Genomic imbalance in rat mammary gland carcinomas induced by 2-amino-1- methyl-6-phenylimidazo(4,5-b)pyridine

Molecular Carcinogenesis

Volumn 27, Issue 2, 2000, Pages 76-83

  Yu, Minshu ^a   Ryu, Doug Young ^a   Snyderwine, Elizabeth G ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Mammary gland; PhIP; Rat

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; 7,12 DIMETHYLBENZ[A]ANTHRACENE;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CONTROLLED STUDY; FEMALE; GENE MUTATION; HETEROZYGOSITY LOSS; LIPID DIET; MICROSATELLITE INSTABILITY; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE STRAND CONFORMATION POLYMORPHISM;

ANIMALS; CARCINOGENS; DIET, FAT-RESTRICTED; DIETARY FATS; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FEMALE; IMIDAZOLES; LOSS OF HETEROZYGOSITY; MAMMARY NEOPLASMS, EXPERIMENTAL; MICROSATELLITE REPEATS; RATS; RATS, SPRAGUE-DAWLEY; TRINUCLEOTIDE REPEAT EXPANSION;

ANIMALIA; RODENTIA;

EID: 0033964593     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(200002)27:2<76::AID-MC3>3.0.CO;2-7     Document Type: Article

References (53)

1. Kerangueven F, Noguchi T, Coulier F, et al. Genome-wide search for loss of heterozygosity shows extensive genetic diversity of human breast carcinomas. Cancer Res 1997;57:5469-5474.
2. Brenner AJ, Aldaz CM. The genetics of sporadic breast cancer. Prog Clin Biol Res 1997;396:63-82
3. Devilee P, Cornelisse C. Somatic genetic changes in human breast cancer. Biochim Biophys Acta 1994;1198:113-130.
4. Osborne RJ, Merlo GR, Mitsudomi T, et al. Mutations in the p53 gene in primary human breast cancers. Cancer Res 1991;51:6194-6198.
5. Loeb LA. Cancer cells exhibit a mutator phenotype. Adv Cancer Res 1998;72:25-66.
6. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996;87:159-170.
7. Thibodeau SN, Bren G, Schaid D. Microsatellite instability in cancer of the proximal colon. Science 1993;260:816-819
8. Dillon EK, de Boer WB, Papadimitriou JM, Turbett GR. Microsatellite instability and loss of heterozygosity in mammary carcinoma and its probable precursors. Brit J Cancer 1997;76:156-162.
9. Patel U, Grundfest-Broniatowski S, Gupta M, Banerjee S. Microsatellite instabilities at five chromosomes in primary breast tumours. Oncogene 1994;9:3695-3700.
10. Wooster R, Cleton-Jansen AM, Collins N, et al. Instability of short tandem repeats (microsatellites) in human cancers. Nat Genet 1994;6:152-156.
11. Myeroff LL, Parsons R, Kim S-J, et al. A transforming growth factor receptor type II gene common in colon and gastric but rare in endometrial cancers with microsatellite instability. Cancer Res 1995;55:5545-5547.
12. Goggins M, Shekher M, Turnacioglu K, Yeo CJ, Hruban RH, Kern SE. Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas. Cancer Res 1998;58:5329-5332
13. Souza RF, Appel R, Yin J, et al. Microsatellite instability in the insulin-like growth factor II recetor gene in gastrointestinal tumours. Nat Genet 1996;14:255-257.
14. Rampino N, Yamamoto H, Ionov Y, et al. Somatic frameshift mutations in the Bax gene in colon cancers of the microsatellite mutator phenotype. Science 1997;275:967-969.
15. El-Bayoumy K. Environmental carcinogens that may be involved in human breast cancer etiology. Chem Res Toxicol 1992;5:585-590.
16. Snyderwine EG. Some perspectives on the nutritional aspects of breast cancer research. Cancer (suppl) 1994;74: 1070-1077.
17. Snyderwine EG. Dietary heterocydic amines and breast cancer. Women Cancer 1999;1:21-29.
18. Layton DW, Bogen KT, Knize MG, Hatch FT, Johnson VM, Felton JS. Cancer risk of heterocyclic amines in cooked foods: an analysis and implications for research. Carcinogenesis 1995;16:39-52.
19. Ito N, Hasegawa R, Sano M et al. A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhlP). Carcinogenesis 1991; 12:1503-1506.
20. Hasegawa R, Sano M, Tamano S, et al. Dose-dependence of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhlP) carcinogenicity in rats. Carcinogenesis 1993;14:2553-2557.
21. Ghoshal A, Preisegger K-H, Takayama S, Thorgeirsson SS, Snyderwine EG. Induction of mammary tumors in female Sprague-Dawley rats by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and effect of dietary fat. Carcinogenesis 1994;15:2429-2433.
22. El-Bayoumy K, Chae Y-H, Upadhyaya P, et al. Comparative tumorigenicity of benzo[a]pyrene, 1-nitropyrene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine administered by gavage to female CD rats. Carcinogenesis 1995;16:431-434.
23. Imaida K, Hagiwara A, Yada H, et al. Dose-dependent induction of mammary carcinomas in female Sprague-Dawley rats with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Japan J Cancer Res 1996;87:1116-1120.
24. Snyderwine EG, Thorgeirsson UP, Venugopal M, Roberts-Thomson SJ. Mammary gland carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhlP) in Sprague-Dawley rats on high and low fat diets. Nut Cancer 1998;31:160-167.
25. Ghoshal A, Davis CD, Schut HAJ, Snyderwine EG. Possible mechanisms for PhlP-DNA adduct formation in the mammary gland of female Sprague-Dawley rats. Carcinogenesis 1995;16:2725-2731.
26. Snyderwine EG, Davis CD, Schut HAJ, Roberts-Thomson SJ. Proliferation, development and DNA adduct levels in the mammary gland of rats given 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a high fat diet. Carcinogenesis 1998;19:1209-1215.
27. Roberts-Thomson SJ, Snyderwine EG. Effect of dietary fat on codon 12 and 13 Ha-ras gene mutations in 2-amino-1-methyl-6-phenylimidazo[4,5-6]pyridine-induced rat mammary gland tumors. Mol Carcinog 1997;20:348-354.
28. Ushijima T, Kakiuchi H, Makino H, et al. Infrequent mutation of Ha-ras and p53 in rat mammary carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Mol Carcinog 1994;10:38-44.
29. Toyota M, Ushijima T, Weisburger JH et al. Microsatellite instability and loss of heterozygosity on chromosome 10 in rat mammary tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Mol Carcinog 1996;15: 176-182.
30. Russo J, Russo IH, van Zwieten MJ, Rogers AE, Gusterson B. Classification of neoplastic and nonneoplastic lesions of the rat mammary gland. In: Jones TC, Mohr U, editors. Integuments and mammary glands. New York: Springer-Verlag; 1989, p 275-304.
31. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning. A laboratory manual 2 ed. New York: Cold Spring Harbor Press; 1989.
32. Wang D, Weghorst CM, Calvert RJ, Stoner GD. Mutations in the p53 tumor suppressor gene in rat esophageal papillomas induced by N-nitrosomethylbenzylamine. Carcinogenesis 1996;17:625-630.
33. Kakiuchi H, Watanabe M, Ushijima T, et al. Specific 5′-GGGA-3′ mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Proc Natl Acad Sci USA 1995;92:910-914.
34. Deng AY, Smith-Mensah WH, Hoebee B, Garrett M, Rapp JP. Linkage mapping of rat chromosome markers generated from chromosome-sorted DNA. Mammalian Genome 1998; 9:38-45.
35. Andoh Y, Kuramoto T, Yokoi N, Maihara T, Kitada K, Serikawa T. Correlation between genetic and cytogenetic maps of the rat. Mam Genome 1998;9:287-293.
36. 94 -> trp) identified in a human breast carcinoma. J Biol Chem 1996;271: 15782-15786.
37. Berx G, Cleton-Jansen A-M, N0ollet F, et al. E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers. EMBO J 1995;14:6107-6115.
38. Berx G, Cleton-Jansen A-M, Strumane K, et al. E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain. Oncogene 1996;13:1919-1925.
39. Medeiros AC, Nagai MA, Neto MM, Brentani RR. Loss of heterozygosity affecting the APC and MCC genetic loci in patients with primary breast carcinomas. Cancer Epidemiol Biomarkers Prev 1994;3:331-333.
40. Kashiwaba M, Tamura G, Ishida M. Aberrations of the APC gene in primary breast carcinoma. J Cancer Res Clin Oncol 1994;120:727-731.
41. Hayashi R, Luk H, Horio D, Dashwood R. Inhibition of apoptosis in colon tumors induced in the rat by 2-amino-3-methy imidazo[4,5-f]quinoline. Cancer Res 1996;56: 4307-4310.
42. Dashwood RH, Suzui M, Nakagama H, Sugimura T, Nagao M. High frequency of B-catenin (Ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat. Cancer Res 1998;58:1127-1129.
43. Venugopal M, Callaway A, and Snyderwine EG. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhlP) retards mammary gland involution in lactating Sprague-Dawley rats. Carcinogenesis 1999;20:1309-1314.
44. Ilyas M, Tomlinson IPM. The interactions of APC, E-cadherin and B-catenin in tumour development and progression J Pathol 1997;182:128-137.
45. McKenzie KE, Armstrong BA, Chen Y, Nagarajan M, Aldaz CM, Sukumar S. Alterations in the Ha-ras-1 and the p53 pathway genes in the progression of N-methyl-N-nitro-sourea-induced rat mammary tumors. Mol Carcinog 1997; 20:194-203.
46. Hartwell LH, Kastan MB. Cell cycle control and cancer. Science 1994;266:1821-1828.
47. Musunuru K, Hinds PW. Cell cycle regulators in cancer. Basel: S. Karger AG; 1997. 162 p.
48. Yoshinaga K, Sasano H, Furukawa T, et al. The PTEN, BAX and IGFIIR genes are mutated in endometrial atypical hyperplasia. Japan J Cancer Res 1998;89: 985-990.
49. Dahiya R, Lee C, Zhu Z, Thompson HJ. Microsatellite instability in an animal model of mammary carcinogenesis. Int J Oncol 1998;13:23-28.
50. Walsh T, Chappell SA, Shaw JA, Walker RA. Microsatellite instability in ductal carcinoma in situ of the breast. J Pathol 1998;185:18-24.
51. Gollahon LS, Chen A, Aldaz CM. Loss of heterozygosity at chromosome 1q loci in rat mammary tumors. Mol Carcinog 1995;12:7-13.
52. Haag JD, Hsu L-C, Newton MA, Gould MN. Allelic imbalance in mammary carcinomas induced by either 7,12-dimethylbenz[a]anthracene or ionizing radiation in rats carrying genes conferring differential susceptibilities to mammary carcinogenesis. Mol Carcinog 1996;17: 134-143.
53. Haag JD, Brasic GM, Shepel LA, et al. A comparative analysis of allelic imbalance events in chemically induced rat mammary, colon, and bladder tumors. Mol Carcinog 1999;24:47-56.