Antigen capture, processing, and presentation by dendritic cells: Recent cell biological studies

Human Immunology

Volumn 60, Issue 7, 1999, Pages 562-567

  Steinman, Ralph M ^a   Inaba, Kayo ^a   Turley, Shannon ^b   Pierre, Philippe ^b   Mellman, Ira ^b  

^a ROCKEFELLER UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antigen presentation; Apoptosis; Dendritic cells; Endocytosis; MHC II compartments; MHC peptide

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN;

ANTIGEN DETECTION; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; CELL DEATH; CELL MATURATION; DENDRITIC CELL; ENDOCYTOSIS; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; REVIEW;

EID: 0032776457     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0198-8859(99)00030-0     Document Type: Article

References (48)

1. Inaba K., Steinman R.M., Van Voorhis W.C., Muramatsu S. Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and man. Proc Natl Acad Sci USA. 80:1983;6041-6045.
2. Inaba K., Steinman R.M. Protein-specific helper T lymphocyte formation initiated by dendritic cells. Science. 229:1985;475-479.
3. Steinman R.M., Witmer M.D. Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice. Proc Natl Acad Sci USA. 75:1978;5132-5136.
4. Steinman R.M., Gutchinov B., Witmer M.D., Nussenzweig M.C. Dendritic cells are the principal stimulators of the primary mixed leukocyte reaction in mice. J Exp Med. 157:1983;613-627.
5. Klinkert W.E.F., Labadie J.H., O'Brien J.P., Beyer C.F., Bowers W.E. Rat dendritic cells function as accessory cells and control the production of a soluble factor required for mitogen responses of T lymphocytes. Proc Natl Acad Sci USA. 77:1978;5414-5418.
6. Knight S.C., Balfour B.M., O'Brien J., Buttifant L., Sumerska T., Clark J. Role of veiled cells in lymphocyte activation. Eur J Immunol. 12:1982;1057-1060.
7. Inaba K., Steinman R.M. Resting and sensitized T lymphocytes exhibit distinct stimulatory [antigen-presenting cell] requirements for growth and lymphokine release. J Exp Med. 160:1984;1717-1735.
8. Inaba K., Metlay J.P., Crowley M.T., Steinman R.M. Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ. J Exp Med. 172:1990;631-640.
9. Steinman R.M., Adams J.C., Cohn Z.A. Identification of a novel cell type in peripheral lymphoid organs of mice. IV. Identification and distribution in mouse spleen. J Exp Med. 141:1975;804-820.
10. Witmer-Pack M.D., Crowley M.T., Inaba K., Steinman R.M. Macrophages, but not dendritic cells, accumulate colloidal carbon following administration in situ. J.Cell Sci. 105:1993;965-973.
11. Steinman R.M., Cohn Z.A. Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional properties in vitro. J Exp Med. 139:1974;380-397.
12. Pierre P., Turley S.J., Gatti E., Hull M., Meltzer J., Mirza A., Inaba K., Steinman R.M., Mellman I. Developmental regulation of MHC class II transport in mouse dendritic cells. Nature. 388:1997;787-792.
13. Zhou L.-J., Tedder T.F. Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. J Immunol. 154:1995;3821-3835.
14. Mosialos G., Birkenbach M., Ayehunie S., Matsumura F., Pinkus G.S., Kieff E., Langhoff E. Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein. Am J Pathol. 148:1996;593-600.
15. de Saint-Vis B., Vincent J., Vandenabeele S., Vanbervliet B., Pin J.-J., Ait-Yahia S., Patel S., Mattei M.-G., Banchereau J., Zurawski S. A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment. Immunology. 9:1998;325-336.
16. Fugier-Vivier I., de Bouteiller O., Guret C., Fossiez F., Banchereau J., Mattei M.-G., Ait-Yahia S., Garcia E., Lebecque S., Liu Y.-J. Molecular cloning of human RP105. Eur J Immunol. 27:1997;1824-1827.
17. Schuler G., Steinman R.M. Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J Exp Med. 161:1985;526-546.
18. Romani N., Koide S., Crowley M., Witmer-Pack M., Livingstone A.M., Fathman C.G., Inaba K., Steinman R.M. Presentation of exogenous protein antigens by dendritic cells to T cell clones intact protein is presented best by immature, epidermal Langerhans cells . J Exp Med. 169:1989;1169-1178.
19. Pure E., Inaba K., Crowley M.T., Tardelli L., Witmer-Pack M.D., Ruberti G., Fathman G., Steinman R.M. Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chain. J Exp Med. 172:1990;1459-1469.
20. Bilyk N., Holt P.G. Inhibition of the immunosuppressive activity of resident pulmonary alveolar macrophages by granulocyte/macrophage colony-stimulating factor. J Exp Med. 177:1993;1773-1777.
21. Stumbles P.A., Thomas J.A., Pimm C.L., Lee P.T., Venaille T.J., Proksch S., Holt P.G. Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity. J Exp Med. 188:1998;2019-2031.
22. Crowley M.T., Inaba K., Witmer-Pack M.D., Gezelter S., Steinman R.M. Use of the fluorescence activated cell sorter to enrich dendritic cells from mouse spleen. J Immunol Meth. 133:1990;55-66.
23. O'Doherty U., Steinman R.M., Peng M., Cameron P.U., Gezelter S., Kopeloff I., Swiggard W.J., Pope M., Bhardwaj N. Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium. J Exp Med. 178:1993;1067-1078.
24. Nijman H.W., Kleijmeer M.J., Ossevoort M.A., Oorschot V.M.J., Vierboom M.P.M., van de Keur M., Kenemans P., Kast W.M., Geuze H.J., Melief C.J.M. Antigen capture and MHC class II compartments of freshly isolated and cultured human blood dendritic cells. J Exp Med. 182:1995;163-174.
25. Inaba K., Inaba M., Naito M., Steinman R.M. Dendritic cell progenitors phagocytose particulates, including Bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo. J Exp Med. 178:1993;479-488.
26. Sallusto F., Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α J Exp Med. 179:1994;1109-1118.
27. Sallusto F., Cella M., Danieli C., Lanzavecchia A. Dendritic cells use macropinocytosis and the mannose receptor to concentrate antigen in the major histocompatibility class II compartment. Downregulation by cytokines and bacterial products. J Exp Med. 182:1995;389-400.
28. Cella M., Sallusto F., Lanzavecchia A. Origin, maturation and antigen presenting function of dendritic cells. Curr Opin Immunol. 9:1997;10-16.
29. Banchereau J., Steinman R.M. Dendritic cells and the control of immunity. Nature. 392:1998;245-252.
30. Reis e Sousa C., Stahl P.D., Austyn J.M. Phagocytosis of antigens by Langerhans cells in vitro. J Exp Med. 178:1993;509-519.
31. Winzler C., Rovere P., Rescigno M., Granucci F., Penna G., Adorini L., Zimmermann V.S., Davoust J., Ricciardi-Castagnoli P. Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures. J Exp Med. 185:1997;317-328.
32. Jiang W., Swiggard W.J., Heufler C., Peng M., Mirza A., Steinman R.M., Nussenzweig M.C. The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature. 375:1995;151-155.
33. Cella M., Engering A., Pinet V., Pieters J., Lanzavecchia A. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature. 388:1997;782-787.
34. Watts C. Inside the gearbox of the dendritic cell. Nature. 388:1997;724-725.
35. Rudensky A.Y., Rath S., Preston-Hurlburt P., Murphy D.B., Janeway C.A. Jr. On the complexity of self. Nature. 353:1991;660-662.
36. Zhong G., Reis e Sousa C., Germain R.N. Antigen-unspecific B cells and lymphoid dendritic cells both show extensive surface expression of processed antigen-major histocompatibility comples class II complexes after soluble protein exposure in vivo or in vitro. J Exp Med. 186:1997;673-682.
37. Lechler R.I., Batchelor J.R. Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells. J Exp Med. 155:1982;31-41.
38. Albert M.L., Sauter B., Bhardwaj N. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature. 392:1998;86-89.
39. Bhardwaj N., Bender A., Gonzalez N., Bui L.K., Garrett M.C., Steinman R.M. Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic responses from human CD8+ T cells. J Clin Invest. 94:1994;797-807.
40. 5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J Exp Med. 188:1998;1359-1368.
41. Inaba K., Turley S., Yamaide F., Iyoda T., Mahnke K., Inaba M., Pack M., Subklewe M., Sauter B., Sheff D. Efficient presentation of phagocytosed cellular fragments on the MHC class II products of dendritic cells. J Exp Med. 188:1998;2163-2173.
42. Inaba K., Pack M., Inaba M., Sakuta H., Isdell F., Steinman R.M. High levels of a major histocompatibility complex II - self peptide complex on dendritic cells from lymph node. J Exp Med. 186:1997;665-672.
43. Fossum S., Rolstad B. The roles of interdigitating cells and natural killer cells in the rapid rejection of allogeneic lymphocytes. Eur J Immunol. 16:1986;440-450.
44. Caux C., Massacrier C., Vanbervliet B., Dubois B., Van Kooten C., Durand I., Banchereau J. Activation of human dendritic cells through CD40 cross-linking. J Exp Med. 180:1994;1263-1272.
45. Wong B.R., Josien R., Lee S.Y., Sauter B., Li H., Steinman R.M., Choi Y. TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell specific survival factor. J Exp Med. 186:1997;2075-2080.
46. Suss G., Shortman K. A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand induced apoptosis. J Exp Med. 183:1996;1789-1796.
47. Kurts C., Kosaka H., Carbone F.R., Miller J.F.A.P., Heath W.R. Class I-restricted cross-presentation of exogenous self antigens leads to deletion of autoreactive CD8+ T cells. J Exp Med. 186:1997;239-245.
48. Forster I., Lieberam I. Peripheral tolerance of CD4 T cells following local activation in adolescent mice. Eur J Immunol. 26:1996;3194-3202.