Interferon-α activates signal transducers and activators of transcription 5 and 6 in Daudi cells

European Journal of Biochemistry

Volumn 254, Issue 3, 1998, Pages 514-519

  Fasler Kan, Elizaveta ^a   Pansky, Andreas ^a   Wiederkehr, Michèle ^a   Battegay, Manuel ^a   Heim, Markus H ^a,b  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b Zentrum für Lehre und Forschung   (Switzerland)

Author keywords

Cytokine receptor; Interferon; Signal transducers and activators of transcription; Signal transduction; Transcription factor

Indexed keywords

ALPHA INTERFERON; STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN;

ARTICLE; DAUDI CELL; HUMAN; HUMAN CELL; IMMUNOREGULATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

JANUS;

EID: 0032526097     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1998.2540514.x     Document Type: Article

References (45)

1. Darnell, J. E. Jr, Kerr, I. M. & Stark, G. R. (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins, Science 264, 1415-1421.
2. Fu, X. Y., Schindler, C., Improta, T., Aebersold, R. & Darnell, J. E. Jr (1992) The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction, Proc. Natl Acad. Sci. USA 89, 7840-7843.
3. Schindler, C., Fu, X. Y., Improta, T., Aebersold, R. & Darnell, J. E. Jr (1992) Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha, Proc. Natl Acad. Sci. USA 89, 7836-7839.
4. Zhong, Z., Wen, Z. & Darnell, J. E. Jr (1994) Stat3 and Stat4: members of the family of signal transducers and activators of transcription, Proc. Natl Acad. Sci. USA 91, 4806-4810.
5. Wegenka, U. M., Lutticken, C., Buschmann, J., Yuan, J., Lottspeich, F., Muller, E. W., Schindler, C., Roeb, E., Heinrich, P. C. & Horn, F. (1994) The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family, Mol. Cell. Biol. 14, 3186-3196.
6. Wakao, H., Gouilleux, F. & Groner, B. (1994) Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response, EMBO J. 13, 2182-2191.
7. Hou, J., Schindler, U., Henzel, W. J., Ho, T. C., Brasseur, M. & McKnight, S. L. (1994) An interleukin-4-induced transcription factor: IL-4 Stat, Science 265, 1701-1706.
8. Akira, S., Nishio, Y., Inoue, M., Wang, X. J., Wei, S., Matsusaka, T., Yoshida, K., Sudo, T., Naruto, M. & Kishimoto, T. (1994) Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway, Cell 77, 63-71.
9. Schindler, C., Shuai, K., Prezioso, V. R. & Darnell, J. E. Jr (1992) Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor, Science 257, 809-813.
10. Seidel, H. M., Milocco, L. H., Lamb, P., Darnell, J. E. Jr, Stein, R. B. & Rosen, J. (1995) Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity, Proc. Natl Acad. Sci. USA 92, 3041-3045.
11. Horvath, C. M., Wen, Z. L. & Darnell, J. E. Jr (1995) A Stat protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain, Genes Dev. 9, 984-994.
12. Shuai, K., Ziemiecki, A., Wilks, A. F., Harpur, A. G., Sadowski, H. B., Gilman, M. Z., & Darnell, J. E. Jr (1993) Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins, Nature 366, 580-583.
13. Muller, M., Briscoe, J., Laxton, C., Guschin, D., Ziemiecki, A., Silvennoinen, O., Harpur, A. G., Barbieri, G., Witthuhn, B. A., Schindler, C., Pellegrini, S., Wilks, A. F., Ihle, J. N., Stark, G. R. & Kerr, I. M. (1993) The protein tyrosine kinase JAK1 complements defects in IFN-αlpha/beta and -gamma signal transduction, Nature 366, 129-135.
14. Velazquez, L., Fellous, M., Stark, G. R. & Pellegrini, S. (1992) A protein tyrosine kinase in the interferon alpha/beta signaling pathway, Cell 70, 313-322.
15. Stahl, N., Farruggella, T. J., Boulton, T. G., Zhong, Z., Darnell, J. E. Jr & Yancopoulos, G. D. (1995) Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors, Science 267, 1349-1353.
16. Heim, M. H., Kerr, I. M., Stark, G. R. & Darnell, J. E. Jr (1995) Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway, Science 267, 1347-1349.
17. Shuai, K., Horvath, C. M., Huang, L. H., Qureshi, S. A., Cowburn, D. & Darnell, J. E. Jr (1994) Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions, Cell 76, 821-828.
18. Levy, D. E., Kessler, D. S., Pine, R., Reich, N. & Darnell, J. E. Jr (1988) Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control, Genes Dev. 2, 383-393.
19. Cho, S. S., Bacon, C. M., Sudarshan, C., Rees, R. C., Finbloom, D., Pine, R. & Oshea, J. J. (1996) Activation of Stat4 by Il-12 and Ifn-alpha - evidence for the involvement of ligand-induced tyrosine and serine phosphorylation, J. Immunol. 157, 4781-4789.
20. Uze, G., Lutfalla, G. & Gresser, I. (1990) Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA, Cell 60, 225-234.
21. Novick, D., Cohen, B. & Rubinstein, M. (1994) The human interferon alpha/beta receptor: characterization and molecular cloning, Cell 77, 391-400.
22. Yan, H., Krishnan, K., Lim, J. T. E., Contillo, L. G. & Krolewski, J. J. (1996) Molecular characterization of an alpha interferon receptor 1 subunit (Ifnar1) domain required for Tyk2 binding and signal transduction, Mol. Cell. Biol. 16, 2074-2082.
23. Yan, H., Krishnan, K., Greenlund, A. C., Gupta, S., Lim, J. T. E., Schreiber, R. D., Schindler, C. W. & Krolewski, J. J. (1996) Phosphorylated interferon-alpha receptor 1 subunit (Ifnar1) acts as a docking site for the latent form of the 113 Kda Stat2 protein, EMBO J. 15, 1064-1074.
24. Lutfalla, G., Holland, S. J., Cinato, E., Monneron, D., Reboul, J., Rogers, N. C., Smith, J. M., Stark, G. R., Gardiner, K., Mogensen, K. E., Kerr, I. M. & Uze, G. (1995) Mutant U5A cells are complemented by an IFN-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster, EMBO J. 14, 5100-5108.
25. Leung, S., Qureshi, S. A., Kerr, I. M., Darnell, J. E. Jr & Stark, G. R. (1995) Role of STAT2 in the alpha interferon signaling pathway, Mol. Cell. Biol. 15, 1312-1317.
26. Meinke, A., Barahmandpour, F., Wohrl, S., Stoiber, D. & Decker, T. (1996) Activation of different Stat5 isoforms contributes to cell-type restricted signaling in response to interferons, Mol. Cell. Biol. 16, 6937-6944.
27. Murata, T., Noguchi, P. D. & Puri, R. K. (1996) Il-13 induces phosphorylation and activation of Jak2 Janus kinase in human colon carcinoma cell lines - similarities between Il-4 and Il-13 signaling, J. Immunol. 156, 2972-2978.
28. Lugli, S. M., Feng, N., Heim, M. H., Adam, M., Schnyder, B., Etter, H., Yamage, M., Eugster, H. P., Lutz, R. A., Zurawski, G. & Moser, R. (1997) Tumor necrosis factor alpha enhances the expression of the interleukin (IL)-4 receptor alpha-chain on endothelial cells increasing IL-4 or IL-13-induced Stat6 activation, J. Biol. Chem. 272, 5487-5494.
29. Ghilardi, N., Ziegler, S., Wiestner, A., Stoffel, R., Heim, M. H. & Skoda, R. C. (1996) Defective Stat signaling by the leptin receptor in diabetic mice, Proc. Natl Acad. Sci. USA 93, 6231-6235.
30. Tony, H. R. Shen, B. J., Reusen, P. & Sebald, W. (1994) Design of human interleukin-4 antagonists inhibiting interleukin-4-dependent and interleukin-13-dependent responses in T-cells and B-cells with high efficiency, Eur. J. Biochem. 225, 659-665.
31. Qureshi, S. A., Salditt-Georgieff, M. & Darnell, J. E. Jr (1995) Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3, Proc. Natl Acad. Sci. USA 92, 3829-3833.
32. McCaleb, M. L. & Donner, D. B. (1981) Affinity of the hepatic insulin receptor is influenced by membrane phospholipids, J. Biol. Chem. 256, 11051-11057.
33. Munson, P. J. & Rodbard, D. (1980) Ligand: a versatile computerized approach tor characterization of ligand-binding systems, Anal. Biochem. 107, 220-239.
34. Reich, N., Evans, B., Levy, D., Fahey, D., Knight, E. J. & Darnell, J. E. Jr (1987) Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element, Proc. Natl Acad. Sci. USA 84, 6394-6398.
35. Rothman, P., Chen, Y. Y., Lutzker, S., Li, S. C., Stewart, V., Coffman, R. & Alt, F. W. (1990) Structure and expression of germ line immunoglobulin heavy-chain epsilon transcripts: interleukin-4 plus lipopolysaccharide-directed switching to C epsilon, Mol. Cell. Biol. 10, 1672-1679.
36. Pfeffer, L. M., Mullersman, J. E., Pfeffer, S. R., Murti, A., Shi, W. & Yang, C. H. (1997) STAT3 as an adapter to couple phosphatidyl-inositol 3-kinase to the IFNAR1 chain of the type I interferon receptor, Science 276, 1418-1420.
37. Kessler, D. S., Pine, R., Pfeffer, L. M., Levy, D. E. & Darnell, J. E. Jr (1988) Cells resistant to interferon are defective in activation of a promoter-binding factor, EMBO J. 7, 3779-3783.
38. Constantinescu, S. N., Croze, E., Murti, A., Wang, C., Basu, L., Hollander, D., Russell-Harde, D., Betts, M., Garcia-Martinez, V., Mullersman, J. E. & Pfeffer, L. M. (1995) Expression and signaling specificity of the IFNAR chain of the type 1 interferon receptor complex, Proc. Natl Acad. Sci. USA 92, 10487-10491.
39. Pfeffer, L. M., Stebbing, N. & Donner, D. B. (1987) Cytoskeletal association of human alpha-interferon-receptor complexes in interferon-sensitive and -resistant lymphoblastoid cells, Proc. Natl Acad. Sci. USA 84, 3249-3253.
40. Greenlund, A. C., Farrar, M. A., Viviano, B. L. & Schreiber, R. D. (1994) Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91), EMBO J. 13, 1591-1600.
41. Wang, L. M., Myers, M. G. Jr, Sun, X. J., Aaronson, S. A., White, M. & Pierce, J. H. (1993) IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells, Science 261, 1591-1594.
42. Sun, X. J., Rothenberg, P., Kahn, C. R., Backer, J. M., Araki, E., Wilden, P. A., Cahill, D. A., Goldstein, B. J. & White, M. F. (1991) Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein, Nature 352, 73-77.
43. Sun, X. J., Miralpeix, M., Myers, M. G. Jr, Glasheen, E. M., Backer, J. M., Kahn, C. R. & White, M. F. (1992) Expression and function of IRS-1 in insulin signal transmission, J. Biol. Chem. 267, 22662-22672.
44. Margolis, B. & Skolnik, E. Y. (1994) Activation of Ras by receptor tyrosine kinases., J. Am. Soc. Nephrol. 5, 1288-1299.
45. Li, X., Leung, S., Kerr, I. M. & Stark, G. R. (1997) Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling, Mol. Cell. Biol. 17, 2048-2056.