Signal transduction in the protozoan host Hartmannella vermiformis upon attachment to Legionella pneumophila

Microbes and Infection

Volumn 2, Issue 8, 2000, Pages 867-875

  Venkataraman, Chandrasekar ^a   Kwaik, Yousef A ^a  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

Cytoskeleton; Intracellular; Invasion; Paxillin; Pili

Indexed keywords

CYTOCHALASIN D; CYTOSKELETON PROTEIN; INTEGRIN RECEPTOR; LECTIN RECEPTOR; N ACETYLGALACTOSAMINE; PAXILLIN; PROTEIN TYROSINE PHOSPHATASE;

ARTICLE; BACTERIAL GROWTH; BACTERIAL VIRULENCE; BACTERIUM ADHERENCE; BACTERIUM PILUS; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVITY; ENZYME INDUCTION; HARTMANNELLA VERMIFORMIS; HOST PARASITE INTERACTION; LEGIONELLA PNEUMOPHILA; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTOZOON; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); HARTMANNELLA VERMIFORMIS; LEGIONELLA PNEUMOPHILA; MAMMALIA; NEGIBACTERIA; PROTOZOA;

EID: 0033928768     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1286-4579(00)00387-7     Document Type: Article

References (67)

1. Finlay B.B., Cossart P. Exploitation of mammalian host cell functions by bacterial pathogens. Science. 276:1997;718-725.
2. Menard R., Dehio C., Sansonetti P.J. Bacterial entry into epithelial cells: the paradigm of Shigella. Trends Microbiol. 4:1996;220-226.
3. Watarai M., Funato S., Sasakawa C. Interaction of Ipa proteins of Shigella Flexneri with 51 integrin promotes entry of the bacteria into mammalian cells. J. Exp. M. 183:1996;991-999.
4. Ireton K., Payrastre B., Chap H., et al. A role for phosphoinositide 3-kinase in bacterial adhesion. Science. 274:1996;780-782.
5. Watarai M., Kamata Y., Kozaki S., Sasakawa C. rho, a small GTP-binding protein, is essential for Shigella invasion of epithelial cells. J. Exp. M. 185:1997;281-292.
6. Adam T., Arpin M., Prevost M.C., Gounon P., Sansonetti P.J. Cytoskeletal rearrangements and functional role of T-plastin during entry of Shigella flexneri into HeLa cells. J. Cell. Biol. 129:1995;367-381.
7. Horwitz M.A., Silverstein S.C. Interaction of the legionnaires′disease bacterium (Legionella pneumophila) with human phagocytes, II, Antibody promotes binding of L, pneumophila to monocytes but does not inhibit intracellular multiplication. J. Exp. M. 153:1981;398-406.
8. Armstrong J.A., Hart P.D. Phagosome-lysosome interactions in cultured macrophages infected with virulent tubercle bacilli. J. Exp. M. 142:1975;1-16.
9. Caron E., Hall A. Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases. Science. 282:1998;1717-1721.
10. Joiner K.A., Fuhrman S.A., Miettinen H.M., Kasper L.H., Mellman I. Toxoplasma gondii: Fusion competence of parasitophorous vacuoles in Fc receptor-transfected fibroblasts. Science. 249:1990;641-646.
11. Clark E.A., Brugge J.S. Integrins and signal transduction pathways: the road taken. Science. 268:1995;233-239.
12. Heldin C.H. Dimerization of cell surface receptors in signal transduction. Cell. 80:1995;213-223.
13. Miyamoto S., Teramoto H., Coso O.A, et al. Integrin function: Molecular hierarchies of cytoskeletal and signaling molecules. J. Cell. Biol. 131:1995;791-805.
14. Defilippi P., Retta S.F., Olivo C, et al. p125FAK tyrosine phosphorylation and focal adhesion assembly: studies with phosphotyrosine phosphatase inhibitors. Exp. Cell. Res. 221:1995;141-152.
15. Angers-Loustau A., Cote' J.F., Charest A., et al. Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts. J. Cell. Biol. 144:1999;1019-1031.
16. Duntlevy J.R., Couchman J.R. Controlled induction of focal adhesion disassembly and migration in primary fibroblasts. J. Cell. Sci. 105:1993;489-500.
17. Nakamura T.Y., Yamamoto I., Nishitani H, et al. Detachment of cultured cells from the substratum induced by the neutrophil-derived oxidant NH2Cl: Synergistic role of phosphotyrosine and intracellular Ca2+ concentration. J. Cell. Biol. 131:1995;509-524.
18. Retta S.F., Barry S.T., Critchley D.R., Defilippi P., Silengo L., Tarone G. Focal adhesion and stress fiber formation is regulated by tyrosine phosphatase activity. Exp. Cell. Res. 229:1996;307-317.
19. Serra-Pages C., Kedershal N.L., Fazikas L., Medley Q., Debant A., Streuli M. The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions. EMBO J. 14:1995;2827-2838.
20. Abu Kwaik Y., Gao L.Y., Stone B.J., Venkataraman C., Harb O.S. Invasion of protozoa by Legionella pneumophila and its role in bacterial ecology and pathogenesis. Appl. Environ. Microbiol. 64:1998;3127-3133.
21. Abu Kwaik Y. The phagosome containing Legionella pneumophila within the protozoan Hartmanella vermiformis is surrounded by the rough endoplasmic reticulum. Appl. Environ. Microbiol. 62:1996;2022-2028.
22. Bozue J.A., Johnson W. Interaction of Legionella pneumophila with Acanthamoeba catellanii: uptake by coiling phagocytosis and inhibition of phagosome-lysosome fusion. Infect. Immun. 64:1996;668-673.
23. Gao L.Y., Harb O.S., Abu Kwaik Y. Utilization of similar mechanisms by Legionella pneumophila to parasitize two evolutionarily distant hosts, mammalian and protozoan cells. Infect. Immun. 65:1997;4738-4746.
24. Gao L.Y., Harb O.S., Abu Kwaik Y. Identification of macrophage-specific infectivity loci (mil) of Legionella pneumophila that are not required for infectivity of protozoa. Infect. Immun. 66:1998;883-892.
25. Cianciotto N.P., Fields B.S. Legionella pneumophila mip gene potentiates intracellular infection of protozoa and human macrophages. Proc. Natl. Acad. Sci. USA. 89:1992;5188-5191.
26. Abu Kwaik Y. Fatal attraction of mammalian cells to Legionella pneumophila. Mol. Microbiol. 30:1998;689-696.
27. Abu Kwaik Y., Gao L.Y., Stone B.J., Harb O.S. Invasion of mammalian and protozoan cells by Legionella pneumophila. Bull. Inst. Pasteur. 96:1998;237-247.
28. Gao L.Y., Stone B.J., Brieland J.K., Abu Kwaik Y. Different fates of Legionella pneumophila pmi and mil mutants within human-derived macrophages and alveolar epithelial cells. Microb. Pathog. 25:1998;291-306.
29. Cianciotto N.P., Eisenstein B.I., Mody C.H., Engleberg N.C. A mutation in the mip gene results in an attenuation of Legionella pneumophila virulence. J. Infect. Dis. 162:1990;121-126.
30. Harb O.S., Abu Kwaik Y. Characterization of a macrophage-specific infectivity locus (milA) of Legionella pneumophila. Infect. Immun. 68:2000;368-376.
31. Stone B.J., Brier A., Abu Kwaik Y. The Legionella pneumophila prp locus; required during infection of macrophages and amoebae. Microb. Pathog. 27:1999;369-376.
32. Horwitz M.A. Formation of a novel phagosome by the Legionnaires′disease bacterium (Legionella pneumophila) in human monocytes. J. Exp. M. 158:1983;1319-1331.
33. Abu Kwaik Y., Gao L.Y., Ticac B., Elhage N., Susa M. Invasion and intracellular replication of Legionella micdadei in a ribosome-free phagosome within human-derived macrophages and alveolar epithelial cells and within protozoa. (UnPub). 9:1998;999-999.
34. Cirillo J.D., Tompkins L.S., Falkow S. Growth of Legionella pneumophila in Acanthamoeba castellanii enhances invasion. Infect. Immun. 62:1994;3254-3261.
35. Abu Kwaik Y., Engleberg N.C. Cloning and molecular characterization of a Legionella pneumophila gene induced by intracellular infection and by various in vitro stress stimuli. Mol. Microbiol. 13:1994;243-251.
36. Abu Kwaik Y., Gao L.Y., Harb O.S., Stone B.J. Transcriptional regulation of the macrophage-induced gene (gspA) of Legionella pneumophila and phenotypic characterization of a null mutant. Mol. Microbiol. 24:1997;629-642.
37. Abu Kwaik Y., Pederson L.L. The use of differential display-PCR to isolate and characterize a Legionella pneumophila locus induced during the intracellular infection of macrophages. Mol. Microbiol. 21:1996;543-556.
38. Abu Kwaik Y., Harb O.S. Phenotypic modulation by intracellular bacterial pathogens. Electrophoresis. 20:1999;2248-2258.
39. Abu Kwaik Y. Induced expression of the Legionella pneumophila gene encoding a 20-kilodalton protein during intracellular infection. Infect. Immun. 66:1998;203-212.
40. Abu Kwaik Y., Eisenstein B.I., Engleberg N.C. Phenotypic modulation by Legionella pneumophila upon infection of macrophages. Infect. Immun. 61:1993;1320-1329.
41. Harb O.S., Abu Kwaik Y. Probing the microenvironment of intracellular bacterial pathogens. Microb. Infect. 1:1999;445-453.
42. Fernandez R.C., Logan S., Lee S.H.S., Hoffman P.S. Elevated levels of Legionella pneumophila stress protein Hsp60 early in infection of human monocytes and L929 cells correlated with virulence. Infect. Immun. 64:1996;1968-1976.
43. Gao L.Y., Abu Kwaik Y. Apoptosis in macrophages and alveolar epithelial cells during early stages of infection by Legionella pneumophila and its role in cytopathogenicity. Infect. Immun. 67:1999;862-870.
44. Gao L.Y., Abu Kwaik Y. The mechanism of killing and exiting the protozoan host Acanthamoeba polyphaga by Legionella pneumophila. Environ. Microbiol. 2:2000;79-90.
45. Harb O.S, Gao L.Y, Abu Kwaik Y. From Protozoa to mammalian cells: A new paradigm in the life cycle of intracellular bacterial pathogens. Environ. Microbiol. 2000.
46. Stone B.J, Abu Kwaik Y. Expression of multiple pili byLegionella pneumophilaIdentification and characterization of a type IV pilin gene and its role in adherence to mammalian and protozoan cells. Infect. Immun. 66:1998;1768-1775.
47. Stone B.J., Abu Kwaik Y. Natural competency for DNA uptake by Legionella pneumophila and its association with expression of type IV pili. J. Bacteriol. 181:1999;1395-1402.
48. Venkataraman C., Haack B.J., Bondada S., Abu Kwaik Y. Identification of a Gal/GalNAc lectin in the protozoan Hartmannella vermiformis as a potential receptor for attachment and invasion by the Legionnaires′ disease bacterium, Legionella pneumophila. J. Exp. M. 186:1997;537-547.
49. Mann B.J., Torian B.E., Vedvick T.S., Petri W.A. Jr. Sequence of a cysteine-rich galactose-specific lectin of Entamoeba histolytica. Proc. Natl. Acad. Sci. USA. 88:1991;3248-3252.
50. Tannich E., Ebert F., Horstmann R.D. Primary structure of the 170-kDa surface lectin of pathogenic Entamoeba histolytica. Proc. Natl. Acad. Sci. USA. 88:1991;1849-1853.
51. Adams S.A., Robson S.C., Gathiram V, et al. Immunological similarity between the 170 kDa amoebic adherence glycoprotein and human 2 integrins. Lancet. 341:1993;17-19.
52. Vines R.R., Ramakrishnan G., Rogers J.B., Lockhart L.A., Mann B.J., Petri W.A. Jr. Regulation of adherence and virulence by the Entamoeba histolytica lectin cytoplasmic domain, which contains a 2 integrin motif. Mol. Biol. Cell. 9:1998;2069-2079.
53. Venkataraman C., Gao L.Y., Bondada S., Abu Kwaik Y. Identification of putative cytoskeletal protein homologues in the protozoan Hartmannella vermiformis as substrates for induced tyrosine phosphatase activity upon attachment to the Legionnaires′ disease bacterium, Legionella pneumophila. J. Exp. M. 188:1998;505-514.
54. Abu Kwaik Y., Venkataraman C., Gao L.Y., Harb O.S. Signal transduction in the protozoan host Hartmannella vermiformis upon attachment and invasion by its bacterial parasite, the Legionnaires′ disease agent, Legionella micdadei. Appl. Environ. Microbiol. 64:1998;3134-3139.
55. Harb O.S., Venkataraman C., Haack B.J., Gao L.Y., Abu Kwaik Y. Heterogeneity in the attachment and uptake mechanisms of the Legionnaires′ disease bacterium, Legionella pneumophila, by protozoan hosts. Appl. Environ. Microbiol. 64:1998;126-132.
56. King C.H., Fields B.S., Shotts E.B. Jr, White E.H. Effects of cytochalasin D and methylamine on intracellular growth of Legionella pneumophila in amoebae and human monocyte-like cells. Infect. Immun. 59:1991;758-763.
57. Abu Kwaik Y., Fields B.S., Engleberg N.C. Protein expression by the protozoan Hartmannella vermiformis upon contact with its bacterial parasite Legionella pneumophila. Infect. Immun. 62:1994;1860-1866.
58. Fields B.S., Nerad T.A., Sawyer T.K, et al. Characterization of an axenic strain of Hartmannella vermiformis obtained from an investigation of nosocomial legionellosis. J. Protozool. 37:1990;581-583.
59. Harb O.S., Abu Kwaik Y. Identification of the aspartate-_-semiadehyde dehydrogenase gene of Legionella pneumophila and characterization of a null mutant. Infect. Immun. 66:1998;1898-1903.
60. Davies P.J.A., Davies D.R., Levitzki A, et al. Transglutaminase is essential in receptor-mediated endocytosis of 2-macroglobulin and polypeptide hormones. Nature. 283:1980;162-167.
61. Castric P. pilO, a gene required for glycosylation of Pseudomonas aeruginosa 1244 pilin. Microbiology. 141:1995;1247-1254.
62. Stimson E., Virji M., Makepeace K, et al. Meningococcal pilin: a glycoprotein substituent with digalactosyl 2, 4-diacetamido-2, 4, 6-trideoxyhexose. Mol. Microbiol. 17:1995;1201-1214.
63. Coxon P.Y., Summersgill J.T., Ramirez J.A., Miller R.D. Signal transduction during Legionella pneumophila entry into human monocytes. Infect. Immun. 66:1998;2905-2913.
64. Kishi Y., Clements C., Mahadeo D.C., Cotter D.A., Sameshima M. High levels of actin tyrosine phosphorylation: correlation with the dormant state of Dictostelium spores. J. Cell. Sci. 111:1998;2923-2932.
65. Gauthier M.L., Lydan M.A., O'Day D.H., Cotter D.A. Endogenous autoinhibitors regulate changes in actin tyrosine phosphorylation during Dictostelium spore germination. Cell. Signal. 9:1997;79-83.
66. Kilvingston S., Price J. Survival of Legionella pneumophila within cysts of Acanthamoeba polyphaga following chlorine exposure. J. Appl. Bacteriol. 68:1990;519-525.
67. Fields B.S. The molecular ecology of legionellae. Trends Microbiol. 4:1996;286-290.