Immunity to plasmodium falciparum malaria sporozoites by somatic transgene immunization

Nature Biotechnology

Volumn 15, Issue 9, 1997, Pages 876-881

  Gerloni, Mara ^a   Ballou, W Ripley ^b   Billetta, Rosario ^a   Zanetti, Maurizio ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

DNA immunization; Malaria; Vaccine design

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; PLASMID DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; GENE THERAPY; IMMUNIZATION; IMMUNOLOGICAL MEMORY; INFECTION PREVENTION; MALARIA CONTROL; MALARIA FALCIPARUM; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SPOROZOITE; TRANSGENE; VACCINATION;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIBODY FORMATION; B-LYMPHOCYTES; DNA, PROTOZOAN; GENES, IMMUNOGLOBULIN; HUMANS; MALARIA, FALCIPARUM; MICE; OLIGOPEPTIDES; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; TRANSGENES; VACCINATION;

ANIMALIA; PLASMODIUM FALCIPARUM;

EID: 0030865220     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt0997-876     Document Type: Article

References (42)

1. Salk, J. and Salk, D. 1977. Control of influenza and poliomyelitis with killed virus vaccines. Science 195:834-847.
2. Zanetti, M., Sercarz, E., and Salk, J. 1987. The immunology of new generation vaccines. Immunol. Today 8:18-25.
3. Cox, G., Zamb, T., and Babiuk, L. 1993. Bovine herpesvirus 1: Immune responses in mice and cattle injected with plasmid DNA. J. Virol. 67:5664-5667.
4. Robinson, H., Hunt, L., and Webster, R. 1993. Protection against a lethal influenza virus challenge by immunization with a haemagglutinin-expressing plasmid. Vaccine 11:957-960.
5. Wang, B., Ugen, K., Srikantan, V., Agadjanyan, M., Dang, Y, Refaeli, A., et al. 1993. Gene inoculation generates immune responses against human Immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 90:4156-4160.
6. Ulmer, J.B., Donnelly, J.J., Parker, S.E., Rhodes, G.H., Felgner, P.L., Dwarki, V.J., et al. 1993. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259:1745-1749.
7. Sedegah, M., Hedstrom, R., Hobart, P., and Hoffman, S.L. 1994. Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein. Proc. Natl. Acad. Sci. USA 91:9866-9870.
8. Raz, E., Carson, D.A., Parker, S.E., Parr, T.B., Abal, A.M., Aichinger, G., et al. 1994. Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses. Proc. Natl. Acad. Sci. USA 91:9519-9523.
9. Davis, H.L., Michel, M.L., Mancini, M., Schleef, M., and Whalen, R.G. 1994. Direct gene transfer in skeletal muscle: plasmid DNA-based immunization against the hepatitis B virus surface antigen. Vaccine 12:1503-1509.
10. Anderson, R., Gao, X.-M., Papakonstantinopoulou, A., Roberts, M., and Dougan, G. 1996. Immune response in mice following immunization with DNA encoding fragment C of tetanus toxin. Infect. Imm. 64:3168-3173.
11. Xiang, Z.Q., Spitalnik, S., Tran, M., Wunner, W.H., Cheng, J., and Erti, H.C. 1994. Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus. Virology 199:132-140.
12. Davis, H.L., Whalen, R.G., and Demeneix, B.A. 1993. Direct gene transfer into skeletal muscle in vivo: factors affecting efficiency of transfer and stability of expression. Hum. Gene Ther. 4:151-159.
13. Gerloni, M., Billetta, R., Xiong, S., and Zanetti, M. 1997. Somatic transgene immunization with DNA encoding an immunoglobulin heavy chain. DNA Cell Biol. 16:611-625.
14. Gillies, S.D., Morrison, S.L., Oi, V.T., and Tonegawa, S. 1983. A tissue-specific transcription enhancer element is located in the. major intron of a rearranged immunoglobulin heavy chain gene. Cell 33:717-728.
15. Xiong, S., Gerloni, M., and Zanetti, M. 1997. In vivo role of B lymphocytes in somatic transgene immunization. Proc. Natl. Acad. Sci. USA 94:6352-6357.
16. Zanetti, M. 1992. Antigenized antibodies. Nature 355:466-477.
17. Billetta, R., Hollingdale, R.M., and Zanetti, M. 1991. Immunogenicity of an engineered internal image antibody. Proc. Natl. Acad. Sci. USA 88:4713-4717.
18. Lanza, P., Billetta, R., Antonenko, S., and Zanetti, M. 1993. Active immunity against the CD4 receptor using an antibody antigenized with residues 41-55 of the first extracellular domain. Proc. Natl. Acad. Sci. USA 90:11683-11687.
19. Rigaudy, P., Simon, S., Hunter, T., Sollazzo, M., Billetta, R., Zanetti, M., and Eckhart, W. 1994. Antibodies specific for the neuronal form of the scr protein elicited by an antigenized antibody. DNA Cell Biol. 13:585-591.
20. Zaghouani, H., Anderson, S.A., Sperber, K.E., Dalan, C., Kennedy, R.C., Mayer, L., and Bona, C.A. 1995. Induction of antibodies to the human immunodeficiency virus type 1 by immunization of baboons with immunoglobulin molecules carrying the principal neutralizing determinant of the envelope protein. Proc. Natl. Acad. Sci. USA 92:631-635.
21. Sollazzo, M., Billetta, R., and Zanetti, M. 1990. Expression of an exogenous peptide epitope genetically engineereed in the variable domain of an immunoglobulin: implications for antibody and peptide folding. Prot. Eng. 4:215-220.
22. Zaghouani, H., Steinman, R., Nonacs, R., Shah, H., Gerhard, W., and Bona, C. 1993. Presentation of a viral T cell epitope expressed in the CDR3 region of a self immunoglobulin molecule. Science 259:224-227.
23. Zavala, F., Tam, J.P., Hollingdale, M.R., Cochrane, A.H., Quakyi, I., Nussenzweig, R.S., and Nussenzweig, V. 1985. Rationale for development of a synthetic vaccine against Plasmodium falciparum malaria. Science 228:1436-1440.
24. Nardin, E.H., Nussenzweig, R.S., McGregor, I.A., and Bryan, J.H. 1979. Antibodies to sporozoites: Their frequent occurrence in individuals living in an area of hyperendemic malaria. Science 206:597-601.
25. Clyde, D.F., McCarthy, V.C., Miller, R.M., and Hornick, R.B. 1973. Specificity of protection of man Immunized against sporozoite-induced falciparum malaria. Am. J. Med. Sci. 266:398-403.
26. Calle, J.M., Nardin, E.H., Clavijo, P., Boudin, C., Stuber, D., Takacs, B., et al. 1992. Recognition of different domains of the Plasmodium falciparum CS protein by the sera of naturally infected individuals compared with those of sporozoite-immunized volunteers. J. Immunol. 149:2695-2701.
27. Egan, J.E., Hoffman, S.L, Haynes, J.D., Sadoff, J.C., Schneider, I., Grau, G.E., et al. 1993. Humoral Immune responses in volunteers Immunized with irradiated Plasmodium falciparum sporozoites. Am. J. Trop. Med. Hyg. 49:166-173.
28. Ballou, W.R., Hoffman, S.L., Sherwood, J.A., Hollingdale, M.R., Neva, F.A., Hockmeyer, W.T., et al. 1987. Safety and efficacy of a recombinant DNA Plasmodium falciparum sporozoite vaccine. Lancet 1:1277-1281.
29. Herrington, D.A., Clyde, D.F., Losonsky, G., Cortesia, M., Murphy, J.R., Davis, J., et al. 1987. Safety and Immunogenicity In man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites. Nature 328:257-259.
30. Edelman, R., Hoffman, S.L, Davis, J.R., Beier, M., Sztein, M.B., Losonsky, G., et al. 1993. Long-term persistence of sterile Immunity in a volunteer immunized with X-irradiated Plasmodium falciparum sporozoites. J Infect Dis 168:1066-1070.
31. Dresser, D.W. and Mitchison, N.A. 1968. The mechanism of immunological paralysis. Adv. Immunol. 8:129-181.
32. Stoute, J.A., Slaoul, M., Heppner, D.G., Momin, P., Kester, K.E., Desmons, P., et al. 1997. A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. RTS, S Malaria Vaccine Evaluation Group [see comments]. New Engl. J. Med. 336:86-91.
33. Munesinghe, D.Y., Clavijo, P., Calle, M.C., Nussenzweig, R.S., and Nardin, E. 1991. Immunogenicity of multiple antigen peptides (MAP) containing T and B cell epitopes of the repeat region of the P. falciparum circumsporozoite protein. Eur. J. Immunol. 21:3015-3020.
34. Xiong, S., Gerloni, M., and Zanetti, M. 1997. Engineering vaccines with heterologous B and T cell epitopes using immunoglobulin genes. Nature Biotechnology 15:882-886.
35. Gerloni, M., Lo, D., and Zanetti, M. 1997. DNA Immunization in relB-deficient mice discloses a role for dendritic cells in IgG1→IgM switch in vivo. Eur. J. Immunol. Eur. J. Immunol. In press.
36. Kemp, D.J., Coppel, R.L., and Anders, R.F. 1987. Repetitive proteins and genes of malaria. Annu. Rev. Microbiol. 41:181-208.
37. Hoffman, S.L., Nussenzweig, V., Sadoff, J.C., and Nussenzweig, R.S. 1991. Progress toward malaria vaccine preerythrocytlc vaccines. Science 252:520-521.
38. Etlinger, H.M. and Trzeciak, A. 1993. Towards a synthetic malaria vaccine: cyclization of a peptide eliminates the production of parasite-unreactive antibody. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 340:69-72.
39. Green, T.J. and Packer, B.J. 1984. A role for rheumatoid factor enhancement of Plasmodium falciparum schizont inhibition in vitro. Infect Immun. 46:668-672.
40. Wirtz, R.A., Ballou, W.R., Schneider, I., Chedid, L., Gross, M.J., Young, J.F., et al. 1987. Plasmodium falciparum: immunogenicity of circumsporozoite protein constructs produced in Escherichia coli. Exp. Parasitol. 63:166-172.
41. Billetta, R. and Zanetti, M. 1992. Ligand expression using antigenization of antibody: Principle and methods. ImmunoMethods 1:41-51.
42. Sollazzo, M., Hasemann, C.A., Meek, K.D., Glotz, D., Capra, J.D., and Zanetti, M. 1989. Molecular characterization of the VH region of murine autoantibodies from neonatal and adult BALB/c mice. Eur. J. Immunol. 19:453-457.