Immune responses but no protection against SHIV by gene-gun delivery of HIV-1 DNA followed by recombinant subunit protein boosts

Virology

Volumn 250, Issue 2, 1998, Pages 293-301

  Putkonen, Per ^a   Quesada Rolander, Marlene ^a   Leandersson, Ann Charlotte ^a   Schwartz, Stefan ^b   Thorstensson, Rigmor ^a   Okuda, Kenji ^c   Wahren, Britta ^a   Hinkula, Jorma ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; IMMUNOGLOBULIN G; PLASMID DNA; RECOMBINANT PROTEIN; REGULATOR PROTEIN; SYNTHETIC PEPTIDE; VIRUS DNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL MODEL; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; GENE TARGETING; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNIZATION; INTRAMUSCULAR DRUG ADMINISTRATION; MONKEY; NONHUMAN; PRIORITY JOURNAL; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS INFECTION; VIRUS REPLICATION;

ANIMALIA; DNA VIRUSES; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA FASCICULARIS; RNA VIRUSES; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS; SIMIAN-HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0032566907     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1998.9379     Document Type: Article

References (36)

1. Andersson S., Mäkitalo B., Thorstensson R., Franchini G., Tartaglia J., Limbach K., Paoletti E., Putkonen P., Biberfeld G. Immunogenicity and protective efficacy of a human immunodeficiency virus type 2 recombinant canarypox (ALVAC) vaccine candidate in cynomolgus monkeys. J. Infect. Dis. 174:1996;977-985.
2. Asakura Y., Hinkula J., Leandersson A.-C., Fukushima J., Okuda K., Wahren B. Induction of HIV-1 specific mucosal immune responses by DNA vaccination. Scand. J. Immunol. 46:1997;326-330.
3. Berglund P., Quesada-Rolander M., Putkonen P., Biberfeld G., Thorstensson R., Liljeström P. Outcome of immunization of cynomolgus monkeys with recombinant Semliki forest virus encoding human immunodeficiency virus type 1 envelope protein and challenge with a high dose of SHIV-4 virus. AIDS Res. Hum. Retroviruses. 13:1997;1487-1495.
4. Bourne N., Milligan G. N., Schleiss M. R., Bernstein D. I., Stanberry L. R. DNA immunization confers protective immunity of mice challenged intravaginally with herpes simplex virus type 2. Vaccine. 14:1996;12130-11234.
5. Boyer J. D., Ugen K. E., Wang B., Agadjanyan M., Gilbert L., Bagarazzi M. L., Chattergoon M., Frost P., Javadian A., Williams W. V., Refaeli Y., Ciccarelli R. B., McCallus D., Coney L., Weiner D. B. Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination. Nature Med. 3:1997;526-531.
6. Calarota S., Bratt G., Nordlund S., Hinkula J., Leandersson A.-C., Sandström E., Wahren B. Cellular cytotoxic response induced by DNA vaccination in HIV-1-infected patients. Lancet. 351:1998;1320-1325.
7. Davis H. L., McCluskie M. J., Gerin J. L., Purcell R. H. DNA vaccine for hepatitis B: Evidence for immunogenicity in chimpanzees and comparison with other vaccines. Proc. Natl. Acad. Sci. USA. 93:1996;7213-7218.
8. Fuller D. H., Murphey-Corb M., Clements J., Barnett S., Haynes J. R. Induction of immunodeficiency virus-specific immune responses in rhesus monkeys following gene gun-mediated DNA vaccination. J. Med. Primatol. 25:1996;236-241.
9. Fuller D. H., Simpson L., Cole K. S., Clements J. E., Panicali D. L., Montelaro R. C., Murphey-Corb M., Haynes J. R. Gene gun based nucleic acid immunization alone or in combination with recombinant vaccinia vectors suppresses virus burden in rhesus macaques challenged with a heterologous SIV. Immunol. Cell Biol. 75:1997;389-396.
10. Fynan E. F., Webster R. G., Fuller D. H., Haynes J. R., Santoro J. C., Robinson H. L. DNA vaccines protective immunization by parental, mucosal, and gene-gun inoculation. Proc. Natl. Acad. Sci. USA. 90:1993;11478-11482.
11. Gonzáles Armas J. C., Morello C. S., Cranmer L. D., Spector D. H. DNA immunization confers protection against murine cytomegalovirus infection. J. Virol. 70:1996;7921-7928.
12. Hinkula J., Svanholm C., Schwartz S., Lundholm P., Brytting M., Engström G., Benthin R., Glaser H., Kohleisen B., Erfle V., Okuda K., Wigzell H, Wahren B. Recognition of prominent viral epitopes induced by immunization with regulatory genes. J. Virol. 71:1997;5528-5539.
13. Jehuda-Cohen T., Powell J. D., Villinger F., Mayne A. E., Sell K. W., Ansari A. A. Evidence for simian immunodeficiency virus-specific IgM and IgG response in peripheral blood mononuclear cells of serum enzyme-linked immunosorbent assay-negative nonhuman primates. J. Acquired Immune Defic. Syndr. 7:1994;539-550.
14. Leong K. H., Ramsay A. J., Ramshaw, Morin M. J., Robinson H. L., Boyle D. B. Generation of enhanced immune responses by consecutive immunization with DNA and recombinant fowl pox vectors. Vaccines 95 - Modern Approaches to New Vaccines Including Prevention of AIDS. 1995;Cold Spring Harbor Lab. Press, Cold Spring Harbor. p. 327-331.
15. Letvin N.L, Montefiori D. C., Yasutomi Y., Perry H. C., Davies M.-E., Lekutis C., Alroy M., Freed D. C., Lord C. I., Handt L. K., Liu M. A., Shiver J. W. Potent, protective anti-HIV immune responses generated by bimodal HIV envelope DNA plus protein vaccination. Proc. Natl. Acad. Sci. USA. 94:1997;9378-9383.
16. Li J., Lord C. I., Haseltine W., Letvin N. L., Sodroski J. Infection of cynomolgus monkeys with a chimeric HIV-1/SIVmac virus that expresses the HIV-1 enevlope glycoproteins. J. Acquired Immune Defic. Syndr. 5:1992;639-646.
17. Lu S., Montefiori D. C., Yasutomi Y., Manson K., Mustafa F., Johnson E., Santaro J. C., Wissink J., Mullins J. I., Haynes J. R., Letvin N. L., Wyand M., Robinson H. L. Simian immunodeficiency virus DNA vaccine trial in macaques. J. Virol. 70:1996;3978-3991.
18. Lyamuya E. Bredberg-Råden U., Massawe A., Urassa E., Kawo G., Msemo G., Kazimoto T., Ostborn A., Karlsson K., Mhalu F., Biberfeld H. Performance of a modified HIV-1 p24 antigen assay for early diagnosis of HIV-1 infection in infants and prediction of mother-to-infant transmission of HIV-1 in Dar es Salaam, Tanzania. J. Acquired Immune Defic. Syndr. 12:1996;421-426.
19. Nilsson C., Thorstensson R., Gilljam G., Sjölander S., Hild K., Broliden K., Åkerblom L., Morein B., Biberfeld G., Putkonen P. Protection against monkey-cell grown cell-free HIV-2 challenge in macaques immunized with native HIV-2 envelope glycoprotein gp 125. Vaccine Res. 4:1995;165-175.
20. Okuda K., Bukawa H., Hamajina K., Kawamoto S., Sekigawa K.-I., Yamada Y., Tanaka S.-I., Ishii N., Aoki I., Nakamura M., Yamamoto H., Cullen B. R., Fukushima J. Induction of potent humoral and cell-mediated immune response following direct injection of DNA encoding the HIV type 1 env and rev gene products. AIDS Res. Hum. Retroviruses. 11:1995;933-943.
21. Pertmer T. M., Eisenbaum M. D., McCabe D., Prayaga S. K., Fuller D. H., Haynes J. R. Gene gun-based nucleic acid immunization: Elicitation of humoral and cytotoxic T lymphocyte responses following epidermal delivery of nanogram quantities of DNA. Vaccine. 13:1995;1427-1430.
22. Putkonen P. Live attenuated AIDS vaccines. Immunologist. 4:1996;142-146.
23. Putkonen P., Mäkitalo B., Böttiger D., Biberfeld G., Thorstensson R. Protection of human immunodeficiency virus type 2-exposed seronegative macaques from mucosal simian immunodeficiency virus transmission. J. Virol. 71:1997;4981-4984.
24. Quesada-Rolander M., Mäkitalo B., Thorstensson R., Zhang Y.-J., Castanos-Velez E., Biberfeld G., Putkonen P. Protection against mucosal SIVsm challenge in macaques infected wth a chimeric SIV that expresses HIV type 1 envelope. AIDS Res. Hum. Retroviruses. 12:1996;993-999.
25. Rud E., Cranage M., Yon J., Quirk J., Ogilvie L., Cook N., Webster S., Dennis M., Clarke B. E. Molecular and biological characterization of simian immunodeficiency virus macaque strain 32H proviral clones containing nef size variants. J. Gen. Virol. 75:1994;529-543.
26. Sundqvist V.-A., Albert J., Ohlsson E., Hinkula J., Fenyö E.-M., Wahren B. HIV-1 p24 antigenic variation in tissue culture of isolates with defined growth characteristics. J. Med. Virol. 29:1989;170-175.
27. Thorstensson R., Walther L., Putkonen P., Albert J., Biberfeld G. A capture immunoassay for detection of HIV-2/SIV antigen. J. Acquired Immune Defic. Syndr. 4:1991;374-379.
28. Ulmer J. B., Donnelly J. J., Parker S. E., Rhodes G. H., Felgner P. L., Dwark V. J., Gromkovski S. H., Deck R. R., DeWitt C. M., Friedman A. F., Hawe L. A., Leander K. R., Martinez D., Perry H. C., Shiver J. W., Montgomery D. L., Liu M. A. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science. 259:1993;1745-1749.
29. Vogel F. R., Sarver N. Nucleic acid vaccines. Clin. Microbiol. Rev. 8:1995;406-410.
30. Wahren B. Gene vaccines. Immunotechnology. 2:1997;77-83.
31. Wahren B., Brytting M. M., Engström G., Hinkula J., Levi M., Ståhle E. L., Ohlsson S., Rudén U., Schwartz S. Immune responses to the HIV rev regulatory gene. Antibiot. Chemother. 48:1996;105-112.
32. Wahren B., Hinkula J., Ljungdahl-Ståhle E., Borrebaeck C. A. K., Schwartz S., Wigzell H. Nucleic acid vaccination with HIV regulatory genes: DNA vaccines, a new era in vaccinology. Ann. NY Acad. Sci. 772:1995;278-281.
33. Wang B., Boyer J., Srikantan V., Ugen K., Gilbert L., Phan C., Dang K., Merva M., Agadjanyan G., Newman M., Carrano R., McCallus D., Coney L., Williams W. V., Weiner D. B. Induction of humoral and cellular immune rresponses to the human immunodeficiency type 1 virus in nonhuman primates by in vivo DNA inoculation. Virology. 211:1995a;101-112.
34. Wang B., Boyer J. D., Ugen K. E., Srikantan V., Ayyaroo V., Agadjanyan M. G., Williams W. V., Newman M., Coney L., Carrano R., Weiner D. B. Nucleic acid-based immunization against HIV-1: Induction of protective immune responses. AIDS. 9:1995b;159-170.
35. Xiang Z. Q., Spitalnik S., Tran M., Wunner W. H., Cheng J., Ertl C. J. Vaccination with plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus. Virology. 199:1994;132-140.
36. Yasutomi Y., Robinson H. L., Lu S. L., Mustafa F., Lekutis C., Arthos J., Mullins J. I., Voss G., Mansson K., Wyand M., Letvin N. L. Simian immunodeficiency virus-specific cytotoxic T-lymphocyte induction through DNA vaccination of rhesus monkeys. J. Virol. 70:1996;678-681.