A new class of HIV-1 integrase inhibitors: The 3,3,3',3'-tetramethyl- 1,1'-spirobi(indan)-5,5',6,6'-tetrol family

Journal of Medicinal Chemistry

Volumn 43, Issue 10, 2000, Pages 2031-2039

  Molteni, Valentina ^a   Rhodes, Denise ^b   Rubins, Kathleen ^b   Hansen, Mark ^b   Bushman, Frederic D ^b   Siegel, Jay S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,3,3',3' TETRAMETHYL 1,1' SPIROBI(INDAN) 5,5',6,6' TETROL DERIVATIVE; CATECHOL DERIVATIVE; INDAN DERIVATIVE; INTEGRASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL REACTION; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; REACTION ANALYSIS; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION;

ANTIVIRAL AGENTS; CATECHOLS; CATIONS, DIVALENT; CELL SURVIVAL; DNA TOPOISOMERASES, TYPE I; HELA CELLS; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; HYDROGEN BONDING; MAGNESIUM; MANGANESE; MOLECULAR STRUCTURE; MOLLUSCUM CONTAGIOSUM VIRUS; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034077984     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990600c     Document Type: Article

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