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Volumn 141, Issue 2, 1999, Pages 264-273

A novel anti-inflammatory drug, SDZ ASM 981, for the treatment of skin diseases: In vitro pharmacology

Author keywords

Allergic contact dermatitis; Anti inflammatory activity; Ascomycin macrolactam derivative; Atopic eczema; Pro inflammatory cytokines; Psoriasis; SDZ ASM 981

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; PHORBOL 13 ACETATE 12 MYRISTATE; PHYTOHEMAGGLUTININ; PIMECROLIMUS;

EID: 0032769627     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.1999.02974.x     Document Type: Article
Times cited : (244)

References (48)
  • 1
    • 2642649496 scopus 로고    scopus 로고
    • Effectiveness of the ascomycin macrolactam SDZ ASM 981 in the topical treatment of atopic dermatitis
    • Van Leent EJM, Græber M, Thurston M et al. Effectiveness of the ascomycin macrolactam SDZ ASM 981 in the topical treatment of atopic dermatitis. Arch Dermatol 1998; 134: 805-9.
    • (1998) Arch Dermatol , vol.134 , pp. 805-809
    • Van Leent, E.J.M.1    Græber, M.2    Thurston, M.3
  • 2
    • 0002501299 scopus 로고    scopus 로고
    • Topical treatment with the anti-inflammoatory macrolactan SDZ ASM 981 inhibits established pickel contact dermatitis
    • Abstr
    • Queille-Roussel C, Graeber M, Wagenaar A et al. Topical treatment with the anti-inflammoatory macrolactan SDZ ASM 981 inhibits established pickel contact dermatitis. Australas J Dermatol 1997; 38 (Suppl. 2): 55 (Abstr).
    • (1997) Australas J Dermatol , vol.38 , Issue.SUPPL. 2 , pp. 55
    • Queille-Roussel, C.1    Graeber, M.2    Wagenaar, A.3
  • 3
    • 0032406844 scopus 로고    scopus 로고
    • The novel ascomycin derivative SDZ ASM 981 is effective for psoriasis when used topically under occlusion
    • Mrowietz U, Bräutigam M, Græber M et al. The novel ascomycin derivative SDZ ASM 981 is effective for psoriasis when used topically under occlusion. Br J Dermatol 1998; 139: 992-6.
    • (1998) Br J Dermatol , vol.139 , pp. 992-996
    • Mrowietz, U.1    Bräutigam, M.2    Græber, M.3
  • 4
    • 0030827498 scopus 로고    scopus 로고
    • A potential new anti-inflammatory drug. SDZ ASM 981, for the topical and oral treatment of skin diseases: In vivo pharmacology
    • Meingassner J, Grassberger M, Fahrngruber H et al. A potential new anti-inflammatory drug. SDZ ASM 981, for the topical and oral treatment of skin diseases: in vivo pharmacology. Br J Dermatol 1997; 137: 568-76.
    • (1997) Br J Dermatol , vol.137 , pp. 568-576
    • Meingassner, J.1    Grassberger, M.2    Fahrngruber, H.3
  • 5
    • 0028057999 scopus 로고
    • Nonradioactive assay for protein phosphatase 2B (calcineurin) activity using a partial sequence of the subunit of cAMP-dependent protein kinase as substrate
    • Enz A, Shapiro G, Chappuis A, Dattler A. Nonradioactive assay for protein phosphatase 2B (calcineurin) activity using a partial sequence of the subunit of cAMP-dependent protein kinase as substrate. Anal Biochem 1994; 216: 147-53.
    • (1994) Anal Biochem , vol.216 , pp. 147-153
    • Enz, A.1    Shapiro, G.2    Chappuis, A.3    Dattler, A.4
  • 6
    • 0015609711 scopus 로고
    • In vitro stimulation of murine spleen cells using a microculture system and a multiple automated sample harvester
    • Strong DM, Ahmed AA, Thurman GB, Sell KW. In vitro stimulation of murine spleen cells using a microculture system and a multiple automated sample harvester. J Immunol Methods 1973; 2: 279-91.
    • (1973) J Immunol Methods , vol.2 , pp. 279-291
    • Strong, D.M.1    Ahmed, A.A.2    Thurman, G.B.3    Sell, K.W.4
  • 7
    • 0003144621 scopus 로고
    • The MLR in the mouse
    • Lelkovits I, Pernis B, eds. New York: Academic Press
    • Meo T. The MLR in the mouse. In: Immunological Methods (Lelkovits I, Pernis B, eds). New York: Academic Press, 1979; 227-39.
    • (1979) Immunological Methods , pp. 227-239
    • Meo, T.1
  • 8
    • 0031053074 scopus 로고    scopus 로고
    • Differentiation of human dendritic cells from monocytes in vitro
    • Chapuis F, Rosenzwajg M, Yagello M et al. Differentiation of human dendritic cells from monocytes in vitro. Eur J Immunol 1997; 27: 431-44.
    • (1997) Eur J Immunol , vol.27 , pp. 431-444
    • Chapuis, F.1    Rosenzwajg, M.2    Yagello, M.3
  • 9
    • 0026639775 scopus 로고
    • Skin-derived aeroallergen-specific T cell clones of Th2 phenotype in patients with atopic dermatitis
    • Van Reijsen FC, Bruijnzeel-Komen CAFM, Kalthoff FS et al. Skin-derived aeroallergen-specific T cell clones of Th2 phenotype in patients with atopic dermatitis. J Allergy Clin Immunol 1992; 90: 184-93.
    • (1992) J Allergy Clin Immunol , vol.90 , pp. 184-193
    • Van Reijsen, F.C.1    Bruijnzeel-Komen, C.A.F.M.2    Kalthoff, F.S.3
  • 10
    • 0026693772 scopus 로고
    • Cyclosporine and its analogue SDZ IMM 125 mediate very similar effects on T-cell activation - A comparative analysis in vitro
    • Baumann G, Andersen E, Quesniaux V, Eberle MK. Cyclosporine and its analogue SDZ IMM 125 mediate very similar effects on T-cell activation - a comparative analysis in vitro. Transplant Proc 1992; 24: 43-8.
    • (1992) Transplant Proc , vol.24 , pp. 43-48
    • Baumann, G.1    Andersen, E.2    Quesniaux, V.3    Eberle, M.K.4
  • 11
    • 15444361105 scopus 로고    scopus 로고
    • Inhibition of Fc∈RI-mediated activation of mast cells by 2, 3, 4-trihydropyrimidino[2, 1-a-]-isoquinolines
    • Scholz D, Schmidt H, Prieschl EE et al. Inhibition of Fc∈RI-mediated activation of mast cells by 2, 3, 4-trihydropyrimidino[2, 1-a-]-isoquinolines. J Med Chem 1998; 41: 1050-9.
    • (1998) J Med Chem , vol.41 , pp. 1050-1059
    • Scholz, D.1    Schmidt, H.2    Prieschl, E.E.3
  • 12
    • 0032524439 scopus 로고    scopus 로고
    • A novel splice variant of the transcription factor Nrfl interacts with the TNFα promoter and stimulates transcription
    • Prieschl EE, Novotny V, Csonga R et al. A novel splice variant of the transcription factor Nrfl interacts with the TNFα promoter and stimulates transcription. Nucleic Acids Res 1998; 26: 2291-7.
    • (1998) Nucleic Acids Res , vol.26 , pp. 2291-2297
    • Prieschl, E.E.1    Novotny, V.2    Csonga, R.3
  • 14
    • 0030587128 scopus 로고    scopus 로고
    • Induction of the: TNFα promoter in the murine dendritic cell line DC18 and the murine mast cell line CPH is differently regulated
    • Prieschl EE, Pendl GG, Elbe A et al. Induction of the: TNFα promoter in the murine dendritic cell line DC18 and the murine mast cell line CPH is differently regulated. J Immunol 1996; 157: 2645-53
    • (1996) J Immunol , vol.157 , pp. 2645-2653
    • Prieschl, E.E.1    Pendl, G.G.2    Elbe, A.3
  • 15
    • 0023852747 scopus 로고
    • Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line
    • Boukamp P, Petrussevska RT, Breitkreutz D et al. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 1988; 106: 761-71.
    • (1988) J Cell Biol , vol.106 , pp. 761-771
    • Boukamp, P.1    Petrussevska, R.T.2    Breitkreutz, D.3
  • 16
    • 0015822275 scopus 로고
    • Culture of human endothelial cells derived from umbilical veins
    • Jaffe EA, Nachman RL, Becker CC, Minick CR. Culture of human endothelial cells derived from umbilical veins. J Clin Invent 1973; 52: 2745-56.
    • (1973) J Clin Invent , vol.52 , pp. 2745-2756
    • Jaffe, E.A.1    Nachman, R.L.2    Becker, C.C.3    Minick, C.R.4
  • 17
    • 0031026226 scopus 로고    scopus 로고
    • Immunofluorescence assay for the quantitative and qualitative evaluation of intracellular interleukin-8 in microtiter plates
    • Wolff B, Zsak M, Rabeck C. Immunofluorescence assay for the quantitative and qualitative evaluation of intracellular interleukin-8 in microtiter plates. Anal Biochem 1997; 244: 33-9.
    • (1997) Anal Biochem , vol.244 , pp. 33-39
    • Wolff, B.1    Zsak, M.2    Rabeck, C.3
  • 18
    • 0000358605 scopus 로고
    • Purification and characterisation of monoclonal and polyclonal antibodies to neutrophil activation peptide (NAP-1). The development of highly sensitive ELISA methods for the determination of NAP-1 and anti-NAP-1 antibodies
    • Ceska M, Effenberger E, Petchl P, Pursch E. Purification and characterisation of monoclonal and polyclonal antibodies to neutrophil activation peptide (NAP-1). The development of highly sensitive ELISA methods for the determination of NAP-1 and anti-NAP-1 antibodies. Cytokine 1989; 1: 136.
    • (1989) Cytokine , vol.1 , pp. 136
    • Ceska, M.1    Effenberger, E.2    Petchl, P.3    Pursch, E.4
  • 19
    • 0025341331 scopus 로고
    • New colorimetric cylotoxicity assay for anticancer-drug screening
    • Skehan P, Storeng R, Scudiero D, Monks A et al. New colorimetric cylotoxicity assay for anticancer-drug screening, J Natl Cancer Inst 1990; 82: 1107-12.
    • (1990) J Natl Cancer Inst , vol.82 , pp. 1107-1112
    • Skehan, P.1    Storeng, R.2    Scudiero, D.3    Monks, A.4
  • 20
    • 0022624677 scopus 로고
    • The presence of IgE molecules on epidermal Langerhans cells in patients with atopic dermatitis
    • Bruijnzeel-Koomen CAFM, Van Wichen DF, Toonstra J et al. The presence of IgE molecules on epidermal Langerhans cells in patients with atopic dermatitis. Arch Dermatol Res 1986; 278; 199-205.
    • (1986) Arch Dermatol Res , vol.278 , pp. 199-205
    • Bruijnzeel-Koomen, C.A.F.M.1    Van Wichen, D.F.2    Toonstra, J.3
  • 21
    • 0027070584 scopus 로고
    • In rfw modulation of the high affinity receptor for IgE (Fc∈RT) on human epidermal Langerhan's cells
    • Bieber T, King J. In rfw modulation of the high affinity receptor for IgE (Fc∈RT) on human epidermal Langerhan's cells. Int Arch Allergy Immunol 1992; 99: 204-7.
    • (1992) Int Arch Allergy Immunol , vol.99 , pp. 204-207
    • Bieber, T.1    King, J.2
  • 23
    • 0029981818 scopus 로고    scopus 로고
    • Biphasic response against acroallergen in atopic dermatitis showing a switch from an initial Th2 response into a Th1 response in situ. An immuno-cytochemical study
    • Thepen T. Langeveld-Wildschut EG, Bihari EC et al. Biphasic response against acroallergen in atopic dermatitis showing a switch from an initial Th2 response into a Th1 response in situ. An immuno-cytochemical study. J Allergy Clin Immunol 1996; 97: 828-37.
    • (1996) J Allergy Clin Immunol , vol.97 , pp. 828-837
    • Thepen, T.1    Langeveld-Wildschut, E.G.2    Bihari, E.C.3
  • 24
    • 0025802903 scopus 로고
    • Characterisation of grass pollen reactive T-cell lines derived from lesional atopic skin
    • Ramb-Lindhauer C, Feldmann A, Rolte M, Neumann C. Characterisation of grass pollen reactive T-cell lines derived from lesional atopic skin. Arch Dermatol Res 1991; 283: 71-6.
    • (1991) Arch Dermatol Res , vol.283 , pp. 71-76
    • Ramb-Lindhauer, C.1    Feldmann, A.2    Rolte, M.3    Neumann, C.4
  • 25
    • 1542396389 scopus 로고
    • IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2
    • Pene J, Rousset F, Briere F, Chretien I et al. IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2. Proc Natl Acad Sci USA 1988; 85: 6880-4.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 6880-6884
    • Pene, J.1    Rousset, F.2    Briere, F.3    Chretien, I.4
  • 26
    • 0027178695 scopus 로고
    • Relative contributions of human types 1 and 2 T-helper cell-derived cosinophilotrophic cytokines to development of eosinophilia
    • Wierenga EA, Backx B, Snoek M et al. Relative contributions of human types 1 and 2 T-helper cell-derived cosinophilotrophic cytokines to development of eosinophilia. Blood 1991; 82: 1471-9.
    • (1991) Blood , vol.82 , pp. 1471-1479
    • Wierenga, E.A.1    Backx, B.2    Snoek, M.3
  • 27
    • 0026556846 scopus 로고
    • The immunology of psoriasis
    • Baker BS, Fry L. The immunology of psoriasis. Br J Dermatol 1992; 126: 1-9.
    • (1992) Br J Dermatol , vol.126 , pp. 1-9
    • Baker, B.S.1    Fry, L.2
  • 28
    • 0027439191 scopus 로고
    • The cytokine network in lesional and lesion-free psoriatic skin is characterized by a T-helper type 1 J cell-mediated response
    • Tiyemura K, Yamamura M, Fivenson DF et al. The cytokine network in lesional and lesion-free psoriatic skin is characterized by a T-helper type 1 J cell-mediated response. J Invest Dermatol 1993; 101: 701-5.
    • (1993) J Invest Dermatol , vol.101 , pp. 701-705
    • Tiyemura, K.1    Yamamura, M.2    Fivenson, D.F.3
  • 29
    • 0028105784 scopus 로고
    • T cells involved in psoriasis vulgaris belong to the Th1 subset
    • Schlank JF. Buslau M. Jochum W et al. T cells involved in psoriasis vulgaris belong to the Th1 subset. J Invest Dermatol 1994; 102: 145-9.
    • (1994) J Invest Dermatol , vol.102 , pp. 145-149
    • Schlank, J.F.1    Buslau, M.2    Jochum, W.3
  • 30
    • 0020595264 scopus 로고
    • Immunocompetent cells in psoriasis. In situ immunophenotyping by monoclonal antibodies
    • Bos JD, Hulsebosch HJ, Krieg SR et al. Immunocompetent cells in psoriasis. In situ immunophenotyping by monoclonal antibodies. Arch Dermatol Res 1983; 275; 181-9.
    • (1983) Arch Dermatol Res , vol.275 , pp. 181-189
    • Bos, J.D.1    Hulsebosch, H.J.2    Krieg, S.R.3
  • 31
    • 0021355272 scopus 로고
    • Epidermal T lymphocytes and HLA-DB expression in psoriasis
    • Baker B, Swain AE, Fry L, Valdimarsson H. Epidermal T lymphocytes and HLA-DB expression in psoriasis. Br J Dermatol 1984; 110: 555-64.
    • (1984) Br J Dermatol , vol.110 , pp. 555-564
    • Baker, B.1    Swain, A.E.2    Fry, L.3    Valdimarsson, H.4
  • 32
    • 0024413413 scopus 로고
    • Remission of psoriatic lesions with monoclonal CD3 (Orthoclone OKT3) treatment
    • Weinshenker BG, Bass BH, Ebers GC, Rice GPA. Remission of psoriatic lesions with monoclonal CD3 (Orthoclone OKT3) treatment. J Am Acad Dermatol 1989; 20: 1132-3.
    • (1989) J Am Acad Dermatol , vol.20 , pp. 1132-1133
    • Weinshenker, B.G.1    Bass, B.H.2    Ebers, G.C.3    Rice, G.P.A.4
  • 33
    • 0025862110 scopus 로고
    • Chimeric CD4 monoclonal antibody in treatment of generalized pustular psoriasis
    • Prinz J, Braun-Falco O, Meurer M. Chimeric CD4 monoclonal antibody in treatment of generalized pustular psoriasis. Lancet 1991; 338: 320-1.
    • (1991) Lancet , vol.338 , pp. 320-321
    • Prinz, J.1    Braun-Falco, O.2    Meurer, M.3
  • 34
    • 0028990380 scopus 로고
    • 389 IL-2) suggest a primary immune but not keratinocyte pathogenic basis
    • 389 IL-2) suggest a primary immune but not keratinocyte pathogenic basis. Nature Med 1995; 1: 442-7.
    • (1995) Nature Med , vol.1 , pp. 442-447
    • Gottlieb, S.1    Gilleandean, D.2    Johnson, R.3
  • 35
    • 0003012098 scopus 로고
    • Immunophilins as drug targets
    • Testa B, Kyburz E, eds. Basel: Helvetica Chimica Acta
    • Stütz A, Grassberger M, Baumann K et al. Immunophilins as drug targets. In: Perspectivesin Medicinal Chemistry (Testa B, Kyburz E, eds). Basel: Helvetica Chimica Acta, 1993; 427-33.
    • (1993) Perspectivesin Medicinal Chemistry , pp. 427-433
    • Stütz, A.1    Grassberger, M.2    Baumann, K.3
  • 36
    • 0000796154 scopus 로고
    • Natural products as probes in the study of cellular functions. Investigations of immunophillis
    • Rosen MK, Schreiber SL. Natural products as probes in the study of cellular functions. Investigations of immunophillis. Angew Chem Int Ed 1992; 104; 413-30.
    • (1992) Angew Chem Int Ed , vol.104 , pp. 413-430
    • Rosen, M.K.1    Schreiber, S.L.2
  • 37
    • 0028050923 scopus 로고
    • Peptidylprolyl-cis/trans-isomerases and their effectors
    • Fischer G. Peptidylprolyl-cis/trans-isomerases and their effectors. Angew Chem Ed 1994; 33: 1415-16.
    • (1994) Angew Chem Ed , vol.33 , pp. 1415-1416
    • Fischer, G.1
  • 38
    • 0029867394 scopus 로고    scopus 로고
    • Structure-function relationships in the FK506-binding protein (FKBP) familly of peptidylprolyl cis-trans isomerases
    • Kuy JE. Structure-function relationships in the FK506-binding protein (FKBP) familly of peptidylprolyl cis-trans isomerases. Biochem J 1996; 314: 361-85.
    • (1996) Biochem J , vol.314 , pp. 361-385
    • Kuy, J.E.1
  • 39
    • 0032168133 scopus 로고    scopus 로고
    • A novel human gene PKBP6 is detected in Williams syndrome
    • Meng X, Lu X, Morris CA et al. A novel human gene PKBP6 is detected in Williams syndrome. Genomics 1998; 52: 130-7.
    • (1998) Genomics , vol.52 , pp. 130-137
    • Meng, X.1    Lu, X.2    Morris, C.A.3
  • 40
    • 0026753687 scopus 로고
    • Inhibition of T cell signaling by immunophilia-ligand complexes correlate with loss of calcineurin phosphatase activity
    • Liu J, Albers MW, Wandless TL et al. Inhibition of T cell signaling by immunophilia-ligand complexes correlate with loss of calcineurin phosphatase activity. Biochemistry 1992; 31: 3896-901.
    • (1992) Biochemistry , vol.31 , pp. 3896-3901
    • Liu, J.1    Albers, M.W.2    Wandless, T.L.3
  • 41
    • 0025255387 scopus 로고
    • Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: The missing link
    • Ullman KS, Northrup JP, Verweij CL, Crabtree GR. Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link. Annu Rev Immunol 1990; 8; 421-52.
    • (1990) Annu Rev Immunol , vol.8 , pp. 421-452
    • Ullman, K.S.1    Northrup, J.P.2    Verweij, C.L.3    Crabtree, G.R.4
  • 42
    • 0030889874 scopus 로고    scopus 로고
    • Gene regulation after F∈RI stimulation in the murine mast cell line CPII
    • Baumruker T, Pendl G G, Prieschl E E. Gene regulation after F∈RI stimulation in the murine mast cell line CPII. Int Arch Allergy Immunol 1997; 113: 39-41.
    • (1997) Int Arch Allergy Immunol , vol.113 , pp. 39-41
    • Baumruker, T.1    Pendl, G.G.2    Prieschl, E.E.3
  • 43
    • 0027327578 scopus 로고
    • Induction of IgE and IgG1 in human B cell cultures with staphylococcal superantigens: Role of helper T cell interaction, resistance to interferon-gamma
    • Armerding D, Van Reijsen FC, Hren A, Mudde GC. Induction of IgE and IgG1 in human B cell cultures with staphylococcal superantigens: Role of helper T cell interaction, resistance to interferon-gamma. Immunobiology 1993; 188: 259-73.
    • (1993) Immunobiology , vol.188 , pp. 259-273
    • Armerding, D.1    Van Reijsen, F.C.2    Hren, A.3    Mudde, G.C.4
  • 44
    • 0025141706 scopus 로고
    • Anti-CD3 antibody-induced expression of both p55 and p75 chains of the high affinity interleukin-2 receptor on human T lymphocytes is inhibited by cyclosporin A
    • Foxwell BMJ, Simon J, Herrero JJ et al. Anti-CD3 antibody-induced expression of both p55 and p75 chains of the high affinity interleukin-2 receptor on human T lymphocytes is inhibited by cyclosporin A. Immunology 1990; 69: 104-9.
    • (1990) Immunology , vol.69 , pp. 104-109
    • Foxwell, B.M.J.1    Simon, J.2    Herrero, J.J.3
  • 45
    • 0025099697 scopus 로고
    • Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin
    • Dumont FJ, Strauch MJ, Koprak SL et al. Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin. J Immunol 1990; 144: 251-8.
    • (1990) J Immunol , vol.144 , pp. 251-258
    • Dumont, F.J.1    Strauch, M.J.2    Koprak, S.L.3
  • 46
    • 2642672331 scopus 로고    scopus 로고
    • SDZ ASM 981-a novel anti-inflammatory macrolactam-inhibits FC∈RT-mediated mast cell activation
    • Abstr.
    • Hultsch T, Mueller KD, Meingassner JG, Knop JG. SDZ ASM 981-a novel anti-inflammatory macrolactam-inhibits FC∈RT-mediated mast cell activation. Australas Dermatol 1997; 38 (Suppl. 2): 286 (Abstr.).
    • (1997) Australas Dermatol , vol.38 , Issue.SUPPL. 2 , pp. 286
    • Hultsch, T.1    Mueller, K.D.2    Meingassner, J.G.3    Knop, J.G.4
  • 47
    • 0003518480 scopus 로고
    • Chichester: John Wiley & Sons
    • Segel IH. Enzyme Kinetics. Chichester: John Wiley & Sons, 1975: 170.
    • (1975) Enzyme Kinetics , pp. 170
    • Segel, I.H.1
  • 48
    • 77049143386 scopus 로고
    • Determination of enzyme-inhibitor constants
    • Dixon M. Determination of enzyme-inhibitor constants. Biochem J 1953; 55; 170-1.
    • (1953) Biochem J , vol.55 , pp. 170-171
    • Dixon, M.1


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