Alterations in the Ha-ras-1 and the p53 pathway genes in the progression of N-methyl-N-nitrosourea-induced rat mammary tumors

Molecular Carcinogenesis

Volumn 20, Issue 2, 1997, Pages 194-203

  McKenzie, Katherine E ^a   Armstrong, Barbara A ^a   Chen, Ying ^a,c   Nagarajan, Mahalakshmi ^a,d   Aldaz, C Marcelo ^b   Sukumar, Saraswati ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d Wilberforce University   (United States)

Author keywords

Ha ras 1; mdm2; N methyl N nitrosourea; p53; Rat mammary carcinoma

Indexed keywords

METHYLNITROSOUREA; PROTEIN P53;

ALLELE; ANIMAL CELL; ARTICLE; BREAST TUMOR; CANCER INVASION; CELL DIFFERENTIATION; GENE AMPLIFICATION; GENE MUTATION; GROWTH REGULATION; HORMONAL REGULATION; METHYLATION; NONHUMAN; ONCOGENE H RAS; PHENOTYPE; PRIORITY JOURNAL; RAT; TUMOR GROWTH;

ANIMALS; CARCINOGENS; DISEASE PROGRESSION; FEMALE; GENE AMPLIFICATION; GENES, P53; GENES, RAS; MAMMARY NEOPLASMS, EXPERIMENTAL; METHYLNITROSOUREA; MUTATION; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASMS, HORMONE-DEPENDENT; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RATS; RATS, INBRED WF; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0030715568     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199710)20:2<194::AID-MC6>3.0.CO;2-N     Document Type: Article

References (56)

1. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 61:759-767, 1990.
2. Vogelstein B, Fearon ER, Kern SE, et al. Allelotype of colorectal carcinomas. Science 244:207-211, 1989.
3. Ahuja H, Bar-Eli M, Advani SH, Benchimol S, Cline MJ. Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia. Proc Natl Acad Sci USA 86:6783-6787, 1989.
4. Stretch JR, Gatter KC, Ralfkiaer E, Lane DP, Harris AL. Expression of mutant p53 in melanoma. Cancer Res 51:5976-5979, 1991.
5. Fujii H, Marsh C, Cairns P, Sidransky D, Gabrielson E. Genetic divergence in the clonal evolution of breast cancer. Cancer Res 56:1493-1497, 1996.
6. Devilee P, Schuuring E, van de Vijver MJ, Cornelisse CJ. Recent developments in the molecular genetic understanding of breast cancer. Crit Rev Oncog 5:247-270, 1995.
7. Sukumar S, Notario V, Martin-Zanca D, Barbacid M. Induction of mammary carcinomas in rats by nitroso-methyl urea involves malignant activation of Ha-ras-1 locus by single point mutations. Nature 306:658-661, 1983.
8. McKenzie K, Sukumar S. Molecular mechanisms of chemical carcinogenesis in rodent models. Cancer Treat Res 71:313-329, 1994.
9. Sukumar S, Carney WP, Barbacid M. Independent molecular pathways in initiation and loss of hormone responsiveness of breast carcinomas. Science 240:524-526, 1988.
10. Dulbecco R, Armstrong BA. Stochastic development of invasive potential in rat mammary tumors induced by N-methyl-N-nitrosourea. Proc Natl Acad Sci USA 85:8659-8663, 1988.
11. Aldaz CM, Gollahon LS, Chen A. Chromosome alterations in rat mammary tumor progression. Prog Clin Biol Res 376:137-153, 1992.
12. Sukumar S, Pulciani S, Doniger J, et al. A transforming ras gene in tumorigenic guinea pig cell lines initiated by diverse chemical carcinogens. Science 223:1197-1199, 1984.
13. Sukumar S. ras oncogenes in chemical carcinogenesis. Curr Top Microbiol lmmunol 148:93-114, 1989.
14. Cha RS, Thilly WG, Zarbl H. N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with pre-existing oncogenic Hras1 gene mutations. Proc Natl Acad Sci USA 91:3749-3753, 1994.
15. Jin Z, Houle B, Mikheev AM, Cha RS, Zarbl H. Alterations in Hras1 promoter conformation during N-nitroso-N-methylurea-induced mammary carcinogenesis and pregnancy. Cancer Res 56:4927-4935, 1996.
16. Kumar R, Sukumar S, Barbacid M. Activation of ras oncogenes precedes the onset of neoplasia. Science 248:1101-1104, 1990.
17. Rovinski B, Benchimol S. Immortalization of rat embryo fibroblasts by the cellular p53 oncogene. Oncogene 2:445-452, 1988.
18. Taylor WR, Egan SE, Mowat M, Greenbeg AH, Wright JA. Evidence for synergistic interactions between ras, myc and a mutant form of p53 in cellular transformation and tumor dissemination. Oncogene 7:1383-1390, 1992.
19. Puisieux A, Lim S, Groopman J, Ozturk M. Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens. Cancer Res 51:6185-6189, 1991.
20. Ogawa K, Tokusashi Y, Fukuda I. Absence of p53 mutations in methylnitrosourea-induced mammary tumors in rats. Cancer Detect Prev 20:214-217, 1996.
21. Kito K, Kihana T, Sugita A, et al. Incidence of p53 and Ha-ras gene mutations in chemically induced rat mammary carcinomas. Mol Carcinog 17:78-83, 1996.
22. Barak Y, Oren M. Enhanced binding of a 95 kDa protein to p53 in cells undergoing p53-mediated growth arrest. EMBO J 11:2115-2121, 1992.
23. Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69:1237-1245, 1992.
24. Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 358:80-82, 1992.
25. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual, 2nd Ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989.
26. Ellis RW, DeFeo D, Maryak JM, et al. Dual evolutionary origin for the rat genetic sequences of Harvey murine sarcoma virus. J Virol 36:408-420, 1980.
27. Soussi T. Structural aspects of p53 protein in relation to gene evolution. Oncogene 5:945-952, 1990.
28. Leach FS, Tokino T, Meltzer P, et al. p53 mutation and MDM2 amplification in human soft tissue sarcomas. Cancer Res 53:2231-2234, 1993.
29. Reifenberger G, Liu L, Inchimura K, Schmidt EE, Collins VP. Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res 53:2736-2739, 1993.
30. Smith HS, Chen LC, Ngo JL, Ljung BM. Molecular and cellular lesions associated with breast cancer progression. Breast Cancer Res Treat 18:(1):551-554, 1991.
31. Aldaz CM, Chen T, Sahin A, Cunningham J, Bondy M. Comparative allelotype of in situ and invasive human breast cancer: High frequency of microsatellite instability in lobular breast carcinomas. Cancer Res 55:3976-3981, 1995.
32. Radford DM, Phillips NJ, Fair KL, et al. Allelic loss and the progression of breast cancer. Cancer Res 55:5180-5183, 1995.
33. Hwang SI, Guzman RC, Swanson SM, Nandi S. Hormone dependent and independent mammary tumor development from N-methyl-N-nitrosourea-treated rat mammary epithelial cell xenografts in the nude mouse - multiple pathways and H-ras activation. Cancer Lett 101:123-134, 1996.
34. Schlatter B, Waghorne CG. Persistence of Ha-ras-induced metastatic potential of SP1 mouse mammary tumors despite loss of the Ha-ras shuttle vector. Proc Natl Acad Sci USA 89:9986-9990, 1992.
35. Balmain A, Pragnell IB. Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene. Nature 303:72-74, 1983.
36. Balmain A, Ramsden M, Bowden GT, Smith J. Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas. Nature 307:658-660, 1984.
37. Quintanilla M, Brown K, Ramsden M, Balmain A. Carcinogen specific amplification of H-ras during mouse skin carcinogenesis. Nature 322:778-780, 1986.
38. Bianchi AB, Aldaz CM, Conti CJ. Nonrandom duplication of the chromosome bearing a mutated Ha-ras-1 allele in mouse skin tumors. Proc Natl Acad Sci USA 87:6902-6906, 1990.
39. Aldaz CM, Gollahon LS, Chen A. Systematic HRAS amplification in ovary-independent mammary tumors: Correlation with progressively anaplastic phenotypes. Cancer Res 53:5339-5344, 1993.
40. Gollahon LS, Chen AC, Aldaz CM. Loss of heterozygosity at chromosome 1q loci in rat mammary tumors. Mol Carcinog 12:7-13, 1995.
41. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW. Participation of p53 protein in the cellular response to DNA damage. Cancer Res 23:6304-6311, 1991.
42. Ushijima T, Kakiuchi H, Makino H, et al. Infrequent mutation of Ha-ras and p53 in rat mammary carcinomas induced by 2-amino-1-methyl-6-phenylimidazol[4,5-b]pyridine. Mol Carcinog 10:38-44, 1994.
43. Sukumar S, Armstrong B, Bruyntjes JP, Leav I, Bosland MC. Frequent activation of the Ki-ras oncogene at codon 12 in N-methyl-N-nitrosourea-induced rat prostate adenocarcinomas and neurogenic sarcomas. Mol Carcinog 4:362-368, 1991.
44. Weghorst CM, Dragnev KH, Buzard GS, et al. Low incidence of point mutations detected in the p53 tumor suppressor gene from chemically induced rat renal mesenchymal tumors. Cancer Res 54:215-219, 1994.
45. Shivapurkar N, Belinsky SA, Wolf DC, Tang Z, Alabaster O. Absence of p53 gene mutations in rat colon carcinomas induced by azoxymethane. Cancer Lett 96:63-70, 1995.
46. Nickell-Brady C, Hahn FF, Finch GL, Belinsky SA. Analysis of K-ras, p53 and c-raf-1 mutations in beryllium-induced rat lung tumors. Carcinogenesis 15:257-262, 1994.
47. Makino H, Ushijima T, Kakiuchi H, et al. Absence of p53 mutations in rat colon tumors induced by 2-amino-6-methyldipyrido[1,2-a:3′,2′-d]imidazole, 2-amino-3-methylimidazo[4,5-f]quinoline, or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Jpn J Cancer Res 85:510-514, 1994.
48. Swafford DS, Nikula KJ, Mitchell CE, Belinsky SA. Low frequency of alterations in p53, K-ras, and mdm2 in rat lung neoplasms induced by diesel exhaust or carbon black. Carcinogenesis 16:1215-1221, 1995.
49. Asamoto M, Mann AM, Cohen SM. p53 mutation is infrequent and might not give a growth advantage in rat bladder carcinogenesis in vivo. Carcinogenesis 15:455-458, 1994.
50. Horesovsky G, Recio L, Everitt J, et al. p53 status in spontaneous and dimethylnitrosamine-induced renal cell tumors from rats. Mol Carcinog 12:235-240, 1995.
51. Jin Y, Burns FJ, Garte SJ, Hosselet S. Infrequent alterations of the p53 gene in rat skin cancer induced by ionizing radiation. Carcinogenesis 17:873-876, 1996.
52. Tokusashi Y, Fukuda I, Ogawa K. Absence of p53 mutations and various frequencies of Ki-ras exon1 mutations in rat hepatic tumors induced by different carcinogens. Mol Carcinog 10:45-51, 1994.
53. Ho YS, Cheng HT, Wang YJ, Lin JK. p53 gene mutational spectra in hepatocellular carcinomas induced by 2-acetylaminofluorene and N-nitroso-2-acetylaminofluorene in rats. Mol Carcinog 13:182-190, 1995.
54. Vancutsem PM, Lazarus P, Williams GM. Frequent and specific mutations of the rat p53 gene in hepatocarcinomas induced by tamoxifen. Cancer Res 54:3864-3867, 1994.
55. Jones RF, Matuszyk J, Debiec-Rychter M, Wang CY. Mutation and altered expression of p53 genes in experimental rat bladder tumor cells. Mol Carcinog 9:95-104, 1994.
56. Wang D, Weghorst CM, Calvert RJ, Stoner GD. Mutations in the p53 tumor suppressor gene in rat esophageal papillomas induced by N-nitrosomethylbenzylamine. Carcinogenesis 17:625-630, 1996.