From complex traits to complex alleles

Trends in Genetics

Volumn 15, Issue 1, 1999, Pages 6-8

  Phillips, Patrick C ^a  

^a UNIVERSITY OF TEXAS AT ARLINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; DROSOPHILA; GENE LOCUS; GENE TARGETING; GENETIC POLYMORPHISM; GENETIC VARIABILITY; MOLECULAR EVOLUTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SEQUENCE ANALYSIS; SHORT SURVEY;

ALLELES; ANIMALS; CHROMOSOME MAPPING; DROSOPHILA MELANOGASTER; EVOLUTION; FEMALE; GENES, INSECT; GENETIC DISEASES, INBORN; GENETIC HETEROGENEITY; HUMANS; INFERTILITY, MALE; MALE; MEMBRANE PROTEINS; PHENOTYPE; POLYMORPHISM, GENETIC; QUANTITATIVE TRAIT, HERITABLE;

EID: 0032943622     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(98)01622-9     Document Type: Short Survey

References (19)

1. Tanksley S.D. Mapping polygenes. Annu. Rev. Genet. 27:1993;205-233.
2. Mackay T.F.C. The genetic basis of quantitative variation: numbers of sensory bristles of Drosophila melanogaster as a model system. Trends Genet. 11:1995;464-470.
3. Long A.D.et al. Two sites in the Delta gene region contribute to naturally occurring variation in bristle number in Drosophila melanogaster. Genetics. 149:1998;999-1017.
4. Long A.D.et al. High resolution mapping of genetic factors affecting abdominal bristle number in Drosophila melanogaster. Genetics. 144:1995;1497-1510.
5. Jan, Y.N., Jan, L.Y. (1993) The Peripheral Nervous System in The Development of Drosophila Melanogaster, Vol 2 (Bate, M, and Martinez Arias, A. Eds), pp 1207-1244, Cold Spring Harbor Laboratory Press.
6. Parks A.L., Muskavitch M.A. Delta function is required for bristle organ determination and morphogenesis in Drosophila. Dev. Biol. 157:1993;484-496.
7. Artavanis-Tsakonas S.et al. Notch signaling. Science. 268:1995;225-232.
8. Long A.D.et al. Genetic interactions between naturally occurring alleles at quantitative trait loci and mutant alleles at candidate loci affecting bristle number in Drosophila melanogaster. Genetics. 144:1996;1497-1510.
9. Lyman R.F., Mackay T.F.C. Candidate quantitative trait loci and naturally occurring phenotypic variation for bristle number in Drosophila melanogaster: the Delta-Hairless gene region. Genetics. 149:1998;983-998.
10. Risch N., Merikangas K. The future of genetic studies of complex human diseases. Science. 273:1996;1516-1517.
11. Haenlin M.et al. Genomic regions regulating early embryonic expression of the Drosophila neurogenic gene Delta. Mech. Dev. 47:1994;99-110.
12. Stam L.F., Laurie C.C. Molecular dissection of a major gene effect on a quantitative trait: the level of alcohol dehydrogenase expression in Drosophila melanogaster. Genetics. 144:1996;1559-1564.
13. Parsch J.et al. Site-directed mutations reveal long-range compensatory interactions in the Adh gene of Drosophila melanogaster. Proc. Natl. Acad. Sci. U. S. A. 94:1997;928-933.
14. Orr H.A., Coyne J.A. The genetics of adaptation: a reassessment. Am. Nat. 140:1992;725-742.
15. Wu C.I., Palopoli M.F. Genetics of postmating reproductive isolation in animals. Annu. Rev. Genet. 27:1994;283-308.
16. Davis A.W., Wu C.I. The broom of the sorcerer's apprentice: the fine structure of a chromosomal region causing reproductive isolation between two sibling species of Drosophila. Genetics. 143:1996;1287-1298.
17. Cystic Fibrosis Genetic Analysis Consortium (1998) Cystic Fibrosis Genetic Database. www.genet.sickkids.on.ca/cftr/
18. Beroud C., Soussi T. p53 gene mutation: software and database. Nucleic Acids Res. 26:1998;200-204.
19. Nickerson D.A.et al. DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene. Nat. Genet. 19:1998;233-240.