Hepatocyte growth factor induces activation of Nck and phospholipase C-γ in lung carcinoma cells

Cancer Letters

Volumn 104, Issue 2, 1996, Pages 163-169

  Kochhar, Kulvinder S ^a   Iyer, Anand P ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Hepatocyte growth factor; Met HGF receptor; Receptor tyrosine kinase; Tyrosine phosphorylation

Indexed keywords

GROWTH FACTOR RECEPTOR; ONCOPROTEIN; PHOSPHOLIPASE C; SCATTER FACTOR;

ARTICLE; AUTOPHOSPHORYLATION; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME SUBUNIT; HUMAN; HUMAN CELL; LUNG CARCINOMA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTO ONCOGENE; RECEPTOR BINDING;

EID: 0029927296     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(96)04244-9     Document Type: Article

References (29)

1. Schlessinger, J. and Ullrich, A. (1992) Growth factor signalling by receptor tyrosine kinases. Neuron, 9, 383-391.
2. Cantley, L.C., Auger, K., Carpenter, C., Duckworth, B., Grazianin, A., Kapeller, R. and Solotoff, S. (1991) Oncogenes and signal transduction. Cell, 64, 281-302.
3. Rubin, J.S., Chan, A.M.-L., Bottaro, D.P., Burgess, W.H., Taylor, W.G., Cech, A.C., Hirschfield, D.W., Wang, J., Miki, T., Finch, P.W. and Aaronson, S.A. (1991) A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor. Proc. Natl. Acad. Sci. USA, 88, 415-419.
4. Montesano, R.K., Matsumoto, K., Nakamura, T. and Orci, L. (1991) Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor. Cell, 67, 901-908.
5. Johnson, M., Koukolis, G., Matsumoto, K., Nakamura, T. and Iyer, A. (1993) Hepatocyte growth factor induces proliferation and morphogenesis in nonparenchymal epithelial liver cells. Hepatology, 17, 1052-1061.
6. Nakamura, T., Nawa, K., Ichihara, A., Kaise, A. and Nishino, T. (1987) Purification and subunit structure of hepatocyte growth factor in rat platelets. FEBS Lett., 224, 311-318.
7. Rosen, E.M., Goldberg, I.D., Kacinski, B.M., Buckhdz, T. and Vinter, D.W. (1989) Smooth muscle releases an epithelial cell scatter factor which binds to heparin. In Vitro Cell Dev. Biol., 25, 163-173.
8. Giordano, S., Ponzetto, C., DiRenzo, M.F., Cooper, C. and Comoglio, P.M. (1989) Tyrosine kinase receptor indistinguishable from the c-met protein. Nature, 339, 155-156.
9. Bottaro, D.P., Rubin, J.S., Faletto, D.L., Chan, A.M.L, Kmiecick, T.E., Vande Woude G.F. and Aaronson, S.A. (1991) Identification of the hepatocyte growth factor receptor as the c-met protooncogene. Science, 251, 802-804.
10. Giordano, S., DiRenzo, M.F., Ferracini, R., Chado-Piat, L. and Comoglio, P.M. (1988) p145, a protein with associated tyrosine kinase activity in a human gastric carcinoma cell line. Mol. Cell Biol., 8, 3510-3517.
11. Tempest, P.R., Stratton, M.R. and Cooper, C.S. (1988) Structure of met protein kinase activity among human tumour cell lines. Br. J. Cancer., 58, 3-7.
12. Gonzatti-Haces, M., Seth, A., Park, M., Copeland, T., Oraszlan, S. and Vande Woude, G.F. (1988) Characterization of the tpr-met oncogene p65 and the met protooncogene p140 protein tyrosine kinases. Proc. Natl. Acad. Sci. USA, 84, 6379-6383.
13. Prat, M., Narsimhan, R.P., Crepaldi, T., Nicotra, M.R., Natali, P.G. and Comoglio, P.M. (1991) The receptor encoded by human c-met oncogene is expressed in hepatocytes, epithelial cells and solid tumors. Int. J. Cancer, 49, 323-328.
14. Cooper, C.S., Tempest, P.R., Beckman, M.P., Heldin, C.-H. and Brookes, P. (1986) Amplification and overexpression of the met gene in spontaneously transformed NIH3T3 fibroblasts. EMBO J., 5, 2623-2628.
15. Kochhar, K.S., Linnekin, D. and Iyer, A.P. (1994) PDGF-independent activation of PDGF-β receptors in NIH-3T3 cells transformed by c-met protooncogene. Exp. Cell Res., 212, 414-421.
16. Giordano, S., Di Renzo, M.F., Narsimhan, R.P., Cooper, C.S., Rosa, C. and Comoglio, P.M. (1989) Biosynthesis of the protein encoded by the c-met proto-oncogene. Oncogene, 4, 1383-1388.
17. Naldini, L., Vigna, E., Narsimhan, R., Gaudino, G., Zarnegar, R., Michalopoulos, G. and Comoglio, P. (1991) Hepatocyte growth factor (HGF) stimulates tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET. Oncogene, 6, 501-504.
18. Naldini, L., Vigna, E., Ferracinin, R., Longatti, P., Gandino, L., Prat, M. and Comoglio, P. (1991) The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation. Mol. Cell Biol., 11, 1793-1803.
19. Koch, C.A., Anderson, A.D., Moran, M.F., Ellis, C. and Pawson, T. (1991) SH2 and SH3 domains: elements that control interactions of cytoplasmic signalling proteins. Science, 251, 668-674.
20. Park, D.J. and Rhee, S.G. (1992) Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate and cyclic AMP. Mol. Cell Biol., 12, 5816-5823.
21. Li, W., Hu, P., Skolnik, E.Y., Ullrich, A. and Schlessinger, J. (1992) The SH2 and SH3 domain containing Nck protein is oncogenic and is a common target for phosphorylation by different surface receptors. Mol. Cell Biol., 12, 5824-5833.
22. Meisenhelder, J. and Hunter, T. (1992) The SH2/SH3 domain-containing protein Nck is recognized by certain antiphospholipase c-γ1 monoclonal antibodies and its phosphorylation in tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment. Mol. Cell Biol., 12, 5843-5856.
23. Lehmann, J.M., Rietmuller, M.G. and Johnson, J.P. (1990) Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3. Nucleic Acids Res., 18, 1048.
24. Kochhar, K.S., Johnson, M., Volvpert, O. and Iyer, A.P. (1995) Evidence for autocrine basis of transformation in NIH-3T3 cells transfected with met/HGF receptor gene. Growth Factors, in press.
25. Kinoshita, T., Tashiro, K. and Nakamura, T. (1989) Marked increase of HGF mRNA in nonparenchymal liver cells of rats treated with hepatotoxins. Biochem. Biophys. Res. Commun., 165, 1229-1234.
26. Nakamura, T. (1991) Structure and function of hepatocyte growth factor. Prog. Growth Factor Res., 3, 67-85.
27. Gherardi, E. and Stoker, M. (1990) Hepatocytes and scatter factor. Nature (London), 346, 228.
28. Yamashita, J., Ogawa, M., Yamashita, S., Nomura, K., Kuramoto, M., Saishoji, T. and Shin, S. (1994) Immunoreactive hepatocyte growth factor is a strong and independent predictor of recurrence and survival in human breast cancer. Cancer Res., 54, 1630-1633.
29. Furlong, R.A., Takehara, T., Taylor, W.G., Nakamura, T. and Rubin, J.S. (1991) Comparison of biological and immunochemical properties indicates that scatter factor and human hepatocyte growth factor are indistinguishable. J. Cell Sci., 180, 765-773.