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Volumn 57, Issue 1, 2000, Pages 1-11

Genetic mapping of complex traits: Promises, problems, and prospects

Author keywords

[No Author keywords available]

Indexed keywords

GENE MAPPING; GENETIC TRAIT;

EID: 0034073938     PISSN: 00405809     EISSN: None     Source Type: Journal    
DOI: 10.1006/tpbi.2000.1449     Document Type: Review
Times cited : (23)

References (102)
  • 1
    • 0031966959 scopus 로고    scopus 로고
    • Multipoint quantitative-trait linkage analysis in general pedigrees
    • Almasy L., Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am. J. Hum. Genet. 62:1998;1198-1211.
    • (1998) Am. J. Hum. Genet. , vol.62 , pp. 1198-1211
    • Almasy, L.1    Blangero, J.2
  • 3
    • 0028058128 scopus 로고
    • Robust variance-components approach for assessing genetic linkage in pedigrees
    • Amos C. I. Robust variance-components approach for assessing genetic linkage in pedigrees. Am. J. Hum. Genet. 54:1994;535-543.
    • (1994) Am. J. Hum. Genet. , vol.54 , pp. 535-543
    • Amos, C.I.1
  • 8
    • 0031442937 scopus 로고    scopus 로고
    • Multipoint oligenic linkage analysis of quantitative traits
    • Blangero J., Almasy L. Multipoint oligenic linkage analysis of quantitative traits. Genet. Epidemiol. 14:1997;959-964.
    • (1997) Genet. Epidemiol. , vol.14 , pp. 959-964
    • Blangero, J.1    Almasy, L.2
  • 9
    • 0019302053 scopus 로고
    • Construction of a genetic linkage map in man using restriction fragment length polymorphisms
    • Botstein D., White R. L., Skolnick M., Davis R. W. Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am. J. Hum. Genet. 32:1980;314-331.
    • (1980) Am. J. Hum. Genet. , vol.32 , pp. 314-331
    • Botstein, D.1    White, R.L.2    Skolnick, M.3    Davis, R.W.4
  • 11
    • 84984932472 scopus 로고    scopus 로고
    • Exploring the new world of the genome with DNA microarrays
    • Brown P. O., Botstein D. Exploring the new world of the genome with DNA microarrays. Nat. Genet. Suppl. 21:1999;33-37.
    • (1999) Nat. Genet. Suppl. , vol.21 , pp. 33-37
    • Brown, P.O.1    Botstein, D.2
  • 13
    • 0032471913 scopus 로고    scopus 로고
    • Genome screens using linkage disequilibrium tests: Optimal marker characteristics and feasibility
    • Chapman N. H., Wijsman E. M. Genome screens using linkage disequilibrium tests: Optimal marker characteristics and feasibility. Am. J. Hum. Genet. 63:1998;1872-1878.
    • (1998) Am. J. Hum. Genet. , vol.63 , pp. 1872-1878
    • Chapman, N.H.1    Wijsman, E.M.2
  • 15
    • 0022728801 scopus 로고
    • Effects of misspecifying genetic parameters in lod score analysis
    • Clerget-Darpoux F., Bonaiti-Pellie C., Hochez J. Effects of misspecifying genetic parameters in lod score analysis. Biometrics. 42:1986;393-399.
    • (1986) Biometrics , vol.42 , pp. 393-399
    • Clerget-Darpoux, F.1    Bonaiti-Pellie, C.2    Hochez, J.3
  • 17
    • 0030688004 scopus 로고    scopus 로고
    • Variations on a theme: Cataloging human DNA sequence variation
    • Collins F. S., Guyer M. S., Charkravarti A. Variations on a theme: Cataloging human DNA sequence variation. Science. 278:1997;1580-1581.
    • (1997) Science , vol.278 , pp. 1580-1581
    • Collins, F.S.1    Guyer, M.S.2    Charkravarti, A.3
  • 20
    • 0031034373 scopus 로고    scopus 로고
    • Current status of linkage for schizophrenia: Polygene of vanishingly small effect or multiple false positives?
    • Crow T. J. Current status of linkage for schizophrenia: Polygene of vanishingly small effect or multiple false positives? Am. J. Med. Genet. 74:1997;99-103.
    • (1997) Am. J. Med. Genet. , vol.74 , pp. 99-103
    • Crow, T.J.1
  • 22
    • 0023111441 scopus 로고
    • Close linkage of c-Harvey-ras-1 and the insulin gene to affective disorder is ruled out in three North American pedigrees
    • Detera-Wadleigh S. D., Berrettini W. H., Goldin L. R., Boorman D., Anderson S., Gershon E. S. Close linkage of c-Harvey-ras-1 and the insulin gene to affective disorder is ruled out in three North American pedigrees. Nature. 325:1987;806-808.
    • (1987) Nature , vol.325 , pp. 806-808
    • Detera-Wadleigh, S.D.1    Berrettini, W.H.2    Goldin, L.R.3    Boorman, D.4    Anderson, S.5    Gershon, E.S.6
  • 23
    • 0030586840 scopus 로고    scopus 로고
    • Disequilibrium mapping: Composite likelihood for pairwise disequilibrium
    • Devlin B., Risch N., Roeder K. Disequilibrium mapping: composite likelihood for pairwise disequilibrium. Genomics. 36:1996;1-16.
    • (1996) Genomics , vol.36 , pp. 1-16
    • Devlin, B.1    Risch, N.2    Roeder, K.3
  • 24
    • 0029061838 scopus 로고
    • Statistical methods for linkage analysis of complex traits from high-resolution maps of identity by descent
    • Dupuis J., Brown P. O., Siegmund D. Statistical methods for linkage analysis of complex traits from high-resolution maps of identity by descent. Genetics. 140:1995;843-856.
    • (1995) Genetics , vol.140 , pp. 843-856
    • Dupuis, J.1    Brown, P.O.2    Siegmund, D.3
  • 26
    • 0015183542 scopus 로고
    • A general model for the genetic analysis of pedigree data
    • Elston R. C., Stewart J. A general model for the genetic analysis of pedigree data. Hum. Hered. 21:1971;523-542.
    • (1971) Hum. Hered. , vol.21 , pp. 523-542
    • Elston, R.C.1    Stewart, J.2
  • 28
    • 0032100266 scopus 로고    scopus 로고
    • Models for haplotype evolution in a nonstationary population
    • Fan R., Lange K. Models for haplotype evolution in a nonstationary population. Theor. Popul. Biol. 53:1998;184-198.
    • (1998) Theor. Popul. Biol. , vol.53 , pp. 184-198
    • Fan, R.1    Lange, K.2
  • 29
    • 0023679928 scopus 로고
    • Behavioral and neurochemical evaluation of a transgenic mouse model of Lesch-Nyhan syndrome
    • Finger S., Heavens R. P., Sirinathsinghji D. J., Kuehn M. R., Dunnett S. B. Behavioral and neurochemical evaluation of a transgenic mouse model of Lesch-Nyhan syndrome. J. Neurol. Sci. 86:1988;203-213.
    • (1988) J. Neurol. Sci. , vol.86 , pp. 203-213
    • Finger, S.1    Heavens, R.P.2    Sirinathsinghji, D.J.3    Kuehn, M.R.4    Dunnett, S.B.5
  • 31
    • 0028132244 scopus 로고
    • Additive multiplicative approximation of genotype-environment interaction
    • Gimelfarb A. Additive multiplicative approximation of genotype-environment interaction. Genetics. 138:1994;1339-1349.
    • (1994) Genetics , vol.138 , pp. 1339-1349
    • Gimelfarb, A.1
  • 33
    • 0025245437 scopus 로고
    • Multipoint analysis of human quantitative genetic variation
    • Goldgar D. E. Multipoint analysis of human quantitative genetic variation. Am. J. Hum. Genet. 47:1990;957-967.
    • (1990) Am. J. Hum. Genet. , vol.47 , pp. 957-967
    • Goldgar, D.E.1
  • 34
    • 0030051903 scopus 로고    scopus 로고
    • Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities
    • Gowen L. C., Johnson B. L., Latour A. M., Sulik K. K., Koller B. H. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nat. Genet. 12:1996;191-194.
    • (1996) Nat. Genet. , vol.12 , pp. 191-194
    • Gowen, L.C.1    Johnson, B.L.2    Latour, A.M.3    Sulik, K.K.4    Koller, B.H.5
  • 35
    • 0032231780 scopus 로고    scopus 로고
    • Inflation of sibling recurrence-risk ratio, due to ascertainment bias and/or overreporting
    • Guo S. W. Inflation of sibling recurrence-risk ratio, due to ascertainment bias and/or overreporting. Am. J. Hum. Genet. 63:1998;252-258.
    • (1998) Am. J. Hum. Genet. , vol.63 , pp. 252-258
    • Guo, S.W.1
  • 36
    • 0032807295 scopus 로고    scopus 로고
    • The behaviors of some heritability estimators in the complete absence of genetic factors
    • Guo S. W. The behaviors of some heritability estimators in the complete absence of genetic factors. Hum. Hered. 49:1999;215-228.
    • (1999) Hum. Hered. , vol.49 , pp. 215-228
    • Guo, S.W.1
  • 37
    • 0034210142 scopus 로고    scopus 로고
    • Familial aggregation of environmental risk factors and familial aggregation of disease
    • Guo S. W. Familial aggregation of environmental risk factors and familial aggregation of disease. Am. J. Epidemiol. 2000a.
    • (2000) Am. J. Epidemiol.
    • Guo, S.W.1
  • 38
    • 0034086537 scopus 로고    scopus 로고
    • Gene-environment interactions and the affected sib-pair designs
    • Guo S. W. Gene-environment interactions and the affected sib-pair designs. Hum. Hered. 2000b.
    • (2000) Hum. Hered.
    • Guo, S.W.1
  • 39
    • 0343817153 scopus 로고    scopus 로고
    • Gene-environment interaction and its impact on mapping
    • Guo S. W. Gene-environment interaction and its impact on mapping. Hum. Hered. 2000c.
    • (2000) Hum. Hered.
    • Guo, S.W.1
  • 40
    • 0343817152 scopus 로고    scopus 로고
    • Does higher concordance in monozygotic twins than in dizygotic twins suggest for a genetic component?
    • Guo S. W. Does higher concordance in monozygotic twins than in dizygotic twins suggest for a genetic component? Hum. Hered. 2000d.
    • (2000) Hum. Hered.
    • Guo, S.W.1
  • 44
    • 0000049938 scopus 로고
    • Chromosome abnormalities in human reproductive wastage
    • Hassold T. J. Chromosome abnormalities in human reproductive wastage. Trends Genet. 2:1986;105-110.
    • (1986) Trends Genet. , vol.2 , pp. 105-110
    • Hassold, T.J.1
  • 46
    • 0019920786 scopus 로고
    • Extensions to multivariate normal models for pedigree analysis
    • Hoppers J. L., Mathews J. D. Extensions to multivariate normal models for pedigree analysis. Ann. Hum. Genet. 46:1982;373-383.
    • (1982) Ann. Hum. Genet. , vol.46 , pp. 373-383
    • Hoppers, J.L.1    Mathews, J.D.2
  • 47
    • 0027480960 scopus 로고
    • Cell. 72:1993;971-983.
    • (1993) Cell , vol.72 , pp. 971-983
  • 49
    • 0028834034 scopus 로고
    • Likelihood methods for locating disease genes in nonequilibrium populations
    • Kaplan N. L., Hill W. G., Weir B. S. Likelihood methods for locating disease genes in nonequilibrium populations. Am. J. Hum. Genet. 56:1995;18-32.
    • (1995) Am. J. Hum. Genet. , vol.56 , pp. 18-32
    • Kaplan, N.L.1    Hill, W.G.2    Weir, B.S.3
  • 51
    • 16044368011 scopus 로고    scopus 로고
    • What's mice got to do with it?
    • Kinzler K. W., Vogelstein B. What's mice got to do with it? Nature. 382:1996;672.
    • (1996) Nature , vol.382 , pp. 672
    • Kinzler, K.W.1    Vogelstein, B.2
  • 52
    • 84984932880 scopus 로고    scopus 로고
    • Array of hope
    • Lander E. S. Array of hope. Nat. Genet. 21:1999;3-4.
    • (1999) Nat. Genet. , vol.21 , pp. 3-4
    • Lander, E.S.1
  • 53
    • 0016732662 scopus 로고
    • Extensions to pedigree analysis. I. Likelihood calculations for simple and complex pedigrees
    • Lange K., Elston R. C. Extensions to pedigree analysis. I. Likelihood calculations for simple and complex pedigrees. Hum. Hered. 25:1975;95-105.
    • (1975) Hum. Hered. , vol.25 , pp. 95-105
    • Lange, K.1    Elston, R.C.2
  • 54
    • 0342894769 scopus 로고    scopus 로고
    • Branching process models for mutant genes in nonstationary populations
    • Lange K., Fan R. Branching process models for mutant genes in nonstationary populations. Theor. Popul. Biol. 51:1997;118-133.
    • (1997) Theor. Popul. Biol. , vol.51 , pp. 118-133
    • Lange, K.1    Fan, R.2
  • 55
    • 0017165430 scopus 로고
    • Extensions to pedigree analysis. III. Variance components by the scoring method
    • Lange K., Westlake J., Spence M. A. Extensions to pedigree analysis. III. Variance components by the scoring method. Ann. Hum. Genet. 39:1976;485-491.
    • (1976) Ann. Hum. Genet. , vol.39 , pp. 485-491
    • Lange, K.1    Westlake, J.2    Spence, M.A.3
  • 56
    • 0031933164 scopus 로고    scopus 로고
    • A conditional inference framework for extending the transmission/disequilibrium test
    • Lazzeroni L. C., Lange K. A conditional inference framework for extending the transmission/disequilibrium test. Hum. Hered. 48:1998;67-81.
    • (1998) Hum. Hered. , vol.48 , pp. 67-81
    • Lazzeroni, L.C.1    Lange, K.2
  • 58
    • 0024514081 scopus 로고
    • A hypervariable microsatellite revealed by in vitro amplification of a dinucleotide repeat within the cardiac muscle actin gene
    • Litt M., Luty J. A. A hypervariable microsatellite revealed by in vitro amplification of a dinucleotide repeat within the cardiac muscle actin gene. Am. J. Hum. Genet. 44:1989;397-401.
    • (1989) Am. J. Hum. Genet. , vol.44 , pp. 397-401
    • Litt, M.1    Luty, J.A.2
  • 59
    • 0015838771 scopus 로고
    • Reproductive lifespan in irradiated and unirradiated chromosomally XO mice
    • Lyon M. F., Hawker S. G. Reproductive lifespan in irradiated and unirradiated chromosomally XO mice. Genet. Res. 21:1973;185-194.
    • (1973) Genet. Res. , vol.21 , pp. 185-194
    • Lyon, M.F.1    Hawker, S.G.2
  • 60
    • 0030087712 scopus 로고    scopus 로고
    • The nature of quantitative genetic variation revisited: Lessons from Drosophila bristles
    • Mackay T. F. The nature of quantitative genetic variation revisited: Lessons from Drosophila bristles. BioEssays. 18:1996;113-121.
    • (1996) BioEssays , vol.18 , pp. 113-121
    • MacKay, T.F.1
  • 63
    • 0043048571 scopus 로고
    • Sequential tests for the detection of linkage
    • Morton N. Sequential tests for the detection of linkage. Am. J. Hum. Genet. 7:1955;277-318.
    • (1955) Am. J. Hum. Genet. , vol.7 , pp. 277-318
    • Morton, N.1
  • 64
    • 0031979443 scopus 로고    scopus 로고
    • Significance levels in complex inheritance
    • Morton N. Significance levels in complex inheritance. Am. J. Hum. Genet. 62:1998;690-697.
    • (1998) Am. J. Hum. Genet. , vol.62 , pp. 690-697
    • Morton, N.1
  • 67
    • 0032453237 scopus 로고    scopus 로고
    • Type II diabetes, essential hypertension, and obesity as "syndromes of impaired genetic homeostasis": The "thrifty genotype" hypothesis enters the 21st century
    • Neel J. V., Weder A. B., Julius S. Type II diabetes, essential hypertension, and obesity as "syndromes of impaired genetic homeostasis": The "thrifty genotype" hypothesis enters the 21st century. Perspect Biol. Med. 42:1998;44-74.
    • (1998) Perspect Biol. Med. , vol.42 , pp. 44-74
    • Neel, J.V.1    Weder, A.B.2    Julius, S.3
  • 69
    • 0017192186 scopus 로고
    • A computer program for linkage analysis of general human pedigrees
    • Ott J. A computer program for linkage analysis of general human pedigrees. Am. J. Hum. Genet. 28:1976;528-529.
    • (1976) Am. J. Hum. Genet. , vol.28 , pp. 528-529
    • Ott, J.1
  • 70
    • 0030827879 scopus 로고    scopus 로고
    • The effect of marker heterozygosity on the power to detect linkage disequilibrium
    • Ott J., Rabinowitz D. The effect of marker heterozygosity on the power to detect linkage disequilibrium. Genetics. 147:1997;927-930.
    • (1997) Genetics , vol.147 , pp. 927-930
    • Ott, J.1    Rabinowitz, D.2
  • 71
    • 0032943622 scopus 로고    scopus 로고
    • From complex traits to complex alleles
    • Phillips P. C. From complex traits to complex alleles. Trends Genet. 15:1999;6-8.
    • (1999) Trends Genet. , vol.15 , pp. 6-8
    • Phillips, P.C.1
  • 72
    • 0033358548 scopus 로고    scopus 로고
    • Use of unlinked genetic markers to detect population stratification in association studies
    • Pritchard J. K., Rosenberg N. A. Use of unlinked genetic markers to detect population stratification in association studies. Am. J. Hum. Genet. 65:1999;220-228.
    • (1999) Am. J. Hum. Genet. , vol.65 , pp. 220-228
    • Pritchard, J.K.1    Rosenberg, N.A.2
  • 73
    • 0033015665 scopus 로고    scopus 로고
    • A genome search identifies major quantitative trait loci on human chromosomes 3 and 4 that influence cholesterol concentrations in small LDL particles
    • Rainwater D. L., Almasy L., Blangero J., Cole S. A., VandeBerg J. L., MacCluer J. W., Hixson J. E. A genome search identifies major quantitative trait loci on human chromosomes 3 and 4 that influence cholesterol concentrations in small LDL particles. Arterioscler. Thromb. Vasc. Biol. 19:1999;777-783.
    • (1999) Arterioscler. Thromb. Vasc. Biol. , vol.19 , pp. 777-783
    • Rainwater, D.L.1    Almasy, L.2    Blangero, J.3    Cole, S.A.4    Vandeberg, J.L.5    MacCluer, J.W.6    Hixson, J.E.7
  • 74
    • 0029916003 scopus 로고    scopus 로고
    • A manic depressive history
    • Risch N., Botstein D. A manic depressive history. Nat. Genet. 12:1996;351-353.
    • (1996) Nat. Genet. , vol.12 , pp. 351-353
    • Risch, N.1    Botstein, D.2
  • 75
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • Risch N., Merikangas K. The future of genetic studies of complex human diseases. Science. 273:1996;1516-1517.
    • (1996) Science , vol.273 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 76
    • 0029001682 scopus 로고
    • Extreme discordant sib pairs for mapping quantitative trait loci in humans
    • Risch N., Zhang H. Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science. 268:1995;1584-1589.
    • (1995) Science , vol.268 , pp. 1584-1589
    • Risch, N.1    Zhang, H.2
  • 77
    • 0033046371 scopus 로고    scopus 로고
    • Case-parents design for gene-environment interaction
    • Schaid D. J. Case-parents design for gene-environment interaction. Genet. Epidemiol. 16:1999;261-273.
    • (1999) Genet. Epidemiol. , vol.16 , pp. 261-273
    • Schaid, D.J.1
  • 78
    • 0027362259 scopus 로고
    • Extended multipoint identity-by-descent analysis of human quantitative traits: Efficiency, power, and modeling considerations
    • Schork N. J. Extended multipoint identity-by-descent analysis of human quantitative traits: Efficiency, power, and modeling considerations. Am. J. Hum. Genet. 53:1993;1306-1319.
    • (1993) Am. J. Hum. Genet. , vol.53 , pp. 1306-1319
    • Schork, N.J.1
  • 79
    • 0342449968 scopus 로고
    • Numerical variants and structural rearrangements
    • M. F. Lyon, & A. G. Searle. Oxford: Oxford Univ. Press
    • Searle A. G. Numerical variants and structural rearrangements. Lyon M. F., Searle A. G. Genetic Variants and Strains of the Laboratory Mouse. 1989;582-616 Oxford Univ. Press, Oxford.
    • (1989) Genetic Variants and Strains of the Laboratory Mouse , pp. 582-616
    • Searle, A.G.1
  • 80
    • 0025164335 scopus 로고
    • Hypertension and vascular disease in India and migrant Indian populations in the world
    • Seedat Y. K. Hypertension and vascular disease in India and migrant Indian populations in the world. J. Hum. Hypertens. 4:1990;421-424.
    • (1990) J. Hum. Hypertens. , vol.4 , pp. 421-424
    • Seedat, Y.K.1
  • 83
    • 0029945706 scopus 로고    scopus 로고
    • Descent graphs in pedigree analysis: Applications to haplotyping, location scores, and marker sharing statistics
    • Sobel E., Lange K. Descent graphs in pedigree analysis: Applications to haplotyping, location scores, and marker sharing statistics. Am. J. Hum. Genet. 58:1996;1323-1337.
    • (1996) Am. J. Hum. Genet. , vol.58 , pp. 1323-1337
    • Sobel, E.1    Lange, K.2
  • 84
    • 0027377799 scopus 로고
    • Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
    • Spielman R. S., McGinnis R. E., Ewens W. J. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am. J. Hum. Genet. 52:1993;506-516.
    • (1993) Am. J. Hum. Genet. , vol.52 , pp. 506-516
    • Spielman, R.S.1    McGinnis, R.E.2    Ewens, W.J.3
  • 85
    • 0026323687 scopus 로고
    • Carcinogenesis and cancer: Different perspectives on the same disease
    • Sporn M. B. Carcinogenesis and cancer: Different perspectives on the same disease. Cancer Res. 51:1991;6215-6218.
    • (1991) Cancer Res. , vol.51 , pp. 6215-6218
    • Sporn, M.B.1
  • 87
    • 84956762643 scopus 로고
    • The linear arrangement of six sex-linked factors in Drosophila, as shown by their mode of association
    • Sturtevant A. H. The linear arrangement of six sex-linked factors in Drosophila, as shown by their mode of association. J. Exp. Zool. 14:1913;43-59.
    • (1913) J. Exp. Zool , vol.14 , pp. 43-59
    • Sturtevant, A.H.1
  • 88
    • 0002710362 scopus 로고
    • Problems of replicating linkage claims in psychiatry
    • E. S. Gershon, & C. R. Cloninger. Washington: American Psychiatric Assoc.
    • Suarez B. K., Hampe C. L., Van Eerdewegh P. Problems of replicating linkage claims in psychiatry. Gershon E. S., Cloninger C. R. Genetic Approaches to Mental Disorders. 1994;23-46 American Psychiatric Assoc. Washington.
    • (1994) Genetic Approaches to Mental Disorders , pp. 23-46
    • Suarez, B.K.1    Hampe, C.L.2    Van Eerdewegh, P.3
  • 89
    • 0030902227 scopus 로고    scopus 로고
    • Population genetics of BRCA1 and BRCA2
    • Szabo C. I., King M.-C. Population genetics of BRCA1 and BRCA2. Am. J. Hum. Genet. 60:1997;1013-1020.
    • (1997) Am. J. Hum. Genet. , vol.60 , pp. 1013-1020
    • Szabo, C.I.1    King, M.-C.2
  • 90
    • 0028968329 scopus 로고
    • A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci
    • Terwilliger J. D. A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci. Am. J. Hum. Genet. 56:1995;777-787.
    • (1995) Am. J. Hum. Genet. , vol.56 , pp. 777-787
    • Terwilliger, J.D.1
  • 91
    • 0026494911 scopus 로고
    • A haplotype-based "haplotype relative risk" approach to detecting allelic associations
    • Terwilliger J. D., Ott J. A haplotype-based "haplotype relative risk" approach to detecting allelic associations. Hum. Hered. 42:1992;337-346.
    • (1992) Hum. Hered. , vol.42 , pp. 337-346
    • Terwilliger, J.D.1    Ott, J.2
  • 93
    • 0022189933 scopus 로고
    • Genotype-environment interaction and the evolution of phenotypic plasticity
    • Via S., Lande R. Genotype-environment interaction and the evolution of phenotypic plasticity. Evolution. 39:1985;505-522.
    • (1985) Evolution , vol.39 , pp. 505-522
    • Via, S.1    Lande, R.2
  • 94
    • 0006951117 scopus 로고    scopus 로고
    • 10 drug makers join to find genetic roots of diseases
    • Wade N. 10 drug makers join to find genetic roots of diseases. New York Times. 1999.
    • (1999) New York Times
    • Wade, N.1
  • 95
    • 0002966223 scopus 로고
    • Familial aggregation and genetic epidemiology of blood pressure
    • J. G. Laragh, & B. M. Brenner. New York: Raven Press
    • Ward R. H. Familial aggregation and genetic epidemiology of blood pressure. Laragh J. G., Brenner B. M. Hypertension: Pathophysiology and Management. 1990;81-100 Raven Press, New York.
    • (1990) Hypertension: Pathophysiology and Management , pp. 81-100
    • Ward, R.H.1
  • 96
    • 0024582686 scopus 로고
    • Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction
    • Weber J. L., May P. E. Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. Am. J. Hum. Genet. 44:1989;388-396.
    • (1989) Am. J. Hum. Genet. , vol.44 , pp. 388-396
    • Weber, J.L.1    May, P.E.2
  • 97
    • 0031949066 scopus 로고    scopus 로고
    • A log-linear approach to case-parent-triad data: Assessing effects of disease genes that act either directly or through maternal effects and that may be subject to parental imprinting
    • Weinberg C. R., Wilcox A. J., Lie R. T. A log-linear approach to case-parent-triad data: Assessing effects of disease genes that act either directly or through maternal effects and that may be subject to parental imprinting. Am. J. Hum. Genet. 62:1998;969-978.
    • (1998) Am. J. Hum. Genet. , vol.62 , pp. 969-978
    • Weinberg, C.R.1    Wilcox, A.J.2    Lie, R.T.3
  • 98
    • 0031687751 scopus 로고    scopus 로고
    • In search of human variation
    • Weiss K. M. In search of human variation. Genome Res. 8:1998;691-697.
    • (1998) Genome Res. , vol.8 , pp. 691-697
    • Weiss, K.M.1
  • 99
    • 84996075779 scopus 로고
    • A New World syndrome of metabolic diseases with a genetic and evolutionary basis
    • Weiss K. M., Ferrell R. E., Hanis C. L. A New World syndrome of metabolic diseases with a genetic and evolutionary basis. Yearbook Phys. Anthropol. 27:1984;153-178.
    • (1984) Yearbook Phys. Anthropol. , vol.27 , pp. 153-178
    • Weiss, K.M.1    Ferrell, R.E.2    Hanis, C.L.3
  • 100
    • 0030994211 scopus 로고    scopus 로고
    • Fine-scale genetic mapping based on linkage disequilibrium: Theory and applications
    • Xiong M., Guo S. W. Fine-scale genetic mapping based on linkage disequilibrium: Theory and applications. Am. J. Hum. Genet. 60:1997;1513-1531.
    • (1997) Am. J. Hum. Genet. , vol.60 , pp. 1513-1531
    • Xiong, M.1    Guo, S.W.2
  • 101
    • 0031793251 scopus 로고    scopus 로고
    • The power of linkage detection by the transmission/disequilibrium tests
    • Xiong M., Guo S. W. The power of linkage detection by the transmission/disequilibrium tests. Hum. Hered. 48:1998;295-312.
    • (1998) Hum. Hered. , vol.48 , pp. 295-312
    • Xiong, M.1    Guo, S.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.