Cannabinoid-precipitated withdrawal: A time-course study of the behavioral aspect and its correlation with cannabinoid receptors and G protein expression

Journal of Pharmacology and Experimental Therapeutics

Volumn 285, Issue 2, 1998, Pages 813-819

  Rubino, Tiziana ^a   Patrini, Gabriela ^a   Massi, Paola ^a   Fuzio, Domenica ^a   Viganò, Daniela ^a   Giagnoni, Gabriela ^a   Parolaro, Daniela ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID; CANNABINOID RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR DISORDER; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG DEPENDENCE; DRUG EFFECT; DRUG TOLERANCE; DRUG WITHDRAWAL; GENE EXPRESSION REGULATION; MALE; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

ANIMALS; BEHAVIOR, ANIMAL; CANNABINOIDS; GTP-BINDING PROTEINS; MALE; PIPERIDINES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; RNA, MESSENGER; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 0031809087     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. 2-tetrahydrocannabinol: Studies on precipitated and abrupt withdrawal. J Pharmacol Exp Ther 278:1290-1295.
2. Aceto MD, Scates SM, Lowe JA and Martin BR (1995) Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR141716A. Eur J Pharmacol 282:R1-R2.
3. Adams IB and Martin BR (1996) Cannabis: Pharmacology and toxicology in animals and humans. Addiction 91:1585-1614.
4. Compton DR, Aceto MD, Lowe J and Martin BR (1996) In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): inhibition of tetrahydrocannabinol-induced responses and apparent agonist activity. J Pharmacol Exp Ther 277:586-594.
5. Dewey WL (1986) Cannabinoid pharmacology. Pharmacol Rev 38:151-178.
6. Durnett Richardson J, Aanonsen L and Hargreaves KM (1997) SR141716A, a cannabinoid receptor antagonist, produces hyperalgesia in untreated mice. Eur J pharmacol 319:R3-R4.
7. Fan F, Tao Q, Abood M and Martin BR (1996) Cannabinoid receptor down-regulation without alteration of the inhibitory effect of CP-55,940 on adenylyl cyclase in the cerebellum of CP-55,940-tolerant mice. Brain Res 706:13-20.
8. Jones RT, Benowitz N and Bachman J (1976) Clinical studies of cannabis tolerance and dependence. Ann N Y Acad Sci 282:221-239.
9. 9-tetrahydrocannabinol-tolerant rats. Psychopharmacology 55:243-249.
10. Leite JR and Carlini EA (1974) Failure to obtain "cannabis directed behavior" and abstinence behavior in rats chronically treated with cannabis sativa extracts, Psychopharmacology 36:133-145.
11. 9-tetrahydrocannabinol: possible involvement of nigrostriatal dopaminergic alterations. Pharmacol Biochem Behav 45:291-298.
12. Oviedo A, Glowa J and Herkenam M (1993) Chronic cannabinoid administration alters cannabinoid receptor binding in rat brain: A quantitative autoradiographic study. Brain Res 616:293-302.
13. Parolaro D, Rubino T, Gori E, Massi P, Bendotti C, Patrini G, Marcozzi C and Parenti M (1993) In situ hybridization reveals specific increases in Gas and Gαo mRNA in discrete brain regions of morphine-tolerant rats. Eur J Pharmacol Mol Pharmacol Sect 244:211-222.
14. Rinaldi-Carmona, M, Barth F, Heaulme M, Shire D, Calandra B, Congy C, Martinez S, Maruani J, Neliat G, Caput D, Ferrara P, Soubrie P, Breliere JC and Le Fur G (1994) SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEES Lett 350:240-244.
15. 9-tetrahydrocannabinol treatment. Pharmacol Biochem Behav 47:33-40.
16. Rubino T, Massi P, Patrini G, Venier I, Giagnoni G and Parolaro D (1994) Chronic CP-55,940 alters cannabinoid receptors mRNA in the rat brain: an in situ hybridization study. Neuroreport 5:2493-2496.
17. Rubino T, Patrini G, Parenti M, Massi P and Parolaro D (1997) Chronic treatment with a synthetic cannabinoid CP-55,940 alters G protein expression in the rat central nervous system. Mol Brain Res 44:191-197.
18. 35S]GTPγS autoradiography in rat brain. J Neurosci 16:8057-8066.
19. 9-tetrahydrocannabinol precipitated by a cannabinoid receptor antagonist. Eur J Pharmacol 280:R13-R15.
20. Zar JH (1974) Biostatistical Analysis. Prentice-Hall, Englewood Cliffs, NJ.