The immune response elicited by mammary adenocarcinoma cells transduced with interferon-γ and cytosine deaminase genes cures lung metastases by parental cells

Human Gene Therapy

Volumn 9, Issue 2, 1998, Pages 217-224

  Nanni, P ^a,d   De Giovanni, C ^a   Nicoletti, G ^a   Landuzzi, L ^a   Rossi, I ^a   Frabetti, F ^a   Giovarelli, M ^b   Forni, G ^b   Cavallo, F ^b   Di Carlo, E ^c   Musiani, P ^c   Lollini, P L ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF CHIETI   (Italy)

^d Cancer Research Center   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER VACCINE; CYTOSINE DEAMINASE; GAMMA INTERFERON;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOMA CELL; FEMALE; GENETIC TRANSDUCTION; GRANULOCYTE; LUNG METASTASIS; LUNG NODULE; MACROPHAGE; MOUSE; NONHUMAN; SUICIDE GENE; T LYMPHOCYTE; TUMOR IMMUNITY; VACCINATION;

ANIMALIA; MURINAE; MUS MUSCULUS;

EID: 17344368405     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.2-217     Document Type: Article

References (7)

1. ALLIONE, A., CONSALVO, M., NANNI, P., LOLLINI, P.-L., CAVALLO, F., GIOVARELLI, M., FORM, M., GULINO, A., COLOMBO, M.P., DELLABONA, P., HOCK, H., BLANKENSTEIN, T., ROSENTHAL, P.M., GANSBACHER, B., BOSCO, M.C., MUSSO, T., GUSELLA, L., and FORMT, G. (1994). Immunizing and curative potential on replicating and nonreplicating murine mammary adenocarcinoma cells engineered with IL-2, IL-4, IL-6, IL-7, IL-10, TNF-alpha, GM-CSF and IFN-gamma gene or admixed with conventional adjuvants. Cancer Res. 54, 6022-6026.
2. BARBA, D., HARDIN, J., SADELAIN, M., and GAGE, F.H. (1994). Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors. Proc. Natl. Acad. Sci. USA 91, 4348-4352.
3. BECK, C., CAYEUX, S., LUPTON, S.D., DORKEN, B., and BLANKENSTEIN, T. (1995). The thymidine kinase/ganciclovir-mediated "suicide" effect is variable in different tumor cells. Hum. Gene Ther. 6, 1525-1530.
4. BERNARD, H.-V., KRAEMER, G., and ROEWENKAMP, W.G. (1985). Construction of a fusion gene that confers resistance against hygromycin B to mammalian cells in culture. Exp. Cell Res. 158, 237-243.
5. CAYEUX, S., BECK, .C., AICHER, A., DORKEN, B., and BLANKENSTEIN, T. (1995). Tumor cells cotransfected with interleukin-7 and B7.1 genes induce CD25 and CD28 on tumor-infiltrating T lymphocytes and are strong vaccines. Eur. J. Immunol. 25, 2325-2331.
6. VILE, R.G., NELSON, J.A., CASTLEDEN, S., CHONG, H., and HART, I.R. (1994). Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component. Cancer Res. 54, 6228-6234.
7. VITADELLO, M., SCHIAFFINO, M.V., PICARD, A., SCARPA, M., and SCHIAFFINO, S. (1994). Gene transfer in regenerating muscle. Hum. Gene Ther. 5, 11-18.