Mutations in the p53 tumor suppressor gene in rat esophageal papillomas induced by N-nitrosomethylbenzylamine

Carcinogenesis

Volumn 17, Issue 4, 1996, Pages 625-630

  Wang, Dian ^a   Weghorst, Christopher M ^a   Calvert, Richard J ^b   Stoner, Gary D ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O METHYLGUANINE; N BENZYL N METHYLNITROSAMINE; PROTEIN P53; CARCINOGEN; DIMETHYLNITROSAMINE; DRUG DERIVATIVE; PRIMER DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CODON; CONTROLLED STUDY; DNA ADDUCT; DNA SEQUENCE; ESOPHAGUS TUMOR; EXON; FRAMESHIFT MUTATION; GENE MUTATION; INTRON; MALE; NONHUMAN; PAPILLOMA; POINT MUTATION; PRIORITY JOURNAL; RAT; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE; ANIMAL; CHEMICALLY INDUCED DISORDER; FISCHER 344 RAT; GENETICS; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE;

ANIMALS; BASE SEQUENCE; CARCINOGENS; DIMETHYLNITROSAMINE; DNA PRIMERS; ESOPHAGEAL NEOPLASMS; EXONS; GENES, P53; INTRONS; MALE; MOLECULAR SEQUENCE DATA; MUTATION; PAPILLOMA; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; RATS; RATS, INBRED F344;

EID: 0029665106     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.4.625     Document Type: Article

References (58)

1. Hollstein,M., Sidransky,D., Vogelstein,B. and Harris,C.C. (1991) p53 Mutations in human cancers. Science, 253, 49-53.
2. Levine,A.J , Momand,J. and Finlay,C.A. (1991) The p53 tumour suppressor gene. Nature, 351, 453-456.
3. Soussi,T., Caron de Fromentel,C., Mechali,M., May,P. and Kress,M. (1987) Cloning and characterization of a cDNA from Xenopus laevis coding for a protein homologous to human and murine p53. Oncogene, 1, 71-78.
4. Nigro,J.M., Baker,S.J., Preisinger,A.C. et al. (1989) Mutations in the p53 gene occur in diverse human tumor types. Nature, 342, 705-708.
5. Harris,C.C. (1993) p53: At the crossroads of molecular carcinogenesis and risk assessment (review). Science, 262, 1980-1981.
6. Vogelstein,B. and Kinzler,K.W. (1994) Carcinogens leave fingerprints. Nature, 355, 209-210.
7. Makino,H., Ushtjima,T., Kakiuchi,H., Onda,M., Ito,N., Sugimura,T. and Nagao,M. (1994) Absence of p53 mutations in rat colon tumors induced by 2-amino-6-methyldipyrido[1,2-α:3′,2′-d]imidazole, 2-amino-3-methyl-imidazo[4,5-b]pyridine. Jpn J. Cancer Res., 85, 510-514.
8. Tokusashi,Y., Fukuda,I. and Ogawa,K. (1994) Absence of p53 mutations and various frequencies of Ki-ras exon 1 mutations in rat hepatic tumors induced by different carcinogens Mol. Carcinogenesis, 10, 45-51.
9. Ushijima,T., Kakiuchi,H., Makino,H et al (1994) Infrequent mutation of Ha-ras and p53 in rat mammary carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4.5-b]pyridine. Mol. Carcinogenesis. 10, 38-44.
10. Asamoto,M., Mann,A.M., Macatee,T.L. and Cohen,S.M. (1994) Mutations and expression of the p53 gene in rat bladder carcinomas and cell lines. Mol. Carcinogenesis, 9, 236-244.
11. Asamoto,M., Mann,A.M. and Cohen,S.M (1994) p53 Mutation is infrequent and might not give a growth advantage in rat bladder carcinogenesis in vivo. Carcinogenesis, 15, 455-458.
12. Nickell-Brady,C., Hahn,F.R., Finch,G.L. and Belinsky,S.A. (1994) Analysis of K-ras. p53. c-raf-1 mutations in beryllium-induced rat lung tumors. Carcinogenesis. 15, 257-262
13. Weghorst,C.M., Dragnev,K.H., Buzard,G.S., Thorne,K.L., Vandeborne,G.F., Vincent,K A. and Rice,J.M. (1994) Low incidence of point mutations detected in the p53 tumor suppressor gene from chemically induced rat mesenchymal tumors. Cancer Res., 54, 215-219
14. Masui,T , Don,I., Takada,N., Ogawa,K., Shirai,T and Fukushima,S. (1994) p53 Mutations in early neoplastic lesions of the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine Carcinogenesis, 15, 2379-2381.
15. Swaim,W.D., Minoguchi,K., Oliver,C., Hamawy,M.M., Kihara,H., Stephan,V., Berenstein,E.H and Siraganian,R.P. (1994) The antiganglioside monoclonal antibody AA4 induces protein tyrosine phosphorylations, but not degranulation, in rat basophilic leukemia cells. J. Biol. Chem., 269, 19466-19473.
16. Makino,H., Ishizaka,Y., Tsujimoto,A., Nakamura,T., Onda,M., Sugimura,T. and Nagao,M. (1992) Rat p53 gene mutations in primary Zymbal gland tumors induced by 2-amino-3-methylimidazol[4.5-f]quinoline, a food mutagen. Proc. Natl Acad. Sci. USA, 89, 4850-4854.
17. Recioi,L., Sisk,S., Pluta,L., Bermudez,E., Gross,E., Chen,Z., Morgan,K. and Walker,C. (1992) p53 Mutations in formaldehyde-induced nasal squamous cell carcinomas in rats. Cancer Res., 52, 6113-6116.
18. Ohgaki,H., Hard,G.C., Hirota,N., Maekawa,A., Takahashi,M. and Kleihues,P. (1992) Selective mutation of codon 204 and 213 of the p53 gene in rat tumors induced by alkylating N-nitroso compounds. Cancer Res., 52, 2995-2998.
19. Lozano,J.C., Nakazawa,H., Cros,M.P., Cabral,R. and Yamasaki,H. (1994) G→A Mutations in p53 and Ha-ras genes in esophageal papillomas induced by N-nitrosomethylbenzylamine in two strains of rats. Mol. Carcinogenesis, 9, 33-39.
20. Hulla,J.E. (1992) The rat genome contains a p53 pseudogene: detection of processed pseudogene using PCR. PCR Methods Appl., 1, 251-254.
21. Weghorst,C.M., Calvert,R.J., Buzard,G.S., Hulla,J.E. and Rice,J.M. (1993) Multiple p53 pseudogenes in the rat genome: potential sources of false 'point mutation' in PCR fragments. Proc. Am. Assoc. Cancer Res., 34, 105.
22. Lin, Y. and Chan,S.H. (1995) Cloning and characterization of two processed p53 pseudogenes from the rat genome. Gene, 156, 83-189.
23. Weghorst,C.M., Buzard,G.S., Calvert,R.J., Hulla,J.E. and Rice,J M. (1995) Cloning and sequence of a processed p53 pseudogene from rat, a potential source of false 'mutations' in PCR fragments of tumor DNA. Gene, in press.
24. Yang,C.S. (1980) Research on esophageal cancer in China: a review. Cancer Res., 40, 2633-2644.
25. National Academy of Sciences. (1981) The health effects of nitrate, nitrite and N-nitroso compounds. National Academy Press, Washington, DC.
26. Van Rensberg,S J. (1981) Epidemiological and dietary evidence for a specific nutritional predisposition to esophageal cancer. J. Natl Cancer Inst., 67, 243-251.
27. Lin,H.J., Chan,W.C, Fong,L.Y.Y. and Newberne,P.M. (1977) Zinc levels in serum, hair, and tumors from patients with esophageal carcinoma. Nutr. Rep. Int., 15, 635-643.
28. 6-Methyldeoxyguanine in oesophageal DNA and among individuals at high risk of oesophageal cancer. Int. J. Cancer, 36, 661-665.
29. Hodgson,R.M., Wiessler,M. and Kleihues,P. (1980) Preferential methylation of target organ DNA by the oesophageal carcinogen N-nitrosomethylbenzylamine. Carcinogenesis, 1, 861-866.
30. Siglin,J.C., Barch,D.H. and Stoner,G.D. (1995) Effects of dietary phenethyl isothiocyanate, ellagic acid, sulindac and calcium on the induction and progression of N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in rats. Carcinogenesis, 16, 1101-1106.
31. Fong,L.Y.Y., Sivak,A. and Newberne,P.M. (1978) Zinc deficiency and methylbenzylnitrosamine-induced esophageal cancer in rats J. Natl Cancer Inst., 61, 145-150.
32. Fong,L.Y., Lin,H.J. and Lee,C.L. (1979) Methylation of DNA in target and non-target organs of the rat with methylbenzylnitrosamine and dimethylnitrosamine. Int. J. Cancer, 23, 679-682.
33. Wang,D., You,L., Sneddon,J., Cheng,S.J., Jamasbi,R. and Stoner,G.D. (1995) Frameshift mutation in codon 176 of the p53 gene in rat esophageal epithelial cells transformed by benzo[a]pyrene-dihydrodiol. Mol. Carcinogenesis, 14, 84-93.
34. Soussi,T., Caron de Fromentel,C, Breugnot,C. and May,E. (1988) Nucleotide sequencing of cDNA encoding the rat p53 nuclear oncoprotein. Nucleic Acids Res., 16, 11384.
35. Hulla,J.E. and Schneider,R.P. (1993) Structure of the rat p53 tumor suppressor gene Nucleic Acids Res., 21, 713-717.
36. Orita,M., Suzuki,Y. Sekiya,T. and Hayashi,K (1989) Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics, 5, 874-879.
37. Hongyo,T., Buzard,G.S., Calvert,R.J and Weghorst,C.M. (1993) 'Cold' SSCP: a simple, rapid and non-radioactive method for optimized single strand conformation polymorphism analyses. Nucleic Acids Res., 16, 3637-3642
38. 6-alkylation of deoxyguanosine to the mutagenicity and carcinogenicity of nitrosamines and nitrosamides. Nature, 223, 206-207.
39. 6-methyldeoxyguanosine at specific sites in a synthetic oligonucleotide designed to resemble a known mutagenic hotspot. J. Biol. Chem., 264, 838-841.
40. Burns,P.A., Gordon,A.J.E. and Glickman,B.W. (1988) Mutational specificity of N-methyl-N-nitrosourea in the lacI gene of Escherichia coli. Carcinogenesis, 9, 1607-1610.
41. Hollstein,M . Metcalf,R.A., Welsh,J., Montesano,R. and Harris,C.C. (1990) Frequent mutation of the p53 gene in human esophageal cancer. Proc. Natl Acad. Sci. USA, 87, 9958-9961.
42. Hollstein,M.C., Peri,L., Mandard,A.M., Welsh,J.A., Montesano,R., Metcalf,R.A., Bak,M. and Harris,C.C. (1991) Genetic analysis of human esophageal tumors from two high incidence geographic areas: frequent p53 base substitution and absence of ras mutations. Cancer Res., 51, 4102-4106.
43. Bennett, W.P., Hollstein, M.C., Metcalf, R.A. et al. (1992) p53 mutation and protein accumulation during multistage human esophageal carcinogenesis. Cancer Res., 52, 6092-6097.
44. Meltzer,S.J., Yin,J., Huang,Y., McDaniel,T.K., Newkirk,C., Iseri,O., Vogelstein,B. and Resau,J.H. (1991) Reduction to homozygosity involving p53 in esophageal cancers demonstrated by the polymerase chain reaction. Proc Natl Acad. Sci. USA. 88, 4976-4980.
45. Greenwald,B.D., Huang,Y., Baum,R. and Meltzer,S.J. (1992) Barrett's carcinoma in a 25-year-old man with point mutation of the p53 tumor suppressor gene. Int. J. Oncol., 1, 271-275.
46. Huang,Y., Mellzer,S.J., Yin,J., Tong,Y., Chang,E.H., Srivastava,S., McDaniel,T., Boynton,R.F. and Zou,Z.-Q. (1993) Altered mRNA and unique mutational profiles of p53 and Rb in human esophageal carcinomas. Cancer Res., 53, 1889-1894
47. Huang,Y., Yin,J. and Meltzer,S.J. (1994) A unique p53 intragenic deletion flanked by short direct repeats results in loss of mRNA expression in human esophageal carcinoma. Carcinogenesis, 8, 1653-1655.
48. Greenblatt,M.S., Bennett,W.P., Hollstein,M. and Harris,C.C. (1994) Mutations in the p53 tumor suppressor gene, clues to cancer etiology and molecular pathogenesis. Cancer Res, 54, 4855-4878.
49. Sagar,P.M. (1989) Aetiology of cancer of the oesophagus: geographical studies in the footsteps of Marco Polo and beyond. Gut. 30, 561-564.
50. Tuyns,A.J., Riboli,E., Doornbos,G. and Pequignot,G. (1987) Diet and esophageal cancer in Calvados. Nutr. Cancer, 9, 81-92.
51. Munoz,N., Victoria,C.G., Crespi,M., Saul,C., Braga,N.M. and Correa,P. (1987) Hot mate drinking and precancerous lesions of the oesophagus: an endoscopic survey in Southern Brazil. Int. J. Cancer, 39, 708-709.
52. Zakut-Houri,R., Ore,M., Bienz,B., Lavie,V., Hazum,S. and Givol,D. (1983) A single gene and a pseudogene for the cellular tumor antigen p53 Nature, 306, 594-597.
53. Takahashi,T., DÀmico,D., Chiba,I., Buchhagen,D.L. and Minna,J.D. (1990) Identification of intronic point mutations as an alternative mechanism for p53 inactivation in lung cancer. J. Clin. Invest., 86, 363-369.
54. Albor,A., Flessate,D.M., Soussi,J. and Notario,V. (1994) 3-Methyl-cholanthrene inactivates the p53 gene in Syrian hamster embryo fibroblasts by inducing a specific intronic point mutation. Cancer Res., 54, 4502-4507
55. Schottenfeld,D. (1984) Epidemiology of cancer of the esophagus. Semin. Oncol., 11, 92-100.
56. Tollefson,L. (1985) The use of epidemiology, scientific data, and regulatory authority to determine risk factors in cancer of some organs of the digestive system. Esophageal cancer. Regul. Toxicol. Pharmacol., 5, 255-275.
57. Hebert,J.R. and Kabat,G.C. (1989) Menthol cigarette smoking and esophageal cancer: results of a case-control study. Int J. Epidemiol., 18, 37-44.
58. Blum,A. (1993) Curtailing the tobacco pandemic. In DeVita,V.T., Hellman,S. and Rosenberg,S.A. (eds), Cancer: Principle and Practice of Oncology. Philadelphia: J.B.Lippincott, Philadelphia, pp. 480-491.