Structural consequences of mono-glucosylation of Ha-Ras by Clostridium sordellii lethal toxin

Journal of Molecular Biology

Volumn 301, Issue 5, 2000, Pages 1091-1095

  Vetter, Ingrid R ^a   Hofmann, Fred ^b,c   Wohlgemuth, Sabine ^a   Herrmann, Christian ^a   Just, Ingo ^b,c  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Crystal structure; Effector loop; Guanine nucleotide; Ha Ras; Mono glucosylation

Indexed keywords

BACTERIAL TOXIN; GLUCOSE; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; PHOSPHOTRANSFERASE; PROTEIN KINASE; RAF PROTEIN; RAS PROTEIN;

ARTICLE; CLOSTRIDIUM SORDELLII; CRYSTAL STRUCTURE; ENZYME CONFORMATION; GLUCOSE TRANSPORT; GLYCOSYLATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; STEREOSPECIFICITY;

BACTERIA (MICROORGANISMS); CLOSTRIDIUM SORDELLII;

EID: 0034283341     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.4045     Document Type: Article

References (23)

1. Toxins from anaerobic bacteria: Specificity and molecular mechanisms of action
2. The structural basis of the activation of Ras by Sos
3. Crystallography and NMR system: A new software system for macromolecular structure determination
4. The CCP4 suite: Programs for protein crystallography
5. An extensively modified version of MOLSCRIPT that includes greatly enhanced coloring capabilities
6. Pseudomonas aeruginosa exoenzyme S ADP-ribosylates Ras at multiple sites
7. Functional consequences of monoglucosylation of H-Ras at effector domain amino acid threonine-35
8. The Ras-related protein Ral is monoglucosylated by Clostridium sordellii lethal toxin
9. Electron-density map interpretation
10. Glucosylation of Rho proteins by Clostridium difficile toxin B
11. The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins
12. Inactivation of Ras by Clostridium sordellii lethal toxin-catalyzed glucosylation
13. Automatic processing of rotation diffraction data from crytals of initially unknown symmetry and cell contents
14. Clostridium difficile colitis
15. Solution structure and dynamics of Ras p21 GDP determined by heteronuclear three- and four-dimensional NMR spectroscopy
16. Clostridium difficile
17. Molecular switch for signal transduction: Structural differences between active and inactive forms of protooncogenic Ras proteins
18. The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue
19. Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation
20. Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: Implications for the mechanism of GTP hydrolysis
21. Ras, Rap, and Rac small GTP-binding proteins are targets for Clostridium sordellii lethal toxin glucosylation
22. The Ras-RasGAP complex: Structural basis for GTPase activation and its loss in oncogenic Ras mutants
23. Clostridium novyi α-toxin-catalyzed incorporation of GlcNAc into Rho subfamily proteins