In vivo efficacy and toxicity of 5-fluorocytosine/cytosine deaminase gene therapy for malignant gliomas mediated by adenovirus

Cancer Gene Therapy

Volumn 7, Issue 1, 2000, Pages 74-82

  Ichikawa, Tomotsugu ^a   Tamiya, Takashi ^a   Adachi, Yoshiaki ^a   Ono, Yasuhiro ^a   Matsumoto, Kengo ^a   Furuta, Tomohisa ^a   Yoshida, Yoko ^b   Hamada, Hirofumi ^b   Ohmoto, Takashi ^a  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b CANCER CHEMOTHERAPY CENTER   (Japan)

Author keywords

Adenovirus vector; Malignant glioma; Neurotoxicity; Suicide gene therapy

Indexed keywords

FLUCYTOSINE; GADOLINIUM;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SENSITIZATION; GENE THERAPY; GLIOBLASTOMA; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RADIODIAGNOSIS; RAT; SAFETY; TREATMENT OUTCOME;

ADENOVIRIDAE; ANIMALIA;

EID: 0033961839     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700086     Document Type: Article

References (41)

1. Burger PC, Green SB. Patient age, histologic features, and length of survival in patients with glioblastoma multiforme. Cancer. 1987;59:1617-1625.
2. Ram Z, Walbridge S, Shawker T, et al. The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats. J Neurosurg. 1994;81:256-260.
3. Martuza RL, Malick A, Markert JM, et al. Experimental therapy of human glioma by means of a genetically engineered virus mutant. Science. 1991;252:854-856.
4. Moolten FL. Drug sensitivity ("suicide") genes for selective cancer chemotherapy. Cancer Gene Ther. 1994;1:279-287.
5. Boviatsis EJ, Chase M, Wei MX, et al. Gene transfer into experimental brain tumors mediated by adenovirus, herpes simplex virus, and retrovirus vectors. Hum Gene Ther. 1994;5:183-191.
6. Wei MX, Tamiya T, Chase M, et al. Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 gene. Hum Gene Ther. 1994;5:969-978.
7. Wei MX, Tamiya T, Rhee RJ, et al. Diffusible cytotoxic metabolites contribute to the in vitro bystander effect associated with the cyclophosphamide/cytochrome P450 2B1 cancer gene therapy. Clin Cancer Res. 1995;1:1171-1177.
8. Tamiya T, Ono Y, Wei MX, et al. Escherichia coli gpt gene sensitizes rat glioma cells to killing by 6-thioxanthine or 6-thioguanine. Cancer Gene Ther. 1996;3:155-162.
9. Ono Y, Ikeda K, Wei MX, et al. Regression of experimental brain tumors with 6-thioxanthine and Escherichia coli gpt gene therapy. Hum Gene Ther. 1997;8:2043-2055.
10. Mullen CA. Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system. Proc Natl Acad Sci USA. 1992;89:33-37.
11. Scholer HJ. Fluorocytosine. In: Spellar DCE, ed. Antifungal Chemotherapy. Chichester, United Kingdom: John Wiley; 1980:36-106.
12. Hirschowitz EA, Ohwada A, Pascal WR, et al. In vivo adenovirus-mediated gene transfer of the Escherichia coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-fluorocytosine. Hum Gene Ther. 1995;6:1055-1063.
13. Ohwada A, Hirschowitz EA, Crystal RG. Regional delivery of an adenovirus vector containing the Escherichia coli cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to liver. Hum Gene Ther. 1996;7:1567-1576.
14. Lan K-H, Kanai F, Shiratori Y, et al. In vivo selective gene expression and therapy mediated by adenoviral vectors for human carcinoembryonic antigen-producing gastric carcinoma. Cancer Res. 1997;57:4279-4284.
15. Kanai F, Lan K-H, Shiratori Y, et al. In vivo gene therapy for a-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene. Cancer Res. 1997;57:461-465.
16. Nanni P, De Giovanni C, Nicoletti G, et al. The immune response elicited by mammary adenocarcinoma cells transduced with interferon-γ and cytosine deaminase genes cures lung metastases by parental cells. Hum Gene Ther. 1998;9:217-224.
17. Dong Y, Wen P, Manome Y, et al. In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizes glioma cells to 5-fluorocytosine. Hum Gene Ther. 1996;7:713-720.
18. Huber BE, Austin EA, Richards CA, et al. Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. Proc Natl Acad Sci USA. 1994;91:8302-8306.
19. Trinh QT, Austin EA, Murray DM, et al. Enzyme/prodrug gene therapy: comparison of cytosine deaminase/5-fluorocytosine versus thymidine kinase/ganciclovir enzyme/prodrug systems in a human colorectal carcinoma cell line. Cancer Res. 1995;55:4808-4812.
20. Hanna NN, Mauceri HJ, Wayne JD, et al. Virally directed cytosine deaminase/5-fluorocytosine gene therapy enhances radiation response in human cancer xenografts. Cancer Res. 1997;57:4205-4209.
21. Pederson LC, Buchsbaum DJ, Vickers SM, et al. Molecular chemotherapy combined with radiation therapy enhances killing of cholangiocarcinoma cells in vitro and in vivo. Cancer Res. 1997:4325-4332.
22. Kanai F, Shiratori Y, Yoshida Y, et al. Gene therapy for a-fetoprotein-producing hepatoma cells by adenovirus-mediated transfer of herpes simplex virus thymidine kinase gene. Hepatology. 1996;23:1359-1368.
23. Kanegae Y, Lee G, Sato Y, et al. Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase. Nucleic Acids Res. 1995;23:3816-3821.
24. Masuike T, Watanabe I, Takemoto Y. Quantitative method of 5-fluorouracil and its metabolites in biological samples using high performance liquid chromatography. Yakugaku Zasshi. 1985;105:1058-1064.
25. Tamiya T, Wei MX, Chase M, et al. Transgene inheritance and retroviral infection contribute to the efficacy of gene expression in solid tumors inoculated with retroviral vector producer cells. Gene Ther. 1995;2:531-538.
26. Ono Y, Tamiya T, Ichikawa T, et al. Malignant astrocytomas with homozygous CDKN2/p16 gene deletions have higher Ki-67 proliferation indices. J Neuropathol Exp Neurol. 1996;55:1026-1031.
27. Viola JJ, Ram Z, Walbridge S, et al. Adenovirally mediated gene transfer into experimental solid brain tumors and leptomeningeal cancer cells. J Neurosurg. 1995;82:70-76.
28. Maron A, Gustin T, Roux AL, et al. Gene therapy of rat C6 glioma using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene: long-term follow-up by magnetic resonance imaging. Gene Ther. 1996; 3:315-322.
29. Badie B, Hunt K, Economou JS, Black KL. Stereotactic delivery of a recombinant adenovirus into a C6 glioma cell line in a rat brain tumor model. Neurosurgery. 1994;35: 910-916.
30. Kajiwara K, Byrnes AP, Charlton HM, et al. Immune response to adenoviral vectors during gene transfer in the brain. Hum Gene Ther. 1997;8:253-265.
31. Byrnes AP. Adenovirus gene transfer causes inflammation in the brain. Neuroscience. 1995;66:1015-1024.
32. Byrnes AP, Wood MJA, Charlton HM. Role of T cells in inflammation caused by adenovirus vectors in the brain. Gene Ther. 1996;3:644-651.
33. Nishiyama T, Kawamura Y, Kawamot K, et al. Antineoplastic effects in rats of 5-fluorocytosine in combination with cytosine deaminase capsules. Cancer Res. 1985;45: 1753-1761.
34. Ge K, Xu L, Zheng Z, et al. Transduction of cytosine deaminase gene makes rat glioma cells highly sensitive to 5-fluorocytosine. Int J Cancer. 1997;71:675-679.
35. Mizushima Y, Miyamoto T. Today's Therapeutic Drugs. 19th ed. Tokyo, Japan: Nankoudou; 1997:95-96.
36. Grignet-Debrus C, Calberg-Bacq C-M. Potential of Varicella zoster virus thymidine kinase as a suicide gene in breast cancer cells. Gene Ther. 1997;4:560-569.
37. Namba H, Iwadate Y, Tagawa M, et al. Evaluation of bystander effect in experimental brain tumors bearing herpes simplex virus-thymidine kinase gene by serial magnetic resonance imaging. Hum Gene Ther. 1996;7:1847-1852.
38. Goodman JC, Trask TW, Chen S-H, et al. Adenoviral-mediated thymidine kinase gene transfer into the primate brain followed by systemic ganciclovir: pathologic, radiologic, and molecular studies. Hum Gene Ther. 1996;7:1241-1250.
39. Watkins SJ, Mesyanzhinov VV, Kurochkina LP, et al. The "adenobody" approach to viral targeting: specific and enhanced adenoviral gene delivery. Gene Ther. 1997;4: 1004-1012.
40. Parr MJ, Manome Y, Tanaka T, et al. Tumor-selective transgene expression in vivo mediated by an E2F-responsive adenoviral vector. Nat Med. 1997;3:1145-1151.
41. Smith JG, Raper SE, Wheeldon EB, et al. Intracranial administration of adenovirus-expressing HSV-TK in combination with ganciclovir produces a dose-dependent, self-limiting inflammatory response. Hum Gene Ther. 1997;8: 943-954.