A novel endogenous antimalarial: Fe(II)-protoporphyrin IXα (heme) inhibits hematin polymerization to β-hematin (malaria pigment) and kills malaria parasites

Biochemistry

Volumn 38, Issue 28, 1999, Pages 8858-8863

  Monti, Diego ^a   Vodopivec, Bruno ^a   Basilico, Nicoletta ^a   Olliaro, Piero ^b   Taramelli, Donatella ^a,c  

^a UNIVERSITY OF MILAN   (Italy)

^b WORLD HEALTH ORGANIZATION   (Switzerland)

^c Istituto di Endocrinologia   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTIMALARIAL AGENT; ARTEMISININ; CHLOROQUINE; CYSTEINE; FERROUS ION; HEMATIN; HEME; HEMOZOIN; HOMOCYSTEINE; PROTOPORPHYRIN;

ARTICLE; CYCLIC POTENTIOMETRY; ELECTROCHEMISTRY; ERYTHROCYTE; HUMAN; HUMAN CELL; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN POLYMERIZATION;

ANIMALS; ANTIMALARIALS; ELECTROCHEMISTRY; ERYTHROCYTES; FERROUS COMPOUNDS; HEME; HEMIN; HUMANS; OXIDATION-REDUCTION; PIGMENTS, BIOLOGICAL; PLASMODIUM FALCIPARUM; POLYMERS; PROTOPORPHYRINS; SULFHYDRYL COMPOUNDS;

PLASMODIUM FALCIPARUM;

EID: 0033551480     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi990085k     Document Type: Article

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