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Volumn 11, Issue 1, 1997, Pages 29-36

Expression of the CYP19 (aromatase) gene: An unusual case of alternative promoter usage

Author keywords

estrogen formation; gene; ontogeny; phylogeny; splicing; tissue specific expression

Indexed keywords

AROMATASE; ESTROGEN;

EID: 0030635820     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.11.1.9034163     Document Type: Review
Times cited : (183)

References (67)
  • 1
    • 0016272566 scopus 로고
    • The involvement of human placental microsomal cytochrome P450 in aromatization
    • Thompson, E. A., Jr., and Siiteri, P. K. (1914) The involvement of human placental microsomal cytochrome P450 in aromatization. J. Biol. Chem. 249, 5373-5378
    • (1914) J. Biol. Chem. , vol.249 , pp. 5373-5378
    • Thompson Jr., E.A.1    Siiteri, P.K.2
  • 2
    • 0022393956 scopus 로고
    • Preparation and characterization of polyclonal and monoclonal antibodies against human aromatase cytochrome P-450 (P-450arom), and their use in its purification
    • Mendelson, C. R., Wright, E. E., Porter, J. C., Evans, C. T., and Simpson, E. R. (1985) Preparation and characterization of polyclonal and monoclonal antibodies against human aromatase cytochrome P-450 (P-450arom), and their use in its purification. Arch. Biochem. Biophys. 243, 480-491
    • (1985) Arch. Biochem. Biophys. , vol.243 , pp. 480-491
    • Mendelson, C.R.1    Wright, E.E.2    Porter, J.C.3    Evans, C.T.4    Simpson, E.R.5
  • 3
    • 0022475441 scopus 로고
    • Purification to homogeneity of aromatase from human placenta
    • Nakajin, S., Shimoda, M., and Hall, P. F. (1986) Purification to homogeneity of aromatase from human placenta. Biochem. Biophys. Res. Commun. 134, 704-710
    • (1986) Biochem. Biophys. Res. Commun. , vol.134 , pp. 704-710
    • Nakajin, S.1    Shimoda, M.2    Hall, P.F.3
  • 4
    • 0023180688 scopus 로고
    • Purification and characterization of human placental aromatase cytochrome P450
    • Kellis, J. T., Jr., and Vickery, L. E. (1987) Purification and characterization of human placental aromatase cytochrome P450. J. Biol. Chem. 262, 4413-4420
    • (1987) J. Biol. Chem. , vol.262 , pp. 4413-4420
    • Kellis Jr., J.T.1    Vickery, L.E.2
  • 6
    • 0016293443 scopus 로고
    • Utilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstenedione
    • Thompson, E. A., Jr., and Siiteri, P. K. (1974) Utilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstenedione. J. Biol. Chem. 249, 5364
    • (1974) J. Biol. Chem. , vol.249 , pp. 5364
    • Thompson Jr., E.A.1    Siiteri, P.K.2
  • 7
    • 0018076843 scopus 로고
    • Phylogenetic distribution of aromatase and other androgen-converting enyzmes in the central nervous sytem
    • Callard, G. V., Petro, Z., and Ryan, K. J. (1900) Phylogenetic distribution of aromatase and other androgen-converting enyzmes in the central nervous sytem. Endocrinology 103, 2283-2290
    • (1900) Endocrinology , vol.103 , pp. 2283-2290
    • Callard, G.V.1    Petro, Z.2    Ryan, K.J.3
  • 8
    • 0019123885 scopus 로고
    • Aromatization and 5a-reduction in brain and non-neural tissues of a cyclostome (Petromyzan marinus)
    • Callard, G. V., Petro, Z., and Ryan, K. J. (1980) Aromatization and 5a-reduction in brain and non-neural tissues of a cyclostome (Petromyzan marinus). Gen. Comp. Endocrinol. 42, 155-159
    • (1980) Gen. Comp. Endocrinol. , vol.42 , pp. 155-159
    • Callard, G.V.1    Petro, Z.2    Ryan, K.J.3
  • 9
    • 0019382028 scopus 로고
    • Aromatization is cyclic AMP-dependent in cultured reptilian brain cells
    • Callard, G. V. (1981) Aromatization is cyclic AMP-dependent in cultured reptilian brain cells. Brain Res. 204, 451-454
    • (1981) Brain Res. , vol.204 , pp. 451-454
    • Callard, G.V.1
  • 10
    • 0021198320 scopus 로고
    • In vitro conversion of androgen to estrogen in amphioxus gonadal tissue
    • Callard, G. V., Pudney, J. A., Kendell, S. L., and Reinboth, R. (1984) In vitro conversion of androgen to estrogen in amphioxus gonadal tissue. Gen. Comp. Endocrinol. 56, 53-58
    • (1984) Gen. Comp. Endocrinol. , vol.56 , pp. 53-58
    • Callard, G.V.1    Pudney, J.A.2    Kendell, S.L.3    Reinboth, R.4
  • 11
    • 0026308375 scopus 로고
    • Hormonal control of behavior: Steroid action in the brain
    • Hutchinson, J. B. (1991) Hormonal control of behavior: Steroid action in the brain. Curr. Opin. Neurobiol. I, 562-570
    • (1991) Curr. Opin. Neurobiol. , vol.1 , pp. 562-570
    • Hutchinson, J.B.1
  • 13
    • 0015984830 scopus 로고
    • Plasma precursors of estrogen. II. Correlation of the extent of conversion of plasma androstenedione to estrone with age
    • Hemsell, D. L., Grodin, J. M., Brenner, P. F., Siiteri, P. K., and MacDonald, P. C. (1974) Plasma precursors of estrogen. II. Correlation of the extent of conversion of plasma androstenedione to estrone with age. J. Clin. Endocrinol. Metab. 38, 476-479
    • (1974) J. Clin. Endocrinol. Metab. , vol.38 , pp. 476-479
    • Hemsell, D.L.1    Grodin, J.M.2    Brenner, P.F.3    Siiteri, P.K.4    MacDonald, P.C.5
  • 14
    • 0001820742 scopus 로고
    • The role of extraglandular estrogen in women in health and disease
    • (James, V. H. T., Serio, M., and Giusti, G., eds) Academic Press, London
    • Edman, C. D., and MacDonald, P. C. (1976) The role of extraglandular estrogen in women in health and disease. In The Endocrine Function of the Human Ovary (James, V. H. T., Serio, M., and Giusti, G., eds) pp. 135-140, Academic Press, London
    • (1976) The Endocrine Function of the Human Ovary , pp. 135-140
    • Edman, C.D.1    MacDonald, P.C.2
  • 15
    • 0023519279 scopus 로고
    • The importance of local synthesis of estrogen within the breast
    • Miller, W. R., and O'Neill, J. (1987) The importance of local synthesis of estrogen within the breast. Steroids 50, 537-548
    • (1987) Steroids , vol.50 , pp. 537-548
    • Miller, W.R.1    O'Neill, J.2
  • 16
    • 0024853552 scopus 로고
    • Structural analysis of the gene encoding human aromatase cytochrome P-450, the enzyme responsible for estrogen biosynthesis
    • Means, G. D., Mahendroo, M., Corbin, C. J., Mathis, J. M., Powell, F. E., Mendelson, C. R., and Simpson, E. R. (1989) Structural analysis of the gene encoding human aromatase cytochrome P-450, the enzyme responsible for estrogen biosynthesis. J. Biol. Chem. 264, 19385-19391
    • (1989) J. Biol. Chem. , vol.264 , pp. 19385-19391
    • Means, G.D.1    Mahendroo, M.2    Corbin, C.J.3    Mathis, J.M.4    Powell, F.E.5    Mendelson, C.R.6    Simpson, E.R.7
  • 19
    • 0026396006 scopus 로고
    • Tissue-specific promoters regulate aromatase cytochrome P450 gene expression in human ovary and fetal tissues
    • Means, G. D., Kilgore, M. W., Mahendroo, M. S., Mendelson, C. R., and Simpson, E. R. (1991) Tissue-specific promoters regulate aromatase cytochrome P450 gene expression in human ovary and fetal tissues. Mol. Endocrinol. 5, 2005-2013
    • (1991) Mol. Endocrinol. , vol.5 , pp. 2005-2013
    • Means, G.D.1    Kilgore, M.W.2    Mahendroo, M.S.3    Mendelson, C.R.4    Simpson, E.R.5
  • 20
    • 0026501834 scopus 로고
    • Alternative promotion of aromatase cytochrome P450 expression in human fetal tissues
    • Kilgore, M. W., Means, G. D., Mendelson, C. R., and Simpson, E. R. (1992) Alternative promotion of aromatase cytochrome P450 expression in human fetal tissues. Mol. Cell. Endocrinol. 83, R9-R16
    • (1992) Mol. Cell. Endocrinol. , vol.83
    • Kilgore, M.W.1    Means, G.D.2    Mendelson, C.R.3    Simpson, E.R.4
  • 21
    • 0027531920 scopus 로고
    • Molecular cloning of a cDNA showing alternative splicing of the 5′-untranslated sequence of mRNA for human aromatase P450
    • Toda, K., and Shizuta, Y. (1993) Molecular cloning of a cDNA showing alternative splicing of the 5′-untranslated sequence of mRNA for human aromatase P450. Eur. J. Biochem. 213, 383-389
    • (1993) Eur. J. Biochem. , vol.213 , pp. 383-389
    • Toda, K.1    Shizuta, Y.2
  • 22
    • 0027441909 scopus 로고
    • Exon-specific northern analysis and rapid amplification oi cDNa ends (RACE) reveal that the proximal promoter II (PII) is responsible for aromatase cytochrome P450 (CYP19) expression in human ovary
    • Jenkins, C., Michael, D., Mahendroo, M., and Simpson, E. (1993) Exon-specific northern analysis and rapid amplification oi cDNa ends (RACE) reveal that the proximal promoter II (PII) is responsible for aromatase cytochrome P450 (CYP19) expression in human ovary. Mol. Cell. Endocrinol. 97, R1-R6
    • (1993) Mol. Cell. Endocrinol. , vol.97
    • Jenkins, C.1    Michael, D.2    Mahendroo, M.3    Simpson, E.4
  • 23
    • 0025914639 scopus 로고
    • Tissue-specific expression of human P450arom: The promoter responsible for expression in adipose is different from that utilized in placenta
    • Mahendroo, M. S., Means, G. D., Mendelson, G. R., and Simpson, E. R. (1991) Tissue-specific expression of human P450arom: the promoter responsible for expression in adipose is different from that utilized in placenta. J. Biol. Chem. 266, 11276-11281
    • (1991) J. Biol. Chem. , vol.266 , pp. 11276-11281
    • Mahendroo, M.S.1    Means, G.D.2    Mendelson, G.R.3    Simpson, E.R.4
  • 24
    • 0027261356 scopus 로고
    • Tissue-specific and hormonally-controlled alternative promoters regulate aromatase cytochrome P450 gene expression in human adipose tissue
    • Mahendroo, M. S., Mendelson, C. R., and Simpson, E. R. (1993) Tissue-specific and hormonally-controlled alternative promoters regulate aromatase cytochrome P450 gene expression in human adipose tissue. J. Biol. Chem. 268, 19463-19470
    • (1993) J. Biol. Chem. , vol.268 , pp. 19463-19470
    • Mahendroo, M.S.1    Mendelson, C.R.2    Simpson, E.R.3
  • 25
    • 0027362649 scopus 로고
    • Tissue-specific expression of the human aromatase cytochrome P450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis
    • Harada, N., Utsume, T., and Takagi, Y. (1993) Tissue-specific expression of the human aromatase cytochrome P450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis. Proc. Natl. Acad. Sci. USA 90, 11312-11316
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 11312-11316
    • Harada, N.1    Utsume, T.2    Takagi, Y.3
  • 26
    • 0028032138 scopus 로고
    • Expression of the gene encoding aromatase cytochrome P450 (CYP19) in fetal tissues
    • Toda, K., Simpson, K. R., Mendelson, C. R., Shizuta, Y., and Kilgore, M. W. (1991) Expression of the gene encoding aromatase cytochrome P450 (CYP19) in fetal tissues. Mol. Endocrinol. 8, 210-217
    • (1991) Mol. Endocrinol. , vol.8 , pp. 210-217
    • Toda, K.1    Simpson, K.R.2    Mendelson, C.R.3    Shizuta, Y.4    Kilgore, M.W.5
  • 27
    • 0028225088 scopus 로고
    • Novel exon 1 of the aromatase gene specific for aromatase transcripts in human brain
    • Honda, S.-I., Harada, N., and Takagi, Y. (1994) Novel exon 1 of the aromatase gene specific for aromatase transcripts in human brain. Biochem. Biophys. Res. Commun. 198, 1133-1160
    • (1994) Biochem. Biophys. Res. Commun. , vol.198 , pp. 1133-1160
    • Honda, S.-I.1    Harada, N.2    Takagi, Y.3
  • 28
    • 85177006800 scopus 로고
    • Ad4BP/SK-1 regulates cyclic AMP-induced transcription from the proximal promoter (PII) of the human aromatase P450 (CYP19) gene in the ovary
    • Michael, M. D., Kilgore, M. W., Morohashi, K.-I., and Simpson, E. R. (1994) Ad4BP/SK-1 regulates cyclic AMP-induced transcription from the proximal promoter (PII) of the human aromatase P450 (CYP19) gene in the ovary. J. Biol. Chem. 270, 13061-13466
    • (1994) J. Biol. Chem. , vol.270 , pp. 13061-13466
    • Michael, M.D.1    Kilgore, M.W.2    Morohashi, K.-I.3    Simpson, E.R.4
  • 29
    • 0026647326 scopus 로고
    • Determination of aromatase cytochrome P450 messenger RNA in human breast tissues by competitive polymerase chain reaction (PCR) amplification
    • Price, T., Aitken, J., Head, J., Mahendroo, M. S., Means, G. D., and Simpson, E. R. (1992) Determination of aromatase cytochrome P450 messenger RNA in human breast tissues by competitive polymerase chain reaction (PCR) amplification. J. Clin. Endocrinol. Metab. 74, 1247-1252
    • (1992) J. Clin. Endocrinol. Metab. , vol.74 , pp. 1247-1252
    • Price, T.1    Aitken, J.2    Head, J.3    Mahendroo, M.S.4    Means, G.D.5    Simpson, E.R.6
  • 31
    • 0001246894 scopus 로고
    • Estrogen formation in stromal cells of adipose tissue of women: Induction by glucocorticosteroids
    • Simpson, E. R., Ackerman, G. E., Smith, M. E., and Mendelson, C. R. (1981) Estrogen formation in stromal cells of adipose tissue of women: induction by glucocorticosteroids. Proc. Natl. Acad. Sci. USA 78, 5690-5694
    • (1981) Proc. Natl. Acad. Sci. USA , vol.78 , pp. 5690-5694
    • Simpson, E.R.1    Ackerman, G.E.2    Smith, M.E.3    Mendelson, C.R.4
  • 32
    • 0028919673 scopus 로고
    • Characterization of the sequences of the human CYP19 (aromatase) gene that mediate regulation by glucocorticoids in adipose stromal cells and fetal hepatocytes
    • Zhao, Y., Mendelson, C. R., and Simpson, E. R. (1995) Characterization of the sequences of the human CYP19 (aromatase) gene that mediate regulation by glucocorticoids in adipose stromal cells and fetal hepatocytes. Mol. Endocrinol. 9, 340-349
    • (1995) Mol. Endocrinol. , vol.9 , pp. 340-349
    • Zhao, Y.1    Mendelson, C.R.2    Simpson, E.R.3
  • 33
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell, J. E., Jr., Kerr, I. M., and Stark, G. R. (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1420
    • (1994) Science , vol.264 , pp. 1415-1420
    • Darnell Jr., J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 34
    • 0026725868 scopus 로고
    • Proteins of transcription factor ISGF-3: One gene encodes the 91- and 84 kDa ISGF-3 proteins that are activated by interferon alpha
    • Schindler, C., Fu, X.-Y., Improta, T., Aebersold, R., and Darnell, J. E., Jr. (1992) Proteins of transcription factor ISGF-3: One gene encodes the 91- and 84 kDa ISGF-3 proteins that are activated by interferon alpha. Proc. Natl. Acad. Sci. USA 89, 7836-7839
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 7836-7839
    • Schindler, C.1    Fu, X.-Y.2    Improta, T.3    Aebersold, R.4    Darnell Jr., J.E.5
  • 35
    • 0028284762 scopus 로고
    • STAT3 and STAT4: Members of the family of signal transducers and activators of transcription
    • Zhong, Z., Wen, Z., and Darnell, J. E. (1994) STAT3 and STAT4: Members of the family of signal transducers and activators of transcription. Proc. Natl. Acad. Sci. USA 91, 4806-4810
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 4806-4810
    • Zhong, Z.1    Wen, Z.2    Darnell, J.E.3
  • 36
    • 0028044678 scopus 로고
    • Competitive RT-PCR analysis indicates levels of aromatase cytochrome P450 transcripts in adipose tissue of buttocks, thighs, and abdomen of women increase with advancing age
    • Bulun, S. E., and Simpson, E. R. (1994) Competitive RT-PCR analysis indicates levels of aromatase cytochrome P450 transcripts in adipose tissue of buttocks, thighs, and abdomen of women increase with advancing age. J. Clin. Endocrinol. Metab. 78, 428-432
    • (1994) J. Clin. Endocrinol. Metab. , vol.78 , pp. 428-432
    • Bulun, S.E.1    Simpson, E.R.2
  • 37
    • 0027131199 scopus 로고
    • A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription
    • Bulun, S. E., Price, T. M., Mahendroo, M. S., Aitken, J., and Simpson, E. R. (1993) A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription. J. Clin. Endocrinol. Metab. 77, 1622-1628
    • (1993) J. Clin. Endocrinol. Metab. , vol.77 , pp. 1622-1628
    • Bulun, S.E.1    Price, T.M.2    Mahendroo, M.S.3    Aitken, J.4    Simpson, E.R.5
  • 38
    • 0028319003 scopus 로고
    • Regulation of the CYP19 (P450arom) gene expression in breast adipose tissue and breast cancer
    • Bulun, S. K., and Simpson, E. R. (1994) Regulation of the CYP19 (P450arom) gene expression in breast adipose tissue and breast cancer. Trends Endocrinol. Metab. 5, 113-120
    • (1994) Trends Endocrinol. Metab. , vol.5 , pp. 113-120
    • Bulun, S.K.1    Simpson, E.R.2
  • 39
    • 0023831082 scopus 로고
    • Aromatase activity in adipose tissue from breast quadrants: A link with tumor site
    • O'Neill, J. S., Elton, R. A., and Miller, W. R. (1988) Aromatase activity in adipose tissue from breast quadrants: a link with tumor site. Br. Med. J. 296, 741-743
    • (1988) Br. Med. J. , vol.296 , pp. 741-743
    • O'Neill, J.S.1    Elton, R.A.2    Miller, W.R.3
  • 41
    • 0028302746 scopus 로고
    • Immunolocalization of aromatase and other steroidogenic enzymes in human breast disorders
    • Sasano, H., Nagura, H., Harada, N., Goukon, Y., and Kimura, M. (1991) Immunolocalization of aromatase and other steroidogenic enzymes in human breast disorders. Human Pathol. 25, 530-535
    • (1991) Human Pathol. , vol.25 , pp. 530-535
    • Sasano, H.1    Nagura, H.2    Harada, N.3    Goukon, Y.4    Kimura, M.5
  • 45
    • 0027328343 scopus 로고
    • The alphas, betas, and kinases of cytokine receptor complexes
    • Stahl, N., and Yancopoulos, G. D. (1993) The alphas, betas, and kinases of cytokine receptor complexes. Cell 74, 587-590
    • (1993) Cell , vol.74 , pp. 587-590
    • Stahl, N.1    Yancopoulos, G.D.2
  • 46
    • 0026485304 scopus 로고
    • Interleukin-6 and its receptor: A paradigm for cytokines
    • Kishimolo, T., Akira, S., and Taga, T. (1992) Interleukin-6 and its receptor: a paradigm for cytokines. Science 258, 593-597
    • (1992) Science , vol.258 , pp. 593-597
    • Kishimolo, T.1    Akira, S.2    Taga, T.3
  • 48
    • 0029002074 scopus 로고
    • Aromatase P450 gene expression in human adipose tissue: Role of a Jak/STAT pathway in regulation of the adipose-specific promoter
    • Zhao, Y., Nichols, J. E., Bulun, S. E., Mendelson, C. R., and Simpson, E. R. (1995) Aromatase P450 gene expression in human adipose tissue: Role of a Jak/STAT pathway in regulation of the adipose-specific promoter. J. Biol. Chem. 270, 16449-16457
    • (1995) J. Biol. Chem. , vol.270 , pp. 16449-16457
    • Zhao, Y.1    Nichols, J.E.2    Bulun, S.E.3    Mendelson, C.R.4    Simpson, E.R.5
  • 49
    • 0028029813 scopus 로고
    • Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes
    • Beadling, C., Guschin, D., Witthuhn, B. A., Ziemieckic A., Ihle, J. N., Kerr, I. M., and Cantrell, D. A. (1994) Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes. EMBO J. 13, 5605-5615
    • (1994) EMBO J. , vol.13 , pp. 5605-5615
    • Beadling, C.1    Guschin, D.2    Witthuhn, B.A.3    Ziemieckic, A.4    Ihle, J.N.5    Kerr, I.M.6    Cantrell, D.A.7
  • 50
    • 0028279791 scopus 로고
    • Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors
    • Boulton, T. G., Stahl, N. S., and Yancopoulos, G. D. (1994) Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. J. Biol. Chem. 269, 11648-11655
    • (1994) J. Biol. Chem. , vol.269 , pp. 11648-11655
    • Boulton, T.G.1    Stahl, N.S.2    Yancopoulos, G.D.3
  • 51
    • 0028931604 scopus 로고
    • Modular tyrosine-based motifs in cytokine receptor specify choice of STATs and other substrates
    • Stahl, N., Farruggella, T., Boulton, T. G., Zhong, Z., Darnell, J. E., and Yancopoulos, G. D. (1995) Modular tyrosine-based motifs in cytokine receptor specify choice of STATs and other substrates. Science 267, 1349-1353
    • (1995) Science , vol.267 , pp. 1349-1353
    • Stahl, N.1    Farruggella, T.2    Boulton, T.G.3    Zhong, Z.4    Darnell, J.E.5    Yancopoulos, G.D.6
  • 52
    • 0024385223 scopus 로고
    • Aromatase activity in microsomal preparations of human genital skin fibroblasts: Influence of glucocorticoids
    • Berkovitz, G. D., Bisat, T., and Carter, K. M. (1989) Aromatase activity in microsomal preparations of human genital skin fibroblasts: Influence of glucocorticoids. J. Steroid Biochem. 33, 341-347
    • (1989) J. Steroid Biochem. , vol.33 , pp. 341-347
    • Berkovitz, G.D.1    Bisat, T.2    Carter, K.M.3
  • 53
    • 0022253816 scopus 로고
    • Factors affecting the conversion of androstenedione to estrogens by human fetal hepatocytes in monolayer culture
    • Lanoux, M. J., Cleland, W. H., Mendelson, C. R., Carr, B. R., and Simpson, E. R. (1985) Factors affecting the conversion of androstenedione to estrogens by human fetal hepatocytes in monolayer culture. Endocrinology 117, 361-367
    • (1985) Endocrinology , vol.117 , pp. 361-367
    • Lanoux, M.J.1    Cleland, W.H.2    Mendelson, C.R.3    Carr, B.R.4    Simpson, E.R.5
  • 54
    • 0027099861 scopus 로고
    • A unique aromatase (P450arom) mRNA formed by alternative use of tissue specific exons I in human skin fibroblasts
    • Harada, N. (1992) A unique aromatase (P450arom) mRNA formed by alternative use of tissue specific exons I in human skin fibroblasts. Biochem. Biophys. Res. Commun. 189, 1001-1007
    • (1992) Biochem. Biophys. Res. Commun. , vol.189 , pp. 1001-1007
    • Harada, N.1
  • 55
    • 0027526513 scopus 로고
    • Cis-acting elements of the rat aromatase promoter required for cAMP induction in ovarian granulosa cells and constitutive expression in R2C Leydig cells
    • Fitzpatrick, S. L., and Richards, J. S. (1993) Cis-acting elements of the rat aromatase promoter required for cAMP induction in ovarian granulosa cells and constitutive expression in R2C Leydig cells. Mol. Endocrinol. 7, 341-354
    • (1993) Mol. Endocrinol. , vol.7 , pp. 341-354
    • Fitzpatrick, S.L.1    Richards, J.S.2
  • 56
    • 0027247823 scopus 로고
    • Interleukin-11 inhibits adipogenesis and stimulates myelopoiesis in human long-term marrow cultures
    • Keller, D. C., Du, X. X., Srour, E. F., Hoffman, R., and Williams, D. A. (1993) Interleukin-11 inhibits adipogenesis and stimulates myelopoiesis in human long-term marrow cultures. Blood 82, 1428-1435
    • (1993) Blood , vol.82 , pp. 1428-1435
    • Keller, D.C.1    Du, X.X.2    Srour, E.F.3    Hoffman, R.4    Williams, D.A.5
  • 58
    • 0008644663 scopus 로고
    • Comparison of aromatase cytochrome P450 mRNA levels in adipose tissue from the abdomen and buttock using competitive polymerase chain reaction amplification
    • 39th Annual Meeting, San Antonio, Texas, abstr.
    • Price, T., O'Brien, S., Dunaif, A., and Simpson, E. R. (1992) Comparison of aromatase cytochrome P450 mRNA levels in adipose tissue from the abdomen and buttock using competitive polymerase chain reaction amplification. 39th Annual Meeting, San Antonio, Texas, Proc. Soc. Gynecol. Invest., p. 179 (abstr.)
    • (1992) Proc. Soc. Gynecol. Invest. , pp. 179
    • Price, T.1    O'Brien, S.2    Dunaif, A.3    Simpson, E.R.4
  • 59
    • 0028273455 scopus 로고
    • The human breast cancer cell line MDA-MB 231 produces an aromatase stimulating activity
    • Schmidt, M., and Loffler, G. (1994) The human breast cancer cell line MDA-MB 231 produces an aromatase stimulating activity. Eur. J. Cell Biol. 63, 96-101
    • (1994) Eur. J. Cell Biol. , vol.63 , pp. 96-101
    • Schmidt, M.1    Loffler, G.2
  • 60
    • 0028957343 scopus 로고
    • Effects of conditioned medium from different cultured cell types on aromatase expression in adipose stromal cells
    • Nichols, J. E., Bulun, S. E., and Simpson, E. R. (1995) Effects of conditioned medium from different cultured cell types on aromatase expression in adipose stromal cells. J. Soc. Gynecol. Invest. 2, 45-50
    • (1995) J. Soc. Gynecol. Invest. , vol.2 , pp. 45-50
    • Nichols, J.E.1    Bulun, S.E.2    Simpson, E.R.3
  • 61
    • 0026557138 scopus 로고
    • Interleukin-1 and interleukin-6 in breast cyst fluid: Their role in regulating aromatase activity in breast cancer cells
    • Reed, M. J., Coldham, N. G., Patel, S. R., Ghilchik, M. W., and James, V. H. T. (1992) Interleukin-1 and interleukin-6 in breast cyst fluid: Their role in regulating aromatase activity in breast cancer cells. J. Endocrinol. 132, R5-R8
    • (1992) J. Endocrinol. , vol.132
    • Reed, M.J.1    Coldham, N.G.2    Patel, S.R.3    Ghilchik, M.W.4    James, V.H.T.5
  • 62
    • 0023284318 scopus 로고
    • Estrogenic regulation of growth and polypeptide growth factor secretion in human breast carcinoma
    • Dickson, K. B., and Lippman, M. E. (1987) Estrogenic regulation of growth and polypeptide growth factor secretion in human breast carcinoma. Endocr. Rev. 8, 29-43
    • (1987) Endocr. Rev. , vol.8 , pp. 29-43
    • Dickson, K.B.1    Lippman, M.E.2
  • 63
    • 0028303959 scopus 로고
    • A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation
    • Luo, X., Ikeda, Y., and Parker, K. L. (1994) A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 77, 481-490
    • (1994) Cell , vol.77 , pp. 481-490
    • Luo, X.1    Ikeda, Y.2    Parker, K.L.3
  • 64
    • 0028276035 scopus 로고
    • Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases
    • Ikeda, Y., Shen, W., Ingraham, H. A., and Parker, K. E. (1994) Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases. Mol. Endocrinol. 9, 656-662
    • (1994) Mol. Endocrinol. , vol.9 , pp. 656-662
    • Ikeda, Y.1    Shen, W.2    Ingraham, H.A.3    Parker, K.E.4
  • 65
    • 0028905825 scopus 로고
    • Structure and promoter analysis of the cytochrome P450 aromatase gene of the teleost fish, medaka (Oryzias latipes)
    • Tanaka, M., Fukada, S., Matsuyama, M., and Nagahama, Y. (1995) Structure and promoter analysis of the cytochrome P450 aromatase gene of the teleost fish, medaka (Oryzias latipes). J. Biochem. 117, 719-725
    • (1995) J. Biochem. , vol.117 , pp. 719-725
    • Tanaka, M.1    Fukada, S.2    Matsuyama, M.3    Nagahama, Y.4
  • 66
    • 0347678290 scopus 로고    scopus 로고
    • Evolutionary and functional significance of two CYP19 genes differentially expressed in brain and ovary of goldfish
    • Tahoe City, California, abstr.
    • Callard, G. V., and Tchoudakova, A. (1996) Evolutionary and functional significance of two CYP19 genes differentially expressed in brain and ovary of goldfish. Proceedings of the IVth International Aromatase Conference, Tahoe City, California, p. 20 (abstr.)
    • (1996) Proceedings of the IVth International Aromatase Conference , pp. 20
    • Callard, G.V.1    Tchoudakova, A.2
  • 67
    • 0029095016 scopus 로고
    • Functional ovarian and placental isoforms of porcine aromatase
    • Corbin, C. J., Khalil, M. W., and Conley, A. J. (1995) Functional ovarian and placental isoforms of porcine aromatase. Mol. Cell. Endocrinol. 113, 29-37
    • (1995) Mol. Cell. Endocrinol. , vol.113 , pp. 29-37
    • Corbin, C.J.1    Khalil, M.W.2    Conley, A.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.