Relative efficacies of cannabinoid CB1 receptor agonists in the mouse brain

European Journal of Pharmacology

Volumn 336, Issue 2-3, 1997, Pages 295-298

  Burkey, Thomas H ^a   Quock, Raymond M ^b   Consroe, Paul ^a   Ehlert, Frederick J ^c   Hosohata, Yoshiaki ^a   Roeske, William R ^a   Yamamura, Henry I ^a  

^a Departments of Pharmacology   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Brain; Cannabinoid receptor; Cannnbinoid; Drug efficacy; Mouse; Partial agonist; Tetrahydrocannabinol

Indexed keywords

4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; ANANDAMIDE; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR AGONIST; DEXANABINOL; DRONABINOL; GUANINE NUCLEOTIDE BINDING PROTEIN; RIMONABANT;

ANALGESIA; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR OCCUPANCY;

EID: 0030720938     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01255-7     Document Type: Article

References (15)

1. Abood M.E., Martin B.R. Neurobiology of marijuana abuse. TIPS. 13:1992;201-206.
2. 9-tetrahydrocannabinol is a partial agonist of cannabinoid receptors in mouse brain. Eur. J. Pharmacol. 323:1997;R3-R4.
3. 50) of an enzymatic reaction. Biochem. Pharmacol. 22:1973;3099-3108.
4. Dewey W. Cannabinoid pharmacology. Pharmacol. Rev. 38:1986;151-178.
5. Ehlert F.J. The relationship between muscarinic receptor occupancy and adenylate cyclase inhibition in the rabbit myocardium. Mol. Pharmacol. 28:1985;410-421.
6. Hollister L.E. Health aspects of cannabis. Pharmacol. Rev. 38:1986;1-20.
7. Mackie K., Hille B. Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells. Proc. Natl. Acad. Sci. USA. 89:1992;3825-3829.
8. Mackie K., Devane W.A., Hille B. Anandamide, an endogenous cannabinoid, inhibits calcium currents as a partial agonist in N18 neuroblastoma cells. Mol. Pharmacol. 44:1993;498-503.
9. Matsuda L.A., Lolait S.J., Brownstein M.J., Young A.C., Bonner T.I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature. 346:1990;561-564.
10. Pacheco M.A., Ward S.J., Childers S.R. Identification of cannabinoid receptors in cultures of rat cerebellar granule cells. Brain Res. 603:1993;102-110.
11. Rinaldi-Carmona M., Barth F., Héaulme M., Shire D., Calandra B., Congy C., Martinez S., Maruani J., Néliat G., Caput D., Ferrara P., Soubrié P., Brelière J.C., LeFur G. SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett. 350:1994;240-244.
12. 35S ]thio)triphosphate binding in rat brain membranes Life Sci. 59:1996;659-668.
13. 35S ]GTPγS autoradiography in rat brain J. Neurosci. 16:1996;8057-8066.
14. Stephenson R.P. A modification of receptor theory. Br. J. Pharmacol. 11:1956;379-393.
15. Welch S.P., Thomas C., Patrick G.S. Modulation of cannabinoid-induces antinociception after intracerebroventricular versus intrathecal administration to mice: Possible mechanisms for interaction with morphine. J. Pharmacol. Exp. Ther. 272:1995;310-321.