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0026659046
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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kD S6 protein kinases
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(1992)
Cell
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Chung1
Kuo2
Crabtree3
Blenis4
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10
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0028137771
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TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast.
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of outstanding interest, First demonstration that the target of rapamycin proteins TOR1 and TOR2 exhibit overlapping as well as distinct cellular functions. Also, identification of mutations which confer rapamycin resistance.
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(1994)
Molecular Biology of the Cell
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Helliwell1
Wagner2
Kunz3
Deuter-Reinhard4
Henriquez5
Hall6
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12
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0028360374
-
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
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of special interest, Cloning of the gene encoding the human target of the rapamycin—FKBP complex, FRAP. The authors demonstrate that the yeast and mammalian targets are conserved. This was one of the first studies to show that the rapamycin—FKBP directly associates with FRAP.
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(1994)
Nature
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Brown1
Albers2
Shin3
Ichikawa4
Keith5
Lane6
Schreiber7
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13
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0028239893
-
RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORS
-
of special interest, Cloning of the gene encoding the rat homolog (RAFT1) of the rapamycin-FKBP target; one of the first studies to show that the rapamycin-FKBP directly associates with RAFT1.
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(1994)
Cell
, vol.78
, pp. 35-43
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Sabatini1
Erdjument-Bromage2
Lui3
Tempst4
Snyder5
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14
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-
0028950217
-
Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
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of special interest, Cloning of the gene encoding the rat homolog (mTOR) of the rapamycin-FKBP target; these studies further demonstrate that rapamycin-resistant T lymphoma cell lines show reduced binding of mTOR to a rapamycin-FKBP affinity column.
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J Biol Chem
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Sabers1
Martin2
Brunn3
Williams4
Dumont5
Wiederrecht6
Abraham7
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15
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0028175455
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s6k: functional requirement for entry into S phase
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1, suggesting a function for the nuclear isoform of the enzyme in cell cycle progression.
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(1994)
EMBO J
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Reinhard1
Fernandez2
Lamb3
Thomas4
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27
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0027211693
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Phospholipase Cγ1 and phosphatidylinositol 3-kinase are the downstream mediators of the PDGF receptor's mitogenic signal
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(1993)
Cell
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Valius1
Kazlauskas2
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28
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0027469604
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The serine-rich cytoplasmic domain of the interleukin-2 receptor β chain is essential for interleukin-2-dependent tyrosine protein kinase and phosphatidylinositol-3-kinase activation
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J Biol Chem
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Merida1
Williamson2
Kuziel3
Greene4
Gaulton5
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30
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0027432424
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Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses
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Biochem J
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Arcaro1
Wymann2
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32
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0028170210
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A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
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(1994)
J Biol Chem
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, pp. 5241-5248
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Vlahos1
Matter2
Hui3
Brown4
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34
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0028036698
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Insulin receptor substrate-1 mediates phosphatidylinositol 3-kinase and p70 S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation
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(1994)
J Biol Chem
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Myers1
Grammer2
Wang3
Sun4
Pierce5
Blenis6
White7
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35
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0027535742
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Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate
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J Biol Chem
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, pp. 13-16
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Nakanishi1
Brewer2
Exton3
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37
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0029079275
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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
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of special interest, Identifies the Akt proto-oncogene as a potential mediator of P13K signalling.
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(1995)
Cell
, vol.81
, pp. 727-736
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Franke1
Yang2
Chan3
Datta4
Kazlauskas5
Morrison6
Kaplan7
Tsichlis8
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39
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0028078824
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A brain serine/threonine kinase activated by Cdc42 and Rac1
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of outstanding interest, First demonstration of a serine/threonine kinase regulated by the Rho family G proteins Cdc42 and Rac1; this kinase is directly activated by a novel mechanism.
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(1994)
Nature
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, pp. 40-46
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Manser1
Leung2
Salihuddin3
Zhao4
Lim5
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42
-
-
0029055145
-
Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue
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of special interest, Identifies a region of FRAP which mediates interaction with rapamycin-FKBP. The authors also provide the biochemical basis for the rapamycin-resistance of yeast strains carrying mutant TOR alleles.
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(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 4947-4951
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Chen1
Zheng2
Brown3
Schreiber4
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43
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0029071264
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TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin
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1 progression, and that the additional unique function of TOR2 which is required for viability is not inhibited by rapamycin.
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(1995)
Cell
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Zheng1
Fiorentino2
Chen3
Crabtree4
Schreiber5
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49
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0027983480
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Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternate route to mitogen-induced gene expression
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Cell
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De Groot1
Ballou2
Sassone-Corsi3
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52
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0027970168
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CD28 signaling causes a sustained down-regulation of I kappa B alpha which can be prevented by the immunosuppressant rapamycin.
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J Biol Chem
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Lai1
Tan2
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53
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Rapamycin selectively blocks interleukin-2-induced proliferating cell nuclear antigen gene expression in T lymphocytes. Evidence for inhibition of CREB/ATF binding activities
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J Biol Chem
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Feuerstein1
Prystowsky2
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57
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0027336491
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Mammalian G1 cyclins
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Cell
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Sherr1
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Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells
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Marx1
Jayaraman2
Go3
Marks4
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69
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Rapamycin-FKBP12 blocks proliferation, induces differentiation and inhibits cdc2 kinase activity in a myogenic cell line
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(1993)
J Biol Chem
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Jayaraman1
Marks2
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