A new variant of the β subunit of the high-affinity receptor for Immunoglobulin E (FcεRI-β E237G): Associations with measures of atopy and bronchial hyper-responsiveness

Human Molecular Genetics

Volumn 5, Issue 7, 1996, Pages 959-962

  Hill, M R ^a   Cookson, W O C M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; GLUTAMIC ACID; GLYCINE; GUANINE; IMMUNOGLOBULIN E RECEPTOR; METHACHOLINE; RECEPTOR SUBUNIT;

ALLERGIC ASTHMA; AMINO ACID SUBSTITUTION; ARTICLE; ATOPY; BETA CHAIN; BRONCHUS HYPERREACTIVITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EXON; GENETIC POLYMORPHISM; GRASS; HOUSE DUST ALLERGY; HUMAN; HYDROPHOBICITY; MAJOR CLINICAL STUDY; NUCLEIC ACID BASE SUBSTITUTION; POLLEN ALLERGY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ASTHMA; BRONCHIAL HYPERREACTIVITY; CHILD; EXONS; FEMALE; GENETIC SCREENING; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULIN E; MALE; POLYMORPHISM, GENETIC; RECEPTORS, IGE; SEQUENCE ANALYSIS, DNA; WESTERN AUSTRALIA;

EID: 0030054886     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/5.7.959     Document Type: Article

References (25)

1. Platts-Mills, T.A. (1994) How environment affects patients with allergic disease: indoor allergens and asthma. Ann. Allergy, 72, 381-384.
2. Cookson, W.O.C.M. (1994) The genetics of atopy. J. Allergy Clin. Immunol., 94, 643-644.
3. Ishizaka, K. (1971) Mechanisms of reaginic hypersensitivity. Clin. Allergy, 1, 9-24.
4. Yan, K., Salome, C. and Woolcock, A.J. (1983) Rapid method of measuring bronchial responsiveness. Thorax, 38, 760-765.
5. Cookson, W.O.C.M., Sharp, P.A., Faux, J.A. and Hopkin, J.M. (1989) Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q. Lancet, 1, 1292-1295.
6. Young, R.P., Lynch, J., Sharp, P.A., Faux, J.A. and Hopkin, J.M. (1992) Confirmation of genetic linkage between atopic IgE responses and chromosome 11q13. J. Med. Genet., 29, 236-238.
7. Collée, J.M., ten Kate, L.P., de Vries, H.G., Kliphuis, J.W., Bouman, K., Scheffer, H. and Gerritsen, J. (1993) Allele sharing on chromosome 11q13 in sibs with asthma and atopy. Lancet, 342, 936.
8. Shirakawa, T., Morimoto, K., Hashimoto, T., Furuyama, J., Yamamoto, M. and Takai, S. (1994) Linkage between severe atopy and chromosome 11q in Japanese families. Clin. Genet., 46, 228-232.
9. Herwerden, L., Harrap, S.B., Wong, Z.Y.H., Abramson, M.J., Kutin, J.J., Forbes, A.B., Raven, J., Lanigan, A. and Walters, E.H. (1995) Linkage of high-affinity IgE receptor gene with bronchial hyperreactivity, even in absence of atopy. Lancet, 346, 1262-1265.
10. Cookson, W.O.C.M, Young, R.P., Sandford, A.J., Moffatt, M.F., Shirakawa, T., Sharp, P.A., Faux, J.A., Julier, C., le Souëf, P.N., Nakamura, Y., Lathrop, G.M. and Hopkin, J.M. (1992) Maternal inheritance of atopic IgE responsiveness on chromosome 11q. Lancet, 340, 381-384.
11. Sandford, A.J., Shirakawa, T., Moffatt, M.F., Daniels, S.E., Ra, C., Faux, J.A., Young, R.P., Nakamura, Y., Lathrop, G.M., Cookson, W.O.C.M. and Hopkin, J.M. (1993) Localisation of atopy and the beta subunit of the high affinity IgE receptor (FcεRI) on chromosome 11q. Lancet, 341, 332-334.
12. Shirakawa, T., Li, A., Dubowitz, M., Dekker, J.W., Shaw, A.W., Faux, J.A., Ra, C., Cookson, W.O.C.M. and Hopkin, J.M. (1994) Association between atopy and variants of the β subunit of the high affinity immunoglobulin E receptor. Nature Genet., 7, 125-129.
13. Hill, M.R., James, A.L., Faux, J.A., Ryan, G., Hopkin, J.M., le Souëf, P., Musk, A.W. and Cookson, W.O.C.M. (1995) FcεRI-β polymorphism and risk of atopy in a general population sample. Br. Med. J., 311, 776-779.
14. Hill, M.R. and Cookson, W.O.C.M. (1995) Atopy in Australia. Nature Genet., 10, 260.
15. Küster, H., Zhang, L., Brini, A.T., MacGlashan, D.W.J. and Kinet, J.P. (1992) The gene and cDNA for the human high affinity immunoglobulin E receptor β chain and expression of the complete human receptor. J. Biol. Chem., 267, 12782-12787.
16. Moffatt, M.F., Hill, M.R., Cornélis, F., Schou, C., Faux, J.A., Young, R.P., James, A.L., Ryan, G., leSouëf, P., Musk, A.W, Hopkin, J.M. and Cookson, W.O.C.M. (1994) Genetic linkage of T-cell receptor α/δ complex to specific IgE responses. Lancet, 343, 1597-1600.
17. Blank, U., Ra, C., Miller, L., White, K., Metzger, H. and Kinet, J.P. (1989) Complete structure and expression in transfected cells of high affinity IgE receptor. Nature, 337, 187-189.
18. Reth, M. (1989) Antigen receptor tail clue. Nature, 338, 383-384.
19. Jouvin, M.H.E., Adamczewski, M., Numerof, R., Letoumeur, O., Vallé, A. and Kinét, J.P. (1994) Differential control of the tyrosine kinases Lyn and Syk by the two signalling chains of the high affinity Immunoglobulin E receptor. J. Biol. Chem., 269, 5918-5925.
20. Cookson, W.O.C.M. and Hopkin, J.M. (1988) Dominant inheritance of atopic immunoglobulin-E responsiveness. Lancet, i. 86-88.
21. Cookson, W.O.C.M., de Klerk, N.H., Ryan, G.R., James, A.L. and Musk, A.W. (1991) Relative risks of bronchial hyperresponsiveness associated with skin-prick test responses to common antigens in young adults. Clin. Exp. Allergy, 21, 473-479.
22. Blin, N. and Stafford, D.W. (1976) A general method for isolation of high molecular weight DNA from eukaryotes. Nucleic Acids Res., 3, 2303.
23. Orita, M., Iwahana, H., Kanazawa, H., Hayashi, K. and Sekiya, T. (1989) Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Proc. Natl Acad. Sci. USA, 86, 2766-2770.
24. Sanger, F., Nicklen, S. and Coulson, A.R. (1977) DNA sequencing with chain-terminating inhibitors. Proc. Natl Acad. Sci. USA, 74, 5463-5467.
25. Newton, C.R., Graham, A., Heptinstall, L.E., Powell, S.J., Summers, C., Kalsheker, N., Smith, J.C. and Markham, A.F. (1989) Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS). Nucleic Acids Res., 17, 2503-2516.