Nephrotoxicity studies of the immunosuppressants tacrolimus (FK506) and ascomycin in rat models

Toxicology

Volumn 125, Issue 2-3, 1998, Pages 169-181

  Mollison, Karl W ^a   Fey, Thomas A ^a   Krause, Ruth A ^a   Andrews, Janet M ^a   Bretheim, Pat T ^a   Cusick, Patrick K ^a   Hsieh, Gin C ^a   Luly, Jay R ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Ascomycin; FK506; Immunophilins; Immunosuppressants; Nephrotoxicity; Pharmacokinetics; Tacrolimus

Indexed keywords

ASCOMYCIN; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CREATININE CLEARANCE; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG POTENCY; IMMUNOREGULATION; MALE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; TOXICITY TESTING;

ANIMALS; BIOLOGICAL AVAILABILITY; DIET, SODIUM-RESTRICTED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; DRUG EVALUATION, PRECLINICAL; IMMUNOSUPPRESSIVE AGENTS; KIDNEY DISEASES; MALE; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED STRAINS; MODELS, BIOLOGICAL; NEPHRECTOMY; RATS; RATS, INBRED STRAINS; TACROLIMUS;

EID: 0032489058     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(97)00167-4     Document Type: Article

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