A novel cytotoxin from Clostridium difficile serogroup F is a functional hybrid between two other large clostridial cytotoxins

Journal of Biological Chemistry

Volumn 274, Issue 16, 1999, Pages 11046-11052

  Chaves Olarte, Esteban ^a,b   Löw, Peter ^c   Freer, Enrique ^b   Norlin, Thomas ^c   Weidmann, Manfred ^d   Von Eichel Streiber, Christoph ^d   Thelestam, Monica ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^c KAROLINSKA INSTITUTE   (Sweden)

^d JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIN; GUANINE NUCLEOTIDE BINDING PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CELL CULTURE; CHO CELL; CLOSTRIDIUM DIFFICILE; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FIBROBLAST; GLYCOSYLATION; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BINDING;

3T3 CELLS; ANIMALS; BACTERIAL TOXINS; BASE SEQUENCE; CELL ADHESION; CLOSTRIDIUM DIFFICILE; CYTOTOXINS; DNA PRIMERS; GLYCOSYLATION; MICE; MICROSCOPY, ELECTRON, SCANNING; RECOMBINANT FUSION PROTEINS;

ANIMALIA; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM SORDELLII;

EID: 0344766074     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.16.11046     Document Type: Article

References (21)

1. Eichel-Streiber, C. V., Boquet, P., Sauerborn, M., and Thelestam, M. (1996) Trends Microbiol. 4, 375-382
2. Theleatam, M., Florin, I., and Chaves-Olarte, E. (1997) in Bacterial Toxins: Tools in Cell Biology and Pharmacology (Aktories, K., ed), pp. 141-158, Chapman & Hall, Weinheim, Germany
3. Aktories, K., and Just, I. (1995) Trends Cell Biol. 5, 441-443
4. Just, I., Selzer, J., Wilm, M., Eichel-Streiber, C. V., Mann, M., and Aktories, K. (1995) Nature 375, 500-503
5. Popoff, M. R., Chaves-Olarte, E., Lemichez, E., Eichel-Streiber, C. V., Thelestam, M., Chardin, P., Cussac, D., Antonny, B., Chavrier, P., Flatau, G., Giry, M., Gunzburg, J., and Boquet, P. (1996) J. Biol. Chem. 271, 10217-10224
6. Just, I., Selzer, J., Hofmann, F., Green, G. A., and Aktories, K. (1996) J. Biol. Chem. 271, 10149-10153
7. Hofmann, F., Rex, G., Aktories, K., and Just, I. (1996) Biochem. Biophys. Res. Commun. 227, 77-81
8. Eichel-Streiber, C. V., Meyer, D., Habermann, E., and Sartingen, S. (1995) Mol. Microbiol. 17, 313-321
9. Depitre, C., Delmee, M., Avesani, V., Haridon, R. L., Roels, A., Popoff, M., and Corthier, G. (1993) J. Med. Microbiol. 38, 434-441
10. Sauerborn, M., Leukel, P., and Eichel-Streiber, Cv. (1997) FEMS Microbiol. Lett. 155, 45-54
11. Eichel-Streiber, C., Harperath, C., Bosse, D., and Hadding, U. (1987) Microb. Pathog. 2, 307-318
12. Huang, X., and Miller, W. (1991) Adv. Appl. Math. 12, 337-357
13. Chaves-Olarte, E., Florin, I., Boquet, P., Popoff, M., von Eichel-Streiber, C., and Thelestam, M. (1996) J. Biol. Chem. 271, 6925-6693
14. Laemmli, U. K. (1970) Nature 227, 680-685
15. O'Farrell, P. Z., Goodman, H. M., and O'Farrell, P. H. (1977) Methods Cell Biol. 16, 407-420
16. Chaves-Olarte, E., Weidmann, M., Eichel-Streiber, C. V., and Thelestam, M. (1997) J. Clin. Invest. 100, 1734-1741
17. Popoff, M. R. (1987) Infect. Immun. 55, 35-43
18. Giry, M., Popoff, M. R., Eichel-Streiber, C., and Boquet, P. (1995) Infect. Immun. 63, 4063-4071
19. Zhang, Z., Vuori, K., Wang, H. G., Reed, J. G., and Ruoslahti, E. (1996) Cell 85, 61-69
20. Lowe, D., Capon, D., Delwart, E., Sakaguchi, A., Naylor, S., and Goeddel, D. (1987) Cell 48, 137-146
21. Huff, S. Y., Quilliam, L. A., Cox, A. D., and Der, C. J. (1997) Oncogene 14, 133-143