MUS81 encodes a novel helix-hairpin-helix protein involved in the response to UV- and methylation-induced DNA damage in Saccharomyces cerevisiae

Molecular and General Genetics

Volumn 263, Issue 5, 2000, Pages 812-827

  Interthal, H ^a   Heyer, W D ^a,b  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

DNA repair; Helix hairpin Helix motif; Methylmethane sulfonate (MMS); Saccharomyces cerevisiae; UV radiation

Indexed keywords

ADENOSINE TRIPHOSPHATASE; HELIX LOOP HELIX PROTEIN; HELIX LOOP HELIX PROTEIN MUS81; MESYLIC ACID METHYL ESTER; UNCLASSIFIED DRUG;

ARTICLE; DNA DAMAGE; DNA METHYLATION; DNA REPAIR; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SPOROGENESIS; ULTRAVIOLET RADIATION;

ARABIDOPSIS THALIANA; CAENORHABDITIS ELEGANS; MAMMALIA; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE;

EID: 0033830809     PISSN: 00268925     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380000241     Document Type: Article

References (102)

1. Semi-dominant suppressors of Srs2 helicase mutations of Saccharomyces cerevisiae map in the RAD51 gene, whose sequence predicts a protein with similarities to procaryotic RecA protein
2. Mammalian DNA nucleotide excision repair reconstituted with purified protein components
3. Conserved domains in DNA repair proteins and evolution of repair systems
4. Saccharomyces cerevisiae cells lacking the homologous pairing protein p175(SEP1) arrest at pachytene during meiotic prophase
5. A Rad52 homolog is required for RAD51-independent mitotic recombination in Saccharomyces cerevisiae
6. Identification of functional domains in the Sep1 protein (= Kem1, Xrn1), which is required for transition through meiotic prophase in Saccharomyces cerevisiae
7. Nucleotide sequence and transcriptional regulation of the yeast recombinational repair gene RAD51
8. DMC1: A meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression
9. Identification of a Saccharomyces cerevisiae Ku80 homologue: Roles in DNA double strand break rejoining and in telomeric maintenance
10. A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae
11. Saccharomyces cerevisiae 3-methyladenine DNA glycosylase has homology to the AlkA glycosylase of E. coli and is induced in response to DNA alkylation damage
12. Repair of MMS-induced DNA double-strand breaks in haploid cells of Saccharomyces cerevisiae, which requires the presence of a duplicate genome
13. Recombinational repair in yeast: Functional interactions between Rad51 and Rad54 proteins
14. Repair systems in Saccharomyces
15. A comprehensive set of sequence analysis programs for the VAX
16. Reconstitution of the DNA base excision-repair pathway
17. The helix-hairpin-helix DNA-binding motif - A structural basis for non-sequence-specific recognition of DNA
18. Homotypic and heterotypic protein associations control Rad51 function in double-strand break repair
19. Evolution of the SNF2 family of proteins: Subfamilies with distinct sequences and functions
20. A novel genetic system to detect protein-protein interactions
21. Interpretation of the shape of survival curves in terms of induction and repair/misrepair of DNA double-strand breaks
22. Novel DNA polymerases offer clues to the molecular basis of mutagenesis
23. Towards a functional analysis of the yeast genome through exhaustive two-hybrid screens
24. DNA double-strand breaks and the RAD50-RAD57 genes in Saccharomyces
25. Synergistic interactions between RAD mutations in yeast
26. A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta
27. Generation of a strong mutator phenotype in yeast by imbalanced base excision repair
28. Interaction trap/two hybrid system to identify interacting proteins
29. Cdil, a human G1-phase and S-phase protein phosphatase that associates with Cdk2
30. In vivo biochemistry: Physical monitoring of recombination induced by site-specific endonucleases
31. Spontaneous mutation by mutagenic repair of spontaneous lesions in DNA
32. DNA repair and mutagenesis in yeast
33. Complex formation in yeast double-strand break repair: Participation of Rad51, Rad52, Rad55, and Rad57 proteins
34. Studies of the interaction between Rad52 protein and the yeast single-stranded DNA binding protein RPA
35. Saccharomyces cerevisiae LIF1: A function involved in DNA double-strand break repair related to mammalian XRCC4
36. Use of monoclonal antibodies in the functional characterization of the Saccharomyces cerevisiae Sep1 protein
37. DNA repair: RAD alert
38. Repair of interstrand cross-links in DNA of Saccharomyces cerevisiae requires two systems for DNA repair: The RAD3 system and the RAD51 system
39. Direct association between the yeast Rad51 and Rad54 recombination proteins
40. Strand exchange protein 1 from Saccharomyces cerevisiae. A novel multifunctional protein that contains DNA strand exchange and exonuclease activities
41. Functional differences and interactions among the putative RecA homologs RAD51, RAD55, and RAD57
42. Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae
43. Recombination and joining: Different means to the same end
44. Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: Evidence for functional conservation
45. Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases
46. Meiosis: How could it work?
47. Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6
48. The Drosophila melanogaster RAD54 homolog, DmRAD54, is involved in the repair of radiation damage and recombination
49. DNA glycosylases in the base excision repair of DNA
50. DNA sequence analysis of spontaneous mutagenesis in Saccharomyces cerevisiae
51. The distribution of the numbers of mutants in bacterial populations
52. The role of DNA repair genes in recombination between repeated sequences in yeast
53. Instability and decay of the primary structure of DNA
54. DNA excision repair pathways
55. Mutations of bacteria from virus sensitivity to virus resistance
56. Involvement of the Saccharomyces cerevisiae HDF1 gene in DNA double-strand break repair and recombination
57. The RAD52 gene is required for homothallic interconversion of mating types and spontaneous mitotic recombination in yeast
58. Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae
59. DNA polymerase beta in abasic site repair: A structurally conserved helix-hairpin-helix motif in lesion detection by base excision repair enzymes
60. Isolation of the Schizosaccharomyces pombe RAD54 homologue, rhp54((+)), a gene involved in the repair of radiation damage and replication fidelity
61. Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA repair protein superfamily
62. Thymine-thymine dimer bypass by yeast DNA polymerase zeta
63. Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A
64. Similarity of the yeast RAD51 filament to the bacterial RecA filament
65. Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis
66. Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP
67. Recombination in yeast
68. Catalysis of homologous pairing by yeast Rad51 and Rad54 proteins
69. Yeast Rad54 promotes Rad51-dependent homologous DNA pairing via ATP hydrolysis-driven change in DNA double helix conformation
70. Isolation and characterization of MMS-sensitive mutants of Saccharomyces cerevisiae
71. The yeast med1 mutant undergoes both meiotic homolog nondisjunction and precocious separation of sister chromatids
72. Roles for two RecA homologs in promoting meiotic chromosome synapsis
73. Meiotic chromosomes: It takes two to tango
74. Genetic control of diploid recovery after γ-irradiation in the yeast Saccharomyces cerevisiae
75. DNA excision repair
76. High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier
77. The Saccharomyces cerevisiae RAD54 gene is important but not essential for natural homothallic mating-type switching
78. Meiotic recombination in RAD54 mutants of Saccharomyces cerevisiae chromosoma
79. Stimulation by Rad52 of yeast Rad51-mediated recombination
80. Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein
81. Characterization of the roles of the Saccharomyces cerevisiae RAD54 gene and a homologue of RAD54, RDH54/TID1, in mitosis and meiosis
82. The Saccharomyces cerevisiae Ku autoantigen homologue affects radiosensitivity only in the absence of homologous recombination
83. A mitotic functions required in meiosis?
84. DNA structure-dependent requirements for yeast RAD genes in gene conversion
85. A single-stranded DNA-binding protein is needed for efficient presynaptic complex formation by the Saccharomyces cerevisiae Rad51 protein
86. Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein
87. Function of yeast Rad52 protein as a mediator between replication protein A and the Rad51 recombinase
88. DNA strand exchange mediated by a RAD51-ssDNA nucleoprotein filament with polarity opposite to that of RecA
89. Staurosporine-sensitive protein phosphorylation is required for postreplication DNA repair in human cells
90. Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae
91. Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure
92. How do DNA repair proteins locate damaged bases in the genome?
93. New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae
94. SGSI, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae
95. What to do at an end: DNA double-strand-break repair
96. Homothallic mating type switching generates lethal chromosome breaks in rad52 strains of Saccharomyces cerevisiae
97. DNA repair in eukaryotes
98. Which DNA polymerases are used for DNA-repair in eukaryotes?
99. Synergism between yeast nucleotide and base excision repair pathways in the protection against DNA methylation damage
100. The repair of DNA methylation damage in Saccharomyces cerevisiae