Toward cell-targeting gene therapy vectors: Selection of cell-binding peptides from random peptide-presenting phage libraries

Nature Medicine

Volumn 2, Issue 3, 1996, Pages 299-305

  Barry, Michael A ^a   Dower, William J ^b   Johnston, Stephen Albert ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b AFFYMAX RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE;

ANIMAL CELL; ARTICLE; BACTERIOPHAGE; EXPRESSION VECTOR; GENE THERAPY; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; BACTERIOPHAGES; BINDING, COMPETITIVE; CELL LINE; FIBROBLASTS; GENE LIBRARY; GENE TARGETING; GENE THERAPY; GENETIC VECTORS; IMMUNOHISTOCHEMISTRY; MICE; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTATION; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 0029880651     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0396-299     Document Type: Article

References (18)

1. Mulligan, R.C. The basic science of gene therapy. Science 260, 926-932 (1993).
2. Feigner, P.L. & Rhodes, G. Gene therapeutics. Nature 349, 351-352 (1991).
3. Pietersz, G.A. & McKenzie, I.F.C. Antibody conjugates for the treatment of cancer. Immunol. Rev. 129, 57-80 (1992).
4. Devlin, J. J., Panganiban, L. C. & Devlin, P. E. Random peptide libraries: a source of specific protein binding molecules. Science 249, 404-406 (1990).
5. Cwirla, S. E., Peters, E. A., Barrett, R. W. & Dower, W. J. Peptides on phage: A vast library of peptides for identifying ligands. Proc. Natl. Acad. Sci. USA 87, 6378-6382 (1990).
6. Hart, S.L., et al. Cell binding and internalization by filamentous phage displaying a cyclic Arg-Gly-Asp-containing peptide. J. Biol. Chem. 269, 12468-12474 (1994).
7. Doorbar, J. & Winter, G. Isolation of a peptide antagonist to the thrombin receptor using phage display. J. Mol. Biol. 244, 361-369 (1994).
8. Cotten, M. et al. Transferrin-polycation-mediated introduction of DNA into human leukemic cells: Stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptors. Proc. Natl. Acad. Sci. USA 87, 4033-4037 (1990).
9. Brown, K.C., Yang, S-H. & Kodadek, T. Highly specific oxidative cross-linking of proteins mediated by a nickel-peptide complex. Biochem. 34, 4733-4739 (1995).
10. Quantin, B., Perricaudet, L.D., Tajbakhsh, S. & Mandel, J.L. Adenovirus as an expression vector in muscle cells in vivo. Proc. Natl. Acad. Sci. USA 89, 2581-2584 (1992).
11. Rosenfeld, M.A. et al. Adenovirus-mediated transfer of a recombinant α1-antitrypsin gene to the lung epithelium in vivo. Science 252, 431-434 (1991).
12. Fong, S., Doyle, L.V., Devlin, J.J. & Doyle, M.V. Scanning whole cells with phage-display libraries: Identification of peptide ligands that modulate cell function. Drug Dev. Res. 33, 64-70 (1994).
13. Hart, S.L. et al. Gene delivery and expression mediated by an integrin-binding peptide. Gene Ther. 2, 552-554 (1995).
14. Yokoyama-Kobayashi, M. & Kato, S. Recombinant f1 phage particles can transfect monkey COS-7 cells by DEAE dextran method. Biochem. Biophys. Res. Commun. 192, 935-939 (1993).
15. Gottschalk, S., Tweten, R.K., Smith, L.C. & Woo, S.L.C. Efficient gene delivery and expression in mammalian cells using DNA coupled with perfringolysin O. Gene Ther. 2, 498-503 (1995).
16. Markland, W., Roberts, B.L., Saxena, M.J., Guterman, S.K. & Ladner, R.C. Design, construction and function of a multicopy display vector using fusions to the major coat protein of bacteriophage M13. Gene 109, 13-19 (1991).
17. Jespers, L.S. et al. Surface expression and ligand-based selection of cDNAs fused to filamentous phage gene VI. Bio/Technology 13, 378-382 (1995).
18. Bassel-Duby, R., Hernandez, M.D., Gonzalez, M.A., Krueger, J.K. & Williams, R.S. A 40-kilodalton protein binds specifically to an upstream sequence element essential for muscle-specific transcription of the human myoglobin promoter. Mol. Cell. Biol. 12, 5024-5032 (1992).