Regulatory cancer risk assessment based on a quick estimate of a benchmark dose derived from the maximum tolerated dose

Regulatory Toxicology and Pharmacology

Volumn 28, Issue 3, 1998, Pages 222-225

  Gaylor, David W ^a   Swirsky Gold, Lois ^b  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN;

ARTICLE; BIOASSAY; CANCER RISK; CHEMICAL CARCINOGENESIS; DOSE RESPONSE; ENVIRONMENTAL PROTECTION; HUMAN; MAXIMUM ALLOWABLE CONCENTRATION; NONHUMAN; PRACTICE GUIDELINE; PRIORITY JOURNAL; RISK ASSESSMENT;

ANIMALIA; RODENTIA;

EID: 0344527998     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1006/rtph.1998.1258     Document Type: Article

References (16)

1. Barnes D. G., Dourson M. Reference dose (RfD): Description and use in health risk assessments. Regul. Toxicol. Pharmacol. 8:1988;471-486.
2. Bernstein L., Gold L. S., Ames B. N., Pike M. C., Hoel D. G. Some autologous aspects of the comparison of carcinogenic potency in rats and mice. Fundam. Appl. Toxicol. 5:1985;79-87.
3. Food Quality Protection Act, 1996, Washington, D. C.
4. Freedman D. A., Gold L. S., Slone T. H. How tautological are inter-species correlations of carcinogenic potency. Risk Anal. 13:1993;265-272.
5. Gaylor D. W. Preliminary estimate of the virtually safe dose for tumors obtained from the maximum tolerated dose. Regul. Toxicol. Pharmacol. 9:1989;101-108.
6. Gaylor D. W. The use of safety factors for controlling risk. J. Toxicol. Environ. Health. 11:1983;329-336.
7. Gaylor D. W., Chen J. J., Sheehan D. M. Uncertainty in cancer risk estimates. Risk Anal. 13:1993;149-154.
8. Gaylor D. W., Gold L. S. Quick estimate of the regulatory virtually safe dose based on the maximum tolerated dose for rodent bioassays. Regul. Toxicol. Pharmacol. 22:1995;57-63.
9. Gold L. S., Wright C., Bernstein L., deVeciana M. Reproducibility of results in "near-replicate" carcinogenesis bioassays. J. Natl. Cancer Inst. 78:1987;1149-1158.
10. Krewski D., Gaylor D. W., Soms A. P., Szyszkowicz M. Risk Anal. 13:1993;383-398.
11. Metzer B., Crouch E., Wilson R. On the relationship between carcinogenicity and acute toxicity. Risk Anal. 9:1989;169-177.
12. Renwick A. G. The use of an additional safety or uncertainty factor for nature of toxicity in the estimation of acceptable daily intake and tolerable daily intake values. Regul. Toxicol. Pharmacol. 22:1995;250-261.
13. Schwartz C. S. A semiquantitative method for selection of safety factors in establishing OELs for pharmaceutical compounds. Hum. Ecol. Risk Assess. 1:1995;527-543.
14. Travis C. C., Richter Pack S. A., Saulsbury A. W., Yambert M. W. Prediction of carcinogenic potency from toxicological data. Mutat. Res. 241:1990;21-36.
15. Fed. Reg. 61:1996;17995-18011.
16. Zeise L., Wilson R., Crouch E. Use of acute toxicity to estimate carcinogenic risk. Risk Anal. 4:1984;187-199.