Role of the cytoplasmic domains of the type I interferon receptor subunits in signaling

Seminars in Cancer Biology

Volumn 10, Issue 2, 2000, Pages 83-92

  Prejean, Christine ^a   Colamonici, Oscar R ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Domains; Interferon; Receptor; Signaling

Indexed keywords

CELL SURFACE RECEPTOR; CYTOKINE; INTERFERON RECEPTOR; TYROSINE;

BETA CHAIN; CELL PROLIFERATION; CYTOPLASM; HUMAN; LIGAND BINDING; NONHUMAN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RECEPTOR POTENTIAL; REVIEW; SIGNAL PROCESSING; VIRUS INFECTION;

EID: 0033925935     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1006/scbi.2000.0311     Document Type: Article

References (101)

1. Isaacs A, Lindenmann J. Virus interference. I. The interferon. Proc R Soc London Ser B. 147:1957;258.
2. Pestka S, Langer J A, Zoon K C, Samuel C E. Interferons and their actions. Annu Rev Biochem. 56:1987;727-777.
3. Sen G C, Lengyel P. The interferon system. A bird's eye view of its biochemistry. J Biol Chem. 267:1992;5017-5020.
4. Mogensen E, Lewerenz M, Reboul J, Lutfalla G, Uzé G. The type I Interferon receptor: structure, function and evolution of family business. J Interferon Cyt Res. 19:1999;1069-1098.
5. Chard T, Craig P H, Menabawey M, Lee C. Alpha interferon in human pregnancy. British Journal of Obstetrics and Gynaecology. 93:1986;1145-1149.
6. Gutterman J U. Cytokine therapeutics: lessons from interferon α Proc Natl Acad Sci. 91:1994;1198-1205.
7. Schindler S, Darnell J JE. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem. 64:1995;621-651.
8. Domanski P, Colamonici O R. The type I interferon receptor. The long and short of it. Cytokine and Growth Factor Rev. 7:1996;143-151.
9. Neumann A U, Lam N P, Dahari H, Gretch D R, Wiley T E, Layden T J, Perelson A S. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon- α therapy. Science. 282:1998;103-107.
10. S, Y, Hwang, P, J, Hertzog, K, A, Holland, S, H, Sumarsono, M, J, Tymms, J, A, Hamilton, G, Whitty, I, Bertoncello, I, Kola, 1995, A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses [published erratum appears in Proc Natl Acad Sci USA 1996 Apr 30;93(9):4519].
11. Proc Natl Acad Sci USA, 92, 11284, 11288.
12. Colamonici O R, Porterfield B, Domanski P, Handa R K, Samuel C, Flex S, Pine R, Diaz M O. Ligand-independent anti-oncogenic activity of α subunit of the Type I IFN receptor. J Biol Chem. 269:1994;27275-27279.
13. Platanias L C, Domanski P, Nadeau O W, Yi T, Uddin S, Fish E, Neel B G, Colamonici O R. Identification of a domain in the β subunit of the Type I Interferon (IFN) receptor that exhibits a negative regulatory effect in the growth inhibitory action of Type I IFNs. J Biol Chem. 273:1998;5577-5581.
14. Arora T, Floyd-Smith G, Espy M J, Jelinek D. Dissociation between interferon- α -induced anti-viral and growth pathways. J Immunol. 162:1999;3289-3297.
15. Taniguchi T, Fujita T, Harada H, Sakakibara J, Watanabe N. Regulation of cellular responses by cytokines: positive and negative transcription factors affecting the interferon system. 1991;Cold Spring Harbor Laboratory Press, New York. p. 501-512.
16. Stahl N, Yancopoulos G D. The alphas, betas, and kinases of cytokine receptor complexes. Cell. 74:1992;587-590.
17. Ihle J N. Cytokine receptor signaling. Nature. 337:1995;591-594.
18. Kishimoto T, Taga T, Akira S. Cytokine signal transduction. Cell. 76:1994;253-262.
19. Ihle J E. STATS:Signal transducers and activators of transcription. Cell. 84:1996;331-334.
20. Darnell J EJ. Stats and gene regulation. Science. 277:1997;1630-1635.
21. Rubinstein M, Dinarello C A, Oppenheim J J, Hertzog P. Recent advances in cytokines, cytokine receptors and signal transduction. Cytokine Growth Factor Rev. 9:1998;175-181.
22. Chumakov I, Rigault P, Guillou S, Ougen P, Billaut A, Guasconi G et al. Continuum overlapping clones spanning the entire human chromosome 21q. Nature. 359:1992;380-387.
23. Cheng J-F, Boyartchuk V, Zhu Y. Isolation and mapping of human chromosome 21 cDNA: Progress in constructing a chromosome 21 expression map. Genomics. 23:1994;75-84.
24. Cheng S, Lutfalla G, Uze G, Chumakov I M, Gardiner K. GART, SON, IFNAR, and CRF2-4 genes cluster on human chromosome 21 and mouse chromosome 16. Mamm Genome. 4:1993;338-342.
25. Cleary C M, Donnelly R J, Soh J, Mariano T M, Pestka S. Knockout and reconstitution of a functional human Type I interferon receptor complex. J Biol Chem. 269:1994;18747-18749.
26. Colamonici O R, Domanski P. Identification of a novel subunit of the type I interferon receptor localized to human chromosome 21. J Biol Chem. 268:1993;10895-10899.
27. Cook J R, Jung V, Schwartz B, Wang P, Pestka S. Structural analysis of the human interferon gamma receptor: a small segment of the intracellular domain is specifically required for class I major histocompatibility complex antigen induction and antiviral activity. Proc Natl Acad Sci USA. 89:1992;11317-11321.
28. Cook J R, Emanuel S L, Donnelly R J, Soh J, Mariano T M, Schwartz B, Rhee S, Pestka S. Sublocalization of the human interferon-gamma receptor accessory factor gene and characterization of accessory factor activity by yeast artificial chromosomal fragmentation. J Biol Chem. 269:1994;7013-7018.
29. Epstein C J, McManus N H, Epstein L B, Branca A A, DAlessandro S B, Baglioni C. Direct evidence that the gene product of the human chromosome 21 locus, IFRC, is the interferon-alpha receptor. Biochem Biophys Res Commun. 107:1982;1060-1066.
30. Gerdes A M, Horder M, Petersen P H, Bonnevie-Nielsen V. Effect of increased gene dosage expression on the alpha-interferon receptors in Down's syndrome. Biochim Biophys Acta. 1181:1993;135-140.
31. Hertzog P, Hwang S Y, Holland K A, Tymms M J, Iannello R, Kola I. A gene on human chromosome 21 located in the region 21q22.2 to 21q22.3 encodes a factor necessary for signal transduction and antiviral response to type I interferons. J Biol Chem. 269:1994;14088-14093.
32. Holland K A, Owczarek C M, Hwang S Y, Tymms M J, Constantinescu S N, Pfeffer L W, Kola I, Hertzog P J. A type I interferon signaling factor, ISF21, encoded on chromosome 21 is distinct from receptor components and their down-regulation and is necessary for transcriptional activation of interferon-regulated genes. J Biol Chem. 272:1997;21045-21051.
33. Lutfalla G, Gardiner K, Proudhon D, Vielh E, Uzé G. The structure of the human interferon α / β receptor gene. J Biol Chem. 267:1992;2802-2809.
34. Lutfalla G, Gardiner K, Uzé G. A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR. Genomics. 16:1993;366-373.
35. Raz r, Cheung K, Ling L, Levy D E. Three distinc loci on human chromosome 21 contribute to intereferon- α / β responsiveness. Somatic Cell and Mol Genet. 21:1995;139-145.
36. Revel M, Bash D, Ruddle F H. Antibodies to a cell-surface component coded by human chromosome 21 inhibit action of interferon. Nature (London). 260:1976;139-141.
37. Shulman L M, Kamarck M E, Slate D L, Ruddle F H, Branca A W, Baglioni C, Maxwell B L, Gutterman J, Anderson P, Nagler C. Antibodies to chromosome 21 coded cell surface components block binding of human alpha interferon but not gamma interferon to human cells. Virology. 137:1984;422-427.
38. Soh J, Donnelly R J, Mariano T M, Cook J R, Schwartz B, Pestka S. Identification of a yeast artificial chromosome clone encoding an accessory factor for the human interferon gamma receptor: evidence for multiple accessory factors. Proc Natl Acad Sci. 90:1993;8737-8741.
39. Tan Y H. Chromosome 21 and the cell growth inhibitory effect of human interferon preparations. Nature (London). 260:1976;141-143.
40. Tan Y H, Schneider E L, Tischfield J, Epstein C J, Ruddle F H. Human chromosome 21 dosage: effect on the expression of the interferon induced antiviral state. Science. 186:1974;61-63.
41. Novick D, Cohen B, Rubinstein M. The human interferon α / β receptor: characterization and molecular cloning. Cell. 77:1994;391-400.
42. Domanski P, Witte M, Kellum M, Menachen R, Larner A, Pitha-Rowe P, Colamonici O R. Cloning and expression of a long form of the β subunit of the interferon α receptor that is required for interferon signaling. J Biol Chem. 270:1995;21606-21611.
43. Lutfalla G, Holland S J, Cinato E, Monneron D, Reboul J, Rogers N C, Smith J M, Stark G R, Gardiner K, Mogensen K E, Kerr I M, Uzé G. Mutant U5A cells are complemented by an interferon- αβ receptor subunit generated by alternative processing a new member of a cytokine receptor gene cluster. Embo J. 14:1995;5100-5108.
44. Müller U, Steinhoff U, Reis L FL, Hemmi S, Pavlovic J, Zinkernagel R M, Aguet M. Functional role of Type I and Type II interferon receptors in antiviral defense. Science. 264:1994;1918-1921.
45. Uzé G, Lutfalla G, Gresser I. Genetic transfer of a functional human interferon receptor into mouse cells: cloning and expression of its cDNA. Cell. 60:1990;225-234.
46. Bazan J F. Haemopoietic receptors and helical cytokines. Immunol Today. 11:1990;350-354.
47. Bazan J F. Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci USA. 87:1990;6934-6938.
48. Bazan J F. Shared architecture of hormone binding domains in type I and II interferon receptors. Cell. 61:1990;753-754.
49. Bazan J F. A novel family of growth factors receptors: A common binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors, and p75 IL-2 receptor β -chain. Biochem Biophys Res Commun. 164:1989;788-795.
50. Yan H, Krishnan K, Lim J TE, Contillo L G, Krolewski J J. Molecular characterization of an interferon- α receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transduction. Mol Cel Biol. 16:1996;2074-2082.
51. tyk 2, an interferon α(IFN α)- activated tyrosine kinase, associates with the IFN α receptor. J Biol Chem. 269:1994;3518-3522.
52. Colamonici O, Yan H, Domanski P, Handa R, Smalley D, Mullersman J, Witte M, Krishnan K, Krolewski J. Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase. Mol Cell Biol. 14:1994;8133-8142.
53. Gibbs V C, Takahashi M, Aguet M, Chuntharapai A. A negative regulatory region in the intracellular domain of the human interferon-alpha receptor. J Biol Chem. 271:1996;28710-22876.
54. Basu L, Yang C H, Murti A, Garcia J V, Croze E, Constantinescu S N, Mullersman J E, Pfeffer L M. The antiviral action of interferon is potentiated by removal of the conserved IRTAM domain of the IFNAR1 chain of the interferon alpha/beta receptor: effects on JAK-STAT activation and receptor down-regulation. Virology. 242:1998;14-21.
55. David M, Chen H E, Goelz S, Larner A C, Neel B G. Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1. Mol Cell Biol. 15:1995;7050-7058.
56. David M, Zhou G, Pine R, Dixon J E, Larner A C. The SH2 domain-containing tyrosine phosphatase PTP1D is required for interferon alpha/beta-induced gene expression. J Biol Chem. 271:1996;15862-15865.
57. You M, Yu D, Feng G. Shp-2 tyrosine phosphatase functionsas anegative regulator of the interferon-stimulated Jak-Stat pathway. Mol Cell Biol. 19:1999;2416-2424.
58. David M, Petricoin E, 3rd, Benjamin C, Pine R, Weber M J, Larner A C. Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins. Science. 269:1995;1721-1723.
59. David M, Petricoin E, 3rd, Larner A C. Activation of protein kinase A inhibits interferon induction of the Jak/Stat pathway in U266 cells. J Biol Chem. 271:1996;4585-4588.
60. Rani M RS, Leaman D W, Han Y, Leung S, Croze E, Fish E N, Wolfman A, Ransohoff R M. Catalytically Active Tyk2 Is Essential for Interferon- β mediated phosphorylation of Stat3 in interferonα receptor 1 (IFNAR1) but not for activation of phospho inositol 3-kinase. J Biol Chem. 274:1999;32507-32511.
61. Kotenko S V, Izotova L S, Mirochnitchenko O V, Lee C, Pestka S. The intracellular domain of interferon-alpha receptor 2c (IFN-alphaR2c) chain is responsible for Stat activation. Proc Natl Acad Sci. 96:1999;5007-5012.
62. Platanias L C, Colamonici O R. Interferon α induces rapid tyrosine phosphorylation of the α subunit of its receptor. J Biol Chem. 267:1992;24053-24057.
63. Constantinescu S N, Croze E, Wang C, Murti A, Basu L, Mullersman J E, Pfeffer L M. Role of interferon alpha/beta receptor chain 1 in the structure and transmembrane signaling of the interferon alpha/beta receptor complex. Proc Natl Acad Sci USA. 91:1994;9602-9606.
64. Yan H, Krishnan K, Greenlund A, Gupta S, Lim J TE, Schreiber R, Schindler C, Krolewski J J. Phosphorylated interferon- α receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa Stat2 protein. EMBO J. 15:1996;1064-1074.
65. Li X, Leung S, Kerr I M, Stark G S. Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor for signaling. Mol Cell Biol. 17:1997;2048-2056.
66. Yang C H, Shi W, Basu L, Murti A, Constantinescu S N, Blatt L, Croze E, Mullersman J E, Pfeffer L M. Direct association of STAT3 with the IFNAR-1 chain of the human type I interferon receptor. J Biol Chem. 271:1996;8057-8061.
67. Pfeffer L M, Mullersman J E, Pfeffer S R, Murti A, Shi W, Yang C H. Stat3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor. Science. 276:1997;1418-1420.
68. Nadeau O W, Usacheva A, Uddin S, Platanias L P, Pitha P, Raz R, Levy D, Majchrzak B, Fish E, Colamonici O R. The proximal tyrosines of the cytoplasmic domain of the β chain of the type I interferon receptor are essential for signal transducer and activator of transcription (Stat) 2 activation. J Biol Chem. 274:1999;4045-4052.
69. Domanski P, Nadeau O W, Fish E, Kellum M, Platanias L C, Pitha P, Colamonici O R. A region of the β subunit of the interferon a receptor different from the box 1 interacts with Jak1 and is sufficient to activate the Jak-Stat pathway and induce an antiviral state. J Biol Chem. 272:1997;26388-26393.
70. Domanski P, Platanias L C, Fish E, Kellum M, Pitha P, Colamonici O R. Differential Use of Distinct Domains of the Type I Interferon (IFN) Receptor β Chain Establishes Signaling Specificity for IFN α 2 and IFN β J Biol Chem. 273:1998;3144-3147.
71. Platanias L C, Uddin S, Colamonici O R. Tyrosine phosphorylation of the α and β subunits of the Type I interferon receptor. Interferon β selectively induces tyrosine phosphorylation of an α -subunit associated protein. J Biol Chem. 269:1994;17761-17764.
72. Platanias L C, Uddin S, Domanski P, Colamonici O R. Differences in interferon α and β signaling. Interferon β selectively induces the interaction of the α and β L subunits of the Type I interferon receptor. J Biol Chem. 271:1996;23630-23633.
73. Croze E, Russell-Harde D, Wagner T C, Pu H, Pfeffer L M, Perez H D. The human type I interferon receptor. Identification of the interferon beta-specific receptor-associated phosphoprotein. J Biol Chem. 271:1996;33165-33168.
74. Leung S, Qureshi S A, Kerr I M, Darnell J EJ, Stark G R. Role of STAT2 in the alpha interferon signaling pathway. Mol Cell Biol. 15:1995;1312-1317.
75. Greenlund A C, Farrar M A, Viviano B L, Schreiber R D. Ligand-induced IFN γ receptor tyrosine phosphorylation couples the receptor to its signal transduction pathway system (p91). Embo J. 13:1994;1591-1600.
76. Greenlund A C, Morales M O, Viviano B L, Yan H, Krolewski J, Schreiber R D. Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process. Immunity. 2:1995;677-687.
77. Stahl N, Farruggella T J, Boulton T J, Zhong Z, Darnell J JE, Yancopoulos G D. Choice of Stats and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science. 267:1995;1349-1353.
78. Raz R, Durbin J E, Levy D E. Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors. J Biol Chem. 269:1994;24391-24395.
79. Fasler-Kan E, Pansky A, Wiederkehr M, Battegay M, Heim M H. Interferon-alpha activates signal transducers and activators of transcription 5 and 6 in Daudi cells. Eur J Biochem. 254:1998;514-519.
80. Matikainen S, Sareneva T, Ronni T, Lehtonen A, Koskinen P J, Julkunen I. Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cells. Blood. 93:1999;1980-1991.
81. Rogge L, D'Ambrosio D, Biffi M, Penna G, Minetti L J, Presky D H, Adorini L, Sinigaglia F. The role of Stat4 in species-specific regulation of Th cell development by type I IFNs. J Immunol. 161:1998;6567-6574.
82. Teglund S, McKay C, Schuetz E, van Deursen J M, Stravopodis D, Wang D, Brown M, Bodner S, Grosveld G, Ihle J N. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell. 93:1998;841-850.
83. Moriggl R, Topham D J, Teglund S, Sexl V, McKay C, Wang D, Hoffmeyer A, van Deursen J, Sangster M Y, Bunting K D, Grosveld G C, Ihle J N. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity. 10:1999;249-259.
84. Thierfelder W E, van Deursen J M, Yamamoto K, Tripp R A, Sarawar S R, Carson R T, Sangster M Y, Vignali D AA, Doherty P C, Grosveld G C, Ihle J N. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature. 382:1996;171-174.
85. Kaplan M H, Sun Y-L, Hoey T, Grusby M J. Impaired IL-12 responses and enhancement of Th2 cells in Stat4-deficient mice. Nature. 382:1996;174-177.
86. Shimoda K, van Deursen J, Sangster M Y, Sarawar S R, Carson R T, Tripp R A, Chu C, Quelle F W, Nosaka T, Vignali D AA, Doherty P C, Grosveld G, Paul W E, Ihle J N. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature. 380:1996;630-633.
87. Takeda K, Tanaka T, Shi W, Matsumoto M, Minami M, Kashiwamura S-i, Nakanishi K, Yoshisa N, kishimoto t, Akira S. Essential role of Stat6 in IL-4 signalling. Nature. 380:1996;637-630.
88. Uddin S, Yenush L, Sun X-J, Sweet M E, White M F, Platanias L C. Interferon- α engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3'-kinase. J Biol Chem. 270:1995;15938-15941.
89. Uddin S, Fish E N, Sher D A, Gardciola C, White M F, Platanias L C. Activation of the phosphatidyl inositol 3 kinase serine kinase by interferon α J Immunol. 158:1997;2390-2397.
90. Vanhaesebroeck B, Waterfield M D. Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res. 253:1999;239-254.
91. Platanias L C, Fish E N. Signaling pathways activated by interferons. Exp Hematol. 27:1999;1583-1592.
92. Cantley L C, Neel B G. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci. 96:1999;4240-4205.
93. Anderson R A, Boronenkov I V, Doughman S D, Kunz J, Loijens J C. Phosphatidylinositol phosphate kinases, a multifaceted family of signaling enzymes. J Biol Chem. 274:1999;9907-9910.
94. Wurmser A E, Gary J D, Emr S D. Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways. J Biol Chem. 274:1999;9129-9132.
95. Rameh L E, Cantley L C. The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem. 274:1999;8347-8350.
96. Wymann M P, Pirola L. Structure and function of phosphoinositide 3-kinases. Biochim Biophys Acta. 1436:1998;127-150.
97. Uddin S, Fish E, Sher D, Garziola C, Colamonici O R, Kellum M, Pitha P M, White M F, Platanias L C. The IRS signaling system mediates common and distinct signals during interferon α or insulin stimulation. Blood. 90:1997;2574-2582.
98. Uddin S, Fish E N, Sher D, Gardziola C, Colamonici O R, Kellum M, Pitha P M, White M F, Platanias L C. The IRS-pathway operates distinctively from the Stat-pathway in hematopoietic cells and transduces common and distinct signals during engagement of the insulin or interferon-alpha receptors. Blood. 90:1997;2574-2582.
99. Burfoot M S, Rogers N C, Watling D, Smith J M, Pons S, Paonessaw G, Pellegrini S, White M F, Kerr I M. Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons. J Biol Chem. 272:1997;24183-24190.
100. Platanias L C, Uddin S, Yetter A, Sun X-J, White M F. The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2. J Biol Chem. 271:1996;278-282.
101. Wen Z, Zhong Z, Darnell J JE. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell. 82:1995;241-250.