Immune signalling: SHP-2 docks at multiple ports

Current Biology

Volumn 9, Issue 4, 1999, Pages

  Huyer, Gregory ^a   Alexander, Denis R ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0033602224     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(99)80080-3     Document Type: Note

References (11)

1. Gu H, Pratt JC, Burakoff SJ, Neel BG: Cloning of p97/Gab2, the major SHP-2 binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. Mol Cell 1998, 2:729-740.
2. Van Vactor D, O'Reilly AM, Neel BG: Genetic analysis of protein tyrosine phosphatases. Curr Opin Genet Dev 1998, 8:112-126.
3. Barford D, Neel BG: Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2. Structure 1998, 6:249-254.
4. Allard JD, Chang HC, Herbst R, McNeill H, Simon MA: The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf. Development 1996, 122:1137-1146.
5. Herbst R, Carroll PM, Allard JD, Schilling J, Raabe T, Simon MA: Daughter of sevenless is a substrate of the phosphotyrosine phosphatase corkscrew and functions during sevenless signaling. Cell 1996, 85:899-909.
6. Raabe T, Riesgo-Escovar J, Liu X, Bausenwein BS, Deak P, Maroy P, Hafen E: DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and RAS1 in Drosophila. Cell 1996, 85:911-920.
7. Frearson JA, Alexander DR: The role of phosphotyrosine phosphatases in haematopoietic cell signal transduction. Bioessays 1997, 19:417-427.
8. Takahashi-Tezuka M, Yoshida Y, Fukada T, Ohtani T, Yamanaka Y, Nishida K, Nakajima K, Hibi M, Hirano T: Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase. Mol Cell Biol 1998, 18:4109-4117.
9. Gu H, Griffin JD, Neel BG: Characterization of two SHP-2-associated binding proteins and potential substrates in hematopoietic cells. J Biol Chem 1997, 272:16421-16430.
10. Craddock BL, Welham MJ: Interleukin-3 induces association of the protein-tyrosine phosphatase SHP2 and phosphatidylinositol 3-kinase with a 100-kDa tyrosine-phosphorylated protein in hemopoietic cells. J Biol Chem 1997, 272:29281-29289.
11. Frearson JA, Alexander DR: The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/Mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells. J Exp Med 1998, 187:1417-1426.