In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizes glioma cells to 5-fluorocytosine

Human Gene Therapy

Volumn 7, Issue 6, 1996, Pages 713-720

  Dong, Yonghe ^a   Wen, Patrick ^b   Manome, Yoshinobu ^a   Parr, Michael ^a   Hirshowitz, Ari ^a   Chen, Ling ^a   Hirschowitz, Edward A ^c   Crystal, Ronald ^c   Weichselbaum, Ralph ^d   Kufe, Donald W ^a   Fine, Howard A ^a,e  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c WEILL CORNELL MEDICAL CENTER   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

^e DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE DEAMINASE; FLUCYTOSINE;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GENE; CELL INTERACTION; CHEMOSENSITIVITY; CONTROLLED STUDY; EXPRESSION VECTOR; GENE THERAPY; GENETIC TRANSFECTION; GLIOMA CELL; HUMAN; HUMAN CELL; MALE; NONHUMAN; RAT; VIRUS REPLICATION;

ADENOVIRUSES, HUMAN; ANIMALS; CELL DIVISION; CELL LINE, TRANSFORMED; CYTOSINE DEAMINASE; DEFECTIVE VIRUSES; FLUCYTOSINE; GENETIC VECTORS; GLIOSARCOMA; HUMANS; MALE; NUCLEOSIDE DEAMINASES; RATS; RATS, INBRED F344; TRANSDUCTION, GENETIC; VIRUS REPLICATION;

EID: 0029995247     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1996.7.6-713     Document Type: Article

References (23)

1. AUSTIN, E.A., and HUBER, B.E. (1993). A first step in development of gene therapy for colorectal carcinoma: Cloning, sequencing, and expression of Escherchia coli cytosine deaminase. Mol. Pharmacol. 43, 380-387.
2. BOURKE, R.S., WEST, C.R., CHHEDA, G., and TOWER, D.B. (1973). Kinetics of entry and distribution of 5-FU in cerebrospinal fluid and brain following intravenous injection in a primate. Cancer Res. 33, 1735-1746.
3. BURGER, P.C., and GREEN, S.B. (1987). Patient age, histologic features, and length of survival in patients with glioblastoma multiforme. Cancer. 59, 1617-1625.
4. CHEN, S.-H., SHINE, H.D., GOODMAN, J.C., GROSSMAN, R.G., and WOO, S.L.C. (1994). Gene therapy for brain tumor: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc. Natl. Acad. Sci. USA. 91, 3054-3057.
5. CULVER, K.W., RAM, Z., WALBRIDGE, S., ISHII, H., OLDFIELD, E.H., and BLAESE, R.M. (1992). In vivo gene transfer with retroviral-vector producer cells for treatment of experimental brain tumors. Science. 256, 1550-1552.
6. DANIELSEN, S., KILSTRUP, M., BARILLA, K., JOCHIMSEN, B., and NEUHARD, J. (1992). Characteristization of the Escherichia coli codBA operon encoding cytosine permease and cytosine deaminase. Mol. Microbiol. 6, 1335-1344.
7. DEMICCO, C. (1989). Immunology of central nervous system tumors. J. Neuroimmunol. 25, 93-108.
8. DONG, Y., PATRICK, W., HERSHOWITZ, A., CHEN, L., MANOME, Y., KUFE, D.W., and FINE, H.A. (1995). Characterization of in vitro and in vivo recombinant adenoviral vector-mediated gene transduction in experimental gliomas (Submitted).
9. FREEMAN, S.M., ABBOUD, C.N., WHARTENBY, K.A., PACKMAN, C.H., KOEPLIN, D.S., MOOLTEN, F.L., and ABRAHAM, G.N. (1993). The "bystander effect": Tumor regression with a fraction of the tumor mass is genetically modified. Cancer Res. 53, 5274-5283.
10. GRAHAM, F.L., and EB, A.J.V.D. (1973). A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology. 52, 456.
11. HIRSCHOWITZ, E., OHWADA, A., PASCAL, W., RUSSI, T., and CRYSTAL, R. (1995). In vivo adenovirus-mediated gene transfer of the E. coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-fluorocytosine. Hum. Gene Ther. 6, 1055-1063.
12. HUBER, B.E., AUSTIN, E.A., GOOD, S.S., KNICK, V.C., TIBBELS, S., and RICHARDS, C.A. (1993). In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase. Cancer Res. 53, 4619-4626.
13. HUBER, B.E., AUSTIN, E.A., RICHARDS, C.A., DAVIS, S.T., and GOOD, S.S. (1994). Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: Significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. Proc. Natl. Acad. Sci. USA. 91, 8302-8306.
14. KOBAYASHI, S., and HOSHINA, T. (1983). Combined cytotoxic effect of low-dose 5-FU and hydroxyurea and hydroxyurea on 9L cells in vitro. Cancer Res. 43, 5309-5313.
15. KORST, R., BEWIG, B., and CRYSTAL, R. (1995). In vivo and in vitro transfer and expression of human surfactant SP-A and SP-B associated protein cDNAs mediated by replication deficient, recombinant adenoviral vectors. Human Gene Ther. 6, 277-287.
16. KUFE, D.W., and MAJOR, P.P. (1981). 5-Fluorouracil incorporation into human breast carcinoma RNA correlates with cytotoxicity. J. Biol. Chem. 256, 9802-9805.
17. MANOME, Y., ABE, M., HAGEN, M.F., FINE, H.A., and KUFE, D.W. (1994). Enhancer sequences of the DF3 gene regulate expression of the herpes simplex virus thymidine kinase gene and confer sensitivity of human breast cancer cells to ganciclovir. Cancer Res. 54, 5408-5413.
18. MOOLTEN, F.L. (1986). Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: Paradigm' for a prospective cancer control strategy. Cancer Res. 46, 5276-5281.
19. MULLEN, C.A., KILSTRUP, M., and BLAESE, R.M. (1992). Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: A negative selection system. Proc. Natl. Acad. Sci. USA. 89, 33-37.
20. OLDFIELD, E.H., RAM, Z., CULVER, K.W., BLAESE, R.M., DEVROOM, H.L., and ANDERSON, W.F. (1993). Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. Hum. Gene Ther. 4, 36-69.
21. PEREZ-CRUET, M.J., TRASK, T.W., CHEN, S.-H., GOODMAN, J.C., WOO, S.L., GROSSMAN, R.G., and SHINE, H.D. (1994). Adenovirus-mediated gene therapy of experimental gliomas. J. Neurosci. Res. 39, 506-511.
22. RAM, Z., CULVER, K.W., WALBRIDGE, S., BLAESE, R.M., and OLDFIELD, E.H. (1993). In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats. Cancer Res. 53, 3475-3485.
23. TAPSCOTT, S.J., MILLER, A.D., OLSON, J.M., BERGER, M.S., GROUDINE, M., and SPENCE, A.M. (1994). Gene therapy of rat 9L gliosarcoma tumors by transduction with selectable genes does not require drug selection. Proc. Natl. Acad. Sci. USA 91, 8185-8189.