Molecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transduction

Molecular and Cellular Biology

Volumn 16, Issue 5, 1996, Pages 2074-2082

  Yan, Hai ^a   Krishnan, Kartik ^a   Lim, Jin T E ^a   Contillo, Leonard G ^b   Krolewski, John J ^a  

^a New York Presbyterian Columbia University Medical Center   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; GLUTATHIONE TRANSFERASE; INTERFERON RECEPTOR; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR; TYROSINE;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; DIMERIZATION; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

EID: 0029863420     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.5.2074     Document Type: Article

References (59)

1. Abramovich, C., L. M. Shulman, E. Ratovitski, S. Harroch, M. Tovey, P. Eid, and M. Revel. 1994. Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN-α and IFN-β. EMBO J. 13:5871-5877.
2. Ahnert-Hilger, G., W. Mach, K. J. Föhr, and M. Gratzl. 1989. Poration by α-toxin and streptoiysin O: an approach to analyze intracellular processes. Methods Cell Biol. 31:63-90.
3. Argetsinger, L. S., G. S. Campbell, X. Yang, B. A. Witthuhn, O. Silvennoinen, J. N. Ihle, and C. Carter-Su. 1993 Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase. Cell 74:237-244.
4. Barbieri, G., L. Velazquez, M. Scrobogna, M. Fellous, and S. Pellegrini. 1994. Activation of the protein kinase tyk2 by interferon α/β Eur. J. Biochem 223:427-435.
5. Binari, R., and N. Perrimon. 1994. Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila. Genes Dev. 8:300-312.
6. Cance, W. G., R. J. Craven, T. M. Weiner, and E. T. Liu. 1993. Novel protein kinases expressed in human breast cancer. Int. J. Cancer 54:571-577.
7. tyk2 tyrosine kinase. Mol. Cell. Biol. 14:8133-8142.
8. tyk2, an interferon-α-activated tyrosine kinase, is physically associated with an interferon-α receptor. J. Biol Chem. 269:3518-3522.
9. Constantinescu, S. N., E. Croze, C. Wang, A. Murti, L. Basu, J. E. Mullersman, and L. M. Pfeffer. 1994. Role of interferon α/β receptor chain 1 in the structure and transmembrane signaling of the interferon α/β receptor complex. Proc. Natl. Acad. Sci. USA 91:9602-9606
10. Darnell, J. E., I. M. Kerr, and G. R. Stark. 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415-1421
11. tyk2, an interferon-α inducible tyrosine kinase, can suppress tumorigenicity. Leukemia, in press.
12. Deen, K. C., J. S. McDougal, R. Inacker, G. Folena-Wasserman, J. Arthos, J. Rosenberg, P. J. Maddon, R. Axel, and R. W. Sweet. 1988 A soluble form of CD4 (T4) protein inhibits AIDS virus infection Nature (London) 331: 82-84.
13. Domanski, P., M. Witte, H. Yan, J. Kroiewski, and O. R. Colamonici. The long form of the β-subunit of the type I IFN receptor interacts directly with Jak-1 and Stat2, and indirectly with Stat1. Submitted for publication.
14. Domanski, P., M. Witte, M. Kellum, M. Rubinstein, R. Hackett, P. Pitha, and O. R. Colamonici. 1995. Cloning and expression of a long form of the β subunit of the interferon α/β receptor that is required for signaling J. Biol Chem. 270:21606-21611.
15. Firmbach-Kraft, I., M. Byers, T. Shows, R. Dalla-Favera, and J. J. Kroiewski. 1990. tyk2, prototype of a novel class of non-receptor tyrosine kinase genes. Oncogene 5:1329-1336.
16. Fu, X.-Y. 1992. A transcription factor with SH2 and SH3 domains is directly activated by an interferon α-induced cytoplasmic protein kinase(s). Cell 70:323-335.
17. Gearing, D. P., C. J. Thut, T. VandenBos, S. D. Gimpel, P. B. Delaney, J. King, V. Price, D. Cosman, and M. P. Beckmann. 1991. Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130 EMBO J. 10:2839-2848.
18. Greenlund, A. C., M. A. Farrar, B. L. Viviano, and R. D. Schreiber. 1994 Ligand-induced IFNγ receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91). EMBO J. 13:1591-1600
19. Hanks, S. K. 1991 Eukaryotic protein kinases. Curr. Opin Struct. Biol. 1:369-383.
20. Harpur, A. G., A.-C. Andres, A. Ziemiecki, R. A. Aston, and A. F. Wilks. 1992. JAK-2, a third member of the JAK family of protein tyrosine kinases Oncogene 7:1347-1353.
21. Horton, R. M., Z. L. Cai, S. N. Ho, and L. R. Pease. 1990. Gene splicing by overlap extension: tailor-made genes using the polymerase chain reaction. BioTechniques 8:528-535.
22. Igarashi, K., G. Garotta, L. Ozmen, A. Zlemiecki, A. F. Wilks, A. G. Harpur, A. C. Larner, and D. S. Finbloom. 1994. Interferon-γ induces tyrosine phosphorylation of interferon-γ receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor J. Biol. Chem. 269:14333-14336.
23. Ihle, J. N. 1995. Cytokine receptor signaling. Nature (London) 377:591-594.
24. Kawamura, M., D. W. McVicar, J. A. Johnston, T. B. Blake, Y.-Q. Chen, B. K. Lal, A. R. Lloyd, D. J. Kelvin, J. E. Staples, J. R. Ortaldo, and J. J. O'Shea. 1994 Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes. Proc Natl. Acad. Sci. USA 91:6374-6378.
25. Kolodziej, P. A., and R. A. Young. 1991. Epitope tagging and protein surveillance. Methods Enzymol. 194:508-519.
26. Krishnan, K., H. Yan, J. T. E. Lim, O. R. Colamonici, and J. J. Krolewski. Dimerization of CD4-IFNaR1 chimeras reconstitutes the signaling events preceding STAT phosphorylation. Oncogene, in press.
27. Lim, J.-K., and J. A. Langer. 1993. Cloning and characterization of a bovine alpha interferon receptor. Biochim Biophys. Acta 1173:314-319.
28. Lutticken, C., U. M. Wegenka, J. Yuan, J. Buschmann, C. Schindler, A. Ziemiecki, A. G. Harpur, A. F. Wilks, K. Yasukawa, T. Taga, T. Kishimoto, G. Barbieri, S. Pellegrini, M. Sendtner, P. C. Heinrich, and F. Horn. 1994. Association of transcription factor APRF and protein kinase JAK1 with the interleukin-6 signal transducer gp130. Science 263:89-92.
29. Miyazaki, T., A. Kawahara, H. Fuji, Y. Nakagawa, Y. Minami, Z.-J. Liu, I. Oishi, O. Silvennoinen, B. A. Witthuhn, J. N. Ihle, and T. Taniguchi. 1994. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science 266:1045-1047.
30. Müller, M., J. Briscoe, C. Laxton, D. Guschin, A. Ziemiecki, O. Silvennoinen, A. Harpur, G. Barbieri, B. Witthuhn, C. Schindler, S. Pellegrini, A. Wilks, J. Ihle, G. Stark, and I. Kerr. 1993. The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction. Nature (London) 366:129-135
31. Murakami, M., M. Narazaki, M. Hibi, H. Yawata, K. Yasukawa, M. Hamaguchi, T. Taga, and T. Kishimoto. 1991 Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family. Proc Natl Acad Sci. USA 88:11349-11353
32. Narazaki, M., A. Kumanogoh, M. Inoue, S. Akira, S. Nagata, J. J. Krolewski, T. Kishimoto, and T. Taga. Distinct roles of conserved cytoplasmic motifs of gp130 in the interaction with selective signaling molecules. Submitted for publication.
33. Narazaki, M., B. A. Witthuhn, K. Yoshida, O. Silvennoinen, K. Yasukawa, J. N. Ihle, T. Kishimoto, and T. Taga. 1994. Activation of JAK2 kinase mediated by the IL-6 signal transducer, gp130. Proc Natl. Acad Sci. USA 91:2285-2289
34. Novick, D., B. Cohen, and M. Rubinstein. 1994. The human interferon α/β receptor: characterization and molecular cloning. Cell 77:391-400.
35. O'Reilly, D. R., L. K. Miller, and V. A. Luckow. 1992. Baculovirus expression vectors: a laboratory manual W H Freeman, New York
36. Platanias, L., S. Uddin, and O. R. Colamonici. 1994. Tyrosine phosphorylation of the α and β subunits of the type I interferon receptor. J. Biol. Chem. 269:17761-17764.
37. Platanias, L. C., and O. R. Colamonici. 1992. Interferon a induces rapid tyrosine phosphorylation of the α subunit of its receptor. J. Biol. Chem. 267:24053-24057
38. c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region. Mol. Cell. Biol. 14:4335-4341.
39. c chains with Jak1 and Jak3: implications for XSCID and XCID. Science 266:1042-1045.
40. Sanchez, M. P., P. Tapley, S. S. Saini, B. He, D. Pulido, and M. Barbacid. 1994. Multiple tyrosine protein kinases in rat hippocampal neurons: isolation of Ptk-3, a receptor expressed in proliferative zones of the developing brain. Proc. Natl Acad. Sci USA 91:1819-1823.
41. Schindler, C., and J. E. Darnell. 1995. Transcriptional responses to polypeptide ligands: the Jak-Stat pathway. Annu. Rev. Biochem. 64:621-651.
42. Schindler, C., X.-Y. Fu, T. Improta, R. Aebersold, and J. E. Darnell. 1992. Proteins of transcription factor ISFG-3: one gene encodes the 91- and 84-kDa ISFG-3 proteins that are activated by interferon α. Proc. Natl. Acad. Sci. USA 89:7836-7839.
43. Schindler, C., K. Shuai, V. R. Prezioso, and J. E. Darnell. 1992. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science 257:809-813.
44. Schlessinger, J., and A. Ullrich. 1992. Growth factor signaling by receptor tyrosine kinase Neuron 9:383-391.
45. Stahl, N., T. G. Boulton, T. Farruggella, N. Y. Ip, S. Davis, B. A. Witthuhn, F. W. Quelle, O. Silvennoinen, G. Barbieri, S. Pellegrini, J. N. Ihle, and G. D. Yancopoulos. 1994. Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6β receptor components. Science 263:92-95.
46. Takakashi, T., and T. Shirasawa. 1994. Molecular cloning of rat JAK3, a novel member of the JAK family of protein tyrosine kinases. FEBS Lett. 342:124-128.
47. Taniguchi, T. 1995. Cytokine signaling through nonreceptor protein tyrosine kinases. Science 268:251-255.
48. Tanner, J. W., W. Chen, R. L. Young, G. D. Longmore, and A. S. Shaw. 1995. The conserved box 1 motif of cytokine receptors is required for association with JAK kinases. J. Biol. Chem. 270:6523-6530.
49. Uzé, G., G. Lutfalla, M.-T. Bandu, D. Proudhon, and K. E. Mogensen. 1992. Behavior of a cloned murine interferon α/β receptor expressed in homospecific or heterospecific background. Proc. Natl. Acad. Sci. USA 89:4774-4778.
50. Uzé, G., G. Lutfalla, and I. Gresser. 1990. Genetic transfer of a functional human interferon a receptor into mouse cells: cloning and expression of its cDNA. Cell 60:225-234.
51. Uzé, G., G. Lutfalla, and K. E. Mogensen. 1995. α and β interferons and their receptors and their friends and relations. J. Interferon Cytokine Res. 15:3-26.
52. VanderKuur, J. A., X. Wang, L. Zhang, G. S. Campbell, G. Allevato, N. Billestrup, G. Norstedt, and C. Carter-Su. 1994. Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase. J. Biol. Chem. 269:21709-21717.
53. Velazquez, L., M. Fellous, G. R. Stark, and S. Pellegrini. 1992. A protein tyrosine kinase in the Interferon α/β signaling pathway. Cell 70:313-322.
54. Wilks, A. F., A. G. Harpur, R. R. Kurban, S. J. Ralph, G. Zürcher, and A. Ziemiecki. 1991. Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol. Cell. Biol. 11:2057-2065.
55. Witthuhn, B. A., F. W. Quelle, O. Silvennoinen, T. Yi, B. Tang, O. Miura, and J. N. Ihle. 1993. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated following stimulation with erythropoietin. Cell 74: 227-236.
56. Witthuhn, B. A., O. Silvennoiaen, O. Miura, K. S. Lai, C. Cwik, E. T. Liu, and J. N. Ihle. 1994. Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature (London) 370: 153-157.
57. Yan, H., K. Krishnan, A. C. Greenland, S. Gupta, J. T. E. Lim, R. D. Schreiber, C. Schindler, and J. J. Krolewski. 1996. Phosphorylated interferon-α receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kD STAT2 protein. EMBO J. 15:1064-1074.
58. Yan, H., J. T. E. Lim, and J. J. Krolewski. 1995. GST fusion proteins mimic receptor dimerization in permeabilized cells. Anal. Biochem. 231:455-458.
59. Zhao, Y., F. Wagner, S. Frank, and A. S. Kraft. 1995. The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor β chain. J. Biol. Chem. 270:13814-13818.