate decarboxylase in insulin-dependent diabetes mellitus. J Clin Invest 89: 283-292
16. 16. Bonifacio E, Genovese S, Braghi S et al. (1995) Islet autoantibody markers in IDDM:risk assessment strategies yielding high sensitivity. Diabetologia 38: 816-822
17. 17. Honeyman MC, Cram DS, Harrison LC (1993) Glutamic acid decarboxylase 67-reactive T cells:A marker of insulin-dependent diabetes. J Exp Med 177: 535-540
18. 18. Lohmann T, Leslie RDG, Hawa M, Geysen M, Rodda S, Londei M (1994) Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus. Lancet 343: 1607-1608
19. 19. Zekzer D, Wong FS, Ayalon O et al. (1998) GAD-reactive CD4 + Th1 cells induce diabetes in NOD/SCID mice. J Clin Invest 101: 68-73
20. 20. Yoon JW, Yoon CS, Lim HW et al. (1999) Control of autoimmune diabetes in NOD mice by GAD expression or suppression in β cells. Science 284: 1183-1187
21. 21. Baekkeskov S, Nielson JH, Marner B, Bilde T, Ludvigsson J, Lermmark A (1982) Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins. Nature 298: 167-169
22. 22. Hou J, Said C, Franchi D, Dockstander P, Chatterjee NK (1994) Antibodies to glutamic acid decarboxylase and P2C peptides in sera from Coxsackie virus B4-induced mice and IDDM patients. Diabetes 43: 1260-1268
23. 23. Tian J, Lehmann PV, Kaufman DL (1994) T cell cross-reactivity between Coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele. J Exp Med 180: 1979-1984
24. 24. Atkinson MA, Bowman MA, Campbell L, Darrow BL, Kaufman DL, Maclaren NK (1994) Cellular immunity to a determinant common to glutamate decarboxylase and Coxsackie virus in insulin-dependent diabetes. J Clin Invest 94: 2125-2129
25. 25. Karounos DG, Wolinsky JS, Thomas JW (1993) Monoclonal antibody to rubella virus capsid protein recognises a β-cell antigen. J Immunol 150: 3080-3085
26. 26. Jones DB, Crosby L (1996) Proliferative lymphocyte responses to virus antigens homologous to GAD65 in IDDM. Diabetologia 39: 1318-1324
27. 27. Monif GRG, Avery GB, Korones SB, Sever JL (1965) Postmortem isolation of rubella virus from three children with rubella-syndrome defects. Lancet i:723-724
28. 28. Numazaki K, Goldman HY, Wong I, Wainberg MA (1989) Infection of cultured human fetal pancreatic islet cells by rubella virus. Am J Clin Pathol 91: 446-451
29. 29. Rubinsten P, Walker ME, Fedun B, Witt ME, Cooper LZ, Ginsberg-Fellner F (1982) The HLA system in congenital rubella patients with and without diabetes. Diabetes 31: 1088-1091
30. + T cell clones from congenital rubella syndrome patients with IDDM recognised overlapping GAD65 protein epitopes:Implications for HLA class I and II allelic linkage to disease susceptibility. Hum Immunol 60: 652-664
31. 31. Ou D, Chong P, Tingle AJ, Gillam S (1993) Mapping T-cell epitopes of rubella virus structural proteins E1, E2, and C recognised by T-cell lines and clones derived from infected and immunized populations. J Med Virol 40: 175-183
32. 32. Ou D, Chong P, Tripet B, Gillam S (1992) Analysis of T-and B-cell epitopes of capsid protein of rubella virus by using synthetic peptides. J Virol 66: 1674-1681
33. 33. Ou D, Mitchell LA, Ho M et al. (1994) Analysis of overlapping T-and B-cell antigenic sites on rubella virus E1 envelop protein:influence of HLA-DR polymorphism of T-cell clonal recognition. Hum Immunol 39: 177-187
34. 34. Ou D, Mitchell LA, Domeier ME et al. (1996) Characterization of HLA restrictive elements of rubella virus-specific cytotoxic T-cell clone:Influence of HLA-DR4β chain residue 74 polymorphism on Ag peptide-T cell interaction. Int Immunol 8: 1577-1586
35. +T-cell epitope on rubella capsid protein. Virology 235: 286-291
36. 36. Hiraiwa A, Yamanaka K, Kwok WW et al. (1990) Structural requirements for recognition of the HLA-Dw14 class II epitope: a key HLA determinant associated with rheumatoid arthritis. Proc Natl Acad Sci USA 87: 8051-8055
37. 37. Kovats S, Drover S, Marshall WH et al. (1994) Coordinate defects in human histocompatibility leukocyte antigen class II expression and antigen presentation in Bare lymphocyte Syndrome. J Exp Med 179: 2017-2022
38. 38. Ou D, Mitchell LA, Décarie D, Tingle AJ, Nepom GT (1998) Promiscuous T-cell recognition of a rubella capsid protein epitope restricted by DRB1*0403 and DRB1*0901 molecules sharing an HLA DR supertype. Hum Immunol 59: 149-157
39. 39. Lohmann T, Leslie RDG, Londei M (1996) T cell clones to epitopes of glutamic acid decarboxylase 65 raised from normal subjects and patients with insulin-dependent diabetes. J Autoimmunity 9: 385-389
40. 40. Neophytou PI, Roep BO, Arden SD et al. (1996) T-cell epitope analysis using subtracted expression libraries (TEASEL): Application to a 38-KDa autoantigen recognised by T cells from an insulin-dependent diabetic patient. Proc Natl Acad Sci USA 93: 2014-2018
41. 41. Wicker LS, Chen SL, Nepom GT et al. (1996) Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the diabetes-associated human MHC class II allele, DRB1*0401. J Clin Invest 98: 2597-2603
42. 42. Rammensee HG, Feiede T, Stevanović S (1995) MHC ligands and peptide motifs: first listing. Immunogenetics 41: 178-228
43. + cytotoxic T cell clones reactive to capsid antigen of rubella virus. Virology 191: 680-686
44. + cytotoxic T cell clones. J Virol 66: 6788-6793
45. 45. Syren K, Lindsay L, Stoehrer B et al. (1996) Immune reactivity of diabetes-associated human monoclonal autoantibodies in glutamate detects two domain boundaries in glutamate decarboxylase. J Immunol 157: 5208-5214
46. 46. Hausmann S, Wucherpfennig W (1997) Activation of autoreactive T cells by peptides from human pathogens. Curr Opin Immunol 9: 831-838
47. 47. Zhao ZS, Granucci F, Yeh L, Schaffer PA, Cantor H (1998) Molecular mimicry by herpes simplex virus-Type I:autoimmune disease after viral infection. Science 279: 1344-1347
48. 48. Mason D (1998) A very high level of crossreactivity is an essential feature of the T-cell receptor. Immunol Today 19: 396-404
49. 49. Hemmer B, Vergelli M, Pinilla C, Houghten R, Martin R (1998) Probing degeneracy in T-cell recognition using peptide combinatorial libraries. Immunol Today 19: 163-168
50. 50. Endl J, Otto H, Jung G et al. (1997) Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients. J Clin Invest 99: 2405-2415
51. 51. Tabata H, Kanai T, Yoshizumi H et al. (1998) Characterization of self-glutamic acid decarboxylase 65-reactive CD4 + T-cell clones established from Japanese patients with insulin-dependent diabetes mellitus. Hum Immunol 59: 549-560
52. 52. Boyton RJ, Lohmann T, Londei M et al. (1998) Glutamic acid decarboxylase T lymphocyte responses associated with susceptibility or resistance to Type I diabetes:analysis in disease discordant human twins, non-obese diabetic mice and HLA-DQ transgenic mice. Int Immunol 10: 1765-1776
53. 53. Kaufman DL, Clare-Salzler M, Tian J et al. (1993) Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366: 69-72
54. 54. Zeche MA, Elliott JF, Atkinson MA, Singh B (1998) Characterization of novel T-cell epitopes on 65 kDa and 67 kDa glutamic acid decarboxylase relevant in autoimmune responses in NOD mice. J Autoimmunity 11: 83-95
55. 55. Panina-Bordignon P, Lang R, van Endert PM et al. (1995) Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes. J Exp Med 181: 1923-1927
56. 56. Tian J, Olcott AP, Hanssen LR, Zekzer D, Middleton B, Kaufman DL (1998) Infectious Th1 and Th2 autoimmunity in diabetes-prone mice. Immunol Rev 164: 119-127
57. 57. Zechel MA, Krawetz MD, Singh B (1998) Epitope dominance:evidence for reciprocal determinant spreading to glutamic acid decarboxylase in non-obese diabetic mice. Immunol Rev 164: 111-118
58. 58. Sercarz EE (1998) Immune focusing vs diversification and their connection to immune regulation. Immunol Rev 164: 5-10
59. 59. Chao CC, Sytwu HK, Chen EL, Toma J, McDevitt HO (1999) The role of MHC class II molecules in susceptibility to Type I diabetes:Identification of peptide epitopes and characterization of the T cell repertoire. Proc Natl Acad Sci USA 96: 9299-9304
60. 60. Herman, AE, Tisch RM, Patel SD et al. (1999) Determination of glutamic acid decarboxylase 65 peptides presented by the Type I diabetes-associated HLA-DQ8 class II molecule identifies an immunogenic peptide motif. J Immunol 163: 6275-6282
61. 61. von Herrath MG (1998) Selective immunotherapy of IDDM:A discussion based on new findings from the RIPLCMV model for autoimmune diabetes. Transplant Proc 30: 4115-4121
62. 62. Wucherpfennig KW, Strominger JL (1995) Molecular mimicry in T cell-mediated autoimmunity:viral peptides activate human T cells clones specific for myelin basic protein. Cell 80: 695-705
63. 63. Rosa FD, Barnaba V (1998) Persisting viruses and chronic inflammation:understanding their relation to autoimmunity. Immunol Rev 164: 17-27
64. 64. Bach JM, Otto H, Jung G et al. (1998) Identification of mimicry peptides base on sequential motifs of epitopes derived from 65-kDa glutamic acid decarboxylase. Eur Immunol 28: 1902-1910
65. 65. Moudgil KD, Sercarz EE, Grewal LS (1998) Modulation of the immunogenicity of antigenic determinants by their flanking residues. Immunol Today 19: 217-220
66. 66. Ding YH, Smith KL, Garboczi DN, Utz U, Biddison WE, Wiley DC (1998) Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Immunity 8: 403-411
67. 67. Janeway CA Jr (1998) A tale of two T cells. Immunity 8: 391-394
68. 68. Schloot NC, Roep BO, Wegmann DR, Yu L, Wang T, Eisenbarth GS (1997) T-cell reactivity of GAD65 peptide sequences shared with Coxsackievirus protein in recent onset IDDM, post onset IDDM patients and control subjects. Diabetologia 40: 332-338