The proximal tyrosines of the cytoplasmic domain of the β chain of the type I interferon receptor are essential for signal transducer and activator of transcription (Stat) 2 activation: Evidence that two Stat2 sites are required to reach a threshold of interferon α-induced Stat2 tyrosine phosphorylation that allows normal formation of interferon-stimulated gene factor 3

Journal of Biological Chemistry

Volumn 274, Issue 7, 1999, Pages 4045-4052

  Nadeau, Owen W ^a   Domanski, Paul ^a   Usacheva, Anna ^a,b   Uddin, Shahab ^c   Platanias, Leonidas C ^c   Pitha, Paula ^d   Raz, Regina ^e   Levy, David ^e   Majchrzak, Beata ^f   Fish, Eleanor ^f   Colamonici, Oscar R ^a,c  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b INSTITUTE OF THEORETICAL AND EXPERIMENTAL BIOPHYSICS   (Russian Federation)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON RECEPTOR; RECEPTOR SUBUNIT; STAT1 PROTEIN; STAT2 PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE ACTIVATION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; BINDING SITES; CELL LINE; CYTOPLASM; DNA-BINDING PROTEINS; HUMANS; INTERFERON-STIMULATED GENE FACTOR 3; INTERFERON-STIMULATED GENE FACTOR 3, GAMMA SUBUNIT; JANUS KINASE 1; MEMBRANE PROTEINS; MICE; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN-TYROSINE KINASES; PROTEINS; RECEPTOR, INTERFERON ALPHA-BETA; RECEPTORS, INTERFERON; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT2 TRANSCRIPTION FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TYK2 KINASE; TYROSINE;

ANIMALIA;

EID: 0033548075     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.7.4045     Document Type: Article

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