Inhibition by the immunosuppressive agent FK-506 of antigen-induced airways eosinophilia and bronchial hyperreactivity in mice

British Journal of Pharmacology

Volumn 120, Issue 1, 1997, Pages 130-136

  Eum, Seok Yong ^a   Zuany Amorim, Claudia ^a   Lefort, Jean ^a   Pretolani, Marina ^a   Vargaftig, B Boris ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

Asthma; Bronchial hyperreactivity in mice; Eosinophils; IL 5; Immunosuppression; T lymphocytes

Indexed keywords

ANTIALLERGIC AGENT; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; IMMUNOGLOBULIN E ANTIBODY; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 5; METHACHOLINE; OVALBUMIN; SEROTONIN; TACROLIMUS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EOSINOPHIL; EOSINOPHILIA; HYPERIMMUNOGLOBULINEMIA E; LUNG LAVAGE; LYMPHOCYTE COUNT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; T LYMPHOCYTE;

ANIMALS; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; EOSINOPHILIA; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; IMMUNOENZYME TECHNIQUES; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-5; LYMPHOCYTE COUNT; MALE; MICE; MICE, INBRED STRAINS; OVALBUMIN; RESPIRATORY FUNCTION TESTS; T-LYMPHOCYTES; TACROLIMUS;

EID: 0031026969     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0700860     Document Type: Article

References (53)

1. AKUTSU, I., FUKUDA, T. & MAKINO, S. (1991). Inhibitory effect of FK-506 on the development of late asthmatic response and bronchial hyperresponsiveness. J. Allergy Clin. Immunol, 87, 205, Abstract.
2. ANDERSON, G.P. & COYLE, A.J. (1994). TH2 and TH2-like cells in allergy and asthma: pharmacological perspectives. Trends Pharmacol. Sci., 15, 324-332.
3. ARM, J.P. & LEE, T.H. (1992). The pathobiology of bronchial asthma. Adv. Immunol., 51, 323-382.
4. AZZIWI, M., BRADLEY, B., JEFFERY, P.K., FREW, A.J., WARDLAW, A.J., KNOWLES, G., ASSOUFI, B., COLLINS, J.V., DURHAM, S. & KAY, A.B. (1990). Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am. Rev. Respir. Dis., 142, 1407-1413.
5. BIOZZI, G., MOUTON, D., SANT'ANNA, O.A., PASSOS, H.C., GENNARI, M., REIS, M.H., FERREIRA, V.C.A., HEUMANN, A.M., BOUTHILLIER, Y., IBANEZ, O.M., STIFFEL, C. & SIQUEIRA, M. (1979). Genetics of immunoresponsiveness to natural antigens in the mouse. Curr. Top. Microbiol. Immunol., 85, 31-98.
6. BOUSHEY, H.A., HOLTZMAN, M.J., SHELLER, J.R. & NADEL, J.A. (1980). Bronchial hyperreactivity. Am. Rev. Respir. Dis., 121, 389-413.
7. BUSSE, W.W., COFFMAN, R.L., GELFAND, E.W., KAY, A.B. & ROSENWASSER, L.J. (1995). Mechanisms of persistant airway inflammation in asthma: a role for T cells and T-cell products. Am. J. Respir. Crit. Care Med., 152, 388-393.
8. CORRIGAN, C.J., HARTNELL, A. & KAY, A.B. (1988). T lymphocyte activation in acute severe asthma. Lancet, 1, 1129-1132.
9. CORRIGAN, C.J. & KAY, A.B. (1990). CD4 T-lymphocyte activation in acute severe asthma. Am. Rev. Respir. Dis., 141, 970-977.
10. DE PAULIS, A., CIRILLO, R., CICCARELLI, A., DE CRESCENZO, G., ORIENTEE, A., MARONE, G., (1991). Characterization of the anti-inflammatory effect of FK-506 on human mast cells. J. Immunol., 147, 4278-4285.
11. DJUKANOVIC, R., ROCHE, W.K., WILSON, J.W., BEASLEY, C.R.W., TWENTYMAN, O.P., HOWARTH, P.H. & HOLGATE, S.T. (1990). Mucosal inflammation in asthma. Am. Rev. Respir. Dis., 142, 434-457.
12. ELLMAN, G., COURTNEY, K., ANDRES, V. & FEATHERSTONE, R. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol., 7, 88-95.
13. EUM, S.Y., HAILÉ, S., LEFORT, J., HUERRE, M. & VARGAFTIG, B.B. (1995). Eosinophil recruitment into the respiratory epithelium following antigenic challenge in hyper-IgE mice is accompanied by interleukin-5-dependent bronchial hyperresponsiveness. Proc. Nail. Acad. Sci. U.S.A., 92, 12290-12294.
14. EUM, S.-Y., CRÉMINON, C., HAILÉ, S., LEFORT, J., VARGAFTIG, B.B. (1996). Inhibition of airways inflammation by dexamethasone is followed by reduced bronchial hyperreactivity in BP2 mice. Clin. Experiment. Allergy., 26, 971-979.
15. FREW, A.J., MOQBEL, R., AZZAWI, M., HARTNELL, A., BARKANS, J., JEFFERY, P.K., KAY, B.. SCHEPER, R.J., VARLEY, J., CHURCH, M.K. & HOLGATE, S.T. (1990). T lymphocytes and eosinophils in allergen-induced late-phase asthmatic reactions in the guinea pig. Am. Rev. Respir. Dis., 141 407-413.
16. GARLISI, C.G., FALCONE, A., KUNG, T.T., STELTS, D., PENNLINE, K.J., BEAVIS, A.J., SMITH, S.R., EGAN, R.W. & UMLAND, S.P. (1995). T cells are necessary for Th2 cytokine production and eosinophil accumulation in airways of antigen-challenged allergic mice. Clin. Immunol. Immunopathol., 75, 75-83.
17. GAVETT, S.H., CHEN, X., FINKELMAN, F. & WILLS-KARP, M. (1994). Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am. J. Respir. Cell Mol. Biol., 10, 587-593.
18. GLEICH, G.J. (1990). The eosinophil and bronchial asthma : Current understanding. J. Allergy Clin. Immunol., 85, 422-436.
19. GONZALO, J.-A., JIA, G.-Q., AGUIRRE, V., FRIEND, D., COYLE, A.J., JENKINS, N.A., LIN, G.-S., KATZ, H., LICHTMAN, A., COPELAND, N., KOPF, M. & GUTIERREZ-RAMOS, J.-C. (1996). Mouse eotaxin expression parallels eosinophil accumulation during lung allergic inflammation but it is not restricted to a Th2-type response. Immunity, 4, 1-14.
20. GRASSI, J., FROBERT, Y., LAMOURETTE, P. & LAGOUTTE, B. (1988). Screening of monoclonal antibodies using antigens labeled with acetylcholinesterase: applications to the peripheral proteins of photosystem 1. Anal. Biochem., 168, 436-450.
21. GRASSI, J., FROBERT, Y., PRADELLES, P., CHERCUITTE, D., GRUAZ, D., DAYER, J.M. & POUBELLE, P. (1989). Production of monoclonal antibodies against interleukins 1α and 1β: development of two enzyme immunometric assays (EIA) using acetylcholinesterase and application to biological media. J. Immunol. Methods, 123, 193-210.
22. HAMID, Q., AZZAWI, M., YING, S., MOQBEL, R., WARDLAW, A.J., CORRIGAN, C.J., BRADLEY, B., DURHAM, S.R., COLLINS, J.V. & JEFFERY, P.K. (1991). Expression of mRNA for interleukin-5 in mucosal biopsies from asthma. J. Clin. Invest., 87, 1541-1546.
23. HATFIELD, S.M. & ROEHM, N.W. (1992). Cyclosporine and FK506 inhibition of murine mast cell cytokine production. J. Pharmacol. Exp. Ther., 260, 680-688.
24. HOM, J.T. & ESTRIDGE, T. (1994). Antigen-induced recruitment of eosinophils: Importance of CD4+ T cells, IL5, and mast cells. Clin. Immunol. Immunopathol., 73, 305-311.
25. HULTSCH, T., ALBERS, M.W., SCHREIBER, S.L., HOHMAN, R.J. (1991). Immunophilin ligands demonstrate common features of signal transduction leading to exocytosis or transcription. Proc. Natl. Acad. Sci. U.S.A., 88, 6229-6233.
26. IWAMOTO, I., TOMOE, S., TOMIOKA, H., TAKATSU, K. & YOSHIDA, S. (1992). Role of CD4+ T lymphocytes and interleukin-5 in antigen-induced eosinophil recruitment into the site of cutaneous late-phase reaction in mice. J. Leukoc. Biol., 52, 572-578.
27. JOSE, P.J., GRIFFITHS-JOHNSON, D.A., COLLINS, P.D., WALSH, D.T., MOQBEL, R., TOTTY, N.F., TRUONG, O., HSUAN, J.J. & WILLIAMS, T.J. (1994). Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea-pig model of allergic airways inflammation. J. Exp. Med., 179, 881-887.
28. KINO, T., HATANAKA, H., MIYATA, S., INAMURA, N., NISHIYAMA, M., YAJIMA, T., GOTO, T., OKUHARA, M., KOHSAKA, M., AOKI, H. & OCHIAI, T. (1987). FK-506, a novel immunosuppressant isolated from a Streptomyces; II. Immunosuppressive effect of FK-506 in vitro. J. Antibiot., XL, 1256-1265.
29. LAPA E SILVA, T.R., BACHELET, C.M., PRETOLANI, M., BAKER, D., SCHEPER, R.J. & VARGAFTIG, B.B. (1993). Immunopathologic alterations in the bronchi of immunized guinea pigs. Am. J. Respir. Cell Mol. Biol., 9, 44-53.
30. LAPA E SILVA, T.R., RUFFIE, C., VARGAFTIG, B.B. & PRETOLANI, M. (1995). Modulation of bronchial inflammation in sensitized guinea pigs by FK-506, nedocromil sodium and dexamethasone. Eur. Respir. J., 8, 1321-1327.
31. LOPEZ, A.F., SANDERSON, C.J. GAMBLE, J.R., CAMPBELL, H.D., YOUNG, I.G. & VADAS, M.A. (1988). Recombinant human interleukin 5 is a selective activator of human eosinophil function. J. Exp. Med., 167, 219-224.
32. MASSOULIE, J. & BON, C. (1976). Affinity chromatography of acetylcholinesterase: the importance of hydrophobic interactions. Eur. J. Biochem., 68, 531-539.
33. MORI, A., SUKO, M., NISHIZAKI, Y., KAMINUMA, O., KOBAYASHI, S., MATSUZAKI, G., YAMAMOTO, K., ITO, K., TSURUOKA, N. & OKUDAIRA, H. (1995). IL-5 production by CD4+ T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin A. Int. Immunol., 7, 449-457.
34. NAGAI, H., YAMAGUCHI, S., TANAKA, H. & INAGAKI, N. (1995). Effect of some immunosuppressors on allergic bronchial inflammation and airway hyperresponsiveness in mice. Int. Arch. Allergy Immunol., 108, 189-195.
35. NAKAJIMA, H., IWAMOTO, I., TOMOE, S., MATSUMURA, R., TOMIOKA, H., TAKATSU, K. & YOSHIDA, S. (1992). CD4+ T-Lymphocytes and Interleukine-5 Mediate Antigen-induced Eosinophil Infiltration into the Mouse Trachea. Am. Rev. Respir. Dis., 146, 374-377.
36. NOGAMI, M., SUKO, M., OKUDAIRA, H., MIYAMOTO, T., SHIGA, J., ITO, M. & KASUYA, S. (1990). Experimental pulmonary eosinophilia in mice by Ascaris suum extract. Am. Rev. Respir. Dis., 141, 1289-1295.
37. OKUDAIRIA, H., NOGAMI, M., MATSUZAKI, G., DOHI, M., SUKO, M., KASUYA, S. & TAKATSU, K. (1991). T-cell-dependent accumulation of eosinophils in the lung and its inhibition by monoclonal anti-interleukin-5. Int. Arch. Allergy Appl. Immunol., 94, 171-173.
38. OWEN, W.F., ROTHENBERG, M.E., SILBERSTEIN, D.S., GASSON, J.C., STEVENS, R.L., AUSTEN, K.F. & SOBERMAN, R.J. (1987). Regulation of human eosinophil viability, density, and function by Granulocyte/Macrophage colony-stimulating factor in the presence of 3T3 fibroblasts. J. Exp. Med., 166, 129-141.
39. PRADELLES, P., GRASSI, J. & MACLOUF, J. (1985). Enzyme immunoassays of eicosanoids using acetylcholinesterase as label. Anal. Chem., 57, 1170-1173.
40. ROBINSON, D., HAMID, Q., BENTLY, A., YING, S., KAY, B. & DURHAM, S.R. (1993). Activation of CD4+ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma. J. Allergy Clin. Immunol., 92, 313-324.
41. ROTHENBERG, M.E., OWEN, W.F., SILBERSTEIN, D.S., WOODS, J., SOBERMAN, R.J., AUSTEN, K.F. & STEVEN, R.L. (1988). Human eosinophils have prolonged survival, enhanced functional properties and become hypodense when exposed to human interleukin 3. J. Clin. Invest., 81, 1986-1992.
42. SAWADA, S., SUZUKI, G., KAWASE, Y. & TAKAKU, F. (1987). Novel immunosuppressive agent, FK506; In vitro effects on the cloned T cell activation. J. Immunol., 139, 1797-1803.
43. SCHREIBER, S.L. & CRABTREE, G.R. (1992). The mechanism of action of cyclosporin A and FK506. Immunol. Today, 13, 136-142.
44. SCHUMACHER, J.H., O'GARRA, A., SHRADER, B., VAN KIMMENADE, A., BOND, M.W., MOSMANN, T.R. & COFFMAN, R.L. (1988). The characterization of four antibodies specific for mouse IL-5 and development of mouse and human IL-5 enzyme-linked immunosorbent assays. J. Immunol., 141, 1576-1581.
45. SIEKIERKA, J.J. & SIGAL, N.H. (1992). FK-506 and cyclosporin A: immunosuppressive mechanism of action and beyond. Curr. Opin. Immunol., 4, 548-552.
46. SILBERSTEIN, D.S. & DAVID, J.R. (1987). The regulation of human eosinophil function by cytokines. Immunol. Today, 8, 380-385.
47. TOCCI, M.J., MATKOVICH, D.A., COLLIER, K.A., KWOK, P., DUMONT, F., LIN, S., DEGUDICIBUS, S., SIEKIERKA, J.J., CHIN, J. & HUTCHINSON, N.I. (1989). The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes. J. Immunol., 143, 718-726.
48. WALKER, C., BODE, L.B.E., HANSEL, T.T., BLASER, K. & VIRCHOW, J.C. (1992). Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am. Rev. Respir. Dis., 146, 109-115.
49. WALKER, C., KAEGI, M.K., BRAUN, P. & BLASER, K. (1991). Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity. J. Allergy Clin. Immunol., 88, 935-942.
50. WALKER, C., VIRCHOW, S.C., BRUIJNZEEL, P.L.B. & BLASER, K. (1991). T cell subsets and their soluble products regulate eosinophilia in allergic and non-allergic asthma. J. Immunol., 146, 1829-1835.
51. WIEDERRECHT, G., LAM, E., HUNG, S., MARTIN, M. & SIGAL, N. (1993). The mechanism of action of FK-506 and cyclosporin A. Ann. N.Y. Acad. Sci., 609, 9-19.
52. YOSHIMURA, N., MATSUI, S., HAMASHIMA, T. & OKA, T. (1989). Effect of a new immunosuppressive agent, FK506, on human lymphocyte responses in vitro; II. Inhibition of the production of IL-2 and IFN-γ, but not B cell-stimulating factor 2. Transplantation, 47, 356-359.
53. ZUANY-AMORIM, C., LEDUC, D., VARGAFTIG, B.B. & PRETOLANI, M. (1994). Modulation by rm interferon-γ and CD4+ T-lymphocytes of allergic eosinophilic accumulation in the mice peritoneal cavity. Ann. N.Y. Acad. Sci., 725, 34-43.