-
1
-
-
0031921466
-
Mutant genes in familial Alzheimer's disease and transgenic models
-
1. Price, D. L., and Sisodia, S. S. (1998) Mutant genes in familial Alzheimer's disease and transgenic models. Annu. Rev. Neurosci. 21, 479-505.
-
(1998)
Annu. Rev. Neurosci.
, vol.21
, pp. 479-505
-
-
Price, D.L.1
Sisodia, S.S.2
-
2
-
-
0023105114
-
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
-
2. Kang, J., Lemaire, H-G., Unterbeck, A., Salbaum, M., Masters, C. L., Grzeschik, K. H., et al. (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 331, 733-736.
-
(1987)
Nature
, vol.331
, pp. 733-736
-
-
Kang, J.1
Lemaire, H.-G.2
Unterbeck, A.3
Salbaum, M.4
Masters, C.L.5
Grzeschik, K.H.6
-
3
-
-
0033595706
-
β-Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
3. Vassar, R., Bennet, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., et al. (1999) β-Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennet, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
-
4
-
-
0033382226
-
Identification of a novel aspartic protease (Asp 2) as β-secretase
-
4. Hussain, I., Powell, D., Howlett, D. R., Tew, D. G., Meek, T. D., Chapman, C., et al. (1999) Identification of a novel aspartic protease (Asp 2) as β-secretase. Mol. Cell. Neurosci. 14, 419-427.
-
(1999)
Mol. Cell. Neurosci.
, vol.14
, pp. 419-427
-
-
Hussain, I.1
Powell, D.2
Howlett, D.R.3
Tew, D.G.4
Meek, T.D.5
Chapman, C.6
-
5
-
-
0033518264
-
Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity
-
5. Yan, R., Bienkowski, M. J., Shuck, M. E., Miao, H., Tory, M. C., Pauley, A. M., et al. (1999) Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity. Nature 402, 533-537.
-
(1999)
Nature
, vol.402
, pp. 533-537
-
-
Yan, R.1
Bienkowski, M.J.2
Shuck, M.E.3
Miao, H.4
Tory, M.C.5
Pauley, A.M.6
-
6
-
-
0033518251
-
Purification and cloning of amyloid precursor protein β-secretase from human brain
-
6. Sinha, S., Anderson, J. P., Barbour, R., Basi, G. S., Caccavello, R., Davis, D., et al. (1999) Purification and cloning of amyloid precursor protein β-secretase from human brain. Nature 420, 537-540.
-
(1999)
Nature
, vol.420
, pp. 537-540
-
-
Sinha, S.1
Anderson, J.P.2
Barbour, R.3
Basi, G.S.4
Caccavello, R.5
Davis, D.6
-
7
-
-
0034652309
-
Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein
-
7. Lin, X., Koelsch, G., Wu, S., Downs, D., Dashti, A., and Tang, J. (2000) Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein. Proc. Natl. Acad. Sci. USA 97, 1456-1460.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 1456-1460
-
-
Lin, X.1
Koelsch, G.2
Wu, S.3
Downs, D.4
Dashti, A.5
Tang, J.6
-
8
-
-
0027333557
-
Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide
-
8. Haass, C., and Selkoe, D. J. (1993) Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide. Cell 75, 1039-1042.
-
(1993)
Cell
, vol.75
, pp. 1039-1042
-
-
Haass, C.1
Selkoe, D.J.2
-
9
-
-
0032146775
-
Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons
-
9. Barnes, N. Y., Li, L., Yoshikawa, K., Schwartz, L. M., Oppenheim, R. W., and Milligan, C. E. (1998) Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons. J. Neurosci. 18, 5869-5880.
-
(1998)
J. Neurosci.
, vol.18
, pp. 5869-5880
-
-
Barnes, N.Y.1
Li, L.2
Yoshikawa, K.3
Schwartz, L.M.4
Oppenheim, R.W.5
Milligan, C.E.6
-
10
-
-
0033617402
-
Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-β precursor protein and amyloidogenic aβ peptide formation
-
10. Gervais, F. G., Xu, D., Robertson, G. S., Vaillancourt, J. P., Zhu, Y., Huang, J., et al. (1999) Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-β precursor protein and amyloidogenic Aβ peptide formation. Cell 97, 395-406.
-
(1999)
Cell
, vol.97
, pp. 395-406
-
-
Gervais, F.G.1
Xu, D.2
Robertson, G.S.3
Vaillancourt, J.P.4
Zhu, Y.5
Huang, J.6
-
11
-
-
0033597884
-
Alternative, non-secretase processing of Alzheimer's β-amyloid precursor protein during apoptosis by caspase-6 and -8
-
11. Pellegrini, L., Passer, B. J., Tabaton, M., Ganjei, J. K., and D'Adamio, L. (1999) Alternative, non-secretase processing of Alzheimer's β-amyloid precursor protein during apoptosis by caspase-6 and -8. J. Biol. Chem. 274, 21011-21016.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 21011-21016
-
-
Pellegrini, L.1
Passer, B.J.2
Tabaton, M.3
Ganjei, J.K.4
D'Adamio, L.5
-
12
-
-
0033605252
-
Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases
-
12. Weidemann, A., Paliga, K., Dürrwang, U., Reinhard, F. B. M., Schukert, O., Evin, G., and Masters, C. L. (1999) Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases. J. Biol. Chem. 274, 5823-5829.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 5823-5829
-
-
Weidemann, A.1
Paliga, K.2
Dürrwang, U.3
Reinhard, F.B.M.4
Schukert, O.5
Evin, G.6
Masters, C.L.7
-
13
-
-
0030931876
-
Caspases: The executioners of apoptosis
-
13. Cohen, G. M. (1997) Caspases: the executioners of apoptosis. Biochem J. 326, 1-16.
-
(1997)
Biochem J.
, vol.326
, pp. 1-16
-
-
Cohen, G.M.1
-
14
-
-
0032575750
-
Caspases: Enemies within
-
14. Thornberry, N. A., and Lazebnik, Y. (1998) Caspases: enemies within. Science 281, 1312-1316.
-
(1998)
Science
, vol.281
, pp. 1312-1316
-
-
Thornberry, N.A.1
Lazebnik, Y.2
-
15
-
-
0030948457
-
Substrate specificities of caspase family proteases
-
15. Talanian, R. V., Quinlan, C., Trautz, S., Hackett, M. C., Mankovitch, J. A., Banach, D., et al. (1997) Substrate specificities of caspase family proteases. J. Biol. Chem. 272, 9677-9682.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 9677-9682
-
-
Talanian, R.V.1
Quinlan, C.2
Trautz, S.3
Hackett, M.C.4
Mankovitch, J.A.5
Banach, D.6
-
16
-
-
0030849093
-
A combinatorial approach defines specificities of members of the caspase family and granzyme B
-
D.M.
-
16. Thornberry, N. A., Rano, T. A., Peterson, E. P., D.M. Rasper, D. M., Timkey, T., Garcia-Calvo, M., et al. (1997) A combinatorial approach defines specificities of members of the caspase family and granzyme B. J. Biol. Chem. 272, 17907-17911.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 17907-17911
-
-
Thornberry, N.A.1
Rano, T.A.2
Peterson, E.P.3
Rasper, D.M.4
Timkey, T.5
Garcia-Calvo, M.6
-
17
-
-
0029068871
-
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
-
17. Nicholson, D. W., Ali, A., Thornberry, N. A., Vaillancourt, J. P., Ding, C. K., Gallant, et al. (1995) Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376, 37-43.
-
(1995)
Nature
, vol.376
, pp. 37-43
-
-
Nicholson, D.W.1
Ali, A.2
Thornberry, N.A.3
Vaillancourt, J.P.4
Ding, C.K.5
Gallant6
-
18
-
-
0033614030
-
Cascades of mammalian caspase activation in the yeast Saccharomyces cerevisiae
-
18. Kang, J. J., Schaber, M. D., Srinivasula, S. M., Alnemri, E. S., Litwack, G., Hall, D. J., and Bjornsti, M-A. (1999) Cascades of mammalian caspase activation in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 274, 3189-3198.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 3189-3198
-
-
Kang, J.J.1
Schaber, M.D.2
Srinivasula, S.M.3
Alnemri, E.S.4
Litwack, G.5
Hall, D.J.6
Bjornsti, M.-A.7
-
19
-
-
0344053451
-
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains
-
19. Fernandes-Alnemri, T., Armstrong, R. C., Krebs, J., Srinivasula, S. M., Wang, L., Bullrich, F., et al. (1996) In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc. Natl. Acad. Sci. USA 93, 7464-7469.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 7464-7469
-
-
Fernandes-Alnemri, T.1
Armstrong, R.C.2
Krebs, J.3
Srinivasula, S.M.4
Wang, L.5
Bullrich, F.6
-
20
-
-
0029905073
-
Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases
-
20. Srinivasula, S. M., Ahmad, M., Fernandes-Alnemri, T., Litwack, G., and Alnemri, E. S. (1996) Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc. Natl. Acad. Sci. USA 93, 14486-14491.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 14486-14491
-
-
Srinivasula, S.M.1
Ahmad, M.2
Fernandes-Alnemri, T.3
Litwack, G.4
Alnemri, E.S.5
-
21
-
-
0032416062
-
Death by a thousand cuts: An ever increasing list of caspase substrates
-
21. Stroh, C., and Schulze-Osthoff, K. (1998) Death by a thousand cuts: an ever increasing list of caspase substrates. Cell Death Differ. 5, 997-1000.
-
(1998)
Cell Death Differ.
, vol.5
, pp. 997-1000
-
-
Stroh, C.1
Schulze-Osthoff, K.2
-
22
-
-
2042528599
-
Isolation of the yeast regulatory gene GAL4 and analysis of its dosage effects on the galactose/melibiose regulon
-
22. Johnston, S. A., and Hopper, J. E. (1982) Isolation of the yeast regulatory gene GAL4 and analysis of its dosage effects on the galactose/melibiose regulon. Proc. Natl. Acad. Sci. USA 79, 6971-6975
-
(1982)
Proc. Natl. Acad. Sci. USA
, vol.79
, pp. 6971-6975
-
-
Johnston, S.A.1
Hopper, J.E.2
-
23
-
-
0026589836
-
Choroquine inhibits intracellular degradation but not secretion of Alzheimer β/A4 amyloid precursor protein
-
23. Caporaso, G. L., Gandy, S. E., Buxbaum, J. D., and Greengard, P. (1992) Choroquine inhibits intracellular degradation but not secretion of Alzheimer β/A4 amyloid precursor protein. Proc. Natl. Acad. Sci. USA 89, 2252-2256.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 2252-2256
-
-
Caporaso, G.L.1
Gandy, S.E.2
Buxbaum, J.D.3
Greengard, P.4
-
24
-
-
0026522375
-
Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid precursor protein
-
24. Estus, S., Golde, T., Kunishita, T., Blades, D., Lowery, D., Eisen, M., et al. (1992) Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid precursor protein. Science 255, 726-728
-
(1992)
Science
, vol.255
, pp. 726-728
-
-
Estus, S.1
Golde, T.2
Kunishita, T.3
Blades, D.4
Lowery, D.5
Eisen, M.6
-
25
-
-
0026539090
-
Processing of the amyloid precursor to potentially amyloidogenic derivatives
-
25. Golde, T. E., Estus, S., Younkin, L. H., Selkoe, D. J., and Younkin, S. G. (1992) Processing of the amyloid precursor to potentially amyloidogenic derivatives. Science 255, 728-730.
-
(1992)
Science
, vol.255
, pp. 728-730
-
-
Golde, T.E.1
Estus, S.2
Younkin, L.H.3
Selkoe, D.J.4
Younkin, S.G.5
-
26
-
-
0026735070
-
Targeting of cell-surface β-amyloid precursor to lysosomes: Alternative processing into amyloid-bearing fragments
-
26. Haass, C., Koo, E. H., Mellon, A., Hung, A. Y., and Selkoe, D. J. (1992) Targeting of cell-surface β-amyloid precursor to lysosomes: alternative processing into amyloid-bearing fragments. Nature 357, 500-503.
-
(1992)
Nature
, vol.357
, pp. 500-503
-
-
Haass, C.1
Koo, E.H.2
Mellon, A.3
Hung, A.Y.4
Selkoe, D.J.5
-
27
-
-
0033057366
-
A cloning method to identify caspases and their regulators in yeast: Identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1
-
27. Hawkins, C. J., Wang, S. L., and Hay, B. A. (1999) A cloning method to identify caspases and their regulators in yeast: Identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1. Proc. Natl. Acad. Sci. USA 96, 2885-2890.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 2885-2890
-
-
Hawkins, C.J.1
Wang, S.L.2
Hay, B.A.3
-
28
-
-
0033452916
-
An in vivo assay for the identification of target proteases which cleave membrane-associated substrates
-
28. Steiner, H., Pesold, B., and Haass, C. (1999) An in vivo assay for the identification of target proteases which cleave membrane-associated substrates. FEBS Let. 463, 245-249.
-
(1999)
FEBS Let.
, vol.463
, pp. 245-249
-
-
Steiner, H.1
Pesold, B.2
Haass, C.3
-
29
-
-
0028569788
-
The expression and processing of β-amyloid peptide precursors in Saccharomyces cerevisiae: Evidence for a novel endopeptidase in the yeast secretory system
-
29. Hines, V., Zhang, W., Ramakrishna, N., Styles, J., Mehta, P., Kim, K. S., et al. (1994) The expression and processing of β-amyloid peptide precursors in Saccharomyces cerevisiae: Evidence for a novel endopeptidase in the yeast secretory system. Cell. Mol. Biol. Res. 40, 273-284.
-
(1994)
Cell. Mol. Biol. Res.
, vol.40
, pp. 273-284
-
-
Hines, V.1
Zhang, W.2
Ramakrishna, N.3
Styles, J.4
Mehta, P.5
Kim, K.S.6
-
30
-
-
0028072316
-
Proteolytic processing and secretion of human β-amyloid precursor protein in yeast
-
30. Zhang, H., Komano, H., Fuller, R. S., Gandy, S. E., and Frail, D. E. (1994) Proteolytic processing and secretion of human β-amyloid precursor protein in yeast. J. Biol. Chem. 269, 27799-27802.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 27799-27802
-
-
Zhang, H.1
Komano, H.2
Fuller, R.S.3
Gandy, S.E.4
Frail, D.E.5
-
31
-
-
0030700930
-
Characterization of β-amyloid peptide precursor processing by the yeast Yap3 and Mkc7 proteases
-
31. Zhang, W., Espinoza, D., Hines, V., Innis, M., Mehta, P., and Miller, D. L. (1997) Characterization of β-amyloid peptide precursor processing by the yeast Yap3 and Mkc7 proteases. Biochim. Biophys. Acta. 1359, 110-122.
-
(1997)
Biochim. Biophys. Acta.
, vol.1359
, pp. 110-122
-
-
Zhang, W.1
Espinoza, D.2
Hines, V.3
Innis, M.4
Mehta, P.5
Miller, D.L.6
-
32
-
-
0032553018
-
Processing of the Alzheimer's disease amyloid precursor protein in Pichia pastoris: Immunodetection of α-, β-, and γ-secretase products
-
32. Le Brocque, D., Henry, A., Cappai, R., Li, Q-X., Tanner, J. E., Galatis, D., et al. (1998) Processing of the Alzheimer's disease amyloid precursor protein in Pichia pastoris: Immunodetection of α-, β-, and γ-secretase products. Biochemistry 37, 14958-14965.
-
(1998)
Biochemistry
, vol.37
, pp. 14958-14965
-
-
Le Brocque, D.1
Henry, A.2
Cappai, R.3
Li, Q.-X.4
Tanner, J.E.5
Galatis, D.6
-
33
-
-
0033607754
-
Generation of the amyloid-β peptide N terminus in Saccharomyces cerevisiae expressing human Alzheimer's amyloid-β precursor protein
-
33. Greenfield, J.P., Xu, H., Greengard, P., Gandy, S., and Seeger, M. (1999) Generation of the amyloid-β peptide N terminus in Saccharomyces cerevisiae expressing human Alzheimer's amyloid-β precursor protein. J. Biol. Chem. 274, 33843-33846.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 33843-33846
-
-
Greenfield, J.P.1
Xu, H.2
Greengard, P.3
Gandy, S.4
Seeger, M.5
-
34
-
-
0027496935
-
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
-
34. Harper, J. W., Adami, G. R., Wei, N., Kayomarsi, K., and Elledge, S. J. (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75, 805-816.
-
(1993)
Cell
, vol.75
, pp. 805-816
-
-
Harper, J.W.1
Adami, G.R.2
Wei, N.3
Kayomarsi, K.4
Elledge, S.J.5
-
35
-
-
0030455820
-
Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast
-
35. James, P., Halladay, J., and Craig, E. A. (1996) Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics 144, 1425-1436.
-
(1996)
Genetics
, vol.144
, pp. 1425-1436
-
-
James, P.1
Halladay, J.2
Craig, E.A.3
-
36
-
-
0025994140
-
Guide to yeast genetics and molecular biology
-
36. Guthrie, C., and Fink, G. R. (1991) Guide to yeast genetics and molecular biology. Methods in Enzymology 194.
-
(1991)
Methods in Enzymology
, vol.194
-
-
Guthrie, C.1
Fink, G.R.2
-
37
-
-
0024266139
-
New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenised yeast genes lacking six-base pair restriction sites
-
37. Gietz, R. D., and Sugino, A. (1988) New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenised yeast genes lacking six-base pair restriction sites. Gene 74, 527-534.
-
(1988)
Gene
, vol.74
, pp. 527-534
-
-
Gietz, R.D.1
Sugino, A.2
-
39
-
-
0021668558
-
A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoroorotic acid resistance
-
39. Boeke, J. D., LaCroute, F., and Fink, G. R. (1984) A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoroorotic acid resistance. Mol. Gen. Genet. 197, 345-346.
-
(1984)
Mol. Gen. Genet.
, vol.197
, pp. 345-346
-
-
Boeke, J.D.1
LaCroute, F.2
Fink, G.R.3
-
40
-
-
0024286214
-
Yeast KEX2 gene encodes an endopeptidase homologous to subtilisin-like serine proteases
-
40. Mizuno, K., Nakamura, T., Ohshima, T., Tanaka, S., and Matsuo, H. (1988) Yeast KEX2 gene encodes an endopeptidase homologous to subtilisin-like serine proteases. Biochem. Biophys. Res. Commun. 156, 246-54.
-
(1988)
Biochem. Biophys. Res. Commun.
, vol.156
, pp. 246-254
-
-
Mizuno, K.1
Nakamura, T.2
Ohshima, T.3
Tanaka, S.4
Matsuo, H.5
-
41
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
41. De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., et al. (1998) Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391, 387-390.
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
Vanderstichele, H.4
Guhde, G.5
Annaert, W.6
-
42
-
-
0033535553
-
Two membrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
-
42. Wolfe, M. S., Xia, W., Ostaszewski, B. L., Diehl, T. S., Kimberly, W. T., and Selkoe, D. J. (1999) Two membrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity. Nature 398, 513-517.
-
(1999)
Nature
, vol.398
, pp. 513-517
-
-
Wolfe, M.S.1
Xia, W.2
Ostaszewski, B.L.3
Diehl, T.S.4
Kimberly, W.T.5
Selkoe, D.J.6
|