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Volumn 21, Issue 10, 1997, Pages 865-873

RU-486 (Mifepristone) ameliorates diabetes but does not correct deficient β-adrenergic signalling in adipocytes from mature C57BL/6J-ob/ob mice

Author keywords

Adenylylcyclase; G proteins; Obesity; Receptor signalling

Indexed keywords

ADENYLATE CYCLASE; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; GLUCOCORTICOID ANTAGONIST; GLUCOSE; GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN; ISOPRENALINE; MESSENGER RNA; MIFEPRISTONE; RECEPTOR SUBTYPE;

EID: 0030772085     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0800479     Document Type: Article
Times cited : (47)

References (50)
  • 1
    • 0017042247 scopus 로고
    • The development of obesity, hyperinsulinemia, and hyperglycemia in ob/ob mice
    • Dubuc PU. The development of obesity, hyperinsulinemia, and hyperglycemia in ob/ob mice. Metabolism 1976; 25: 1567-1574.
    • (1976) Metabolism , vol.25 , pp. 1567-1574
    • Dubuc, P.U.1
  • 2
    • 0017608237 scopus 로고
    • Lipolysis and cyclic AMP levels in epididymal adipose tissue of obese-hyperglycaemic mice
    • Dehaye JP, Winand J, Christophe J. Lipolysis and cyclic AMP levels in epididymal adipose tissue of obese-hyperglycaemic mice. Diabetologia 1977; 13: 553-561.
    • (1977) Diabetologia , vol.13 , pp. 553-561
    • Dehaye, J.P.1    Winand, J.2    Christophe, J.3
  • 3
    • 0017610297 scopus 로고
    • Increased response of adipose tissue of the ob/ob mouse to the action of adrenaline after treatment with thyroxin
    • Begin-Heick N, Heick HM. Increased response of adipose tissue of the ob/ob mouse to the action of adrenaline after treatment with thyroxin. Can J Physiol Pharmacol 1977; 55: 1320-1329.
    • (1977) Can J Physiol Pharmacol , vol.55 , pp. 1320-1329
    • Begin-Heick, N.1    Heick, H.M.2
  • 4
    • 0013582877 scopus 로고
    • The influence of epinephrine and fasting on adipose tissue content and release of free fatty acids in obese-hyperglycemic and lean mice
    • Marshall NB, Engel FL. The influence of epinephrine and fasting on adipose tissue content and release of free fatty acids in obese-hyperglycemic and lean mice. J Lipid Res 1960; 1: 339-342.
    • (1960) J Lipid Res , vol.1 , pp. 339-342
    • Marshall, N.B.1    Engel, F.L.2
  • 5
    • 0026049423 scopus 로고
    • Alterations in mRNA levels, expression, and function of GTP-binding regulatory proteins in adipocytes from obese mice (C57BL/6J-ob/ob)
    • Gettys TW, Ramkumar V, Uhing RJ, Seger L, Taylor IL. Alterations in mRNA levels, expression, and function of GTP-binding regulatory proteins in adipocytes from obese mice (C57BL/6J-ob/ob). J Biol Chem 1991; 266: 15949-15955.
    • (1991) J Biol Chem , vol.266 , pp. 15949-15955
    • Gettys, T.W.1    Ramkumar, V.2    Uhing, R.J.3    Seger, L.4    Taylor, I.L.5
  • 6
    • 0028281432 scopus 로고
    • Impaired expression and functional activity of the β-3 and β-1 adrenergic receptor in adipose tissue of congenitally obese (C57BLJ6-ob/ob) mice
    • Collins S, Daniel KW, Rohlfs EM, Ramkumar V, Taylor IL, Gettys TW. Impaired expression and functional activity of the β-3 and β-1 adrenergic receptor in adipose tissue of congenitally obese (C57BLJ6-ob/ob) mice. Mol Endocrinol 1994; 8: 518-527.
    • (1994) Mol Endocrinol , vol.8 , pp. 518-527
    • Collins, S.1    Daniel, K.W.2    Rohlfs, E.M.3    Ramkumar, V.4    Taylor, I.L.5    Gettys, T.W.6
  • 7
    • 0026780384 scopus 로고
    • Inhibition by dexamethasone of β3-adrenergic receptor responsiveness in 3T3-F442A adipocytes. Evidence for a transcriptional mechanism
    • Feve B, Baude B, Krief S, Strosberg AD, Pairault J, Emorine LJ. Inhibition by dexamethasone of β3-adrenergic receptor responsiveness in 3T3-F442A adipocytes. Evidence for a transcriptional mechanism. J Biol Chem 1992; 267: 15909-15915.
    • (1992) J Biol Chem , vol.267 , pp. 15909-15915
    • Feve, B.1    Baude, B.2    Krief, S.3    Strosberg, A.D.4    Pairault, J.5    Emorine, L.J.6
  • 8
    • 0021336612 scopus 로고
    • Fat cell β adrenergic receptors in the hypothyroid rat
    • Malbon CC, Graziano MP, Johnson GL. Fat cell β adrenergic receptors in the hypothyroid rat. J Biol Chem 1984; 259: 3254-3260.
    • (1984) J Biol Chem , vol.259 , pp. 3254-3260
    • Malbon, C.C.1    Graziano, M.P.2    Johnson, G.L.3
  • 9
    • 0023121392 scopus 로고
    • Increased sensitivity of the genetically obese mouse to corticosterone
    • Tokuyama K, Himms-Hagen J. Increased sensitivity of the genetically obese mouse to corticosterone. Am J Physiol 1987; 252: E202-E208.
    • (1987) Am J Physiol , vol.252
    • Tokuyama, K.1    Himms-Hagen, J.2
  • 10
    • 0024456675 scopus 로고
    • Enhanced acute response to corticosterone in genetically obese (ob/ob) mice
    • Tokuyama K, Himms-Hagen J. Enhanced acute response to corticosterone in genetically obese (ob/ob) mice. Am J Physiol 1989; 257: E133-E138.
    • (1989) Am J Physiol , vol.257
    • Tokuyama, K.1    Himms-Hagen, J.2
  • 11
    • 0026545598 scopus 로고
    • Glucocorticoids in the CNS regulate BAT metabolism and plasma insulin in ob/ob mice
    • Walker HC, Romsos DR. Glucocorticoids in the CNS regulate BAT metabolism and plasma insulin in ob/ob mice. Am J Physiol 1992; 262: E110-E117.
    • (1992) Am J Physiol , vol.262
    • Walker, H.C.1    Romsos, D.R.2
  • 12
    • 0025684636 scopus 로고
    • Ineffectiveness of parenteral fluoxetine or RU-486 to alter long-term food intake, body weight or body composition of genetically obese mice
    • Dubuc PU, Peterson CM. Ineffectiveness of parenteral fluoxetine or RU-486 to alter long-term food intake, body weight or body composition of genetically obese mice. J Pharmacol Exp Ther 1990; 255: 976-979.
    • (1990) J Pharmacol Exp Ther , vol.255 , pp. 976-979
    • Dubuc, P.U.1    Peterson, C.M.2
  • 13
    • 0024556332 scopus 로고
    • Thermogenic effects of the antiglucocorticoid RU-486 in the rat: Involvement of corticortropin-releasing factor and sympathetic activation of brown adipose tissue
    • Hardwick AJ, Linton EA, Rothwell NJ. Thermogenic effects of the antiglucocorticoid RU-486 in the rat: involvement of corticortropin-releasing factor and sympathetic activation of brown adipose tissue. Endocrinology 1989; 124: 1684-1688.
    • (1989) Endocrinology , vol.124 , pp. 1684-1688
    • Hardwick, A.J.1    Linton, E.A.2    Rothwell, N.J.3
  • 14
    • 0025046510 scopus 로고
    • Effects of antiglucocorticoid RU 486 on development of obesity in obese fa/fa Zucker rats
    • Langley SC, York DA. Effects of antiglucocorticoid RU 486 on development of obesity in obese fa/fa Zucker rats. Am J Physiol 1990; 259: R539-R544
    • (1990) Am J Physiol , vol.259
    • Langley, S.C.1    York, D.A.2
  • 15
    • 0026633858 scopus 로고
    • Mifepristone (RU 486), a blocker of type II glucocorticoid and progestin receptors, reverses a dietary form of obesity
    • Okada S, York DA, Bray GA. Mifepristone (RU 486), a blocker of type II glucocorticoid and progestin receptors, reverses a dietary form of obesity. Am J Physiol Regul Integr Comp Physiol 1992; 262: R1106-R1110.
    • (1992) Am J Physiol Regul Integr Comp Physiol , vol.262
    • Okada, S.1    York, D.A.2    Bray, G.A.3
  • 17
    • 78651166782 scopus 로고
    • Metabolism of isolated fat cells. I. Effects of hormones on glucose metabolism and lipolysis
    • Rodbell M, Metabolism of isolated fat cells. I. Effects of hormones on glucose metabolism and lipolysis. J Biol Chem 1964; 239: 375-380.
    • (1964) J Biol Chem , vol.239 , pp. 375-380
    • Rodbell, M.1
  • 18
    • 0023140952 scopus 로고
    • Short-term feedback regulation of cAMP by accelerated degradation in rat tissues
    • Gettys TW, Blackmore PF, Redmon JB, Beebe SJ, Corbin JD Short-term feedback regulation of cAMP by accelerated degradation in rat tissues. J Biol Chem 1987; 262: 333-339.
    • (1987) J Biol Chem , vol.262 , pp. 333-339
    • Gettys, T.W.1    Blackmore, P.F.2    Redmon, J.B.3    Beebe, S.J.4    Corbin, J.D.5
  • 19
    • 0024747496 scopus 로고
    • Preparation of mammalian plasma membranes by aqueous two-phase partition
    • Morre DJ, Morre DM. Preparation of mammalian plasma membranes by aqueous two-phase partition. Biotechniques 1989; 7: 946-958.
    • (1989) Biotechniques , vol.7 , pp. 946-958
    • Morre, D.J.1    Morre, D.M.2
  • 20
    • 0023665166 scopus 로고
    • Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain
    • Goldsmith P, Gierschik P, Milligan G, Unson CG, Vinitsky R, Malech HL, Spiegel AM. Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain. J Biol Chem 1987; 262: 14683-14688.
    • (1987) J Biol Chem , vol.262 , pp. 14683-14688
    • Goldsmith, P.1    Gierschik, P.2    Milligan, G.3    Unson, C.G.4    Vinitsky, R.5    Malech, H.L.6    Spiegel, A.M.7
  • 22
    • 0028178975 scopus 로고
    • Characterization and use of crude alpha-subunit preparations for quantitative immunoblotting of G proteins
    • Gettys TW, Sheriff-Carter K, Moomaw J, Taylor IL, Raymond JR. Characterization and use of crude alpha-subunit preparations for quantitative immunoblotting of G proteins. Anal Biochem 1994; 220: 82-91.
    • (1994) Anal Biochem , vol.220 , pp. 82-91
    • Gettys, T.W.1    Sheriff-Carter, K.2    Moomaw, J.3    Taylor, I.L.4    Raymond, J.R.5
  • 23
    • 0025921771 scopus 로고
    • Purification of recombinant Gi-alpha and Go-alpha proteins from Escherichia coli
    • Linder ME, Gilman AG. Purification of recombinant Gi-alpha and Go-alpha proteins from Escherichia coli. Methods Enzymol 1991; 195: 202-215.
    • (1991) Methods Enzymol , vol.195 , pp. 202-215
    • Linder, M.E.1    Gilman, A.G.2
  • 24
    • 0023202996 scopus 로고
    • Isolation of GTP-binding proteins from myeloid HL-60 cells
    • Uhing RJ, Polakis PG, Snyderman R. Isolation of GTP-binding proteins from myeloid HL-60 cells. J Biol Chem 1987; 262: 15575-15579.
    • (1987) J Biol Chem , vol.262 , pp. 15575-15579
    • Uhing, R.J.1    Polakis, P.G.2    Snyderman, R.3
  • 25
    • 0023906372 scopus 로고
    • Chromatographic resolution and immunologie identification of the alpha-40 and alpha-41 subunits of guanine nucleotide-binding regulatory proteins
    • Mumby S, Pang I-K, Gilman AG, Sternweiss PC. Chromatographic resolution and immunologie identification of the alpha-40 and alpha-41 subunits of guanine nucleotide-binding regulatory proteins. J Biol Chem 1988; 263: 2020-2026.
    • (1988) J Biol Chem , vol.263 , pp. 2020-2026
    • Mumby, S.1    Pang, I.-K.2    Gilman, A.G.3    Sternweiss, P.C.4
  • 26
    • 0028985831 scopus 로고
    • Age-dependent changes in β-adrenergic receptor subtypes and adenylyl cyclase activation in adipocytes from Fischer 344 rats
    • Gettys TW, Rohlfs EM, Prpic V, Daniel KW, Taylor IL, Collins S. Age-dependent changes in β-adrenergic receptor subtypes and adenylyl cyclase activation in adipocytes from Fischer 344 rats. Endocrinology 1995; 136: 2022-2032.
    • (1995) Endocrinology , vol.136 , pp. 2022-2032
    • Gettys, T.W.1    Rohlfs, E.M.2    Prpic, V.3    Daniel, K.W.4    Taylor, I.L.5    Collins, S.6
  • 30
    • 0028324115 scopus 로고
    • Selective activation of inhibitory G protein alpha-subunits by partial agonists of the human 5-HRT1A receptor
    • Gettys TW, Fields TA, Raymond JR. Selective activation of inhibitory G protein alpha-subunits by partial agonists of the human 5-HRT1A receptor. Biochemistry 1994; 33: 4283-4290.
    • (1994) Biochemistry , vol.33 , pp. 4283-4290
    • Gettys, T.W.1    Fields, T.A.2    Raymond, J.R.3
  • 31
    • 0022534266 scopus 로고
    • Adrenalectomy reduces but does not reverse obesity in ob/ob mice
    • Dubuc PU, Wilden NJ. Adrenalectomy reduces but does not reverse obesity in ob/ob mice. Int J Obesity 1986; 10: 91-98.
    • (1986) Int J Obesity , vol.10 , pp. 91-98
    • Dubuc, P.U.1    Wilden, N.J.2
  • 32
    • 0021238950 scopus 로고
    • Adrenalectomy and food restriction in the genetically obese (ob/ob) mouse
    • Saito M, Bray GA. Adrenalectomy and food restriction in the genetically obese (ob/ob) mouse. Am J Physiol 1984; 248: E20-E25.
    • (1984) Am J Physiol , vol.248
    • Saito, M.1    Bray, G.A.2
  • 33
    • 0026507487 scopus 로고
    • Pathophysiology of obesity
    • Bray GA. Pathophysiology of obesity. Am J Clin Nutr 1992; 55 Suppl.: 488S-494S.
    • (1992) Am J Clin Nutr , vol.55 , Issue.SUPPL.
    • Bray, G.A.1
  • 34
    • 0015083628 scopus 로고
    • Genetically transmitted obesity in rodents
    • Bray GA, York DA. Genetically transmitted obesity in rodents. Physiol Rev 1979; 51: 598-646.
    • (1979) Physiol Rev , vol.51 , pp. 598-646
    • Bray, G.A.1    York, D.A.2
  • 35
    • 0028024916 scopus 로고
    • Dexamethasone down-regulation of insulin receptor substrate-1 in 3T3-L1 adipocytes
    • Turnbow MA, Keller SR, Rice KM, Garner CW. Dexamethasone down-regulation of insulin receptor substrate-1 in 3T3-L1 adipocytes. J Biol. Chem 1994; 269: 2516-2520.
    • (1994) J Biol. Chem , vol.269 , pp. 2516-2520
    • Turnbow, M.A.1    Keller, S.R.2    Rice, K.M.3    Garner, C.W.4
  • 36
    • 0027953703 scopus 로고
    • Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes
    • Kahn CR. Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes 1994; 43: 1066-1084.
    • (1994) Diabetes , vol.43 , pp. 1066-1084
    • Kahn, C.R.1
  • 37
    • 0028921575 scopus 로고
    • Enhanced sensitivity of pancreatic islets from preobese 2-week-old ob/ob mice to neurohormonal stimulation of insulin secretion
    • Chen NG, Romsos DR. Enhanced sensitivity of pancreatic islets from preobese 2-week-old ob/ob mice to neurohormonal stimulation of insulin secretion. Endocrinology 1995; 136: 505-511.
    • (1995) Endocrinology , vol.136 , pp. 505-511
    • Chen, N.G.1    Romsos, D.R.2
  • 38
    • 0026578767 scopus 로고
    • Insulin secretion from ob/ob mouse pancreatic islets: Effects of neurotransmitters
    • Tassava TM, Okuda T, Romsos DR. Insulin secretion from ob/ob mouse pancreatic islets: Effects of neurotransmitters. Am J Physiol Endocrinol Metab 1992; 262: E338-E343.
    • (1992) Am J Physiol Endocrinol Metab , vol.262
    • Tassava, T.M.1    Okuda, T.2    Romsos, D.R.3
  • 39
    • 0026403606 scopus 로고
    • Central glucocorticoid regulation of parasympathetic drive to pancreatic B-cells in the obese fa/fa rat
    • Stubbs M, York DA. Central glucocorticoid regulation of parasympathetic drive to pancreatic B-cells in the obese fa/fa rat. Int J Obesity 1991; 15: 547-553.
    • (1991) Int J Obesity , vol.15 , pp. 547-553
    • Stubbs, M.1    York, D.A.2
  • 40
    • 0028528816 scopus 로고
    • Decreased expression of insulin-sensitive glucose transporter mRNA (GLUT-4) in adipose tissue of non-insulin-dependent diabetic and obese patients: Evaluation by a simplified quantitative PCR assay
    • Giacchetti G, Faloia E, Taccaliti A, Morosini PP, Arnaldi G, Soletti F, Mantero F, Accili D, De Pirro R. Decreased expression of insulin-sensitive glucose transporter mRNA (GLUT-4) in adipose tissue of non-insulin-dependent diabetic and obese patients: Evaluation by a simplified quantitative PCR assay. J Endocrinol Invest 1994; 17: 709-715.
    • (1994) J Endocrinol Invest , vol.17 , pp. 709-715
    • Giacchetti, G.1    Faloia, E.2    Taccaliti, A.3    Morosini, P.P.4    Arnaldi, G.5    Soletti, F.6    Mantero, F.7    Accili, D.8    De Pirro, R.9
  • 41
    • 0026502258 scopus 로고
    • Alterations in glucose transporter expression and function in diabetes: Mechanisms for insulin resistance
    • Kahn BB. Alterations in glucose transporter expression and function in diabetes: Mechanisms for insulin resistance. J Cell Biochem 1992; 48: 122-128.
    • (1992) J Cell Biochem , vol.48 , pp. 122-128
    • Kahn, B.B.1
  • 42
    • 0026720656 scopus 로고
    • Tissue-specific regulation of glucose transporters in different forms of obesity
    • Kahn BB, Pedersen O. Tissue-specific regulation of glucose transporters in different forms of obesity. Proc Soc Exp Biol Med 1992; 200: 214-217.
    • (1992) Proc Soc Exp Biol Med , vol.200 , pp. 214-217
    • Kahn, B.B.1    Pedersen, O.2
  • 43
    • 0026681195 scopus 로고
    • Divergent regulation of the Glut 1 and Glut 4 glucose transporters in isolated adipocytes from Zucker rats
    • Pedersen O, Kahn CR, Kahn BB. Divergent regulation of the Glut 1 and Glut 4 glucose transporters in isolated adipocytes from Zucker rats. J Clin Invest 1992; 89: 1964-1973.
    • (1992) J Clin Invest , vol.89 , pp. 1964-1973
    • Pedersen, O.1    Kahn, C.R.2    Kahn, B.B.3
  • 44
    • 0029062839 scopus 로고
    • Transcriptional regulation of gene expression during adipocyte differentiation
    • MacDougal OA, Lane MD. Transcriptional regulation of gene expression during adipocyte differentiation. Annu Rev Biochem 1995; 64: 345-373.
    • (1995) Annu Rev Biochem , vol.64 , pp. 345-373
    • MacDougal, O.A.1    Lane, M.D.2
  • 45
    • 0021327070 scopus 로고
    • β-Adrenergic receptors: Biochemical mechanisms of physiological regulation
    • Stiles GL, Caron MG, Lefkowitz RJ. β-Adrenergic receptors: biochemical mechanisms of physiological regulation. Physiol Rev 1984; 64: 661-761.
    • (1984) Physiol Rev , vol.64 , pp. 661-761
    • Stiles, G.L.1    Caron, M.G.2    Lefkowitz, R.J.3
  • 46
    • 0023819348 scopus 로고
    • Beta-2 adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids
    • Collins S, Caron MG, Lefkowitz RJ. Beta-2 adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids. J Biol Chem 1988; 263: 9067-9070.
    • (1988) J Biol Chem , vol.263 , pp. 9067-9070
    • Collins, S.1    Caron, M.G.2    Lefkowitz, R.J.3
  • 48
    • 0028358937 scopus 로고
    • 3-adrenergic receptor expression in 3T3-F442A adipocytes: A mechanism for repressing the cAMP signalling pathway
    • 3-adrenergic receptor expression in 3T3-F442A adipocytes: A mechanism for repressing the cAMP signalling pathway. Proc Natl Acad Sci USA 1994; 91: 5677-5681.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 5677-5681
    • Fève, B.1    Elhadri, K.2    Quignard-Boulangé, A.3    Pairault, J.4
  • 50
    • 0023947758 scopus 로고
    • Regulation of the Beta-2 adrenergic receptor in the rat ventral prostate by testosterone
    • Collins S, Quarmby VE, French F, Lefkowitz RJ, Caron MG. Regulation of the Beta-2 adrenergic receptor in the rat ventral prostate by testosterone. FEBS Lett 1988; 233: 173-176.
    • (1988) FEBS Lett , vol.233 , pp. 173-176
    • Collins, S.1    Quarmby, V.E.2    French, F.3    Lefkowitz, R.J.4    Caron, M.G.5


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