Effectiveness of the ascomycin macrolactam SDZ ASM 981 in the topical treatment of atopic dermatitis

Archives of Dermatology

Volumn 134, Issue 7, 1998, Pages 805-809

  Van Leent, Edwin J M ^a   Gräber, Michael ^b   Thurston, Mark ^b   Wagenaar, Annie ^b   Spuls, Phyllis I ^a   Bos, Jan D ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; ASCOMYCIN DERIVATIVE; PIMECROLIMUS; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ATOPIC DERMATITIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOMODULATION; IMMUNOPATHOGENESIS; MALE; PHASE 2 CLINICAL TRIAL; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ADOLESCENT; ADULT; DERMATITIS, ATOPIC; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; TACROLIMUS; TIME FACTORS; TREATMENT OUTCOME;

EID: 2642649496     PISSN: 0003987X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archderm.134.7.805     Document Type: Article

References (21)

1. Scheffer H. Search for genes predisposing to atopic diseases. Lancet. 1996;348:560-561.
2. Kay J, Gawkrodger DJ, Mortimer MJ, Jaron AG. The prevalence of childhood atopic eczema in a general population. J Am Acad Dermatol. 1994;30:35-39.
3. Dotterud LK, Kvammen B, Lund E, Falk ES. Prevalence and some clinical aspects of atopic dermatitis in the community of Sor-Varanger. Acta Derm Venereol. 1995;75:50-53.
4. Williams HC. Is the prevalence of atopic dermatitis increasing? Exp Dermatol. 1992;17:385-391.
5. Schultz Larsen F, Hanifin JM. Secular change in the occurrence of atopic dermatitis. Acta Derm Venereol Suppl (Stockh). 1992;176:7-12.
6. Schultz Larsen F, Diepgen T, Svensson A. The occurence of atopic dermatitis in north Europe: an international questionnaire study. J Am Acad Dermatol. 1996;34:760-764.
7. Boguniewicz M, Leung DYM. Management of atopic dermatitis. In: Leung DYM, ed. Atopic Dermatitis: From Pathogenesis to Treatment. Heidelberg, Germany: Springer-Verlag; 1996:185-220.
8. Griffiths WAD, Wilkinson JD. Topical therapy. In: Champion RH, Burton JL, Ebling FJG, eds. Textbook of Dermatology. Vol. 4. 5th ed. Oxford, England: Blackwell Scientific Publications; 1996:3037-3084.
9. Bos JD, Kapsenberg ML, Sillevis Smitt JH. Pathogenesis of atopic eczema. Lancet. 1994;343:1338-1341.
10. Sowden JM, Berth-Jones J, Ross JS, et al. Double-blind, controlled, crossover study of cyclosporin in adults with severe refractory atopic dermatitis. Lancet. 1991;338:137-140.
11. van Joost T, Kozel MM, Tank B, Troost R, Prens EP. Cyclosporine in atopic dermatitis: modulation in the expression of immunologic markers in lesional skin. J Am Acad Dermatol. 1992;27:922-928.
12. Korstanje MJ, van de Staak WJ. Cyclosporin maintenance therapy for severe atopic dermatitis. Acta Derm Venereol. 1991;71:356-357.
13. de Rie MA, Meinardi MMHM, Bos JD. Lack of efficacy of topical cyclosporin A in atopic dermatitis and allergic contact dermatitis. Acta Derm Venereol. 1991;71:452-454.
14. Nakagawa H, Ethoh T, Ishibashi Y, et al. Tacrolimus ointment for atopic dermatitis. Lancet. 1994;344:883.
15. Ruzicka T, Bieber T, Schöpf E, et al. A short-term trial of tacrolimus ointment for atopic dermatitis. N Engl J Med. 1997;337:816-821.
16. Meingasser JG, Stütz A. Immunosuppressive macrolides: a novel class of topical agents for treatment of skin disease. J Invest Dermatol. 1992;98:851-855.
17. Meingasser JG, Grassberger M, Fahrngruber H, Moore HD, Schuurman H, Stütz A. A novel anti-inflammatory drug, SDZ ASM 981, for the topical and oral treatment of skin diseases: in vivo pharmacology. Br J Dermatol. 1997;137:568-576.
18. Baumruker T, Bevec D, Kalthoff F, et al. SDZ ASM 981, a novel anti-inflammatory macrolactam: pharmacological activities in vitro. Aust J Dermatol. 1997;38:285.
19. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol Suppl (Stockh). 1980;92:44-47.
20. Hanifin JM. Standardized grading of subjects for clinical research studies in atopic dermatitis: workshop report. Acta Derm Venereol Suppl (Stockh). 1989;144:28-30.
21. Kawashima M, Nakagawa H, Ohtsuki M, Tamaki K. Tacrolimus concentrations in blood during topical treatment of atopic dermatitis. Lancet. 1996;348:1240-1241.