Arsenic(III), but not antimony(III), induces DNA-protein crosslinks

Anticancer Research

Volumn 18, Issue 6 A, 1998, Pages 4253-4257

  Gebel, T ^a   Birkenkamp, P ^a   Luthin, S ^a   Dunkelberg, H ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Antimony; Arsenic; Comet assay; DNA protein crosslinks; Micronucleus test

Indexed keywords

ANTIMONY; ARSENIC; NEUTRAL RED;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; CROSS LINKING; CYTOKINESIS; CYTOTOXICITY; DNA REPAIR; DNA STRAND; GENOTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION;

ANIMALS; ANTIMONY; ARSENITES; CELL LINE; CHLORIDES; CRICETINAE; CRICETULUS; CROSS-LINKING REAGENTS; DNA; DNA REPAIR; DNA-BINDING PROTEINS; KINETICS; MICRONUCLEUS TESTS; SODIUM COMPOUNDS;

EID: 0032439879     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Elinder CG, Friberg L: Antimony. In: Handbook on the toxicology of metals. Vol. II: Specific Metals (Friberg L, Nordberg GF, Vouk VB, eds). Amsterdam, Elsevier, 1986, pp 26-42
2. Norseth T, Martinsen I: Biological monitoring of antimony. In: Biological monitoring of toxic metals. (Clarkson TW, Friberg L, Nordberg GF, Sager PR, eds). New York, Plenum Press, 1988, pp 337-367.
3. Kuroda K, Endo G, Okamoto A, Yoo YS, Horiguchi S: Genotoxicity of beryllium, gallium and antimony in short-term assays. Mutat Res 264: 163-170, 1991.
4. Rossman TG, Stone D, Molina M, Troll W: Absence of arsenite mutagenicity in E coli and Chinese hamster cells. Environ Mutagen 2: 371-379, 1981.
5. Lee TC, Oshimura M, Barrett JC: Comparison of arsenic-induced cell transformation, cytotoxicity, mutation and cytogenetic effects in Syrian hamster embryo cells in culture. Carcinogenesis 6: 1421-1426, 1985.
6. Gebel T: Arsenic and antimony: comparative approach on mechanistic toxicology. Chem Biol Interact 107: 131-144, 1997.
7. Hartwig A, Groeblinghoff UD, Beyersmann D, Natarajan AT, Filon R, Mullenders LH: Interaction of arsenic(III) with nucleotide excision repair in UV-irradiated human fibroblasts. Carcinogenesis 18: 399-405, 1997.
8. Lee Chen SF, Yu CT, Jan KY: Effect of arsenite on the DNA repair of UV-irradiated Chinese hamster ovary cells. Mutagenesis 7: 51-55, 1992.
9. Jones RD: Survey of antimony workers: mortality 1961-1992. Occup Environ Med 51: 772-776, 1994.
10. Schnorr TM, Steenland K, Thun MJ, Rinsky RA: Mortality in a cohort of antimony smelter workers. Am J Ind Med 27: 759-770, 1995.
11. Groth DH, Stettler LE, Burg JR, Busey WM, Grant GC, Wong L: Carcinogenic effects of antimony trioxide and antimony ore concentrate in rats. J Toxicol Environ Health 18: 607-626, 1986.
12. Newton PE, Bolte HF, Daly IW, Pillsbury BD, Terrill JB, Drew RT, Ben Dyke R, Sheldon AW, Rubin LF: Subchronic and chronic inhalation toxicity of antimony trioxide in the rat. Fundam Appl Toxicol 22: 561-576, 1994.
13. Gebel T: Suppression of arsenic-induced chromosome mutagenicity by antimony in V79 cells. Mutat Res 412: 213-218, 1998.
14. Fenech M: The cytokinesis-block technique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutat Res 285: 35-44, 1993.
15. Eastmond DA, Tucker JD: Identification of aneuploidy-inducing agents using cytokinesis-blocked human lymphocytes and an anti-kinetochore antibody. Environ Mol Mutagen 13: 34-43, 1989.
16. Singh NP, Stephens RE, Schneider EL: Modifications of alkaline microgel electrophoresis for sensitive detection of DNA damage. Int J Radiat Biol 66: 23-28, 1994.
17. Klaude M, Eriksson S, Nygren J, Ahnstrom G: The comet assay: mechanisms and technical considerations. Mutat Res 363: 89-96, 1996.
18. Gebel T, Kevekordes S, Schaefer J, von Platen H, Dunkelberg H: Assessment of a possible genotoxic environmental risk in sheep bred on grounds with strongly elevated contents of mercury, arsenic and antimony. Mutat Res 368: 267-74, 1996.
19. Dong JT, Luo XM: Arsenic-induced DNA-strand breaks associated with DNA-protein crosslinks in human fetal lung fibroblasts. Mutat Res 302: 97-102, 1993.
20. Oleinick ML, Chiu SM, Ramakrishnan N, and Xue LY: The formation, identification, and significance of DNA-protein cross-links in mammalian cells. British J Cancer (Suppl.) 8: 135-140, 1987.