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Volumn 25, Issue 3, 2000, Pages 269-277

Ascomycin derivatives and their use as immunosupprossive agents

Author keywords

[No Author keywords available]

Indexed keywords

1 (3,3 DIMETHYL 1,2 DIOXOPENTYL) 2 PYRROLIDINECARBOXYLIC ACID 3 (3 PYRIDYL)PROPYL ESTER; 32 O [1 (2 HYDROXYETHYL) 5 INDOLYL]ASCOMYCIN; A 119435; ABT 281; ASCOMYCIN; CP 123369; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; L 685818; L 733725; MACROLIDE; PIMECROLIMUS; SDZ 281240; SDZ MDL 987; TACROLIMUS; UNCLASSIFIED DRUG;

EID: 0034051644     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2000.025.03.574454     Document Type: Review
Times cited : (5)

References (75)
  • 1
    • 40849148976 scopus 로고
    • Ascomycin, an antifungal antibiotic
    • Ser. A
    • Aral, T., Koyama, Y., Suenaga, T., Honda, H. Ascomycin, an antifungal antibiotic. J Antibiotics 1962, Ser. A 15: 231-2.
    • (1962) J Antibiotics , vol.15 , pp. 231-232
    • Aral, T.1    Koyama, Y.2    Suenaga, T.3    Honda, H.4
  • 3
    • 0023245677 scopus 로고
    • FK-506, a novel immunosuppressant isolated from a streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics
    • Kino, T., Hatanaka, H., Hashimoto, M. et al. FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics. J Antibiotics 1987, 40: 1249-55.
    • (1987) J Antibiotics , vol.40 , pp. 1249-1255
    • Kino, T.1    Hatanaka, H.2    Hashimoto, M.3
  • 4
    • 0023264587 scopus 로고
    • Structure of FK506: A novel immunosuppressant isolated from streptomyces
    • Tanaka, H., Kuroda, A., Marusawa, H. et al. Structure of FK506: A novel immunosuppressant isolated from Streptomyces. J Am Chem Soc 1987, 109: 5031-3.
    • (1987) J Am Chem Soc , vol.109 , pp. 5031-5033
    • Tanaka, H.1    Kuroda, A.2    Marusawa, H.3
  • 5
    • 0023708531 scopus 로고
    • FR-900520 and FR-900523, novel immunosuppressants isolated from a streptomyces. I. Taxonomy of the producing strain
    • Hatanaka, H., Iwami, M., Kino, T., Goto, T., Okuhara, M. FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. I. Taxonomy of the producing strain. J Antibiotics 1988, 41: 1586-91.
    • (1988) J Antibiotics , vol.41 , pp. 1586-1591
    • Hatanaka, H.1    Iwami, M.2    Kino, T.3    Goto, T.4    Okuhara, M.5
  • 6
    • 0023691846 scopus 로고
    • FR-900520 and FR-900523, novel immunosuppressants isolated from a streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics
    • Hatanaka, H., Kino, T., Miyata, S. et al. FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics. J Antibiotics 1988, 41: 1592-601.
    • (1988) J Antibiotics , vol.41 , pp. 1592-1601
    • Hatanaka, H.1    Kino, T.2    Miyata, S.3
  • 7
    • 0026503793 scopus 로고
    • Identity of immunosuppressant FR-900520 with ascomycin
    • Morisaki, M., Aral, T. Identity of immunosuppressant FR-900520 with ascomycin. J Antibiotics 1992, 45: 126-8.
    • (1992) J Antibiotics , vol.45 , pp. 126-128
    • Morisaki, M.1    Aral, T.2
  • 8
    • 0027441751 scopus 로고
    • The chemistry of ascomycin: Structure determination and synthesis of pyrazole analogues
    • Or, Y.S., Clark, R.F., Qinghua, X. et al. The chemistry of ascomycin: Structure determination and synthesis of pyrazole analogues. Tetrahedron Lett 1993, 49: 8771-86.
    • (1993) Tetrahedron Lett , vol.49 , pp. 8771-8786
    • Or, Y.S.1    Clark, R.F.2    Qinghua, X.3
  • 9
    • 0017157814 scopus 로고
    • Biological effects of cyclosporin a: A new antilymphocytic agent
    • Borel, J.F., Feurer, C., Gubler, H.U., Stahelin, H. Biological effects of cyclosporin A: A new antilymphocytic agent. Agents Actions 1976, 6: 468-75.
    • (1976) Agents Actions , vol.6 , pp. 468-475
    • Borel, J.F.1    Feurer, C.2    Gubler, H.U.3    Stahelin, H.4
  • 10
    • 0025893168 scopus 로고
    • Calcineurin is a common target of cyclophilincyclosporin A and FKBP-FK506 complexes
    • Liu, J. Farmer, J.D., Lane, W.S., Friedman, J., Weissman, I., Schreiber, S.L. Calcineurin is a common target of cyclophilincyclosporin A and FKBP-FK506 complexes. Cell 1991, 66: 807-15.
    • (1991) Cell , vol.66 , pp. 807-815
    • Liu, J.1    Farmer, J.D.2    Lane, W.S.3    Friedman, J.4    Weissman, I.5    Schreiber, S.L.6
  • 12
    • 0027485716 scopus 로고
    • Tacrolimus. A review of its pharmacology, and therapeutic potential in hepatic and renal transplantation
    • Peters, D.H., Fitton, A., Plosker, G.L., Faulds, D. Tacrolimus. A review of its pharmacology, and therapeutic potential in hepatic and renal transplantation. Drugs 1993, 46: 746-94.
    • (1993) Drugs , vol.46 , pp. 746-794
    • Peters, D.H.1    Fitton, A.2    Plosker, G.L.3    Faulds, D.4
  • 13
    • 0024992684 scopus 로고
    • Emerging indications for the use of cyclosporin in organ transplantation and autoimmunity
    • Keown, P.A. Emerging indications for the use of cyclosporin in organ transplantation and autoimmunity. Drugs 1990, 40: 315-25.
    • (1990) Drugs , vol.40 , pp. 315-325
    • Keown, P.A.1
  • 14
    • 0032705262 scopus 로고    scopus 로고
    • Tacrolimus (FK506) in the treatment of severe, refractory rheumatoid arthritis: Initial experience in 12 patients
    • Gremillion, R.B., Posever, J.O., Manek, N., West, J.P., Van Vollen-Hoven, R.F. Tacrolimus (FK506) in the treatment of severe, refractory rheumatoid arthritis: Initial experience in 12 patients. J Rheumatol 1999, 26: 2332-6.
    • (1999) J Rheumatol , vol.26 , pp. 2332-2336
    • Gremillion, R.B.1    Posever, J.O.2    Manek, N.3    West, J.P.4    Van Vollen-Hoven, R.F.5
  • 15
    • 0026644138 scopus 로고
    • Clinical experience with sandimmune (cyclosporine) in autoimmune diseases
    • Feutren, G. Clinical experience with Sandimmune (cyclosporine) in autoimmune diseases. Transplant Proc 1992, 24: 55-60.
    • (1992) Transplant Proc , vol.24 , pp. 55-60
    • Feutren, G.1
  • 16
    • 0032953631 scopus 로고    scopus 로고
    • Tacrolimus: The drug for the turn of the millennium?
    • Ruzicka, T., Assmann, T., Homey, B. Tacrolimus: The drug for the turn of the millennium? Arch Dermatol 1999, 135: 574-80.
    • (1999) Arch Dermatol , vol.135 , pp. 574-580
    • Ruzicka, T.1    Assmann, T.2    Homey, B.3
  • 17
    • 8244228685 scopus 로고    scopus 로고
    • Treatment of psoriasis with intermittent short course cyclosporin (neoral). A multicentre study
    • Berth-Jones, J., Henderson, C.A., Munro, C.S. et al. Treatment of psoriasis with intermittent short course cyclosporin (Neoral). A multicentre study. Br J Dermatol 1997, 136: 527-30.
    • (1997) Br J Dermatol , vol.136 , pp. 527-530
    • Berth-Jones, J.1    Henderson, C.A.2    Munro, C.S.3
  • 18
    • 0030071686 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled study of cyclosporin A as a corticosteroid-sparing agent in corticosteroid-dependent asthma
    • Lock, S.H., Kay, A.B., Barnes, N.C. Double-blind, placebo-controlled study of cyclosporin A as a corticosteroid-sparing agent in corticosteroid-dependent asthma. Am J Respir Crit Care Med 1996, 153: 509-14.
    • (1996) Am J Respir Crit Care Med , vol.153 , pp. 509-514
    • Lock, S.H.1    Kay, A.B.2    Barnes, N.C.3
  • 19
    • 0028309623 scopus 로고
    • Immunosuppressive agents in chronic severe asthma
    • Kay, A.B. Immunosuppressive agents in chronic severe asthma. Allergy Proc 1994, 15: 147-50.
    • (1994) Allergy Proc , vol.15 , pp. 147-150
    • Kay, A.B.1
  • 20
    • 0031907368 scopus 로고    scopus 로고
    • Effect of inhaled ingredients of a commercial cyclosporin A ampoule on airway inflammation
    • Ceyhan, B., Sungur, M., Celikel, C.A., Celikel, T. Effect of inhaled ingredients of a commercial cyclosporin A ampoule on airway inflammation. Respiration 1998, 65: 89.
    • (1998) Respiration , vol.65 , pp. 89
    • Ceyhan, B.1    Sungur, M.2    Celikel, C.A.3    Celikel, T.4
  • 21
    • 0029146704 scopus 로고
    • Effect of some immunosuppressors on allergic bronchial inflammation and airway hyperresponsiveness in mice
    • Nagai, H., Yamaguchi, S., Tanaka, H., Inagaki, N. Effect of some immunosuppressors on allergic bronchial inflammation and airway hyperresponsiveness in mice. Int Arch Allergy Immunol 1995, 108: 189-95.
    • (1995) Int Arch Allergy Immunol , vol.108 , pp. 189-195
    • Nagai, H.1    Yamaguchi, S.2    Tanaka, H.3    Inagaki, N.4
  • 22
    • 0031026969 scopus 로고    scopus 로고
    • Inhibition by the immunosuppressive agent FK506 of antigen-induced airways eosinophilia and bronchial hyperre-activity in mice
    • Eum, S.-Y., Zuany-Amorim, C., Lefort, J., Pretolani, M., Vargaftic, B. Inhibition by the immunosuppressive agent FK506 of antigen-induced airways eosinophilia and bronchial hyperre-activity in mice. Br J Pharmacol 1997, 120: 130-6.
    • (1997) Br J Pharmacol , vol.120 , pp. 130-136
    • Eum, S.-Y.1    Zuany-Amorim, C.2    Lefort, J.3    Pretolani, M.4    Vargaftic, B.5
  • 23
    • 0033033204 scopus 로고    scopus 로고
    • Cyclospohne and tacrolimus (FK506): A comparison of efficacy and safety profiles
    • Henry, M.L. Cyclospohne and tacrolimus (FK506): A comparison of efficacy and safety profiles. Clin Transplant 1999, 13: 209-20.
    • (1999) Clin Transplant , vol.13 , pp. 209-220
    • Henry, M.L.1
  • 25
    • 0032489058 scopus 로고    scopus 로고
    • Nephrotoxicity studies of the immunosuppressants tacrolimus (FK506) and ascomycin in rat models
    • Mollison, K.W., Fey, T.A., Krause, R.A. et al. Nephrotoxicity studies of the immunosuppressants tacrolimus (FK506) and ascomycin in rat models. Toxicology 1998, 125: 169-81.
    • (1998) Toxicology , vol.125 , pp. 169-181
    • Mollison, K.W.1    Fey, T.A.2    Krause, R.A.3
  • 26
    • 0028329373 scopus 로고
    • Tacrolimus, a new immunosuppressant - A review of the literature
    • Hooks, M.A. Tacrolimus, a new immunosuppressant - A review of the literature. Ann Pharmacother 1994, 28: 501-11.
    • (1994) Ann Pharmacother , vol.28 , pp. 501-511
    • Hooks, M.A.1
  • 27
    • 0026768730 scopus 로고
    • The immunosuppressive and toxic effects of FK-506 are mechanistically related: Pharmacology of a novel antagonist of FK-506 and rapamycin
    • Dumont, F.J., Staruch, M.J., Koprak., S.L. et al. The immunosuppressive and toxic effects of FK-506 are mechanistically related: Pharmacology of a novel antagonist of FK-506 and rapamycin. J Exp Med 1992, 176: 751-60.
    • (1992) J Exp Med , vol.176 , pp. 751-760
    • Dumont, F.J.1    Staruch, M.J.2    Koprak, S.L.3
  • 28
    • 0029133116 scopus 로고
    • X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex
    • Griffith, J.P., Kim, J.L., Kim, E.E. et al. X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex. Cell 1995, 82: 507-22.
    • (1995) Cell , vol.82 , pp. 507-522
    • Griffith, J.P.1    Kim, J.L.2    Kim, E.E.3
  • 29
    • 0028954844 scopus 로고
    • The C-32 triacetyl-L-rhamnose derivative of ascomycin: A potent, orally active macrolactone immunosuppressant
    • Koch, K., Newborg, M.F., Hanson, D.C. et al. The C-32 triacetyl-L-rhamnose derivative of ascomycin: A potent, orally active macrolactone immunosuppressant. J Med Chem 1995, 38: 1255-8.
    • (1995) J Med Chem , vol.38 , pp. 1255-1258
    • Koch, K.1    Newborg, M.F.2    Hanson, D.C.3
  • 30
    • 15444350659 scopus 로고    scopus 로고
    • Discovery of less nephrotoxic FK506 analogs and determining immunophilin dependence of immunosuppressant nephrotoxicity with a novel single-dose rat cisplatin potentiation assay
    • Mollison, K.W., Fey, T.A., Krause, R.A. et al. Discovery of less nephrotoxic FK506 analogs and determining immunophilin dependence of immunosuppressant nephrotoxicity with a novel single-dose rat cisplatin potentiation assay. J Pharmacol Exp Ther 1997, 283: 1509-19.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 1509-1519
    • Mollison, K.W.1    Fey, T.A.2    Krause, R.A.3
  • 31
    • 0029018792 scopus 로고
    • Preparation and in vitro activity of aryl ether derivatives of the FK-506 related immunosuppressive macrolides ascomycin and L-683,742
    • Sinclair, P.J., Wong, F., Wyvratt, M., Staruch, M.J., Dumont, F. Preparation and in vitro activity of aryl ether derivatives of the FK-506 related immunosuppressive macrolides ascomycin and L-683,742. Bioorg Med Chem Lett 1995, 5: 1035-8.
    • (1995) Bioorg Med Chem Lett , vol.5 , pp. 1035-1038
    • Sinclair, P.J.1    Wong, F.2    Wyvratt, M.3    Staruch, M.J.4    Dumont, F.5
  • 32
    • 0030591689 scopus 로고    scopus 로고
    • Preparation and in vitro activities of naphthyl and indolyl ether derivatives of the FK-506 related immunosuppressive macrolide ascomycin
    • Sinclair, P.J., Wong, F., Staruch, M.J., et al. Preparation and in vitro activities of naphthyl and indolyl ether derivatives of the FK-506 related immunosuppressive macrolide ascomycin. Bioorg Med Chem Lett 1996, 6: 2193-6.
    • (1996) Bioorg Med Chem Lett , vol.6 , pp. 2193-2196
    • Sinclair, P.J.1    Wong, F.2    Staruch, M.J.3
  • 33
    • 0031888520 scopus 로고    scopus 로고
    • A tacrolimus-related immunosuppressant with biochemical properties distinct from those of tacrolimus
    • Peterson, L.B., Cryan, J.G., Rosa, R. et al. A tacrolimus-related immunosuppressant with biochemical properties distinct from those of tacrolimus. Transplantation 1998, 65: 10-8.
    • (1998) Transplantation , vol.65 , pp. 10-18
    • Peterson, L.B.1    Cryan, J.G.2    Rosa, R.3
  • 34
    • 0031888792 scopus 로고    scopus 로고
    • A tacrolimus-related immunosuppressant with reduced toxicity
    • Dumont, F.J., Koprak, S., Staruch, M.J. et al. A tacrolimus-related immunosuppressant with reduced toxicity. Transplantation 1998, 65: 18-26.
    • (1998) Transplantation , vol.65 , pp. 18-26
    • Dumont, F.J.1    Koprak, S.2    Staruch, M.J.3
  • 35
    • 0028226859 scopus 로고
    • Alkyl ether analogs of the FK-506 related immunosuppressive macrolide L-683,590 (ascomycin)
    • Goulet, M.T., Hodkey, D.W., Staruch, M.J. et al. Alkyl ether analogs of the FK-506 related immunosuppressive macrolide L-683,590 (ascomycin). Bioorg Med Chem Lett 1994, 4: 921-6.
    • (1994) Bioorg Med Chem Lett , vol.4 , pp. 921-926
    • Goulet, M.T.1    Hodkey, D.W.2    Staruch, M.J.3
  • 36
    • 0033584201 scopus 로고    scopus 로고
    • C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: A tether length study
    • Goulet, M.T., Sinclair, P.J., Wong, F. et al. C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: A tether length study. Bioorg Med Chem Lett 1999, 9: 2085-8.
    • (1999) Bioorg Med Chem Lett , vol.9 , pp. 2085-2088
    • Goulet, M.T.1    Sinclair, P.J.2    Wong, F.3
  • 37
    • 0033584181 scopus 로고    scopus 로고
    • Potent immunosuppressive C(32)-O-arylethyl ether derivatives of ascomycin with reduced toxicity
    • Armstrong, H.M., Wong, F., Holmes, M.A. et al. Potent immunosuppressive C(32)-O-arylethyl ether derivatives of ascomycin with reduced toxicity. Bioorg Med Chem Lett 1999, 9: 2089-94.
    • (1999) Bioorg Med Chem Lett , vol.9 , pp. 2089-2094
    • Armstrong, H.M.1    Wong, F.2    Holmes, M.A.3
  • 38
    • 0032544146 scopus 로고    scopus 로고
    • C32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential
    • Goulet, M.T., McAlpine, S.R., Staruch, M.J. et al. C32-O-Imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential. Bioorg Med Chem Lett 1998, 8: 2253-8.
    • (1998) Bioorg Med Chem Lett , vol.8 , pp. 2253-2258
    • Goulet, M.T.1    McAlpine, S.R.2    Staruch, M.J.3
  • 39
    • 0032544472 scopus 로고    scopus 로고
    • Mild aryl ether formation in the semisynthesis of the novel macrolide immunosuppressant L-732,531
    • Brands, K.M., Dolling, U.-H., Jobson, R.B., Marchesini, G., Reamer, R.A., Williams, J.M. Mild aryl ether formation in the semisynthesis of the novel macrolide immunosuppressant L-732,531. J Org Chem 1998, 63: 6721-6.
    • (1998) J Org Chem , vol.63 , pp. 6721-6726
    • Brands, K.M.1    Dolling, U.-H.2    Jobson, R.B.3    Marchesini, G.4    Reamer, R.A.5    Williams, J.M.6
  • 40
    • 0033583152 scopus 로고    scopus 로고
    • Highly chemoselective trichloroacetimidate-mediated alkylation of ascomycin: A convergent, practical synthesis of the immunosupressant L-733,725
    • Song, Z., DeMarco, A., Zhao, M. et al. Highly chemoselective trichloroacetimidate-mediated alkylation of ascomycin: A convergent, practical synthesis of the immunosupressant L-733,725. J Org Chem 1999, 64: 1859-67.
    • (1999) J Org Chem , vol.64 , pp. 1859-1867
    • Song, Z.1    DeMarco, A.2    Zhao, M.3
  • 41
    • 0033614989 scopus 로고    scopus 로고
    • 32-indolyl ether derivatives of ascomycin: Three-dimensional structures of complexes with FK506-binding protein
    • Becker, J.W., Rotonda, J., Cryan, J.G. et al. 32-Indolyl ether derivatives of ascomycin: Three-dimensional structures of complexes with FK506-binding protein. J Med Chem 1999, 42: 2798-804.
    • (1999) J Med Chem , vol.42 , pp. 2798-2804
    • Becker, J.W.1    Rotonda, J.2    Cryan, J.G.3
  • 43
    • 0025265156 scopus 로고
    • CD4 T-lymphocyte activation in acute severe asthma. Relationship to disease severity and atopic status
    • Corrigan, C.J., Kay, A.B. CD4 T-lymphocyte activation in acute severe asthma. Relationship to disease severity and atopic status. Am Rev Respir Dis 1990, 141: 970-7.
    • (1990) Am Rev Respir Dis , vol.141 , pp. 970-977
    • Corrigan, C.J.1    Kay, A.B.2
  • 44
    • 0026333085 scopus 로고
    • Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity
    • Walker, C., Kaegi, M.K., Braun, P., Blaser, K. Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity. J Allergy Clin Immunol 1991, 88: 935-42.
    • (1991) J Allergy Clin Immunol , vol.88 , pp. 935-942
    • Walker, C.1    Kaegi, M.K.2    Braun, P.3    Blaser, K.4
  • 46
    • 0028956973 scopus 로고
    • Inhaled glucocorticoids for asthma
    • Barnes, P.J. Inhaled glucocorticoids for asthma. N Engl J Med 1995, 332: 868-75.
    • (1995) N Engl J Med , vol.332 , pp. 868-875
    • Barnes, P.J.1
  • 47
    • 0031008530 scopus 로고    scopus 로고
    • Effect of cyclosporin A on the allergen-induced late asthmatic reaction
    • Sihra, B.S., Kon, O.M., Durham, S.R., Walker, S., Barnes, N.C., Kay, A.B. Effect of cyclosporin A on the allergen-induced late asthmatic reaction. Thorax 1997, 52: 447-52.
    • (1997) Thorax , vol.52 , pp. 447-452
    • Sihra, B.S.1    Kon, O.M.2    Durham, S.R.3    Walker, S.4    Barnes, N.C.5    Kay, A.B.6
  • 48
    • 0033579950 scopus 로고    scopus 로고
    • Preparation and immunosuppressive activity of 32-(O)-acylated and 32-(O)-thioacylated analogues of ascomycin
    • Hersperger, R., Schuler, W., Zenke, G. Preparation and immunosuppressive activity of 32-(O)-acylated and 32-(O)-thioacylated analogues of ascomycin. Bioorg Med Chem Lett 1999, 9: 227-32.
    • (1999) Bioorg Med Chem Lett , vol.9 , pp. 227-232
    • Hersperger, R.1    Schuler, W.2    Zenke, G.3
  • 49
    • 0021210779 scopus 로고
    • Soft drugs: Principles and methods for the design of safe drugs
    • Bodor, N. Soft drugs: Principles and methods for the design of safe drugs. Med Res Rev 1984, 4: 449-69.
    • (1984) Med Res Rev , vol.4 , pp. 449-469
    • Bodor, N.1
  • 50
    • 0342347676 scopus 로고    scopus 로고
    • Unpublished results
    • Unpublished results.
  • 51
    • 0026316957 scopus 로고
    • Characterization of allergen-induced bronchial hyperresponsiveness and airway inflammation in actively sensitized Brown-Norway rats
    • Elwood, W., Lotvall, J.O., Barnes, P.J., Chung, K.F. Characterization of allergen-induced bronchial hyperresponsiveness and airway inflammation in actively sensitized Brown-Norway rats. J Allergy Clin Immunol 1991, 88: 951-60.
    • (1991) J Allergy Clin Immunol , vol.88 , pp. 951-960
    • Elwood, W.1    Lotvall, J.O.2    Barnes, P.J.3    Chung, K.F.4
  • 52
    • 0031307832 scopus 로고    scopus 로고
    • Kinetics and quantitation of eosinophil and neutrophil recruitment to allergic lung inflammation in a Brown-Norway rat model
    • Schneider, T. Van Velzen, D., Moqbel, R., Issekutz, A.C. Kinetics and quantitation of eosinophil and neutrophil recruitment to allergic lung inflammation in a Brown-Norway rat model. Am J Respir Cell Mol Biol 1997, 17: 702-12.
    • (1997) Am J Respir Cell Mol Biol , vol.17 , pp. 702-712
    • Schneider, T.1    Van Velzen, D.2    Moqbel, R.3    Issekutz, A.C.4
  • 55
    • 0029036752 scopus 로고
    • Effectiveness of topical therapy for psoriasis: Results of a national survey
    • Liem, W.H., McCullough, J. L., Weinstein, G.D. Effectiveness of topical therapy for psoriasis: Results of a national survey. Cutis 1995, 55: 306-10.
    • (1995) Cutis , vol.55 , pp. 306-310
    • Liem, W.H.1    McCullough, J.L.2    Weinstein, G.D.3
  • 56
    • 0342347654 scopus 로고    scopus 로고
    • Side effects of topical use of steroids
    • Kohda, H. Side effects of topical use of steroids. Asian Med J 1996, 39: 583-89.
    • (1996) Asian Med J , vol.39 , pp. 583-589
    • Kohda, H.1
  • 57
    • 0032769834 scopus 로고    scopus 로고
    • Macrolide immunosuppressants
    • Mrowietz, U. Macrolide immunosuppressants. Eur J Dermatol 1999, 9: 346-51.
    • (1999) Eur J Dermatol , vol.9 , pp. 346-351
    • Mrowietz, U.1
  • 58
    • 0343652880 scopus 로고    scopus 로고
    • SCRIP Daily, Nov 24, 1999
    • SCRIP Daily, Nov 24, 1999.
  • 59
    • 0029846441 scopus 로고    scopus 로고
    • Tacrolimus concentrations in blood during topical treatment of atopic dermatitis
    • Kawashima, M., Nakagawa, H., Ohtsuki, M., Tamaki, K., Ishibashi, Y. Tacrolimus concentrations in blood during topical treatment of atopic dermatitis. Lancet 1996, 348: 1240-1.
    • (1996) Lancet , vol.348 , pp. 1240-1241
    • Kawashima, M.1    Nakagawa, H.2    Ohtsuki, M.3    Tamaki, K.4    Ishibashi, Y.5
  • 60
    • 0342782719 scopus 로고    scopus 로고
    • (Sandoz Corp; Sandoz Patent GmbH; Sandoz Erfindungen VmbH). EP 465426
    • Baumann, K. (Sandoz Corp; Sandoz Patent GmbH; Sandoz Erfindungen VmbH). Preparation of FR 520 analogs. EP 465426.
    • Preparation of FR 520 Analogs
    • Baumann, K.1
  • 61
    • 0030010432 scopus 로고    scopus 로고
    • Clearing of psoriasis by a novel immunosuppressive macrolide
    • Rappersberger, K., Meingassner, J.G., Fialla, R. et al. Clearing of psoriasis by a novel immunosuppressive macrolide. J Invest Dermatol 1996, 106: 701-10.
    • (1996) J Invest Dermatol , vol.106 , pp. 701-710
    • Rappersberger, K.1    Meingassner, J.G.2    Fialla, R.3
  • 64
    • 0032769627 scopus 로고    scopus 로고
    • A novel anti-inflammatory drug SDZ ASM 981, for the treatment of skin diseases: In vitro pharmacology
    • Grassberger, M., Baumruker, T., Enz, A. et al. A novel anti-inflammatory drug SDZ ASM 981, for the treatment of skin diseases: In vitro pharmacology. Br J Dermatol 1999, 141: 264-73.
    • (1999) Br J Dermatol , vol.141 , pp. 264-273
    • Grassberger, M.1    Baumruker, T.2    Enz, A.3
  • 65
    • 0031695577 scopus 로고    scopus 로고
    • Ascomycin macrolactam derivative SDZ ASM981 inhibits the release of granule-associated mediators and of newly synthesized cytokines in RBL 2H3 mast cells in an immunophilin-dependent manner
    • Hultsch, T., Muller, K.D., Meingassner, J.G., Grassberger, M., Schopf, R.E., Knop, J. Ascomycin macrolactam derivative SDZ ASM981 inhibits the release of granule-associated mediators and of newly synthesized cytokines in RBL 2H3 mast cells in an immunophilin-dependent manner. Arch Dermatol Res 1998, 290: 501-7.
    • (1998) Arch Dermatol Res , vol.290 , pp. 501-507
    • Hultsch, T.1    Muller, K.D.2    Meingassner, J.G.3    Grassberger, M.4    Schopf, R.E.5    Knop, J.6
  • 66
    • 0030827498 scopus 로고    scopus 로고
    • A novel anti-inflammatory drug, SDZASM981, for the topical and oral treatment of skin diseases: In vivo pharmacology
    • Meingassner, J.G., Grassberger, M., Fahrngruber, H., Moore, H.D., Scuurman, H., Stutz, A. A novel anti-inflammatory drug, SDZASM981, for the topical and oral treatment of skin diseases: In vivo pharmacology. Br J Dermatol 1997, 137: 568-76.
    • (1997) Br J Dermatol , vol.137 , pp. 568-576
    • Meingassner, J.G.1    Grassberger, M.2    Fahrngruber, H.3    Moore, H.D.4    Scuurman, H.5    Stutz, A.6
  • 67
    • 0032406844 scopus 로고    scopus 로고
    • The novel ascomycin derivative SDZ ASM981 is effective for psoriasis when used topically under occlusion
    • Mrowietz, U., Graeber, M., Brautigam, M. et al. The novel ascomycin derivative SDZ ASM981 is effective for psoriasis when used topically under occlusion. Br J Dermatol 1998, 139: 992-6.
    • (1998) Br J Dermatol , vol.139 , pp. 992-996
    • Mrowietz, U.1    Graeber, M.2    Brautigam, M.3
  • 68
    • 2642649496 scopus 로고    scopus 로고
    • Effectiveness of the ascomycin macrolactam SDZ ASM981 in the topical treatment of atopic dermatitis
    • Van Leent, E.J.M., Graeber, M., Thurston, M., Wagenaar, A. Effectiveness of the ascomycin macrolactam SDZ ASM981 in the topical treatment of atopic dermatitis. Arch Dermatol 1998, 134:805-9.
    • (1998) Arch Dermatol , vol.134 , pp. 805-809
    • Van Leent, E.J.M.1    Graeber, M.2    Thurston, M.3    Wagenaar, A.4
  • 69
    • 7344223256 scopus 로고    scopus 로고
    • Discovery of ascomycin analogues with potent topical but weak systemic activity for treatment of inflammatory skin diseases
    • Mollison, K.W., Fey, T.A., Gauvin, D.A. et al. Discovery of ascomycin analogues with potent topical but weak systemic activity for treatment of inflammatory skin diseases. Curr Pharm Des 1998, 4: 367-79.
    • (1998) Curr Pharm Des , vol.4 , pp. 367-379
    • Mollison, K.W.1    Fey, T.A.2    Gauvin, D.A.3
  • 70
    • 0032941677 scopus 로고    scopus 로고
    • A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases
    • Mollison, K.W., Fey, T.A., Gauvin, D.A. et al. A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases. J Invest Dermatol 1999, 112: 729-38.
    • (1999) J Invest Dermatol , vol.112 , pp. 729-738
    • Mollison, K.W.1    Fey, T.A.2    Gauvin, D.A.3
  • 71
    • 0028202076 scopus 로고
    • Immunosuppressant FK506 promotes neunte outgrowth in cultures of PC12 cells and sensory ganglia
    • Lyons, W.E., George, E.B., Dawson, T.M., Steiner, J.P., Snyder, S.H. Immunosuppressant FK506 promotes neunte outgrowth in cultures of PC12 cells and sensory ganglia. Proc Natl Acad Sci USA 1994, 91: 3191-5.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3191-3195
    • Lyons, W.E.1    George, E.B.2    Dawson, T.M.3    Steiner, J.P.4    Snyder, S.H.5
  • 72
    • 0028352763 scopus 로고
    • The immunosuppressant FK506 increases functional recovery and nerve regeneration following peripheral nerve injury
    • Gold, B.G., Storm-Dickerson, T., Austin, D.R. The immunosuppressant FK506 increases functional recovery and nerve regeneration following peripheral nerve injury. Restor Neurol Neurosci 1994, 6: 287.
    • (1994) Restor Neurol Neurosci , vol.6 , pp. 287
    • Gold, B.G.1    Storm-Dickerson, T.2    Austin, D.R.3
  • 73
    • 0028783373 scopus 로고
    • The immunosuppressant FK506 increases the rate of axonal regeneration in rat sciatic nerve
    • Gold, B.G., Katoh, K., Storm-Dickerson, T. The immunosuppressant FK506 increases the rate of axonal regeneration in rat sciatic nerve. J Neurosci 1995, 15: 7509-16.
    • (1995) J Neurosci , vol.15 , pp. 7509-7516
    • Gold, B.G.1    Katoh, K.2    Storm-Dickerson, T.3
  • 74
    • 0030975605 scopus 로고    scopus 로고
    • Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A
    • Steiner, J.P., Connolly, M.A., Valentine, H.L. et al. Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A. Nat Med 1997, 3: 421-8.
    • (1997) Nat Med , vol.3 , pp. 421-428
    • Steiner, J.P.1    Connolly, M.A.2    Valentine, H.L.3
  • 75
    • 0032542346 scopus 로고    scopus 로고
    • Immunophilins: Beyond immunosuppression
    • Hamilton, G.S., Steiner, J.P. Immunophilins: Beyond immunosuppression. J Med Chem 1998, 41: 5119-43.
    • (1998) J Med Chem , vol.41 , pp. 5119-5143
    • Hamilton, G.S.1    Steiner, J.P.2


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