In vivo selective gene expression and therapy mediated by adenoviral vectors for human carcinoembryonic antigen-producing gastric carcinoma

Cancer Research

Volumn 57, Issue 19, 1997, Pages 4279-4284

  Lan, Keng Hsin ^a   Kanai, Fumihiko ^a,b   Shiratori, Yasushi ^a   Ohashi, Makoto ^a   Tanaka, Torao ^a   Okudaira, Takehito ^a   Yoshida, Yoko ^b   Hamada, Hirofumi ^b   Omata, Masao ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b CANCER INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CARCINOEMBRYONIC ANTIGEN; CYTOSINE DEAMINASE; FLUCYTOSINE; MESSENGER RNA; VIRUS VECTOR;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GRAFT; CANCER INHIBITION; CANCER SURVIVAL; CONTROLLED STUDY; GENE EXPRESSION; GENE THERAPY; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STOMACH CARCINOMA; TRANSGENE;

ANIMALS; ANTIGENS, NEOPLASM; ANTIMETABOLITES, ANTINEOPLASTIC; BETA-GALACTOSIDASE; CARCINOEMBRYONIC ANTIGEN; CYTOSINE DEAMINASE; ESCHERICHIA COLI; FLUOROURACIL; GENE EXPRESSION REGULATION, VIRAL; HUMANS; MICE; MICE, NUDE; NUCLEOSIDE DEAMINASES; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; STOMACH NEOPLASMS; TRANSPLANTATION, HETEROLOGOUS;

EID: 0030767678     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Ikeda, Y., Mori, M., Adachi, Y., Matsushima, T., Sugimachi, K., and Saku, M. Carcinoembryonic antigen (CEA) in stage IV gastric cancer as a risk factor for liver metastasis: a univariate and multivariate analysis. J. Surg. Oncol., 53: 235-238, 1993.
2. Asao, T., Fukuda, T., Yazawa, S., and Nagamachi, Y. Carcinoembryonic antigen levels in peritoneal washing can predict peritoneal recurrence after curative resection of gastric cancer. Cancer (Phila.), 68: 44-47, 1991.
3. Dorudi, S., Northover, J. M. A., and Vile, R. G. Gene transfer therapy in cancer. Br. J. Surg., 80: 566-572, 1993.
4. Nishiyama, T., Kawamura, Y., Kawamoto, K., Matsumura, H., Yamamoto, N., Ito, T., Ohyama, A., Katsuragi, T., and Sakai, T. Antineoplastic effects in rats of 5-fluorocytosine in combination with cytosine deaminase capsules. Cancer Res., 45: 1753-1761, 1985.
5. Shively, J. E., and Beatty, J. D. CEA-related antigens: molecular biology and clinical significance. CRC Crit. Rev. Oncol. Hematol., 2: 355-399, 1985.
6. Austin, E. A., and Huber, B. E. A first step in the development of gene therapy for colorectal carcinoma: cloning, sequencing, and expression of Escherichia coli cytosine deaminase. Mol. Pharmacol., 43: 380-387, 1993.
7. Wilson, J. M. Adenoviruses as gene-delivery vehicles. N. Engl. J. Med., 334: 1185-1187, 1996.
8. Miller, N., and Vile, R. Target vectors for gene therapy. FASEB J., 9: 190-199, 1995.
9. Lan, K-H., Kanai, F., Shiratori, Y., Okabe, S., Yoshida, Y., Wakimoto, H., Hamada, H., Tanaka, T., Ohashi, M., and Omata, M. Tumor-specific gene expression in carcinoembryonic antigen-producing gastric cancer cells using adenovirus vectors. Gastroenterology, 111: 1241-1251, 1996.
10. Miyake, S., Makimura, M., Kanegae, Y., Harada, S., Sato, Y., Takamori, K., Tokuda, C., and Saito, I. Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing full-length virus genome. Proc. Natl. Acad. Sci. USA, 93: 1320-1324, 1996.
11. Kanegae, Y., Lee, G., Sato, Y., Tanaka, M., Nakai, M., Sakaki, T., Sugano, S., and Saito, I. Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase. Nucleic Acids Res., 23: 3816-3821, 1995.
12. Niwa, H., Yamamura, K-I., and Miyazaki, J-I. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene. 108: 193-200, 1991.
13. Zhang, W-W., Koch, P. E., and Roth, J. A. Detection of wild-type contamination in a recombinant adenoviral preparation by PCR. BioTechniques, 18: 444-447, 1995.
14. Smythe, W. R., Kaiser, L. R., Hwang, H. C., Amin, K. M., Pilewski, J. M., Eck, S. J., Wilson, J. M., and Albelda, S. M. Successful adenovirus-mediated gene transfer in an in vivo model of human malignant mesothelioma. Ann. Thorac. Surg., 57: 1395-1401, 1994.
15. Elshami, A. A., Kucharczuk, J. C., Zhang, H. B., Smythe, W. R., Hwang, H. C., Litzky, L. A., Kaiser, L. R., and Albelda, S. M. Treatment of pleural mesothelioma in an immunocompetent rat model utilizing adenoviral transfer of the herpes simplex virus thymidine kinase gene. Hum. Gene Ther., 7: 141-148, 1996.
16. Chen, L., Chen, D., Manome, Y., Dong, Y., Fine, H. A. and Kufe, D. W. Breast cancer selective gene expression and therapy mediated by recombinant adenoviruses containing the DF3/MUC1 promoter. J. Clin. Invest., 96: 2775-2782, 1995.
17. Qian, C., Bilbao, R., Bruna, O., and Prieto, J. Induction of sensitivity to ganciclovir in human hepatocellular carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase. Hepatology, 22: 118-123, 1995.
18. Kanai, F., Lan, K-H., Shiratori, Y., Tanaka, T., Ohashi, M., Okudaira, T., Yoshida, Y., Wakimoto, H., Hamada, H., Nakabayashi, H., Tamaoki, T., and Omata, M. In vivo gene therapy for α-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene. Cancer Res., 57: 461-465, 1997.
19. Tanaka, T., Kanai, F., Okabe, S., Yoshida, Y., Wakimoto, H., Hamada, H., Shiratori, Y., Lan, K-H., Ishitobi, M., and Omata, M. Adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing human gastric cells in vitro. Cancer Res., 56: 1341-1345, 1996.
20. Kanai, F., Shiratori, Y., Yoshida, Y., Wakimoto, H., Hamada, H., Kanegae, Y., Saito, I., Nakabayashi, H., Tamaoki, T., Tanaka, T., Lan, K-H., Kato, N., Shiina, S., and Omata, M. Gene therapy for α-fetoprotein producing human hepatoma cells by adenovirus-mediated transfer of herpes simplex virus thymidine kinase gene. Hepatology, 23: 1359-1368, 1996.
21. Trinh, Q. T., Austin, E. A., Murray, D. M., Knick, V. C., and Huber, B. E. Enzyme/prodrug gene therapy: comparison of cytosine deaminase/5-fluorocytosine versus thymidine kinase/ganciclovir enzyme/prodrug systems in a human colorectal carcinoma cell line. Cancer Res., 55: 4808-4812, 1995.
22. Hoganson, D. K., Batra, R. K., Olsen, J. C., and Boucher, R. C. Comparison of the effects of three different toxin genes and their levels of expression on cell growth and bystander effect in lung adenocarcinoma. Cancer Res., 56: 1315-1323, 1996.
23. Rogers, R. P., Ge, J-Q., Holley-Guthrie, E., Hoganson, D. K., Comstock, K. E., Olsen, J. C., and Kenney, S. Killing Epstein-Barr virus-positive B lymphocytes by gene therapy comparing the efficacy of cytosine deaminase and herpes simplex virus thymidine kinase. Hum. Gene Ther., 7: 2235-2245, 1996.
24. Domin, B. A., Mahony, W. B., and Zimmerman, T. P. Transport of 5-fluorouracil and uracil into human erythrocytes. Biochem. Pharmacol., 46: 503-510, 1993.