C32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 16, 1998, Pages 2253-2258

  Goulet, Mark T ^a   McAlpine, Shelli R ^a   Staruch, Mary Jo ^a   Koprak, Samuel ^a   Dumont, Francis J ^a   Cryan, John G ^a   Wiederrecht, Gregory J ^a   Rosa, Raymond ^b   Wilusz, Mary Beth ^b   Peterson, Laurence B ^b   Wyvratt, Matthew J ^a   Parsons, William H ^a  

^a Department of Medicinal Chemistry ^*  (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCOMYCIN; DIMETHYL ETHER; IMMUNOSUPPRESSIVE AGENT; T LYMPHOCYTE RECEPTOR; TACROLIMUS;

ARTICLE; AUTOIMMUNITY; BINDING AFFINITY; DERIVATIZATION; DRUG POTENCY; GRAFT REJECTION; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; LIPOPHILICITY; NONHUMAN;

ANIMALS; BIOLOGICAL AVAILABILITY; HYPOTHERMIA; IMIDAZOLES; IMMUNOPHILINS; IMMUNOSUPPRESSIVE AGENTS; INDICATORS AND REAGENTS; KIDNEY; MICE; MICE, INBRED BALB C; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NEUROTOXINS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES; TACROLIMUS; TACROLIMUS BINDING PROTEINS;

EID: 0032544146     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00397-7     Document Type: Article

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26. 3CN; 3. HF·pyr., THF.
27. 4OH, MeOH; 2. HF·pyridine, THF.