Evaluation of the bystander effect in experimental brain tumors bearing herpes simplex virus-thymidine kinase gene by serial magnetic resonance imaging

Human Gene Therapy

Volumn 7, Issue 15, 1996, Pages 1847-1852

  Namba, Hiroki ^a   Iwadate, Yasuo ^a   Tagawa, Masatoshi ^b   Kimura, Masaki ^a,b   Shimizu, Hideki ^a   Sato, Yasuo ^a   Sueyoshi, Kanji ^a   Sakiyama, Shigeru ^a  

^a CHIBA CANCER CENTER   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN TUMOR; CANCER SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; GENE THERAPY; GENE TRANSFER; GENETIC TRANSDUCTION; GLIOSARCOMA; HERPES SIMPLEX VIRUS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; RAT; SURVIVAL TIME; TUMOR GROWTH; TUMOR REGRESSION; TUMOR VOLUME;

ANIMALIA; HERPES; MARTES PENNANTI; SIMPLEXVIRUS;

EID: 0029952922     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1996.7.15-1847     Document Type: Article

References (20)

1. ARIENTI, F., SULÉ-SUSO, J., MELANI, C., MACCALLI, C., BELLI, F., ILLENI, M.T., ANICHINI, A., CASCINELLI, N., COLOMBO, M.P., and PARMIANI, G. (1994). Interleukin-2 gene-transduced human melanoma cells efficiently stimulate MHC-unrestricted and MHC-restricted autologous lymphocytes. Hum. Gene Ther. 5, 1139-1150.
2. BARBA, D., HARDIN, J., RAY, J., and GAGE, F.H. (1993). Thymidine kinase-mediated killing of rat brain tumors. J. Neurosurg. 79, 729-735.
3. BI, W.L., PARYSEK, L.M., WARNICK, R., and STAMBROOK, P.J. (1993). In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSVtk retroviral gene therapy. Hum. Gene Ther. 4, 725-731.
4. CULVER, K.W., RAM, Z., WALLBRIDGE, S., ISHII, H., OLDFIELD, E.H., and BLAESE, R.M. (1992). In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumor. Science 256, 1550-1552.
5. DAUMAS-DUPORT, C., SCHEITHAUSER, B., O'FALLON, J., and KELLY, P. (1988). Grading of astrocytomas: A simple and reproducible method. Cancer 62, 2152-2165.
6. FIELD, A.K., DAVIES, M.E., DEWITT, C., PERRY, H.C., LIOU, R., GERMERSHAUSEN, J., KARKAS, J.D., ASHTON, W.T., JOHNSTON, D.B.R., and TOLMAN, R.L. (1983). 9-{[2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl} guanine: a selective inhibitor of herpes group virus replication. Proc. Natl. Acad. Sci. USA 80, 4139-4143.
7. FREEMAN, S.M., ABBOUD, C.N., WARTENBY, K.A., PACKMAN, C.H., KOEPLIN, D.S., MOOLTEN, F.L., and ABRAHAM, G.N. (1993). The "bystander effect": Tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res. 53, 5274-5283.
8. IZQUIERDO, M., CORTÉS, M., DE FELIPE, P., MARTÍN, V., DÍEZ-GUERRA, J., TALAVERA, A., and PEREZ-HIGUERAS, A. (1995). Long-term rat survival after malignant brain tumor regression by retroviral gene therapy. Gene Ther. 2, 66-69.
9. KIM, T.S., HALLIDAY, A.L., HEDLEY-WHYTE, E.T., and CONVERY, K. (1991). Correlates of survival and the Daumas-Duport grading system for astrocytomas. J Neurosurg. 74, 27-37.
10. MAHALEY, M.S., JR., METTLIN, C., NATARAJAN, N., LAWS, E.R., JR., and PEACE, B.B. (1989). National survey of patterns of care for brain-tumor patients. J. Neurosurg. 71, 826-836.
11. MARON, A., GUSTIN, T., MOTTET, I., DEMEURE, R., and OCTAVE, J.N. (1995). Ganciclovir mediated regression of rat brain tumors expressing the herpes simplex virus thymidine kinase imaged by magnetic resonance. J. Neuro-Oncol. 24, 259-265.
12. McKNIGHT, S.L. (1980). The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene. Nucleic Acids Res. 8, 5949-5964.
13. MOOTEN, F.L. (1986). Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res. 46, 5276-5281.
14. MOOLTEN, F.L., and WELLS, J.M. (1990). Curability of tumors bearing heipes thymidine kinase gene transfected by retroviral vectors. J. Natl. Cancer Inst. 82, 297-300.
15. OLDFIELD, E.H. (1993). Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. Hum. Gene Ther. 4, 39-69.
16. RAM, Z., CULVER, K.W., WALLBRIDGE, S., BLAESE, R.M., and OLDFIELD, E.H. (1993). In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats. Cancer Res. 53, 83-88.
17. SAIKI, R.K., SCHARF, S., FALOONA, F., MULLIS, K.B., HORN, G.T., ERLICH, H.A., and ARNHEIM, N. (1985). Enzymatic amplification of β-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230, 1350-1354.
18. SAMEJIMA, Y., and MERUELO, D. (1995). Bystander killing induces apoptosis and is inhibited by forskolin. Gene Ther. 2, 50-58.
19. WALKER, M.D., GREEN, S.B., BYAR, S.P., ALEXANDER, E. JR., BATZDORF, U., BRROKS, W.H., HUNT, W.E., MACCARTY, C.S., MAHALEY, M.S. JR., MEALEY, J., JR. OWENS, G., RANSOHOFF, J. II, ROBERTSON, J.T., SHAPIRO, W.R., SMITH, K.R., JR., WILSON, C.B., and STRIKE, T.A. (1980). Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. N. Engl. J. Med. 303, 1323-1329.
20. WU, J.K., CANO, W.G., MEYLAERTS, S.A.G., QI, P., VRIONIS, F., and CHERINGTON, V. (1994). Bystander tumoricidal effect in the treatment of experimental brain tumors. Neurosurgery 35, 1094-1103.