Polarized efflux of mono- and diacid metabolites of ME3229, an ester-type prodrug of a glycoprotein IIb/IIIa receptor antagonist, in rat small intestine

Journal of Pharmacology and Experimental Therapeutics

Volumn 295, Issue 2, 2000, Pages 717-723

  Okudaira, N ^a   Komiya, I ^a   Sugiyama, Y ^a  

^a MEIJI SEIKA KAISHA LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; 1 NAPHTHOL; BROMSULFOPHTHALEIN; DRUG METABOLITE; EF 5139; FIBRINOGEN RECEPTOR ANTAGONIST; GLYCOPROTEIN P; INDOMETACIN; ME 3229; ME 3277; PM 10; PM 11; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL TISSUE; ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG METABOLISM; DRUG PENETRATION; DRUG UPTAKE; INTESTINE EPITHELIUM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SMALL INTESTINE ABSORPTION; TRANSPORT KINETICS;

AMIDES; ANIMAL; BIOLOGICAL TRANSPORT; CACO-2 CELLS; FIBRINOLYTIC AGENTS; HUMAN; INDICATORS AND REAGENTS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; NAPHTHOLS; PIPERIDINES; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; SULFOBROMOPHTHALEIN; THIOPHENES;

EID: 0033771681     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Efflux of biscarboxyethyl-carboxyfluorescein (BCECF) by a novel ATP-dependent transport mechanism in epithelial cells
2. Drug exsorption from blood into the gastrointestinal tract
3. Intestinal absorption barriers and transport mechanisms, including secretory transport, for a cyclic peptide, fibrinogen antagonist
4. Polarized efflux of 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein from cultured epithelial cell monolayers
5. Hepatic, intestinal and renal transport of 1-naphthol-beta-D-glucuronide in mutant rats with hereditary-conjugated hyperbilirubinemia
6. Involvement of an organic anion transporter (canalicular multispecific organic anion tansporter/multidrug resistance-associated protein 2) in gastrointestinal secretion of glutathione conjugates in rats
7. Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2)
8. Hepatic expression of multidrug resistance-associated protein-like proteins maintained in Eisai hyperbilirubinemic rats
9. Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3)
10. ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3)
11. Age-dependent expression of P-glycoprotein gp170 in Caco-2 cell monolayers
12. The function of Gp170, the multidrugresistance gene product, in the brush border of rat intestinal mucosa
13. Intestinal secretion of drugs. The role of Pglycoprotein and related drug efflux systems in limiting oral drug absorption
14. Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR
15. Prodrug approach for αIIbβ3-peptidomimetic antagonists to enhance their transport in monolayers of a human intestinal cell line (Caco-2): Comparison of in vitro and in vivo data
16. Hepatic canalicular membrane 5: Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver
17. Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated drug resistance
18. The role of P-glycoprotein and canalicular multispecific organic anion transporter in the hepatobiliary excretion of drugs
19. Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells
20. A study of the intestinal absorption of an ester-type prodrug, ME3229 in rats: Active efflux transport as a cause of poor bioavailability of the active drug
21. Hepatobiliary secretion of organic compounds: Molecular mechanisms of membrane transport
22. In vitro and in vivo evaluations of intestinal barriers for the zwitterion L-767,679 and its carboxyl ester prodrug L-775,318. Roles of efflux and metabolism
23. The secretory intestinal transport of some beta-lactam antibiotics and anionic compounds: A mechanism contributing to poor oral absorption
24. Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins
25. Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine
26. Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2
27. Effect of cyclosporin analogues and FK506 on transcellular transport of daunorubicin and vinblastine via P-glycopretein
28. Cellular localization of the multidrug-resistance gene product Pglycoprotein in normal human tissues
29. Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics
30. Pharmacokinetics and pharmacodynamics of Ro 44-3888 after single ascending oral doses of sibrafiban, an oral platelet aggregation inhibitor, in healthy male volunteers